|
US527565A
(en)
*
|
|
1894-10-16 |
|
tripp |
|
US3034507A
(en)
|
1960-05-10 |
1962-05-15 |
American Cyanamid Co |
Intracutaneous injection device
|
|
US3539465A
(en)
|
1968-10-08 |
1970-11-10 |
Ncr Co |
Encapsulation of hydrophilic liquid-in-oil emulsions
|
|
US3675766A
(en)
|
1970-02-04 |
1972-07-11 |
Sol Roy Rosenthal |
Multiple puncture injector device
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
IE61148B1
(en)
*
|
1988-03-10 |
1994-10-05 |
Ici Plc |
Method of detecting nucleotide sequences
|
|
US5674844A
(en)
|
1991-03-11 |
1997-10-07 |
Creative Biomolecules, Inc. |
Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
|
|
US6506729B1
(en)
|
1991-03-11 |
2003-01-14 |
Curis, Inc. |
Methods and compositions for the treatment and prevention of Parkinson's disease
|
|
US5849686A
(en)
|
1991-03-11 |
1998-12-15 |
Creative Biomolecules, Inc. |
Morphogen-induced liver regeneration
|
|
US5656593A
(en)
|
1991-03-11 |
1997-08-12 |
Creative Biomolecules, Inc. |
Morphogen induced periodontal tissue regeneration
|
|
US6800603B2
(en)
|
1991-03-11 |
2004-10-05 |
Curis, Inc. |
Morphogen-induced neural cell adhesion
|
|
US6949505B1
(en)
|
1991-03-11 |
2005-09-27 |
Curis, Inc. |
Morphogen-induced dendritic growth
|
|
US5993434A
(en)
|
1993-04-01 |
1999-11-30 |
Genetronics, Inc. |
Method of treatment using electroporation mediated delivery of drugs and genes
|
|
US5843780A
(en)
|
1995-01-20 |
1998-12-01 |
Wisconsin Alumni Research Foundation |
Primate embryonic stem cells
|
|
US5711964A
(en)
|
1995-06-07 |
1998-01-27 |
United States Of America |
Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D
|
|
KR20000064752A
(ko)
|
1996-03-22 |
2000-11-06 |
더 제네랄 호스피탈 코포레이션 |
중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
|
|
US6498142B1
(en)
|
1996-05-06 |
2002-12-24 |
Curis, Inc. |
Morphogen treatment for chronic renal failure
|
|
US6602693B1
(en)
|
1996-07-03 |
2003-08-05 |
Clear Solutions Biotech, Inc. |
Gene encoding hyaluronan synthase
|
|
US6413544B1
(en)
|
1996-08-19 |
2002-07-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
US6770291B2
(en)
|
1996-08-30 |
2004-08-03 |
The United States Of America As Represented By The Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
US6653104B2
(en)
|
1996-10-17 |
2003-11-25 |
Immunomedics, Inc. |
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
|
|
CA2277278A1
(en)
|
1997-01-10 |
1998-07-16 |
Life Technologies, Inc. |
Embryonic stem cell serum replacement
|
|
US6316260B1
(en)
|
1997-08-22 |
2001-11-13 |
Bernina Biosystems Gmbh |
Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraether lipid derivatives, and use thereof
|
|
US20030083272A1
(en)
|
1997-09-19 |
2003-05-01 |
Lahive & Cockfield, Llp |
Sense mrna therapy
|
|
DK1129064T3
(da)
|
1998-11-12 |
2008-04-28 |
Invitrogen Corp |
Transfektionsreagenser
|
|
GB9902000D0
(en)
|
1999-01-30 |
1999-03-17 |
Delta Biotechnology Ltd |
Process
|
|
US7390780B2
(en)
|
1999-04-23 |
2008-06-24 |
Alza Corporation |
Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification
|
|
EP1187653B1
(en)
|
1999-06-04 |
2010-03-31 |
Georgia Tech Research Corporation |
Devices for enhanced microneedle penetration of biological barriers
