JP2019524648A5 - - Google Patents
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- JP2019524648A5 JP2019524648A5 JP2018563781A JP2018563781A JP2019524648A5 JP 2019524648 A5 JP2019524648 A5 JP 2019524648A5 JP 2018563781 A JP2018563781 A JP 2018563781A JP 2018563781 A JP2018563781 A JP 2018563781A JP 2019524648 A5 JP2019524648 A5 JP 2019524648A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- particle
- amino acid
- sugar
- micrometers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 21
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 16
- 229960002715 nicotine Drugs 0.000 claims 14
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 14
- 229940024606 amino acid Drugs 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 5
- 239000007788 liquid Substances 0.000 claims 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 claims 3
- VWTHFJXLFGINSW-PPHPATTJSA-N 2-hydroxypropanoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound CC(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 VWTHFJXLFGINSW-PPHPATTJSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 229940009098 aspartate Drugs 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- DNDWZFHLZVYOGF-KKUMJFAQSA-N Leu-Leu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O DNDWZFHLZVYOGF-KKUMJFAQSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 108010049589 leucyl-leucyl-leucine Proteins 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031716A JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16177163.9 | 2016-06-30 | ||
| EP16177163 | 2016-06-30 | ||
| PCT/IB2017/053543 WO2018002756A1 (en) | 2016-06-30 | 2017-06-14 | Nicotine particles and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031716A Division JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524648A JP2019524648A (ja) | 2019-09-05 |
| JP2019524648A5 true JP2019524648A5 (https=) | 2020-07-09 |
Family
ID=56296661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563781A Pending JP2019524648A (ja) | 2016-06-30 | 2017-06-14 | ニコチン粒子および組成物 |
| JP2022031716A Pending JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031716A Pending JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20190133940A1 (https=) |
| EP (1) | EP3478264B1 (https=) |
| JP (2) | JP2019524648A (https=) |
| KR (1) | KR102523677B1 (https=) |
| CN (1) | CN109310622A (https=) |
| AR (1) | AR108920A1 (https=) |
| AU (1) | AU2017286864A1 (https=) |
| CA (1) | CA3023630A1 (https=) |
| ES (1) | ES3055891T3 (https=) |
| IL (1) | IL263355A (https=) |
| MX (1) | MX385972B (https=) |
| PH (1) | PH12018502714A1 (https=) |
| PL (1) | PL3478264T3 (https=) |
| RU (1) | RU2767064C2 (https=) |
| SG (1) | SG11201809594WA (https=) |
| TW (1) | TW201801716A (https=) |
| UA (1) | UA124535C2 (https=) |
| WO (1) | WO2018002756A1 (https=) |
| ZA (1) | ZA201806949B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3055891T3 (en) * | 2016-06-30 | 2026-02-16 | Philip Morris Products Sa | Nicotine particles and compositions |
| WO2020071448A1 (ja) * | 2018-10-02 | 2020-04-09 | 学校法人名城大学 | 吸入粉末剤、その評価方法及びその用途 |
| EP3946262B1 (en) * | 2019-08-30 | 2024-07-31 | Evie Sa | Loaded granules, their process of production and their uses |
| CN110384700A (zh) * | 2019-09-03 | 2019-10-29 | 云南喜科科技有限公司 | 一种合成尼古丁的组合物 |
| UA130281C2 (uk) | 2019-11-14 | 2026-01-07 | Філіп Морріс Продактс С.А. | Сухий порошковий склад зі смаком тютюну, спосіб його одержання та порошкова система |
| KR20220119101A (ko) | 2019-12-19 | 2022-08-26 | 쥴 랩스, 인크. | 유기 기반 니코틴 겔 조성물 |
| EP4076026A1 (en) | 2019-12-19 | 2022-10-26 | Juul Labs, Inc. | Metal oxide-based gel nicotine compositions |
| CA3164639A1 (en) | 2019-12-20 | 2021-06-24 | Juul Labs, Inc. | Hydrated ionic clay and tobacco material compositions |
