JP7471774B2 - ニコチン粒子 - Google Patents

ニコチン粒子 Download PDF

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Publication number
JP7471774B2
JP7471774B2 JP2018563818A JP2018563818A JP7471774B2 JP 7471774 B2 JP7471774 B2 JP 7471774B2 JP 2018563818 A JP2018563818 A JP 2018563818A JP 2018563818 A JP2018563818 A JP 2018563818A JP 7471774 B2 JP7471774 B2 JP 7471774B2
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particles
nicotine
acid
micrometers
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Japanese (ja)
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JP2019519542A (ja
JP2019519542A5 (https=
Inventor
ニコロ ヴォルペ
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フィリップ・モーリス・プロダクツ・ソシエテ・アノニム
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Priority to JP2022080744A priority Critical patent/JP7583764B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018563818A 2016-06-30 2017-06-21 ニコチン粒子 Active JP7471774B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022080744A JP7583764B2 (ja) 2016-06-30 2022-05-17 ニコチン粒子

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16177156.3 2016-06-30
EP16177156 2016-06-30
PCT/IB2017/053710 WO2018002779A1 (en) 2016-06-30 2017-06-21 Nicotine particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022080744A Division JP7583764B2 (ja) 2016-06-30 2022-05-17 ニコチン粒子

Publications (3)

Publication Number Publication Date
JP2019519542A JP2019519542A (ja) 2019-07-11
JP2019519542A5 JP2019519542A5 (https=) 2020-07-27
JP7471774B2 true JP7471774B2 (ja) 2024-04-22

Family

ID=56296658

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018563818A Active JP7471774B2 (ja) 2016-06-30 2017-06-21 ニコチン粒子
JP2022080744A Active JP7583764B2 (ja) 2016-06-30 2022-05-17 ニコチン粒子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022080744A Active JP7583764B2 (ja) 2016-06-30 2022-05-17 ニコチン粒子

Country Status (18)

Country Link
US (2) US11458093B2 (https=)
EP (1) EP3478265B1 (https=)
JP (2) JP7471774B2 (https=)
KR (1) KR102559152B1 (https=)
CN (1) CN109310623B (https=)
AU (1) AU2017290610A1 (https=)
BR (1) BR112018075017A2 (https=)
CA (1) CA3023626A1 (https=)
ES (1) ES3005760T3 (https=)
IL (1) IL263340A (https=)
MX (1) MX387520B (https=)
PH (1) PH12018502715A1 (https=)
PL (1) PL3478265T3 (https=)
RU (1) RU2741309C2 (https=)
SG (1) SG11201809630RA (https=)
UA (1) UA126853C2 (https=)
WO (1) WO2018002779A1 (https=)
ZA (1) ZA201807080B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3055891T3 (en) * 2016-06-30 2026-02-16 Philip Morris Products Sa Nicotine particles and compositions
KR20190126772A (ko) * 2017-03-07 2019-11-12 필립모리스 프로덕츠 에스.에이. 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법
UA130281C2 (uk) * 2019-11-14 2026-01-07 Філіп Морріс Продактс С.А. Сухий порошковий склад зі смаком тютюну, спосіб його одержання та порошкова система
ES3040112T3 (en) * 2020-06-15 2025-10-28 Philip Morris Products Sa Anatabine powder compositions
US12594238B2 (en) * 2020-09-03 2026-04-07 Philip Morris Products S.A. Low hygroscopicity active powder compositions
WO2022049488A1 (en) * 2020-09-03 2022-03-10 Philip Morris Products S.A. Spray dried low hygroscopicity active powder compositions
US20220313678A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Spray dried nicotine for inclusion in oral products
USD1081739S1 (en) 2021-04-06 2025-07-01 Altria Client Services Llc Die for gum forming
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
WO2024090890A1 (ko) * 2022-10-27 2024-05-02 주식회사 케이티앤지 흡입용 저용량 니코틴 건조 분말 조성물
JP2026509962A (ja) * 2022-10-27 2026-03-26 ケーティー アンド ジー コーポレイション 吸入用ニコチン乾燥粉末の製造方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003507412A (ja) 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ，インコーポレイテッド 多孔性粒子を形成するための単純アミノ酸の使用
JP2006514879A (ja) 2002-12-19 2006-05-18 アキュスフィア， インコーポレイテッド 噴霧乾燥器およびインラインジェットミルを用いる粒子を製造するための方法および装置
JP2009512663A (ja) 2005-10-21 2009-03-26 エラテック エス．アール．エル． 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法
JP2012509922A (ja) 2008-11-27 2012-04-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規粉末化結晶質吸入薬
JP2015509788A (ja) 2012-02-29 2015-04-02 パルマトリックス，インコーポレイテッド 吸入に適した乾燥粉末
JP2016515640A (ja) 2013-04-10 2016-05-30 エラテック エス．アール．エル．Ｅｒａｔｅｃｈ Ｓ．Ｒ．Ｌ． 製剤の安定性を向上させるための、噴霧乾燥により得られる少なくとも２つの乾燥粉末類を含む組成物