|
|
US20110171185A1
(en)
|
1999-06-30 |
2011-07-14 |
Klimanskaya Irina V |
Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
|
|
US20020054895A1
(en)
|
1999-07-23 |
2002-05-09 |
Alwyn Company, Inc. |
Allantoin-containing skin cream
|
|
US6595947B1
(en)
|
2000-05-22 |
2003-07-22 |
Becton, Dickinson And Company |
Topical delivery of vaccines
|
|
AU9475001A
(en)
|
2000-09-26 |
2002-04-08 |
Hybridon Inc |
Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
|
|
US7189759B2
(en)
|
2001-05-23 |
2007-03-13 |
Medicis Pharmaceutical Corporation |
Compositions for the treatment of pigmentation disorders and methods for their manufacture
|
|
AU2002313817A1
(en)
|
2001-08-27 |
2003-03-10 |
Advanced Cell Technology, Inc. |
Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
|
|
CA2461185A1
(en)
|
2001-09-21 |
2003-04-03 |
Japan Science And Technology Corporation |
Method of screening reprogramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs
|
|
CA2463914A1
(en)
|
2001-10-18 |
2003-04-24 |
Ixion Biotechnology, Inc. |
Conversion of liver stem and progenitor cells to pancreatic functional cells
|
|
US7276489B2
(en)
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
GB0202149D0
(en)
|
2002-01-30 |
2002-03-20 |
Univ Edinburgh |
Pluripotency determining factors and uses thereof
|
|
US20030186249A1
(en)
|
2002-04-01 |
2003-10-02 |
Zairen Sun |
Human TARPP genes and polypeptides
|
|
JP3785508B2
(ja)
|
2002-04-15 |
2006-06-14 |
学校法人慶應義塾 |
遺伝子治療における免疫応答を解析できる実験モデルマウス
|
|
DE10234192B4
(de)
|
2002-07-26 |
2009-11-26 |
Epoplus Gmbh Co.Kg |
Verwendung von Erythropoetin
|
|
US7737182B2
(en)
|
2002-08-09 |
2010-06-15 |
Taisho Pharmaceutical Co., Ltd. |
Pharmaceuticals for xerosis
|
|
BRPI0410886A
(pt)
|
2003-06-03 |
2006-07-04 |
Isis Pharmaceuticals Inc |
composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
|
|
US7682828B2
(en)
|
2003-11-26 |
2010-03-23 |
Whitehead Institute For Biomedical Research |
Methods for reprogramming somatic cells
|
|
AU2005282414C1
(en)
|
2004-09-08 |
2011-04-07 |
Wisconsin Alumni Research Foundation |
Culturing human embryonic stem cells
|
|
CN101052712A
(zh)
|
2004-09-08 |
2007-10-10 |
威斯康星校友研究基金会 |
培养人胚胎干细胞
|
|
WO2006047728A2
(en)
|
2004-10-27 |
2006-05-04 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Bmp gene and fusion protein
|
|
WO2006081249A2
(en)
|
2005-01-25 |
2006-08-03 |
Cell Therapeutics, Inc. |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
ES2397851T3
(es)
|
2005-07-13 |
2013-03-11 |
Novo Nordisk Health Care Ag |
Células de inactivación proteínica de la célula huésped para la producción de proteínas terapéuticas
|
|
AU2006272634B2
(en)
|
2005-07-26 |
2013-01-24 |
Sangamo Therapeutics, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
|
US8323666B2
(en)
|
2005-08-01 |
2012-12-04 |
Allergan, Inc. |
Botulinum toxin compositions
|
|
US9012219B2
(en)
|
2005-08-23 |
2015-04-21 |
The Trustees Of The University Of Pennsylvania |
RNA preparations comprising purified modified RNA for reprogramming cells
|
|
EP3611266B1
(en)
|
2005-08-23 |
2022-11-09 |
The Trustees of the University of Pennsylvania |
Rna containing modified nucleosides and methods of use thereof
|
|
WO2007026353A2
