JP2019532644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019532644A5 JP2019532644A5 JP2019517305A JP2019517305A JP2019532644A5 JP 2019532644 A5 JP2019532644 A5 JP 2019532644A5 JP 2019517305 A JP2019517305 A JP 2019517305A JP 2019517305 A JP2019517305 A JP 2019517305A JP 2019532644 A5 JP2019532644 A5 JP 2019532644A5
- Authority
- JP
- Japan
- Prior art keywords
- casx
- seq
- nucleic acid
- polypeptide
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022199477A JP7808332B2 (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402846P | 2016-09-30 | 2016-09-30 | |
| US62/402,846 | 2016-09-30 | ||
| PCT/US2017/054081 WO2018064371A1 (en) | 2016-09-30 | 2017-09-28 | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022199477A Division JP7808332B2 (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532644A JP2019532644A (ja) | 2019-11-14 |
| JP2019532644A5 true JP2019532644A5 (enExample) | 2020-11-12 |
Family
ID=61760962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517305A Pending JP2019532644A (ja) | 2016-09-30 | 2017-09-28 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2022199477A Active JP7808332B2 (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A Pending JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022199477A Active JP7808332B2 (ja) | 2016-09-30 | 2022-12-14 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2025133612A Pending JP2025166123A (ja) | 2016-09-30 | 2025-08-08 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US11873504B2 (enExample) |
| EP (1) | EP3523426A4 (enExample) |
| JP (3) | JP2019532644A (enExample) |
| KR (2) | KR20230170126A (enExample) |
| CN (1) | CN110023494A (enExample) |
| AU (1) | AU2017335890B2 (enExample) |
| BR (1) | BR112019006384A2 (enExample) |
| CA (1) | CA3038960A1 (enExample) |
| EA (1) | EA201990861A1 (enExample) |
| GB (1) | GB2569733B (enExample) |
| IL (1) | IL265598B2 (enExample) |
| MX (1) | MX2019003674A (enExample) |
| NZ (1) | NZ751946A (enExample) |
| WO (1) | WO2018064371A1 (enExample) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| EP3294896A1 (en) | 2015-05-11 | 2018-03-21 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| EP3919622A1 (en) | 2015-06-01 | 2021-12-08 | Temple University - Of The Commonwealth System of Higher Education | Methods and compositions for rna-guided treatment of hiv infection |
| KR102796744B1 (ko) | 2015-06-09 | 2025-04-15 | 에디타스 메디신, 인코포레이티드 | 이식의 개선을 위한 crispr/cas-관련 방법 및 조성물 |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| WO2017180694A1 (en) | 2016-04-13 | 2017-10-19 | Editas Medicine, Inc. | Cas9 fusion molecules gene editing systems, and methods of use thereof |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| JP2019532644A (ja) | 2016-09-30 | 2019-11-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| WO2018064352A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| SG11201903089RA (en) | 2016-10-14 | 2019-05-30 | Harvard College | Aav delivery of nucleobase editors |
| WO2018119010A1 (en) | 2016-12-19 | 2018-06-28 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3565907B1 (en) | 2017-01-06 | 2022-05-04 | Editas Medicine, Inc. | Methods of assessing nuclease cleavage |
| WO2018136396A2 (en) * | 2017-01-18 | 2018-07-26 | Excision Biotherapeutics, Inc. | Crisprs |
| US20190367924A1 (en) * | 2017-02-17 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| WO2018176009A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US11499151B2 (en) | 2017-04-28 | 2022-11-15 | Editas Medicine, Inc. | Methods and systems for analyzing guide RNA molecules |
| WO2018202800A1 (en) * | 2017-05-03 | 2018-11-08 | Kws Saat Se | Use of crispr-cas endonucleases for plant genome engineering |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| JP7518620B2 (ja) | 2017-06-09 | 2024-07-18 | エディタス・メディシン，インコーポレイテッド | 操作されたｃａｓ９ヌクレアーゼ |
