JP2019519542A5 - - Google Patents
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- Publication number
- JP2019519542A5 JP2019519542A5 JP2018563818A JP2018563818A JP2019519542A5 JP 2019519542 A5 JP2019519542 A5 JP 2019519542A5 JP 2018563818 A JP2018563818 A JP 2018563818A JP 2018563818 A JP2018563818 A JP 2018563818A JP 2019519542 A5 JP2019519542 A5 JP 2019519542A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- particles
- micrometers
- particle size
- volume
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 27
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 16
- 229960002715 nicotine Drugs 0.000 claims 15
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 229940024606 amino acid Drugs 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 238000003801 milling Methods 0.000 claims 4
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 claims 3
- VWTHFJXLFGINSW-PPHPATTJSA-N 2-hydroxypropanoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound CC(O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 VWTHFJXLFGINSW-PPHPATTJSA-N 0.000 claims 3
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 229940009098 aspartate Drugs 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- DNDWZFHLZVYOGF-KKUMJFAQSA-N Leu-Leu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O DNDWZFHLZVYOGF-KKUMJFAQSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 108010049589 leucyl-leucyl-leucine Proteins 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000000647 trehalose group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080744A JP7583764B2 (ja) | 2016-06-30 | 2022-05-17 | ニコチン粒子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16177156.3 | 2016-06-30 | ||
| EP16177156 | 2016-06-30 | ||
| PCT/IB2017/053710 WO2018002779A1 (en) | 2016-06-30 | 2017-06-21 | Nicotine particles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080744A Division JP7583764B2 (ja) | 2016-06-30 | 2022-05-17 | ニコチン粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519542A JP2019519542A (ja) | 2019-07-11 |
| JP2019519542A5 true JP2019519542A5 (https=) | 2020-07-27 |
| JP7471774B2 JP7471774B2 (ja) | 2024-04-22 |
Family
ID=56296658
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563818A Active JP7471774B2 (ja) | 2016-06-30 | 2017-06-21 | ニコチン粒子 |
| JP2022080744A Active JP7583764B2 (ja) | 2016-06-30 | 2022-05-17 | ニコチン粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080744A Active JP7583764B2 (ja) | 2016-06-30 | 2022-05-17 | ニコチン粒子 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11458093B2 (https=) |
| EP (1) | EP3478265B1 (https=) |
| JP (2) | JP7471774B2 (https=) |
| KR (1) | KR102559152B1 (https=) |
| CN (1) | CN109310623B (https=) |
| AU (1) | AU2017290610A1 (https=) |
| BR (1) | BR112018075017A2 (https=) |
| CA (1) | CA3023626A1 (https=) |
| ES (1) | ES3005760T3 (https=) |
| IL (1) | IL263340A (https=) |
| MX (1) | MX387520B (https=) |
| PH (1) | PH12018502715A1 (https=) |
| PL (1) | PL3478265T3 (https=) |
| RU (1) | RU2741309C2 (https=) |
| SG (1) | SG11201809630RA (https=) |
| UA (1) | UA126853C2 (https=) |
| WO (1) | WO2018002779A1 (https=) |
| ZA (1) | ZA201807080B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3055891T3 (en) * | 2016-06-30 | 2026-02-16 | Philip Morris Products Sa | Nicotine particles and compositions |
| KR20190126772A (ko) * | 2017-03-07 | 2019-11-12 | 필립모리스 프로덕츠 에스.에이. | 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법 |
| UA130281C2 (uk) * | 2019-11-14 | 2026-01-07 | Філіп Морріс Продактс С.А. | Сухий порошковий склад зі смаком тютюну, спосіб його одержання та порошкова система |
| ES3040112T3 (en) * | 2020-06-15 | 2025-10-28 | Philip Morris Products Sa | Anatabine powder compositions |
| US12594238B2 (en) * | 2020-09-03 | 2026-04-07 | Philip Morris Products S.A. | Low hygroscopicity active powder compositions |