(en)
|
2005-08-29 |
2007-03-08 |
Technion Research & Development Foundation Ltd. |
Media for culturing stem cells
|
|
TW200732347A
(en)
|
2005-10-06 |
2007-09-01 |
Trophogen Inc |
VEGF analogs and methods of use
|
|
BRPI0619794B8
(pt)
|
2005-12-13 |
2022-06-14 |
Univ Kyoto |
Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
|
|
US8129187B2
(en)
|
2005-12-13 |
2012-03-06 |
Kyoto University |
Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
|
|
US8278104B2
(en)
|
2005-12-13 |
2012-10-02 |
Kyoto University |
Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
|
|
CA2634329A1
(en)
|
2005-12-22 |
2007-07-19 |
Csl Behring Gmbh |
Octanoate-reduced human albumin
|
|
US7658728B2
(en)
|
2006-01-10 |
2010-02-09 |
Yuzhakov Vadim V |
Microneedle array, patch, and applicator for transdermal drug delivery
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
GB0623635D0
(en)
|
2006-11-27 |
2007-01-03 |
Stem Cell Sciences Uk Ltd |
Pluripotent cell growth media
|
|
US7785301B2
(en)
|
2006-11-28 |
2010-08-31 |
Vadim V Yuzhakov |
Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
|
|
EP2099496A2
(en)
|
2006-12-08 |
2009-09-16 |
Massachusetts Institute of Technology |
Delivery of nanoparticles and/or agents to cells
|
|
CN101200758A
(zh)
|
2006-12-15 |
2008-06-18 |
华中科技大学 |
一种检测col7a1基因突变的方法及其用途
|
|
US10829733B2
(en)
|
2007-01-04 |
2020-11-10 |
Biolamina Ab |
Composition and method for enabling proliferation of pluripotent human stem cells
|
|
JP2010515464A
(ja)
|
2007-01-11 |
2010-05-13 |
イエール・ユニバーシテイ |
Ｈｉｖ細胞表面受容体の標的化不活性化のための組成物および方法
|
|
US9249423B2
(en)
|
2007-02-02 |
2016-02-02 |
Yale University |
Method of de-differentiating and re-differentiating somatic cells using RNA
|
|
US8859229B2
(en)
|
2007-02-02 |
2014-10-14 |
Yale University |
Transient transfection with RNA
|
|
DK3399025T3
(da)
|
2007-03-23 |
2025-06-16 |
Wisconsin Alumni Res Found |
Omprogrammering af somatiske celler
|
|
EP2626416A3
(en)
|
2007-04-07 |
2013-12-18 |
The Whitehead Institute for Biomedical Research |
Reprogramming of somatic cells
|
|
EP2167539A2
(en)
*
|
2007-06-15 |
2010-03-31 |
Charite-Universitätsmedizin Berlin |
Methods for producing glycosylated human alpha-1 antitrypsin (a1at) in mammalian host cells
|
|
JP2008307007A
(ja)
|
2007-06-15 |
2008-12-25 |
Bayer Schering Pharma Ag |
出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
|
|
JP5558097B2
(ja)
|
2007-12-10 |
2014-07-23 |
国立大学法人京都大学 |
効率的な核初期化方法
|
|
EP2234929A1
(en)
|
2007-12-14 |
2010-10-06 |
DSM IP Assets B.V. |
Sol-gel process with a protected catalyst
|
|
EP2072618A1
(en)
|
2007-12-14 |
2009-06-24 |
Johannes Gutenberg-Universität Mainz |
Use of RNA for reprogramming somatic cells
|
|
EP2222696A1
(en)
|
2007-12-21 |
2010-09-01 |
Stryker Corporation |
Bmp mutants with decreased susceptibility to noggin
|
|
SG188904A1
(en)
|
2008-03-17 |
2013-04-30 |
Scripps Research Inst |
Combined chemical and genetic approaches for generation of induced pluripotent stem cells
|
|
US20110045001A1
(en)
|
2008-03-28 |
2011-02-24 |
Biontex Laboratories Gmbh |
Transfection results of non-viral gene delivery systems by influencing of the innate immune system
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
