CN110023494A - Rna指导的核酸修饰酶及其使用方法 - Google Patents

Rna指导的核酸修饰酶及其使用方法 Download PDF

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CN110023494A
CN110023494A CN201780074116.1A CN201780074116A CN110023494A CN 110023494 A CN110023494 A CN 110023494A CN 201780074116 A CN201780074116 A CN 201780074116A CN 110023494 A CN110023494 A CN 110023494A
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casx
activity
polypeptide
seq
cell
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J·A·多德纳
J·F·班菲尔德
D·伯斯坦
L·B·哈林顿
S·C·斯图特
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University of California San Diego UCSD
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CN201780074116.1A 2016-09-30 2017-09-28 Rna指导的核酸修饰酶及其使用方法 Pending CN110023494A (zh)

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US201662402846P 2016-09-30 2016-09-30
US62/402,846 2016-09-30
PCT/US2017/054081 WO2018064371A1 (en) 2016-09-30 2017-09-28 Rna-guided nucleic acid modifying enzymes and methods of use thereof

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US (4) US11873504B2 (enExample)
EP (1) EP3523426A4 (enExample)
JP (3) JP2019532644A (enExample)
KR (2) KR20190071725A (enExample)
CN (1) CN110023494A (enExample)
AU (1) AU2017335890B2 (enExample)
BR (1) BR112019006384A2 (enExample)
CA (1) CA3038960A1 (enExample)
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WO2021073173A1 (zh) * 2019-10-18 2021-04-22 福州大学 一种在鱼类胚胎中实现精确定点 rna 剪切的技术
CN113969281A (zh) * 2021-12-24 2022-01-25 汕头大学 经修饰的CrRNA片段及非洲猪瘟病毒试剂盒
CN114729368A (zh) * 2019-09-09 2022-07-08 斯克里贝治疗公司 用于免疫疗法的组合物和方法
CN114829595A (zh) * 2019-10-17 2022-07-29 成对植物服务股份有限公司 Cas12a核酸酶的变体及其制备方法和用途
CN114901816A (zh) * 2019-12-30 2022-08-12 帝斯曼知识产权资产管理有限公司 脂肪酶修饰的菌株
CN115175921A (zh) * 2019-12-06 2022-10-11 斯克里贝治疗公司 颗粒递送系统
CN115279184A (zh) * 2020-03-04 2022-11-01 雷杰纳荣制药公司 B4galt1介导的功能的啮齿动物模型
CN115698041A (zh) * 2019-12-23 2023-02-03 加利福尼亚大学董事会 Crispr-cas效应多肽及其使用方法
CN116926043A (zh) * 2023-04-28 2023-10-24 新乡医学院第三附属医院 一种dCasX蛋白核酸酶、重组载体及其应用
CN119709771A (zh) * 2024-10-24 2025-03-28 四川轻化工大学 马铃薯drm3基因及其在马铃薯保鲜中的应用

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US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
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US9840699B2 (en) 2013-12-12 2017-12-12 President And Fellows Of Harvard College Methods for nucleic acid editing
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AU2015330699B2 (en) 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
EP4464338A3 (en) 2014-11-07 2025-02-12 Editas Medicine, Inc. Systems for improving crispr/cas-mediated genome-editing
JP7030522B2 (ja) 2015-05-11 2022-03-07 エディタス・メディシン、インコーポレイテッド 幹細胞における遺伝子編集のための最適化ｃｒｉｓｐｒ／ｃａｓ９システムおよび方法
CA2987927C (en) 2015-06-01 2024-03-19 Temple University - Of The Commonwealth System Of Higher Education Methods and compositions for rna-guided treatment of hiv infection
CN108026526B (zh) 2015-06-09 2023-05-12 爱迪塔斯医药公司 用于改善移植的crispr/cas相关方法和组合物
AU2016326711B2 (en) 2015-09-24 2022-11-03 Editas Medicine, Inc. Use of exonucleases to improve CRISPR/Cas-mediated genome editing
IL258821B (en) 2015-10-23 2022-07-01 Harvard College Nucleobase editors and their uses
WO2017165826A1 (en) 2016-03-25 2017-09-28 Editas Medicine, Inc. Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
EP4047092B1 (en) 2016-04-13 2025-07-30 Editas Medicine, Inc. Cas9 fusion molecules, gene editing systems, and methods of use thereof
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