| WO2019014564A1 (en) | 2017-07-14 | 2019-01-17 | Editas Medicine, Inc. | SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US11578334B2 (en) * | 2017-10-25 | 2023-02-14 | Monsanto Technology Llc | Targeted endonuclease activity of the RNA-guided endonuclease CasX in eukaryotes |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| US12227753B2 (en) | 2017-11-01 | 2025-02-18 | The Regents Of The University Of California | CasY compositions and methods of use |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| US11661599B1 (en) | 2017-12-14 | 2023-05-30 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR-Cas based system for targeting single-stranded sequences |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3755792A4 (en) | 2018-02-23 | 2021-12-08 | Pioneer Hi-Bred International, Inc. | NEW CAS9 ORTHOLOGIST |
| US11807877B1 (en) | 2018-03-22 | 2023-11-07 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR/Cas activity assays and compositions thereof |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| CA3101648A1 (en) | 2018-06-07 | 2019-12-12 | Arc Bio, Llc | Compositions and methods for making guide nucleic acids |
| US20190390193A1 (en) * | 2018-06-23 | 2019-12-26 | John Lawrence Mee | Reversible method for sustainable human cognitive enhancement |
| AU2019291918B2 (en) | 2018-06-29 | 2025-06-12 | Editas Medicine, Inc. | Synthetic guide molecules, compositions and methods relating thereto |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| US20210284981A1 (en) * | 2018-07-24 | 2021-09-16 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| WO2020028729A1 (en) | 2018-08-01 | 2020-02-06 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| EP3841205A4 (en) * | 2018-08-22 | 2022-08-17 | The Regents of The University of California | Variant type v crispr/cas effector polypeptides and methods of use thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN113166744B (zh) | 2018-12-14 | 2025-02-07 | 先锋国际良种公司 | 用于基因组编辑的新颖crispr-cas系统 |
| EP3931313A2 (en) | 2019-01-04 | 2022-01-05 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| MX2021008487A (es) | 2019-01-14 | 2021-11-12 | Univ Rochester | Escisión y poliadenilación del arn nuclear dirigido con crispr-cas. |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP4219700A1 (en) | 2019-03-07 | 2023-08-02 | The Regents of the University of California | Crispr-cas effector polypeptides and methods of use thereof |
| US20220145333A1 (en) | 2019-03-11 | 2022-05-12 | Sorrento Therapeutics, Inc. | Improved process for integration of dna constructs using rna-guided endonucleases |
| EP3942043A2 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CN113923983B (zh) * | 2019-04-03 | 2024-02-27 | 乔治亚大学研究基金公司 | 通过细胞外囊泡来递送crispr/mcas9以用于基因组编辑 |
| US20220186290A1 (en) | 2019-04-09 | 2022-06-16 | Arc Bio, Llc | Compositions and methods for nucleotide modification-based depletion |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| KR20220032050A (ko) | 2019-06-07 | 2022-03-15 | 스크라이브 테라퓨틱스 인크. | 조작된 casx 시스템 |
| JP2022536474A (ja) * | 2019-06-10 | 2022-08-17 | アクセス ツー アドバンスト ヘルス インスティチュート | アストロウイルスレプリコンの方法および組成物 |
| JP2022540153A (ja) * | 2019-07-11 | 2022-09-14 | アーバー バイオテクノロジーズ， インコーポレイテッド | 新規ｃｒｉｓｐｒ ｄｎａターゲティング酵素及びシステム |
| JP7630904B2 (ja) * | 2019-07-23 | 2025-02-18 | 株式会社東芝 | 核酸導入キャリア、核酸導入キャリアセット、核酸導入組成物及び核酸導入方法 |
| EP4028522A1 (en) * | 2019-09-09 | 2022-07-20 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of sod1 |
| AU2020344553A1 (en) * | 2019-09-09 | 2022-04-07 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| MX2022004549A (es) * | 2019-10-17 | 2022-07-21 | Pairwise Plants Services Inc | Variantes de nucleasas cas12a, metodos de fabricacion y uso de las mismas. |
| CN110669795A (zh) * | 2019-10-18 | 2020-01-10 | 福州大学 | 一种在鱼类胚胎中实现精确定点rna剪切的技术 |