JP2011160661A
(ja)
|
2008-06-02 |
2011-08-25 |
Kyowa Hakko Kirin Co Ltd |
血球細胞の初期化法
|
|
EP3279314A1
(en)
|
2008-06-04 |
2018-02-07 |
Cellular Dynamics International, Inc. |
Methods for the production of ips cells using non-viral approach
|
|
GB2460552B
(en)
|
2008-06-05 |
2011-09-07 |
Iti Scotland Ltd |
Stem cell culture media and methods
|
|
US8669048B2
(en)
|
2008-06-24 |
2014-03-11 |
Parkinson's Institute |
Pluripotent cell lines and methods of use thereof
|
|
US20100184033A1
(en)
|
2008-07-16 |
2010-07-22 |
West Michael D |
Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
|
|
EP2151248A1
(en)
|
2008-07-30 |
2010-02-10 |
Johann Bauer |
Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
|
|
WO2010022194A2
(en)
|
2008-08-20 |
2010-02-25 |
Virxsys Corporation |
Compositions and methods for generation of pluripotent stem cells
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
CA2741090C
(en)
|
2008-10-24 |
2018-10-16 |
Wisconsin Alumni Research Foundation |
Pluripotent stem cells obtained by non-viral reprogramming
|
|
JP2012509106A
(ja)
|
2008-11-18 |
2012-04-19 |
スリーエム イノベイティブ プロパティズ カンパニー |
中空のマイクロニードルアレイ及び方法
|
|
EP2881461A1
(en)
|
2008-11-21 |
2015-06-10 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Reprogramming cells toward a pluripotent state
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
EP2412800A1
(en)
|
2010-07-29 |
2012-02-01 |
Koninklijke Nederlandse Akademie van Wetenschappen |
Liver organoid, uses thereof and culture method for obtaining them
|
|
WO2010093655A2
(en)
|
2009-02-10 |
2010-08-19 |
University Of Dayton |
Enhanced method for producing stem-like cells from somatic cells
|
|
US10894944B2
(en)
|
2009-04-10 |
2021-01-19 |
Monash University |
Cell culture media
|
|
US20100273220A1
(en)
|
2009-04-22 |
2010-10-28 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long rna molecules
|
|
US10837020B2
(en)
|
2009-04-22 |
2020-11-17 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long RNA molecules
|
|
US20100272695A1
(en)
|
2009-04-22 |
2010-10-28 |
Alan Agulnick |
Cell compositions derived from dedifferentiated reprogrammed cells
|
|
EP2251437B1
(en)
|
2009-05-13 |
2013-12-04 |
Hannelore Breitenbach-Koller |
Method for identifying compounds that control the translational activity of ribosomal proteins in differential mRNA expression
|
|
US8496941B2
(en)
|
2009-06-03 |
2013-07-30 |
National Institute Of Advanced Industrial Science And Technology |
Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
|
|
CA2765700C
(en)
|
2009-06-16 |
2021-01-05 |
Opko Curna, Llc |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
|
BR112012002291A2
(pt)
|
2009-07-31 |
2016-11-29 |
Ethris Gmbh |
"polirribonucleotídeo com uma sequência que codifica uma proteína ou fragmento de proteína, implante, e, processo para a seleção de sequências de nucleotídeos"
|
|
ES2539487T3
(es)
|
2009-11-04 |
2015-07-01 |
Cellular Dynamics International, Inc. |
Reprogramación episómica con compuestos químicos
|
|
EP2499239A1
(en)
|
2009-11-11 |
2012-09-19 |
Sanford-Burnham Medical Research Institute |
METHOD FOR GENERATION AND REGULATION OF iPS CELLS AND COMPOSITIONS THEREOF
|
|
US20130189741A1