| WO2022049488A1 (en) * | 2020-09-03 | 2022-03-10 | Philip Morris Products S.A. | Spray dried low hygroscopicity active powder compositions |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
| USD1081739S1 (en) | 2021-04-06 | 2025-07-01 | Altria Client Services Llc | Die for gum forming |
| US12295412B2 (en) | 2022-01-28 | 2025-05-13 | Altria Client Services Llc | Oral pouch product |
| WO2024090890A1 (ko) * | 2022-10-27 | 2024-05-02 | 주식회사 케이티앤지 | 흡입용 저용량 니코틴 건조 분말 조성물 |
| JP2026509962A (ja) * | 2022-10-27 | 2026-03-26 | ケーティー アンド ジー コーポレイション | 吸入用ニコチン乾燥粉末の製造方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4655231A (en) | 1984-01-09 | 1987-04-07 | Advanced Tobacco Products, Inc. | Snuff and preparation thereof |
| JP3388896B2 (ja) * | 1994-08-08 | 2003-03-24 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
| GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
| CA2231968A1 (en) | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US20120042886A1 (en) | 1998-03-11 | 2012-02-23 | Hanna Piskorz | Method of producing a nicotine medicament and a medicament made by the method |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US20080138398A1 (en) | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| ITMI20051999A1 (it) | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| FI20060428A7 (fi) | 2006-05-03 | 2007-11-04 | Esko Kauppinen | Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia |
| US20080286340A1 (en) | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| JP2012509922A (ja) | 2008-11-27 | 2012-04-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規粉末化結晶質吸入薬 |
| PL3111927T3 (pl) | 2009-05-29 | 2020-06-29 | Pearl Therapeutics, Inc. | Kompozycje do wziewnego podawania środków aktywnych oraz związane z nimi sposoby i systemy |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| SE536491C2 (sv) | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
| US20140261474A1 (en) | 2013-03-15 | 2014-09-18 | Aradigm Corporation | Methods for inhalation of smoke-free nicotine |
| ITMI20130572A1 (it) | 2013-04-10 | 2014-10-11 | Eratech Srl | Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione |
| KR102490695B1 (ko) | 2013-05-06 | 2023-01-19 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법 |
| CA2944471C (en) * | 2014-04-08 | 2020-03-31 | Philip Morris Products S.A. | Nicotine formulations and methods of making the same |
| CA2943746C (en) * | 2014-04-28 | 2023-08-15 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
-
2017
- 2017-06-21 PL PL17734491.8T patent/PL3478265T3/pl unknown
- 2017-06-21 EP EP17734491.8A patent/EP3478265B1/en active Active
- 2017-06-21 ES ES17734491T patent/ES3005760T3/es active Active
- 2017-06-21 WO PCT/IB2017/053710 patent/WO2018002779A1/en not_active Ceased
- 2017-06-21 US US16/309,787 patent/US11458093B2/en active Active
- 2017-06-21 SG SG11201809630RA patent/SG11201809630RA/en unknown
- 2017-06-21 JP JP2018563818A patent/JP7471774B2/ja active Active
- 2017-06-21 MX MX2018015119A patent/MX387520B/es unknown
- 2017-06-21 CN CN201780035401.2A patent/CN109310623B/zh active Active
- 2017-06-21 BR BR112018075017-4A patent/BR112018075017A2/pt not_active Application Discontinuation
- 2017-06-21 CA CA3023626A patent/CA3023626A1/en not_active Abandoned
- 2017-06-21 RU RU2018144108A patent/RU2741309C2/ru active
- 2017-06-21 AU AU2017290610A patent/AU2017290610A1/en not_active Abandoned
- 2017-06-21 KR KR1020187034508A patent/KR102559152B1/ko active Active
- 2017-06-21 UA UAA201810804A patent/UA126853C2/uk unknown
-
2018
- 2018-10-24 ZA ZA2018/07080A patent/ZA201807080B/en unknown
- 2018-11-28 IL IL263340A patent/IL263340A/en unknown
- 2018-12-21 PH PH12018502715A patent/PH12018502715A1/en unknown
-
2022
- 2022-05-17 JP JP2022080744A patent/JP7583764B2/ja active Active
- 2022-09-07 US US17/939,348 patent/US12048762B2/en active Active
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