JP2019526273A5 - - Google Patents
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- JP2019526273A5 JP2019526273A5 JP2019518147A JP2019518147A JP2019526273A5 JP 2019526273 A5 JP2019526273 A5 JP 2019526273A5 JP 2019518147 A JP2019518147 A JP 2019518147A JP 2019518147 A JP2019518147 A JP 2019518147A JP 2019526273 A5 JP2019526273 A5 JP 2019526273A5
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- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 6
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940027941 immunoglobulin g Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022052202A JP7464644B2 (ja) | 2016-06-20 | 2022-03-28 | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352482P | 2016-06-20 | 2016-06-20 | |
| US62/352,482 | 2016-06-20 | ||
| PCT/EP2017/065073 WO2017220569A1 (en) | 2016-06-20 | 2017-06-20 | Binding molecules binding pd-l1 and lag-3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022052202A Division JP7464644B2 (ja) | 2016-06-20 | 2022-03-28 | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526273A JP2019526273A (ja) | 2019-09-19 |
| JP2019526273A5 true JP2019526273A5 (OSRAM) | 2020-07-30 |
| JP7085709B2 JP7085709B2 (ja) | 2022-06-17 |
Family
ID=59631719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518147A Active JP7085709B2 (ja) | 2016-06-20 | 2017-06-20 | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
| JP2022052202A Active JP7464644B2 (ja) | 2016-06-20 | 2022-03-28 | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022052202A Active JP7464644B2 (ja) | 2016-06-20 | 2022-03-28 | Ｐｄ－ｌ１及びｌａｇ－３に結合する結合分子 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11214620B2 (OSRAM) |
| EP (2) | EP3472207B1 (OSRAM) |
| JP (2) | JP7085709B2 (OSRAM) |
| KR (2) | KR102664891B1 (OSRAM) |
| CN (1) | CN109563171B (OSRAM) |
| AR (1) | AR110101A1 (OSRAM) |
| AU (1) | AU2017283181B2 (OSRAM) |
| BR (1) | BR112018076519A8 (OSRAM) |
| CA (1) | CA3027612A1 (OSRAM) |
| CY (1) | CY1124232T1 (OSRAM) |
| DK (1) | DK3472207T3 (OSRAM) |
| ES (1) | ES2858091T3 (OSRAM) |
| HR (1) | HRP20210602T1 (OSRAM) |
| HU (1) | HUE053742T2 (OSRAM) |
| IL (1) | IL263730B2 (OSRAM) |
| LT (1) | LT3472207T (OSRAM) |
| MX (1) | MX2018016320A (OSRAM) |
| PL (1) | PL3472207T3 (OSRAM) |
| PT (1) | PT3472207T (OSRAM) |
| RS (1) | RS61705B1 (OSRAM) |
| SG (1) | SG11201811064TA (OSRAM) |
| SI (1) | SI3472207T1 (OSRAM) |
| SM (1) | SMT202100213T1 (OSRAM) |
| TW (1) | TW201803906A (OSRAM) |
| WO (1) | WO2017220569A1 (OSRAM) |
Families Citing this family (98)
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| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| CN114081946A (zh) | 2014-03-12 | 2022-02-25 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| TWI756187B (zh) | 2015-10-09 | 2022-03-01 | 美商再生元醫藥公司 | 抗ｌａｇ３抗體及其用途 |
| NZ743881A (en) | 2016-02-06 | 2023-11-24 | Epimab Biotherapeutics Inc | Fabs-in-tandem immunoglobulin and uses thereof |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| SG11201811184UA (en) | 2016-06-20 | 2019-01-30 | F Star Beta Ltd | Lag -3 binding members |
| BR112018076519A8 (pt) * | 2016-06-20 | 2022-07-12 | F Star Delta Ltd | Moléculas de ligação que se ligam a pd-l1 e lag-3 |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN110650974B (zh) | 2017-02-10 | 2024-04-19 | 瑞泽恩制药公司 | 用于免疫-pet成像的放射性标记的抗-lag3抗体 |
| EP3630842A2 (en) | 2017-05-30 | 2020-04-08 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
| MX2019012076A (es) | 2017-05-30 | 2019-12-09 | Bristol Myers Squibb Co | Composiciones que comprenden un anticuerpo anti gen-3 de activacion del linfocito (lag-3) o un anticuerpo anti-lag-3 y un anticuerpo anti muerte celular programada 1 (pd-1) o anti ligando 1 de muerte celular programada (pd-l1). |
| AU2018277824A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Treatment of LAG-3 positive tumors |
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| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| WO2019129054A1 (zh) * | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 三链抗体、其制备方法及其用途 |
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| CN110343178B (zh) * | 2018-04-03 | 2022-07-22 | 上海开拓者生物医药有限公司 | 抗人lag-3单克隆抗体及其应用 |
| MX2020011588A (es) | 2018-05-03 | 2020-12-07 | Shanghai Epimab Biotherapeutics Co Ltd | Anticuerpos de alta afinidad a pd-1 y lag-3 y proteinas de union bispecificas preparadas a partir de las mismas. |
| AU2019269641A1 (en) * | 2018-05-17 | 2020-12-03 | Immunome, Inc. | CH3 domain epitope tags |
| WO2019246142A1 (en) * | 2018-06-18 | 2019-12-26 | Haiming Chen | Soluble bispecific fusion proteins for cancer immunotherapy |