(en)
|
2009-12-07 |
2013-07-25 |
Cellscript, Inc. |
Compositions and methods for reprogramming mammalian cells
|
|
KR20240136456A
(ko)
|
2009-12-07 |
2024-09-13 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
세포 리프로그래밍을 위한 정제된 변형 ｒｎａ를 포함하는 ｒｎａ 제제
|
|
HUE041436T2
(hu)
|
2009-12-10 |
2019-05-28 |
Univ Minnesota |
Tal-effektor-közvetített DNS-módosítás
|
|
US8557972B2
(en)
|
2009-12-21 |
2013-10-15 |
University Of Washington Through Its Center For Commercialization |
Compositions and methods for transfection of RNA and controlled stabilization of transfected RNA
|
|
CA2788635A1
(en)
|
2010-02-01 |
2011-08-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enhanced efficiency of induced pluripotent stem cell generation
|
|
US20140194482A1
(en)
|
2010-02-02 |
2014-07-10 |
Scioderm, Inc. |
Compositions and methods of treatment of inflammatory skin conditions using allantoin
|
|
JPWO2011102532A1
(ja)
|
2010-02-16 |
2013-06-17 |
国立大学法人九州大学 |
誘導肝細胞
|
|
WO2011110886A1
(en)
|
2010-03-09 |
2011-09-15 |
Biolamina Ab |
Composition and method for enabling proliferation of pluripotent human stem cells
|
|
CA2796464C
(en)
|
2010-04-16 |
2021-08-03 |
Immune Disease Institute, Inc. |
Sustained polypeptide expression from synthetic, modified rnas and uses thereof
|
|
CN102234627B
(zh)
|
2010-04-30 |
2015-06-03 |
中国科学院广州生物医药与健康研究院 |
一种培养基添加剂及其应用
|
|
WO2011140397A2
(en)
|
2010-05-05 |
2011-11-10 |
The Regents Of The University Of California Office Of The President |
Stem cell defined media for xeno-free and feeder free conditions and uses thereof
|
|
US8048675B1
(en)
|
2010-05-12 |
2011-11-01 |
Ipierian, Inc. |
Integration-free human induced pluripotent stem cells from blood
|
|
US20130145487A1
(en)
|
2010-05-12 |
2013-06-06 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
EP2392208B1
(en)
|
2010-06-07 |
2016-05-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
|
|
AU2011265733B2
(en)
|
2010-06-14 |
2014-04-17 |
Iowa State University Research Foundation, Inc. |
Nuclease activity of TAL effector and Foki fusion protein
|
|
EP2601288B1
(en)
|
2010-08-05 |
2016-04-06 |
Wisconsin Alumni Research Foundation |
Simplified basic media for human pluripotent cell culture
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012021632A2
(en)
|
2010-08-10 |
2012-02-16 |
The Johns Hopkins University |
Generation and use of pluripotent stem cells
|
|
GB201014169D0
(en)
*
|
2010-08-25 |
2010-10-06 |
Cambridge Entpr Ltd |
In vitro hepatic differentiation
|
|
JP5794588B2
(ja)
|
2010-09-14 |
2015-10-14 |
国立大学法人京都大学 |
効率的な人工多能性幹細胞の樹立方法
|
|
RU2013120302A
(ru)
|
2010-10-01 |
2014-11-20 |
Модерна Терапьютикс, Инк. |
Сконструированные нуклеиновые кислоты и способы их применения
|
|
WO2012048213A1
(en)
|
2010-10-08 |
2012-04-12 |
Regents Of The University Of Minnesota |
A method to increase gene targeting frequency
|
|
JP5888753B2
(ja)
|
2010-11-04 |
2016-03-22 |
国立大学法人京都大学 |
効率的な人工多能性幹細胞の樹立方法
|
|
WO2012094132A1
(en)
|
2011-01-05 |
2012-07-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
|
CA2832807A1
(en)
|
2011-03-07 |
2012-09-13 |
Massachusetts Institute Of Technology |
Methods for transfecting cells with nucleic acids