| EP4069845A1 (en) | 2019-12-06 | 2022-10-12 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of rhodopsin |
| EP4069716A1 (en) | 2019-12-06 | 2022-10-12 | Scribe Therapeutics Inc. | Particle delivery systems |
| WO2021113769A1 (en) | 2019-12-07 | 2021-06-10 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of htt |
| IL292896A (en) * | 2019-12-23 | 2022-07-01 | Univ California | CRISPR-Cas execution poplipeptides and methods of using them |
| EP4085132A1 (en) * | 2019-12-30 | 2022-11-09 | DSM IP Assets B.V. | Lipase-modified strain |
| CN115427570A (zh) | 2020-01-10 | 2022-12-02 | 斯克里贝治疗公司 | 用于靶向pcsk9的组合物和方法 |
| WO2021152402A1 (en) * | 2020-01-29 | 2021-08-05 | Jenthera Therapeutics Inc. | Nuclease-scaffold composition delivery platform |
| CN115485300A (zh) | 2020-02-26 | 2022-12-16 | 索伦托药业有限公司 | 具有通用掩蔽部分的可活化的抗原结合蛋白 |
| EP4114173A1 (en) * | 2020-03-04 | 2023-01-11 | Regeneron Pharmaceuticals, Inc. | A rodent model of b4galt1-mediated functions |
| US20240247258A1 (en) * | 2020-03-12 | 2024-07-25 | Frest Inc. | Oligonucleotide and target rna site-specific editing method |
| CN116096885A (zh) * | 2020-03-18 | 2023-05-09 | 斯克里贝治疗公司 | 用于靶向C9orf72的组合物和方法 |
| WO2021217083A1 (en) | 2020-04-24 | 2021-10-28 | Sorrento Therapeutics, Inc. | Memory dimeric antigen receptors |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| CA3190477A1 (en) * | 2020-07-30 | 2022-02-03 | Adarx Pharmaceuticals, Inc. | Adar dependent editing compositions and methods of use thereof |
| CN116829707A (zh) | 2020-11-11 | 2023-09-29 | 孟山都技术公司 | 提高定点整合频率的方法 |
| EP4256045A4 (en) * | 2020-12-02 | 2025-01-08 | The Regents of the University of California | Crispr-cas effector polypeptides and methods of use thereof |
| PE20231178A1 (es) * | 2020-12-03 | 2023-08-01 | Scribe Therapeutics Inc | Sistemas crispr tipo v clase 2 disenados por ingenieria |
| GB2616795B (en) * | 2020-12-03 | 2025-08-13 | Scribe Therapeutics Inc | Compositions and methods for the targeting of BCL11A |
| WO2022120089A1 (en) * | 2020-12-03 | 2022-06-09 | Scribe Therapeutics Inc. | Compositions and methods for the targeting of ptbp1 |
| KR20230129395A (ko) * | 2020-12-09 | 2023-09-08 | 스크라이브 테라퓨틱스 인크. | 유전자 편집을 위한 aav 벡터 |
| AU2021409729A1 (en) | 2020-12-22 | 2023-07-13 | Nchroma Bio, Inc. | Compositions and methods for epigenetic editing |
| WO2022256440A2 (en) | 2021-06-01 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
| EP4351660A2 (en) | 2021-06-09 | 2024-04-17 | Scribe Therapeutics Inc. | Particle delivery systems |
| KR20240095525A (ko) | 2021-09-21 | 2024-06-25 | 스크라이브 테라퓨틱스 인크. | 조작된 casx 억제 시스템 |
| CN113969281B (zh) * | 2021-12-24 | 2022-04-01 | 汕头大学 | 经修饰的CrRNA片段及非洲猪瘟病毒试剂盒 |
| GB2634837A (en) | 2022-06-07 | 2025-04-23 | Scribe Therapeutics Inc | Compositions and methods for the targeting of PCSK9 |
| CN120712355A (zh) | 2023-02-15 | 2025-09-26 | 阿伯生物技术公司 | 用于抑制抑微管装配蛋白2（stmn2）转录物中的异常剪接的基因编辑方法 |
| WO2024206565A1 (en) * | 2023-03-29 | 2024-10-03 | Scribe Therapeutics Inc. | Repressor fusion protein systems |
| CN116926043B (zh) * | 2023-04-28 | 2024-09-06 | 新乡医学院第三附属医院 | 一种dCasX蛋白核酸酶、重组载体及其应用 |
| WO2024233366A2 (en) * | 2023-05-05 | 2024-11-14 | Aera Therapeutics, Inc. | Modified cas9-iid nucleases and uses thereof |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| CN119709771B (zh) * | 2024-10-24 | 2025-11-25 | 四川轻化工大学 | 马铃薯drm3基因及其在马铃薯保鲜中的应用 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| JP2004521606A (ja) | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Ｒｎａの検出法 |
| US6773885B1 (en) | 2000-09-29 | 2004-08-10 | Integrated Dna Technologies, Inc. | Compositions and methods for visual ribonuclease detection assays |
| CN1886512A (zh) | 2002-04-23 | 2006-12-27 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
| EP1580273A1 (en) | 2004-03-26 | 2005-09-28 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Peptide-based method for monitoring gene expression in a host cell |