| GB201811450D0 (en) | 2018-07-12 | 2018-08-29 | F Star Delta Ltd | Mesothelin and CD137 binding molecules |
| MX2021000399A (es) | 2018-07-12 | 2021-05-27 | F Star Therapeutics Ltd | Moleculas de anticuerpo que se unen a cd137 y ox40. |
| GB201811415D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Anti-Mesothelin Anti bodies |
| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
| AU2019301204B2 (en) | 2018-07-12 | 2025-10-23 | Invox Pharma Limited | Antibody molecules that bind PD-L1 and CD137 |
| GB201811408D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | CD137 Binding Molecules |
| GB201811403D0 (en) * | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
| AU2019309849A1 (en) | 2018-07-26 | 2021-03-18 | Bristol-Myers Squibb Company | LAG-3 combination therapy for the treatment of cancer |
| ES2986921T3 (es) | 2018-10-19 | 2024-11-13 | Bristol Myers Squibb Co | Terapia combinada para el melanoma |
| AU2019406313A1 (en) * | 2018-12-17 | 2021-01-07 | Illumina, Inc. | Flow cells and sequencing kits |
| TWI756621B (zh) * | 2019-01-25 | 2022-03-01 | 大陸商信達生物製藥（蘇州）有限公司 | 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體 |
| US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
| EP3715376A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of myasthenia gravis |
| EP3715375A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of pre-eclampsia |
| EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| MX2021013943A (es) * | 2019-05-14 | 2022-01-04 | F Star Therapeutics Ltd | Pautas posologicas para la administracion de un anticuerpo biespecifico frente a lag-3/pd-l1. |
| EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| KR20220016155A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법 |
| CN114174538A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 适合于免疫肿瘤学疗法的多肿瘤基因特征 |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| BR112022004316A2 (pt) | 2019-09-22 | 2022-06-21 | Bristol Myers Squibb Co | Caracterização espacial quantitativa para terapia de antagonista lag-3 |
| KR20220103095A (ko) * | 2019-09-26 | 2022-07-21 | 우시 바이올로직스 아일랜드 리미티드 | 신규 항-pd-l1/항-lag-3 이중특이적 항체 및 그의 용도 |
| WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
| KR20220093349A (ko) | 2019-11-08 | 2022-07-05 | 브리스톨-마이어스 스큅 컴퍼니 | 흑색종에 대한 lag-3 길항제 요법 |
| CN110950966B (zh) * | 2019-12-13 | 2020-12-11 | 启辰生生物科技(珠海)有限公司 | 融合蛋白、编码核酸和细胞及用途 |
| KR20220119694A (ko) * | 2019-12-23 | 2022-08-30 | 마크로제닉스, 인크. | 암 치료를 위한 요법 |
| KR20220124718A (ko) | 2020-01-07 | 2022-09-14 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 암 치료를 위한 개선된 인간 메틸 티오아데노신/아데노신 고갈 효소 변이체 |
| EP4100426A1 (en) | 2020-02-06 | 2022-12-14 | Bristol-Myers Squibb Company | Il-10 and uses thereof |
| CA3158607A1 (en) * | 2020-05-12 | 2021-11-18 | Astrazeneca Ab | Methods and combinations for the treatment of cancer using immune checkpoint inhibitor antibodies |
| KR20230035576A (ko) | 2020-07-07 | 2023-03-14 | 비온테크 에스이 | Hpv 양성 암 치료용 rna |
| MX2023002332A (es) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia con antagonistas del gen 3 de activacion de linfocitos (lag-3) para carcinoma hepatocelular. |
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| CN114621345B (zh) * | 2020-12-10 | 2022-11-29 | 北京东方百泰生物科技股份有限公司 | 一种抗lag-3的单克隆抗体、其抗原结合片段及其应用 |
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| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
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| AU2022253474A1 (en) | 2021-04-08 | 2023-11-16 | Board Of Regents, The University Of Texas System | Compounds and methods for theranostic targeting of parp activity |
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| CN118176214A (zh) | 2021-10-29 | 2024-06-11 | 百时美施贵宝公司 | 血液癌症的lag-3拮抗剂疗法 |
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2017
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- 2017-06-20 ES ES17752291T patent/ES2858091T3/es active Active
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- 2017-06-20 EP EP17752291.9A patent/EP3472207B1/en active Active
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- 2017-06-20 DK DK17752291.9T patent/DK3472207T3/da active
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- 2017-06-20 KR KR1020237006538A patent/KR102664891B1/ko active Active
- 2017-06-20 SM SM20210213T patent/SMT202100213T1/it unknown
- 2017-06-20 WO PCT/EP2017/065073 patent/WO2017220569A1/en not_active Ceased
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- 2017-06-20 CA CA3027612A patent/CA3027612A1/en active Pending
- 2017-06-20 KR KR1020197001122A patent/KR20190019144A/ko not_active Abandoned
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