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Publication number Priority date Publication date Assignee Title
US4655231A (en) 1984-01-09 1987-04-07 Advanced Tobacco Products, Inc. Snuff and preparation thereof
JP3388896B2 (ja) * 1994-08-08 2003-03-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
CA2231968A1 (en) 1998-03-11 1999-09-11 Smoke-Stop, A Partnership Consisting Of Art Slutsky Method of producing a nicotine medicament
US20120042886A1 (en) 1998-03-11 2012-02-23 Hanna Piskorz Method of producing a nicotine medicament and a medicament made by the method
US8256433B2 (en) 1999-07-16 2012-09-04 Aradigm Corporation Systems and methods for effecting cessation of tobacco use
US20080138398A1 (en) 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US6799576B2 (en) 1999-07-16 2004-10-05 Aradigm Corporation System for effecting smoking cessation
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
FI20060428A7 (fi) 2006-05-03 2007-11-04 Esko Kauppinen Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia
US20080286340A1 (en) 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
PL3111927T3 (pl) 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Kompozycje do wziewnego podawania środków aktywnych oraz związane z nimi sposoby i systemy
SE536491C2 (sv) 2012-03-26 2013-12-27 Bionicotine Ab Påse innehållande nikotin och en tuggummikomposition
US20140261474A1 (en) 2013-03-15 2014-09-18 Aradigm Corporation Methods for inhalation of smoke-free nicotine
KR102490695B1 (ko) 2013-05-06 2023-01-19 쥴 랩스, 인크. 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법
CA2944471C (en) * 2014-04-08 2020-03-31 Philip Morris Products S.A. Nicotine formulations and methods of making the same
CA2943746C (en) * 2014-04-28 2023-08-15 Philip Morris Products S.A. Flavoured nicotine powder inhaler

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003507412A (ja) 1999-08-25 2003-02-25 アドバンスト インハレーション リサーチ，インコーポレイテッド 多孔性粒子を形成するための単純アミノ酸の使用
JP2006514879A (ja) 2002-12-19 2006-05-18 アキュスフィア， インコーポレイテッド 噴霧乾燥器およびインラインジェットミルを用いる粒子を製造するための方法および装置
JP2009512663A (ja) 2005-10-21 2009-03-26 エラテック エス．アール．エル． 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法
JP2012509922A (ja) 2008-11-27 2012-04-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規粉末化結晶質吸入薬
JP2015509788A (ja) 2012-02-29 2015-04-02 パルマトリックス，インコーポレイテッド 吸入に適した乾燥粉末
JP2016515640A (ja) 2013-04-10 2016-05-30 エラテック エス．アール．エル．Ｅｒａｔｅｃｈ Ｓ．Ｒ．Ｌ． 製剤の安定性を向上させるための、噴霧乾燥により得られる少なくとも２つの乾燥粉末類を含む組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｒｅｓｅａｒｃｈ，２００７年，Ｖｏｌ．２５， Ｎｏ．５，ｐｐ．９９９－１０２２

Also Published As

Publication number Publication date
CN109310623B (zh) 2022-10-21
PH12018502715A1 (en) 2019-07-29
BR112018075017A2 (pt) 2019-03-19
ES3005760T3 (en) 2025-03-17
EP3478265B1 (en) 2025-01-01
EP3478265C0 (en) 2025-01-01
US11458093B2 (en) 2022-10-04
AU2017290610A1 (en) 2018-11-15
MX2018015119A (es) 2019-04-15
RU2018144108A3 (https=) 2020-07-30
US20190117567A1 (en) 2019-04-25
CA3023626A1 (en) 2018-01-04
US20230000767A1 (en) 2023-01-05
ZA201807080B (en) 2019-07-31
UA126853C2 (uk) 2023-02-15
EP3478265A1 (en) 2019-05-08
JP2019519542A (ja) 2019-07-11
JP7583764B2 (ja) 2024-11-14
SG11201809630RA (en) 2018-11-29
JP2022116082A (ja) 2022-08-09
RU2018144108A (ru) 2020-07-30
MX387520B (es) 2025-03-18
IL263340A (en) 2018-12-31
KR20190026655A (ko) 2019-03-13
PL3478265T3 (pl) 2025-04-14
WO2018002779A1 (en) 2018-01-04
US12048762B2 (en) 2024-07-30
RU2741309C2 (ru) 2021-01-25
CN109310623A (zh) 2019-02-05
KR102559152B1 (ko) 2023-07-26

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