| ZA200803368B (en) | 2005-10-07 | 2009-09-30 | Univ California | Nucleic acids encoding modified cytochrome P450 enzymes and methods of use thereof |
| US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| WO2010075303A1 (en) | 2008-12-23 | 2010-07-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Splicing factors with a puf protein rna-binding domain and a splicing effector domain and uses of same |
| WO2011100749A2 (en) | 2010-02-15 | 2011-08-18 | Cascade Biosystems, Inc. | Methods and materials for detecting viral or microbial infections |
| JP2013531983A (ja) | 2010-06-11 | 2013-08-15 | パソジェニカ，インコーポレイテッド | 多重生物検出のための核酸ならびにその使用および製造方法 |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| US9580714B2 (en) | 2010-11-24 | 2017-02-28 | The University Of Western Australia | Peptides for the specific binding of RNA targets |
| US9730967B2 (en) * | 2011-02-04 | 2017-08-15 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
| US8815782B2 (en) | 2011-11-11 | 2014-08-26 | Agilent Technologies, Inc. | Use of DNAzymes for analysis of an RNA sample |
| CA2873073A1 (en) | 2012-04-16 | 2013-10-24 | The University Of Western Australia | Peptides for the binding of nucleotide targets |
| LT3401400T (lt) | 2012-05-25 | 2019-06-10 | The Regents Of The University Of California | Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui |
| EP3135765A1 (en) | 2012-12-06 | 2017-03-01 | Sigma-Aldrich Co. LLC | Crispr-based genome modification and regulation |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| IL239317B (en) | 2012-12-12 | 2022-07-01 | Broad Inst Inc | Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications |
| WO2014093701A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| CN114634950A (zh) | 2012-12-12 | 2022-06-17 | 布罗德研究所有限公司 | 用于序列操纵的crispr-cas组分系统、方法以及组合物 |
| ES2576126T3 (es) | 2012-12-12 | 2016-07-05 | The Broad Institute, Inc. | Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| JP2016504026A (ja) | 2012-12-12 | 2016-02-12 | ザ・ブロード・インスティテュート・インコーポレイテッド | 配列操作のための系、方法および最適化ガイド組成物のエンジニアリング |
| EP2896697B1 (en) | 2012-12-12 | 2015-09-02 | The Broad Institute, Inc. | Engineering of systems, methods and optimized guide compositions for sequence manipulation |
| AU2013359146B2 (en) | 2012-12-13 | 2017-12-07 | Corteva Agriscience Llc | DNA detection methods for site specific nuclease activity |
| SG10201912991WA (en) | 2012-12-17 | 2020-03-30 | Harvard College | Rna-guided human genome engineering |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| EP2958996B1 (en) | 2013-02-25 | 2019-10-16 | Sangamo Therapeutics, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
| SG11201507378UA (en) | 2013-03-14 | 2015-10-29 | Caribou Biosciences Inc | Compositions and methods of nucleic acid-targeting nucleic acids |
| US20140349400A1 (en) | 2013-03-15 | 2014-11-27 | Massachusetts Institute Of Technology | Programmable Modification of DNA |
| US20140364333A1 (en) | 2013-03-15 | 2014-12-11 | President And Fellows Of Harvard College | Methods for Live Imaging of Cells |
| US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| US10378027B2 (en) | 2013-03-15 | 2019-08-13 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| US20140273230A1 (en) | 2013-03-15 | 2014-09-18 | Sigma-Aldrich Co., Llc | Crispr-based genome modification and regulation |
| US20140273235A1 (en) | 2013-03-15 | 2014-09-18 | Regents Of The University Of Minnesota | ENGINEERING PLANT GENOMES USING CRISPR/Cas SYSTEMS |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| RU2723130C2 (ru) | 2013-04-05 | 2020-06-08 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Способы и композиции для встраивания экзогенной последовательности в геном растений |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| CA2910427C (en) | 2013-05-10 | 2024-02-20 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| WO2014190181A1 (en) | 2013-05-22 | 2014-11-27 | Northwestern University | Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis |