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
WO2012131090A1
(en)
|
2011-03-31 |
2012-10-04 |
Galderma Research & Development |
Method for treatment of xeroderma pigmentosum
|
|
EP2694660B1
(en)
|
2011-04-03 |
2018-08-08 |
The General Hospital Corporation |
Efficient protein expression in vivo using modified rna (mod-rna)
|
|
EP2694089B1
(en)
|
2011-04-05 |
2024-06-05 |
Cellectis |
New tale-protein scaffolds and uses thereof
|
|
KR102068107B1
(ko)
*
|
2011-04-27 |
2020-01-20 |
아미리스 인코퍼레이티드 |
게놈 변형 방법
|
|
WO2012174224A2
(en)
|
2011-06-17 |
2012-12-20 |
Calando Pharmaceuticals, Inc. |
Methods for administering nucleic acid-based therapeutics
|
|
WO2012176015A1
(en)
|
2011-06-24 |
2012-12-27 |
Leo Pharma A/S |
Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate
|
|
US9862926B2
(en)
|
2011-06-27 |
2018-01-09 |
Cellscript, Llc. |
Inhibition of innate immune response
|
|
WO2013009825A1
(en)
|
2011-07-11 |
2013-01-17 |
Cellular Dynamics International, Inc. |
Methods for cell reprogramming and genome engineering
|
|
WO2013020064A1
(en)
|
2011-08-03 |
2013-02-07 |
Lotus Tissue Repair Inc. |
Collagen 7 and related methods
|
|
AU2012312260B2
(en)
*
|
2011-09-21 |
2017-08-31 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of transgene expression
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
EP3279324B1
(en)
|
2011-10-11 |
2021-02-17 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Exon skipping therapy for dystrophic epidermolysis bullosa
|
|
BR112014008694A2
(pt)
|
2011-10-11 |
2017-06-20 |
Novartis Ag |
moléculas de ácido nucleico policistrônico recombinante
|
|
WO2013078199A2
(en)
|
2011-11-23 |
2013-05-30 |
Children's Medical Center Corporation |
Methods for enhanced in vivo delivery of synthetic, modified rnas
|
|
KR102320571B1
(ko)
|
2011-12-05 |
2021-11-02 |
팩터 바이오사이언스 인크. |
세포를 형질감염시키는 방법들 및 생성물들
|
|
US8497124B2
(en)
|
2011-12-05 |
2013-07-30 |
Factor Bioscience Inc. |
Methods and products for reprogramming cells to a less differentiated state
|
|
WO2013090186A1
(en)
|
2011-12-14 |
2013-06-20 |
modeRNA Therapeutics |
Modified nucleic acids, and acute care uses thereof
|
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
|
JP2015510495A
(ja)
|
2011-12-21 |
2015-04-09 |
モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
器官または器官移植片の生存可能性または寿命を延長する方法
|
|
EP4721752A2
(en)
|
2011-12-30 |
2026-04-08 |
Cellscript, Llc |
Herstellung und verwendung von in vitro-synthetisierter ssrna zur einführung in säugetierzellen zur induktion einer biologischen oder biochemischen wirkung
|
|
US9340784B2
(en)
*
|
2012-03-19 |
2016-05-17 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
WO2013152220A2
(en)
|
2012-04-04 |
2013-10-10 |
Life Technologies Corporation |
Tal-effector assembly platform, customized services, kits and assays
|
|
WO2013158046A1
(en)
|
2012-04-20 |
2013-10-24 |
Agency For Science, Technology And Research |
Rnai-based therapies for cardiomyopathies, muscular dystrophies and laminopathies
|
|
RU2696071C2
(ru)
|
2012-04-24 |
2019-07-30 |
Виселл Терапеутикс, Инк. |
Получение плюрипотентных клеток de novo
|
|
KR102215413B1
(ko)
|
2012-05-13 |
2021-02-16 |
알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. |
