JP2019531474A5 - - Google Patents
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- Publication number
- JP2019531474A5 JP2019531474A5 JP2019512260A JP2019512260A JP2019531474A5 JP 2019531474 A5 JP2019531474 A5 JP 2019531474A5 JP 2019512260 A JP2019512260 A JP 2019512260A JP 2019512260 A JP2019512260 A JP 2019512260A JP 2019531474 A5 JP2019531474 A5 JP 2019531474A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- group
- spacer molecule
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000006850 spacer group Chemical group 0.000 claims 25
- 229920001223 polyethylene glycol Polymers 0.000 claims 18
- 125000000304 alkynyl group Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 239000007850 fluorescent dye Substances 0.000 claims 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 125000001589 carboacyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000003827 glycol group Chemical group 0.000 claims 6
- 125000005496 phosphonium group Chemical group 0.000 claims 6
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 238000010791 quenching Methods 0.000 claims 4
- 230000000171 quenching effect Effects 0.000 claims 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 3
- -1 alkenoyl Chemical group 0.000 claims 3
- 229960003237 betaine Drugs 0.000 claims 3
- 150000007942 carboxylates Chemical group 0.000 claims 3
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- 230000001268 conjugating effect Effects 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000001215 fluorescent labelling Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022179386A JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662382594P | 2016-09-01 | 2016-09-01 | |
| US62/382,594 | 2016-09-01 | ||
| PCT/US2017/049838 WO2018045278A1 (en) | 2016-09-01 | 2017-09-01 | Compositions and methods for enhanced fluorescence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022179386A Division JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531474A JP2019531474A (ja) | 2019-10-31 |
| JP2019531474A5 true JP2019531474A5 (https=) | 2020-10-15 |
| JP7216638B2 JP7216638B2 (ja) | 2023-02-01 |
Family
ID=59846737
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019512260A Active JP7216638B2 (ja) | 2016-09-01 | 2017-09-01 | 増強された蛍光のための組成物および方法 |
| JP2022179386A Pending JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A Pending JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022179386A Pending JP2023025018A (ja) | 2016-09-01 | 2022-11-09 | 増強された蛍光のための組成物および方法 |
| JP2024196507A Pending JP2025028883A (ja) | 2016-09-01 | 2024-11-11 | 増強された蛍光のための組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20180092993A1 (https=) |
| EP (2) | EP3507603B1 (https=) |
| JP (3) | JP7216638B2 (https=) |
| CN (1) | CN109844538A (https=) |
| ES (1) | ES2979129T3 (https=) |
| WO (1) | WO2018045278A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US9851359B2 (en) | 2016-04-06 | 2017-12-26 | Sony Corporation Of America | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| KR102526802B1 (ko) | 2016-05-11 | 2023-05-02 | 소니그룹주식회사 | 초고명도 이량체성 또는 중합체성 염료 |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| EP3507603B1 (en) * | 2016-09-01 | 2024-03-06 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| JP7270254B2 (ja) | 2017-06-16 | 2023-05-10 | デューク ユニバーシティ | 改善された標識検出、演算、検体感知、および調整可能な乱数生成のための共鳴体ネットワーク |
| CN111093711A (zh) | 2017-10-05 | 2020-05-01 | 索尼公司 | 可编程的树枝状药物 |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| US20190154669A1 (en) * | 2017-11-20 | 2019-05-23 | Vector Laboratories, Inc. | Methods and systems for species-on-species immunoassay detection |
| CN111565756A (zh) | 2018-01-12 | 2020-08-21 | 索尼公司 | 包含生物活性化合物的具有刚性间隔基团的聚合物 |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US11874280B2 (en) | 2018-03-19 | 2024-01-16 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| CN119220109A (zh) | 2018-03-30 | 2024-12-31 | 贝克顿·迪金森公司 | 含侧基发色团的水溶性聚合染料 |
| US12006438B2 (en) | 2018-06-27 | 2024-06-11 | Sony Group Corporation | Polymeric dyes with linker groups comprising deoxyribose |
| CN109086566B (zh) * | 2018-07-12 | 2021-06-18 | 浙江工业大学 | 一种基于片段重采样的群体蛋白质结构预测方法 |
| EP3820944A1 (en) | 2018-07-13 | 2021-05-19 | Sony Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| JP2022533145A (ja) * | 2019-05-13 | 2022-07-21 | シャンハイ ポラリス バイオロジー カンパニー， リミテッド | 生体分子を標識するためのタグ |
| US20220229047A1 (en) * | 2019-06-20 | 2022-07-21 | Konica Minolta, Inc. | Linked body for fluorescent labeling agents |
| WO2021062176A2 (en) | 2019-09-26 | 2021-04-01 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| CN115023611A (zh) * | 2020-03-25 | 2022-09-06 | 积水医疗株式会社 | 免疫学分析方法和免疫学分析试剂盒 |