| US11414695B2 (en) | 2013-05-29 | 2022-08-16 | Agilent Technologies, Inc. | Nucleic acid enrichment using Cas9 |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| CA2930877A1 (en) * | 2013-11-18 | 2015-05-21 | Crispr Therapeutics Ag | Crispr-cas system materials and methods |
| EP3835419A1 (en) | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
| US9850525B2 (en) | 2014-01-29 | 2017-12-26 | Agilent Technologies, Inc. | CAS9-based isothermal method of detection of specific DNA sequence |
| EP3126498A4 (en) | 2014-03-20 | 2017-08-23 | Université Laval | Crispr-based methods and products for increasing frataxin levels and uses thereof |
| WO2015157534A1 (en) | 2014-04-10 | 2015-10-15 | The Regents Of The University Of California | Methods and compositions for using argonaute to modify a single stranded target nucleic acid |
| WO2015191693A2 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| US20180320226A1 (en) | 2014-08-19 | 2018-11-08 | President And Fellows Of Harvard College | RNA-Guided Systems For Probing And Mapping Of Nucleic Acids |
| WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
| EP3230451B1 (en) | 2014-12-12 | 2021-04-07 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
| US11180792B2 (en) * | 2015-01-28 | 2021-11-23 | The Regents Of The University Of California | Methods and compositions for labeling a single-stranded target nucleic acid |
| AU2016279077A1 (en) | 2015-06-18 | 2019-03-28 | Omar O. Abudayyeh | Novel CRISPR enzymes and systems |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
| EP3436575A1 (en) | 2015-06-18 | 2019-02-06 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| IL293323B2 (en) | 2015-06-18 | 2024-01-01 | Massachusetts Inst Technology | Crispr enzyme mutations reducing off-target effects |
| US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
| CN109153980B (zh) | 2015-10-22 | 2023-04-14 | 布罗德研究所有限公司 | Vi-b型crispr酶和系统 |
| EP3400299B1 (en) | 2016-01-08 | 2020-11-11 | University of Georgia Research Foundation, Inc. | Methods for cleaving dna and rna molecules |
| US11441146B2 (en) * | 2016-01-11 | 2022-09-13 | Christiana Care Health Services, Inc. | Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system |
| US9896696B2 (en) * | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
| CN109312336A (zh) | 2016-02-23 | 2019-02-05 | 阿克生物公司 | 用于靶标检测的方法和组合物 |
| WO2017176529A1 (en) | 2016-04-06 | 2017-10-12 | Temple Univesity-Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
| US11371081B2 (en) | 2016-05-25 | 2022-06-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Portable, low-cost pathogen detection and strain identification platform |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| US11788083B2 (en) | 2016-06-17 | 2023-10-17 | The Broad Institute, Inc. | Type VI CRISPR orthologs and systems |
| ES2915562T3 (es) * | 2016-06-24 | 2022-06-23 | Univ Colorado Regents | Métodos para generar bibliotecas combinatorias con código de barras |
| US12431216B2 (en) | 2016-08-17 | 2025-09-30 | Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
| WO2018064352A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| JP2019532644A (ja) | 2016-09-30 | 2019-11-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| CN106701830B (zh) | 2016-12-07 | 2020-01-03 | 湖南人文科技学院 | 一种敲除猪胚胎p66shc基因的方法 |
| BR112018015871B1 (pt) | 2016-12-09 | 2021-12-07 | The Broad Institute, Inc. | Sistema, método e dispositivo para detectar a presença de uma sequência alvo de ácido nucleico em uma amostra |
| CN110914433A (zh) | 2017-03-24 | 2020-03-24 | 库尔维科公司 | 编码crispr相关蛋白质的核酸及其用途 |
