JP2019531705A5 - - Google Patents
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- JP2019531705A5 JP2019531705A5 JP2019505188A JP2019505188A JP2019531705A5 JP 2019531705 A5 JP2019531705 A5 JP 2019531705A5 JP 2019505188 A JP2019505188 A JP 2019505188A JP 2019505188 A JP2019505188 A JP 2019505188A JP 2019531705 A5 JP2019531705 A5 JP 2019531705A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- less
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- mutations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 154
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 154
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 154
- 230000035772 mutation Effects 0.000 claims description 87
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 21
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 19
- 238000003556 assay Methods 0.000 claims description 12
- 238000001727 in vivo Methods 0.000 claims description 11
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 10
- 238000000423 cell based assay Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 8
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 8
- 239000012636 effector Substances 0.000 claims description 8
- 230000006870 function Effects 0.000 claims description 8
- 230000009827 complement-dependent cellular cytotoxicity Effects 0.000 claims description 7
- 230000001419 dependent effect Effects 0.000 claims description 7
- 102100023431 E3 ubiquitin-protein ligase TRIM21 Human genes 0.000 claims description 6
- 101000685877 Homo sapiens E3 ubiquitin-protein ligase TRIM21 Proteins 0.000 claims description 6
- 108010073807 IgG Receptors Proteins 0.000 claims description 6
- 102000009490 IgG Receptors Human genes 0.000 claims description 6
- 230000008827 biological function Effects 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 239000001393 triammonium citrate Substances 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 238000002965 ELISA Methods 0.000 claims description 4
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims description 4
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims description 4
- 206010057249 Phagocytosis Diseases 0.000 claims description 4
- 239000001825 Polyoxyethene (8) stearate Substances 0.000 claims description 4
- 238000010494 dissociation reaction Methods 0.000 claims description 4
- 230000005593 dissociations Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 230000008782 phagocytosis Effects 0.000 claims description 4
- 230000003834 intracellular effect Effects 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000004220 aggregation Methods 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 238000010171 animal model Methods 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 230000001447 compensatory effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 230000002209 hydrophobic effect Effects 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims description 2
- 108010068617 neonatal Fc receptor Proteins 0.000 claims description 2
- 230000031998 transcytosis Effects 0.000 claims description 2
- 150000001413 amino acids Chemical group 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 238000012258 culturing Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022096036A JP2022120132A (ja) | 2016-08-02 | 2022-06-14 | 操作されたポリペプチドおよびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370201P | 2016-08-02 | 2016-08-02 | |
| US62/370,201 | 2016-08-02 | ||
| US201762485671P | 2017-04-14 | 2017-04-14 | |
| US62/485,671 | 2017-04-14 | ||
| PCT/US2017/045126 WO2018052556A1 (en) | 2016-08-02 | 2017-08-02 | Engineered polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096036A Division JP2022120132A (ja) | 2016-08-02 | 2022-06-14 | 操作されたポリペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531705A JP2019531705A (ja) | 2019-11-07 |
| JP2019531705A5 true JP2019531705A5 (OSRAM) | 2020-09-10 |