| WO2021201258A1 (ja) * | 2020-04-01 | 2021-10-07 | 株式会社ＳｔａｔｅＡｒｔ | 核酸含有組成物、核酸含有組成物の製造方法及び核酸導入方法 |
| ES3040112T3 (en) * | 2020-06-15 | 2025-10-28 | Philip Morris Products Sa | Anatabine powder compositions |
| BR112023003114A2 (pt) * | 2020-09-03 | 2023-04-04 | Philip Morris Products Sa | Composições em pó ativas de baixa higroscopicidade liofilizadas |
| WO2022049488A1 (en) * | 2020-09-03 | 2022-03-10 | Philip Morris Products S.A. | Spray dried low hygroscopicity active powder compositions |
| US12594238B2 (en) * | 2020-09-03 | 2026-04-07 | Philip Morris Products S.A. | Low hygroscopicity active powder compositions |
| USD1081739S1 (en) | 2021-04-06 | 2025-07-01 | Altria Client Services Llc | Die for gum forming |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| JP2001151673A (ja) * | 1999-09-06 | 2001-06-05 | Nikken Chem Co Ltd | 吸入用粉末製剤の製造方法 |
| NZ518401A (en) * | 1999-10-29 | 2004-01-30 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
| SK11142002A3 (sk) * | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
| CA2418960A1 (en) * | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| MX2007004495A (es) * | 2004-10-15 | 2007-05-10 | Pfizer Prod Inc | Composiciones y procedimientos para la administracion intranasal, bucal, sublingual y pulmonar de vareniclina. |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| ITMI20051999A1 (it) * | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| FI20060428A7 (fi) * | 2006-05-03 | 2007-11-04 | Esko Kauppinen | Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| GB0801876D0 (en) * | 2008-02-01 | 2008-03-12 | Vectura Group Plc | Suspension formulations |
| CA2944471C (en) * | 2014-04-08 | 2020-03-31 | Philip Morris Products S.A. | Nicotine formulations and methods of making the same |
| CA2943746C (en) * | 2014-04-28 | 2023-08-15 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
| US10149844B2 (en) * | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US9585835B1 (en) * | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| ES3055891T3 (en) * | 2016-06-30 | 2026-02-16 | Philip Morris Products Sa | Nicotine particles and compositions |
| PL3478265T3 (pl) * | 2016-06-30 | 2025-04-14 | Philip Morris Products S.A. | Cząstki nikotyny |
| IL269275B2 (en) * | 2017-06-28 | 2023-04-01 | Philip Morris Products Sa | Container with particles for use with an inhaler |
-
2017
- 2017-06-14 ES ES17732583T patent/ES3055891T3/es active Active
- 2017-06-14 CA CA3023630A patent/CA3023630A1/en not_active Abandoned
- 2017-06-14 WO PCT/IB2017/053543 patent/WO2018002756A1/en not_active Ceased
- 2017-06-14 CN CN201780034796.4A patent/CN109310622A/zh active Pending
- 2017-06-14 AU AU2017286864A patent/AU2017286864A1/en not_active Abandoned
- 2017-06-14 RU RU2018145313A patent/RU2767064C2/ru active
- 2017-06-14 PL PL17732583.4T patent/PL3478264T3/pl unknown
- 2017-06-14 KR KR1020187035098A patent/KR102523677B1/ko active Active
- 2017-06-14 JP JP2018563781A patent/JP2019524648A/ja active Pending
- 2017-06-14 SG SG11201809594WA patent/SG11201809594WA/en unknown
- 2017-06-14 UA UAA201810794A patent/UA124535C2/uk unknown
- 2017-06-14 US US16/309,742 patent/US20190133940A1/en not_active Abandoned
- 2017-06-14 MX MX2018015118A patent/MX385972B/es unknown
- 2017-06-14 EP EP17732583.4A patent/EP3478264B1/en active Active
- 2017-06-29 TW TW106121799A patent/TW201801716A/zh unknown
- 2017-06-29 AR ARP170101809A patent/AR108920A1/es unknown
-
2018
- 2018-10-18 ZA ZA2018/06949A patent/ZA201806949B/en unknown
- 2018-11-28 IL IL263355A patent/IL263355A/en unknown
- 2018-12-21 PH PH12018502714A patent/PH12018502714A1/en unknown
-
2021
- 2021-08-05 US US17/394,623 patent/US20210361567A1/en not_active Abandoned
-
2022
- 2022-03-02 JP JP2022031716A patent/JP2022071106A/ja active Pending
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