| ES2992912T3 (en) | 2017-04-21 | 2024-12-19 | Massachusetts Gen Hospital | Variants of cpf1 (cas12a) with altered pam specificity |
| CN111373040B (zh) | 2017-08-09 | 2024-07-12 | 本森希尔股份有限公司 | 修饰基因组的组合物和方法 |
| US11970719B2 (en) | 2017-11-01 | 2024-04-30 | The Regents Of The University Of California | Class 2 CRISPR/Cas compositions and methods of use |
| US20200339967A1 (en) | 2017-11-01 | 2020-10-29 | The Regents Of The University Of California | Cas12c compositions and methods of use |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| US12227753B2 (en) | 2017-11-01 | 2025-02-18 | The Regents Of The University Of California | CasY compositions and methods of use |
| US10253365B1 (en) | 2017-11-22 | 2019-04-09 | The Regents Of The University Of California | Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs |
| CA3086550A1 (en) | 2017-12-22 | 2019-06-27 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
-
2017
- 2017-09-28 JP JP2019517305A patent/JP2019532644A/ja active Pending
- 2017-09-28 BR BR112019006384-6A patent/BR112019006384A2/pt not_active Application Discontinuation
- 2017-09-28 KR KR1020237041555A patent/KR20230170126A/ko not_active Ceased
- 2017-09-28 GB GB1905575.5A patent/GB2569733B/en active Active
- 2017-09-28 WO PCT/US2017/054081 patent/WO2018064371A1/en not_active Ceased
- 2017-09-28 MX MX2019003674A patent/MX2019003674A/es unknown
- 2017-09-28 EA EA201990861A patent/EA201990861A1/ru unknown
- 2017-09-28 CA CA3038960A patent/CA3038960A1/en active Pending
- 2017-09-28 IL IL265598A patent/IL265598B2/en unknown
- 2017-09-28 EP EP17857442.2A patent/EP3523426A4/en active Pending
- 2017-09-28 AU AU2017335890A patent/AU2017335890B2/en active Active
- 2017-09-28 US US16/335,516 patent/US11873504B2/en active Active
- 2017-09-28 KR KR1020197012244A patent/KR20190071725A/ko not_active Ceased
- 2017-09-28 NZ NZ751946A patent/NZ751946A/en unknown
- 2017-09-28 CN CN201780074116.1A patent/CN110023494A/zh active Pending
-
2018
- 2018-08-03 US US16/054,513 patent/US10570415B2/en active Active
-
2019
- 2019-05-24 US US16/422,824 patent/US11795472B2/en active Active
-
2022
- 2022-12-14 JP JP2022199477A patent/JP7808332B2/ja active Active
-
2023
- 2023-11-17 US US18/513,347 patent/US20240167052A1/en active Pending
-
2025
- 2025-08-08 JP JP2025133612A patent/JP2025166123A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019534695A5 (enExample) | ||
| JP2021121205A5 (enExample) | ||
| JP7154248B2 (ja) | 標的遺伝子座を修飾するための方法及び組成物 | |
| JP7095066B2 (ja) | 単一ステップの複数標的化を通じた標的化された遺伝子修飾のための方法及び組成物 | |
| US12173339B2 (en) | Variants of Cpf1 (Cas12a) with altered PAM specificity | |
| JP2024095765A (ja) | Ｓ．ピオゲネスｃａｓ９変異遺伝子及びこれによってコードされるポリペプチド | |
| US20220119785A1 (en) | Cas variants for gene editing | |
| JP2023153907A (ja) | Ｒｎａ標的化方法および組成物 | |
| JP2015503535A5 (enExample) | ||
| JP2023541400A5 (enExample) | ||
| JP2022522650A5 (enExample) | ||
| KR20190025565A (ko) | 프로그램가능한 dna 결합 단백질을 사용한, 표적화된 게놈 변형의 개선 | |
| AU2016297167A1 (en) | Editing mitochondrial DNA | |
| US20110059502A1 (en) | Multiple domain proteins | |
| US8975042B2 (en) | Fluorescent and colored proteins and methods for using them | |
| JP2022541273A5 (enExample) | ||
| US9771402B2 (en) | Fluorescent and colored proteins and methods for using them | |
| WO2020077138A2 (en) | Selective curbing of unwanted rna editing (secure) dna base editor variants | |
| WO2024198961A1 (zh) | 一种Cas蛋白及其突变体、其相应的基因编辑系统及应用 | |
| US20200199556A1 (en) | Rna targeting methods and compositions | |
| KR20210141536A (ko) | 타우 응집과 관련된 유전적 취약성을 식별하기 위한 CRISPR/Cas 드랍아웃 스크리닝 플랫폼 | |
| Wei et al. | Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals | |
| WO2024240053A1 (zh) | 一种基因编辑蛋白、其相应的基因编辑系统及应用 | |
| CN109402115B (zh) | 靶向Rett突变基因RNA的gRNA及Rett突变基因的检测方法、检测试剂盒 | |
| CN109295055B (zh) | 基于C2c2的肿瘤相关突变基因的gRNA、检测方法、检测试剂盒 |