합성 메신저 rna에 의한 인간 유도 만능 줄기 세포의 피더프리 유래
|
|
US10155929B2
(en)
|
2012-05-13 |
2018-12-18 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
|
|
US10119150B2
(en)
|
2012-05-13 |
2018-11-06 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
|
|
US20140031295A1
(en)
|
2012-07-19 |
2014-01-30 |
Lotus Tissue Repair, Inc. |
Recombinant C7 and Methods of Use
|
|
EP2906684B8
(en)
*
|
2012-10-10 |
2020-09-02 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
|
WO2014071219A1
(en)
|
2012-11-01 |
2014-05-08 |
Factor Bioscience Inc. |
Methods and products for expressing proteins in cells
|
|
RU2718988C2
(ru)
*
|
2013-02-22 |
2020-04-15 |
Куревак Аг |
Комбинация противораковой рнк-вакцины и ингибитора пути pd-1 и ее применение
|
|
ES3047667T3
(en)
|
2013-02-22 |
2025-12-04 |
Univ Leland Stanford Junior |
Methods relating to telomere extension
|
|
CN105229144A
(zh)
|
2013-02-22 |
2016-01-06 |
细胞动力学国际有限公司 |
通过组合的遗传工程和化学工程经由正向编程产生肝细胞
|
|
WO2014134412A1
(en)
|
2013-03-01 |
2014-09-04 |
Regents Of The University Of Minnesota |
Talen-based gene correction
|
|
MX2015017312A
(es)
*
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
DK3444350T3
(da)
|
2013-07-03 |
2022-02-07 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder og sammensætninger til specifik hæmning af alpha-1 antitrypsin ved dobbeltstrenget rna
|
|
SG11201601939VA
(en)
|
2013-09-16 |
2016-04-28 |
Agency Science Tech & Res |
Method
|
|
SG10201811729PA
(en)
|
2013-12-12 |
2019-02-27 |
Life Technologies Corp |
Membrane-penetrating peptides to enhance transfection and compositions and methods for using same
|
|
US20150165054A1
(en)
*
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
ES2939542T3
(es)
*
|
2014-01-31 |
2023-04-24 |
Factor Bioscience Inc |
Métodos y productos para la producción y la administración de ácido nucleico
|
|
ES3063961T3
(en)
*
|
2014-02-14 |
2026-04-21 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
CA2945335A1
(en)
*
|
2014-04-18 |
2015-10-22 |
Editas Medicine, Inc. |
Crispr-cas-related methods, compositions and components for cancer immunotherapy
|
|
SG10201912038TA
(en)
*
|
2014-04-23 |
2020-02-27 |
Modernatx Inc |
Nucleic acid vaccines
|
|
WO2016069282A1
(en)
*
|
2014-10-31 |
2016-05-06 |
The Trustees Of The University Of Pennsylvania |
Altering gene expression in modified t cells and uses thereof
|
|
CA3197849A1
(en)
*
|
2014-12-29 |
2016-07-07 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
JP7199809B2
(ja)
|
2015-02-13 |
2023-01-06 |
ファクター バイオサイエンス インコーポレイテッド |
核酸製品及びその投与方法
|
|
CA3006618A1
(en)
*
|
2015-12-01 |
2017-06-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of alpha-1 antitrypsin deficiency
|
|
KR102438360B1
(ko)
*
|
2016-03-04 |
2022-08-31 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cpf1-관련 방법, 조성물 및 구성성분
|
|
WO2017165862A1
(en)
*
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
US11377637B2
(en)
*
|
2016-04-15 |
2022-07-05 |
Memorial Sloan Kettering Cancer Center |
Transgenic T cell and chimeric antigen receptor T cell compositions and related methods
|
|
US10576167B2
(en)
*
|
2016-08-17 |
2020-03-03 |
Factor Bioscience Inc. |
Nucleic acid products and methods of administration thereof
|