| CN113913404B (zh) * | 2020-07-10 | 2025-08-12 | 上海米然生物科技有限公司 | 一种荧光交联RNase H突变体缀合物及其应用 |
| US11408825B2 (en) | 2020-08-28 | 2022-08-09 | Hong Kong Applied Science and Technology Research Institute Company Limited | Forensic detector and the system thereof |
| US12203914B2 (en) | 2020-11-12 | 2025-01-21 | Sartorius Bioanalytical Instruments, Inc. | Viral clearance evaluation for biological medical product preparation processes |
| WO2022125564A1 (en) | 2020-12-07 | 2022-06-16 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| CN117642413A (zh) * | 2021-08-31 | 2024-03-01 | 富士胶片株式会社 | 化合物及使用了该化合物的标记生物物质 |
| CN116148462B (zh) * | 2021-11-22 | 2025-11-18 | 菲鹏生物股份有限公司 | 一种捕获法检测抗体的方法和应用 |
| CN115466960B (zh) * | 2022-09-15 | 2023-05-26 | 河北工业大学 | 一种含苯并噻唑基团改性聚天冬氨酸荧光缓蚀剂的制备方法和应用 |
| WO2025182762A1 (ja) * | 2024-02-29 | 2025-09-04 | 富士レビオ株式会社 | 検出方法、並びに、これに用いる標識体及びキット |
| WO2025230756A1 (en) * | 2024-05-01 | 2025-11-06 | BioLegend, Inc. | Compositions for use with multiple fluorophores and methods of using |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459272A (en) | 1990-10-16 | 1995-10-17 | Research Corporation Technologies | Quinoline-2-(carboxaldehyde) reagents for detection of primary amines |
| AU2002306620A1 (en) | 2001-02-28 | 2002-09-12 | Stratagene | Fluorescent dye |
| US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
| ATE343789T1 (de) * | 2002-06-03 | 2006-11-15 | Pamgene Bv | Biomolekulares kinetik-messverfahren mit hilfe von einem durchfluss-mikroarray |
| CN1863549A (zh) * | 2003-08-08 | 2006-11-15 | 费森尤斯卡比德国有限公司 | 通过肟连接基团进行连接的聚合物和蛋白质的缀合物 |
| WO2007120762A2 (en) * | 2006-04-14 | 2007-10-25 | Cambrios Technologies Corporation | Fluorescent particles bound to multifunctional scaffolds and their uses |
| WO2008017122A1 (en) | 2006-08-11 | 2008-02-14 | Starpharma Pty Ltd | Polylysine dendrimer contrast agent |
| US8609423B2 (en) * | 2007-05-18 | 2013-12-17 | Life Technologies Corporation | Rapid protein labeling and analysis |
| GB0711560D0 (en) * | 2007-06-14 | 2007-07-25 | Innova Biosciences Ltd | Improvements in or relating to production of conjugates |
| US9097667B2 (en) * | 2007-12-14 | 2015-08-04 | Biotium, Inc. | Fluorescent compounds |
| JP6073684B2 (ja) * | 2010-01-19 | 2017-02-01 | シリゲン セカンド リミテッド | 指向性バイオマーカーシグナル増幅のための新規の試薬 |
| JP5540964B2 (ja) * | 2010-07-23 | 2014-07-02 | コニカミノルタ株式会社 | 蛍光標識剤、並びにこれを用いた結合体及びバイオアッセイ法 |
| US9448173B2 (en) | 2011-03-08 | 2016-09-20 | The Board Of Trustees Of The University Of Illinois | Dye-conjugated dendrimers |
| WO2013033476A1 (en) | 2011-08-30 | 2013-03-07 | Quanta Biodesign, Ltd. | Branched discrette peg constructs |
| US8835000B2 (en) * | 2011-12-23 | 2014-09-16 | General Electric Company | High-density fluorescent dye clusters |
| AU2013229631B2 (en) | 2012-03-05 | 2017-09-14 | Bracco Imaging Spa | Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues |
| CN102692508B (zh) * | 2012-04-28 | 2014-12-17 | 广州鸿琪光学仪器科技有限公司 | 一种快速定量检测肌钙蛋白t的免疫荧光试纸条组件及其制成的检测卡组件和制备方法 |
| US10107799B2 (en) * | 2012-09-18 | 2018-10-23 | Biotium, Inc. | Methods, compositions and kits for labeling of proteins |
| WO2014138186A1 (en) * | 2013-03-05 | 2014-09-12 | The Johns Hopkins University | Bioorthogonal two-component delivery systems for enhanced internalization of nanotherapeutics |
| US9670318B2 (en) | 2015-05-28 | 2017-06-06 | Miltenyi Biotec Gmbh | Bright fluorochromes based on multimerization of fluorescent dyes |
| EP3507603B1 (en) * | 2016-09-01 | 2024-03-06 | Life Technologies Corporation | Compositions and methods for enhanced fluorescence |
| CN109640722B (zh) | 2016-09-01 | 2022-05-06 | 耐克创新有限合伙公司 | 通风服装 |
-
2017
- 2017-09-01 EP EP17765041.3A patent/EP3507603B1/en active Active
- 2017-09-01 CN CN201780062491.4A patent/CN109844538A/zh active Pending
- 2017-09-01 WO PCT/US2017/049838 patent/WO2018045278A1/en not_active Ceased
- 2017-09-01 ES ES17765041T patent/ES2979129T3/es active Active
- 2017-09-01 JP JP2019512260A patent/JP7216638B2/ja active Active
- 2017-09-01 US US15/693,772 patent/US20180092993A1/en not_active Abandoned
- 2017-09-01 EP EP24161100.3A patent/EP4425179A3/en not_active Withdrawn
-
2020
- 2020-03-11 US US16/816,015 patent/US11857643B2/en active Active
- 2020-05-22 US US16/882,271 patent/US11865191B2/en active Active
-
2022
- 2022-11-09 JP JP2022179386A patent/JP2023025018A/ja active Pending
-
2023
- 2023-10-16 US US18/380,388 patent/US20240042062A1/en active Pending
-
2024
- 2024-11-11 JP JP2024196507A patent/JP2025028883A/ja active Pending
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