| JP7464389B2 JP7464389B2 (ja) | 2024-04-09 |
Family
ID=59656189
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019505188A Active JP7464389B2 (ja) | 2016-08-02 | 2017-08-02 | 操作されたポリペプチドおよびその使用 |
| JP2022096036A Withdrawn JP2022120132A (ja) | 2016-08-02 | 2022-06-14 | 操作されたポリペプチドおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022096036A Withdrawn JP2022120132A (ja) | 2016-08-02 | 2022-06-14 | 操作されたポリペプチドおよびその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11858980B2 (OSRAM) |
| EP (1) | EP3494134B1 (OSRAM) |
| JP (2) | JP7464389B2 (OSRAM) |
| KR (2) | KR102777127B1 (OSRAM) |
| CN (3) | CN118085091A (OSRAM) |
| AU (2) | AU2017325654B2 (OSRAM) |
| BR (1) | BR112019001989A2 (OSRAM) |
| CA (1) | CA3032820A1 (OSRAM) |
| CL (3) | CL2019000261A1 (OSRAM) |
| CO (1) | CO2019000931A2 (OSRAM) |
| IL (2) | IL315729A (OSRAM) |
| MX (1) | MX2019001458A (OSRAM) |
| SG (1) | SG11201900616UA (OSRAM) |
| WO (1) | WO2018052556A1 (OSRAM) |
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| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
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| WO2021262999A1 (en) | 2020-06-24 | 2021-12-30 | Visterra, Inc. | Antibody molecules to april and uses thereof |
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| TW202246331A (zh) | 2021-01-13 | 2022-12-01 | 美商威特拉公司 | 人源化補體５ａ受體１抗體及其使用方法 |
| JP2024503506A (ja) | 2021-01-20 | 2024-01-25 | ビステラ， インコーポレイテッド | インターロイキン－２変異体およびその使用 |
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| CN119013034A (zh) | 2022-02-11 | 2024-11-22 | 威特拉公司 | 用于治疗自身免疫性疾病的白细胞介素-2突变蛋白 |
| TW202400637A (zh) | 2022-04-25 | 2024-01-01 | 美商威特拉公司 | April之抗體分子及其用途 |
| CN115028738B (zh) * | 2022-06-14 | 2025-05-16 | 天津医科大学 | 一种Fc融合蛋白双重靶向降解剂及应用 |
| WO2024027793A1 (en) * | 2022-08-05 | 2024-02-08 | I-Mab Biopharma (Hangzhou) Co., Ltd. | Bispecific antibodies targeting ifnar1 and blys |
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2017
- 2017-08-02 JP JP2019505188A patent/JP7464389B2/ja active Active
- 2017-08-02 WO PCT/US2017/045126 patent/WO2018052556A1/en not_active Ceased
- 2017-08-02 AU AU2017325654A patent/AU2017325654B2/en active Active
- 2017-08-02 SG SG11201900616UA patent/SG11201900616UA/en unknown
- 2017-08-02 EP EP17754535.7A patent/EP3494134B1/en active Active
- 2017-08-02 US US15/667,309 patent/US11858980B2/en active Active
- 2017-08-02 IL IL315729A patent/IL315729A/en unknown
- 2017-08-02 CN CN202410254572.6A patent/CN118085091A/zh active Pending
- 2017-08-02 MX MX2019001458A patent/MX2019001458A/es unknown
- 2017-08-02 CA CA3032820A patent/CA3032820A1/en active Pending
- 2017-08-02 CN CN201780059776.2A patent/CN110072887A/zh active Pending
- 2017-08-02 CN CN202410254540.6A patent/CN118388638A/zh active Pending
- 2017-08-02 KR KR1020197006298A patent/KR102777127B1/ko active Active
- 2017-08-02 BR BR112019001989-8A patent/BR112019001989A2/pt unknown
- 2017-08-02 KR KR1020257006561A patent/KR20250036943A/ko active Pending
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2019
- 2019-01-30 CO CONC2019/0000931A patent/CO2019000931A2/es unknown
- 2019-01-31 CL CL2019000261A patent/CL2019000261A1/es unknown
- 2019-01-31 IL IL264590A patent/IL264590B1/en unknown
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2020
- 2020-04-10 US US16/845,894 patent/US20200277358A1/en not_active Abandoned
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2022
- 2022-01-06 CL CL2022000036A patent/CL2022000036A1/es unknown
- 2022-06-14 JP JP2022096036A patent/JP2022120132A/ja not_active Withdrawn
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2024
- 2024-10-23 CL CL2024003234A patent/CL2024003234A1/es unknown
- 2024-12-03 AU AU2024270619A patent/AU2024270619A1/en active Pending
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2025
- 2025-06-04 US US19/227,822 patent/US20250296982A1/en active Pending
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