JP2019534695A5 - - Google Patents
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- JP2019534695A5 JP2019534695A5 JP2019517246A JP2019517246A JP2019534695A5 JP 2019534695 A5 JP2019534695 A5 JP 2019534695A5 JP 2019517246 A JP2019517246 A JP 2019517246A JP 2019517246 A JP2019517246 A JP 2019517246A JP 2019534695 A5 JP2019534695 A5 JP 2019534695A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 58
- 229920001184 polypeptide Polymers 0.000 claims 56
- 102000004196 processed proteins & peptides Human genes 0.000 claims 56
- 230000000694 effects Effects 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 31
- 102000039446 nucleic acids Human genes 0.000 claims 31
- 150000007523 nucleic acids Chemical class 0.000 claims 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 108020005004 Guide RNA Proteins 0.000 claims 21
- 230000004927 fusion Effects 0.000 claims 14
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 10
- 210000003527 eukaryotic cell Anatomy 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 108060004795 Methyltransferase Proteins 0.000 claims 3
- 230000002255 enzymatic effect Effects 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 239000004209 oxidized polyethylene wax Substances 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 2
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 2
- 241000270322 Lepidosauria Species 0.000 claims 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 claims 2
- 102000016397 Methyltransferase Human genes 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 210000003763 chloroplast Anatomy 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 2
- 210000001163 endosome Anatomy 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 241000239290 Araneae Species 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000238421 Arthropoda Species 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 108010046331 Deoxyribodipyrimidine photo-lyase Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 102100034343 Integrase Human genes 0.000 claims 1
- 108010061833 Integrases Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 102100025169 Max-binding protein MNT Human genes 0.000 claims 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 108091093078 Pyrimidine dimer Proteins 0.000 claims 1
- 102000018120 Recombinases Human genes 0.000 claims 1
- 108010091086 Recombinases Proteins 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 102000008579 Transposases Human genes 0.000 claims 1
- 108010020764 Transposases Proteins 0.000 claims 1
- 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 claims 1
- 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 230000006154 adenylylation Effects 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000022811 deglycosylation Effects 0.000 claims 1
- 230000006114 demyristoylation Effects 0.000 claims 1
- 230000027832 depurination Effects 0.000 claims 1
- 230000009504 deubiquitination Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000007498 myristoylation Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 239000013635 pyrimidine dimer Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 108091006107 transcriptional repressors Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022202406A JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402849P | 2016-09-30 | 2016-09-30 | |
| US62/402,849 | 2016-09-30 | ||
| PCT/US2017/054047 WO2018064352A1 (en) | 2016-09-30 | 2017-09-28 | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202406A Division JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534695A JP2019534695A (ja) | 2019-12-05 |
| JP2019534695A5 true JP2019534695A5 (enExample) | 2020-11-12 |
| JP7306696B2 JP7306696B2 (ja) | 2023-07-11 |
Family
ID=61760117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517246A Active JP7306696B2 (ja) | 2016-09-30 | 2017-09-28 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| JP2022202406A Pending JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202406A Pending JP2023030067A (ja) | 2016-09-30 | 2022-12-19 | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11371062B2 (enExample) |
| EP (1) | EP3532089A4 (enExample) |
| JP (2) | JP7306696B2 (enExample) |
| KR (2) | KR20190072548A (enExample) |
| CN (1) | CN110418647B (enExample) |
| AU (1) | AU2017335883B2 (enExample) |
| BR (1) | BR112019006388A2 (enExample) |
| CA (1) | CA3038982A1 (enExample) |
| EA (1) | EA201990860A1 (enExample) |
| GB (1) | GB2569734B (enExample) |
| IL (1) | IL265599A (enExample) |
| MX (1) | MX2019003678A (enExample) |
| SA (1) | SA519401442B1 (enExample) |
| WO (1) | WO2018064352A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| US11911415B2 (en) | 2015-06-09 | 2024-02-27 | Editas Medicine, Inc. | CRISPR/Cas-related methods and compositions for improving transplantation |
| CA2999500A1 (en) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017165826A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
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| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| JP2019532644A (ja) | 2016-09-30 | 2019-11-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| CA3038982A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
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