GB2569733B - RNA-guided nucleic acid modifying enzymes and methods of use thereof - Google Patents

RNA-guided nucleic acid modifying enzymes and methods of use thereof Download PDF

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Publication number
GB2569733B
GB2569733B GB1905575.5A GB201905575A GB2569733B GB 2569733 B GB2569733 B GB 2569733B GB 201905575 A GB201905575 A GB 201905575A GB 2569733 B GB2569733 B GB 2569733B
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rna
methods
nucleic acid
modifying enzymes
acid modifying
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GB2569733A (en
GB201905575D0 (en
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A Doudna Jennifer
F Banfield Jillian
Burstein David
Benjamin Harrington Lucas
C Strutt Steven
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University of California Berkeley
University of California San Diego UCSD
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University of California Berkeley
University of California San Diego UCSD
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
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    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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GB1905575.5A 2016-09-30 2017-09-28 RNA-guided nucleic acid modifying enzymes and methods of use thereof Active GB2569733B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662402846P 2016-09-30 2016-09-30
PCT/US2017/054081 WO2018064371A1 (en) 2016-09-30 2017-09-28 Rna-guided nucleic acid modifying enzymes and methods of use thereof

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GB201905575D0 GB201905575D0 (en) 2019-06-05
GB2569733A GB2569733A (en) 2019-06-26
GB2569733B true GB2569733B (en) 2022-09-14

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EP (1) EP3523426A4 (enExample)
JP (3) JP2019532644A (enExample)
KR (2) KR20230170126A (enExample)
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WO2018064352A1 (en) 2016-09-30 2018-04-05 The Regents Of The University Of California Rna-guided nucleic acid modifying enzymes and methods of use thereof
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