BR112022002013A2 - Anticorpo biespecífico anti-ctla4/anti-pd-1 e uso do mesmo - Google Patents

Anticorpo biespecífico anti-ctla4/anti-pd-1 e uso do mesmo

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Publication number
BR112022002013A2
BR112022002013A2 BR112022002013A BR112022002013A BR112022002013A2 BR 112022002013 A2 BR112022002013 A2 BR 112022002013A2 BR 112022002013 A BR112022002013 A BR 112022002013A BR 112022002013 A BR112022002013 A BR 112022002013A BR 112022002013 A2 BR112022002013 A2 BR 112022002013A2
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BR
Brazil
Prior art keywords
ctla4
antibody
bispecific
specifically
bispecific antibody
Prior art date
Application number
BR112022002013A
Other languages
English (en)
Inventor
Baiyong Li
Peng Zhang
Yu Xia
Zhongmin Wang
Original Assignee
Akeso Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Akeso Pharmaceuticals Inc filed Critical Akeso Pharmaceuticals Inc
Publication of BR112022002013A2 publication Critical patent/BR112022002013A2/pt

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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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Abstract

anticorpo biespecífico anti-ctla4/anti-pd-1 e uso do mesmo. a presente invenção refere-se ao campo de tratamento de tumores e imunologia molecular e, particularmente, a um anticorpo biespecífico anti-ctla4/anti-pd-1 e uso do mesmo. especificamente, o anticorpo bifuncional anti-ctla4/anti-pd-1 compreende uma primeira região funcional de proteína direcionada a pd-1 e uma segunda região funcional de proteína direcionada a ctla4, em que, de acordo com o sistema de numeração eu, a região constante da cadeia pesada da imunoglobulina compreendida no anticorpo biespecífico tem mutações em quaisquer 2 ou 3 das posições 234, 235 e 237, e a constante de afinidade do anticorpo biespecífico para fc¿riiia e/ou c1q é reduzida após a mutação em comparação com aquela antes da mutação. o anticorpo bifuncional da presente invenção pode se ligar bem e especificamente a ctla4 e pd-1, aliviar especificamente a imunossupressão de ctla4 e pd-1 em um organismo e ativar linfócitos t, tendo assim uma boa perspectiva de aplicação.
BR112022002013A 2019-08-02 2020-07-31 Anticorpo biespecífico anti-ctla4/anti-pd-1 e uso do mesmo BR112022002013A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910711122 2019-08-02
CN201911224135 2019-12-02
PCT/CN2020/106309 WO2021023117A1 (zh) 2019-08-02 2020-07-31 抗ctla4-抗pd-1双特异性抗体及其用途

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BR112022002013A2 true BR112022002013A2 (pt) 2022-03-29

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US (1) US20220275089A1 (pt)
EP (1) EP4008730A4 (pt)
JP (1) JP2022542450A (pt)
KR (1) KR20220053578A (pt)
CN (1) CN112300286A (pt)
AU (1) AU2020325350A1 (pt)
BR (1) BR112022002013A2 (pt)
CA (1) CA3146780A1 (pt)
IL (1) IL290255A (pt)
MX (1) MX2022001321A (pt)
WO (1) WO2021023117A1 (pt)

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EP4114464A4 (en) * 2020-03-05 2024-05-01 Merck Sharp & Dohme Llc METHOD OF TREATING CANCER WITH A COMBINATION OF A PD-1 ANTAGONIST, A CTLA4 ANTAGONIST AND LENVATINIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
BR112023018457A2 (pt) * 2021-03-12 2023-10-10 Akeso Biopharma Inc Combinação farmacêutica contendo anticorpo biespecífico anti-pd-1-anti-vegfa e uso da mesma
WO2022188867A1 (zh) * 2021-03-12 2022-09-15 中山康方生物医药有限公司 提高含有免疫球蛋白Fc片段的药物的安全性的方法
KR20230170648A (ko) * 2021-04-14 2023-12-19 아케소 바이오파마, 인크. 항-cd47 단일클론 항체 및 이의 용도
IL307494A (en) * 2021-04-14 2023-12-01 Akeso Pharmaceuticals Inc Antibody use in antitumor therapy
KR20240038043A (ko) 2021-07-23 2024-03-22 아케소 바이오파마, 인크. 약학적 조성물 및 용도
CN116637182A (zh) * 2022-02-24 2023-08-25 康方药业有限公司 包含抗ctla4-抗pd-1双特异性抗体和西奥罗尼的药物组合
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