CN109310623B - 尼古丁颗粒 - Google Patents

尼古丁颗粒 Download PDF

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Publication number
CN109310623B
CN109310623B CN201780035401.2A CN201780035401A CN109310623B CN 109310623 B CN109310623 B CN 109310623B CN 201780035401 A CN201780035401 A CN 201780035401A CN 109310623 B CN109310623 B CN 109310623B
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China
Prior art keywords
particles
nicotine
particle size
acid
less
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CN201780035401.2A
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English (en)
Chinese (zh)
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CN109310623A (zh
Inventor
N·沃尔普
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Philip Morris Products SA
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Philip Morris Products SA
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Publication of CN109310623A publication Critical patent/CN109310623A/zh
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Publication of CN109310623B publication Critical patent/CN109310623B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780035401.2A 2016-06-30 2017-06-21 尼古丁颗粒 Active CN109310623B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16177156.3 2016-06-30
EP16177156 2016-06-30
PCT/IB2017/053710 WO2018002779A1 (en) 2016-06-30 2017-06-21 Nicotine particles

Publications (2)

Publication Number Publication Date
CN109310623A CN109310623A (zh) 2019-02-05
CN109310623B true CN109310623B (zh) 2022-10-21

Family

ID=56296658

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780035401.2A Active CN109310623B (zh) 2016-06-30 2017-06-21 尼古丁颗粒

Country Status (18)

Country Link
US (2) US11458093B2 (https=)
EP (1) EP3478265B1 (https=)
JP (2) JP7471774B2 (https=)
KR (1) KR102559152B1 (https=)
CN (1) CN109310623B (https=)
AU (1) AU2017290610A1 (https=)
BR (1) BR112018075017A2 (https=)
CA (1) CA3023626A1 (https=)
ES (1) ES3005760T3 (https=)
IL (1) IL263340A (https=)
MX (1) MX387520B (https=)
PH (1) PH12018502715A1 (https=)
PL (1) PL3478265T3 (https=)
RU (1) RU2741309C2 (https=)
SG (1) SG11201809630RA (https=)
UA (1) UA126853C2 (https=)
WO (1) WO2018002779A1 (https=)
ZA (1) ZA201807080B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3055891T3 (en) * 2016-06-30 2026-02-16 Philip Morris Products Sa Nicotine particles and compositions
KR20190126772A (ko) * 2017-03-07 2019-11-12 필립모리스 프로덕츠 에스.에이. 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법
UA130281C2 (uk) * 2019-11-14 2026-01-07 Філіп Морріс Продактс С.А. Сухий порошковий склад зі смаком тютюну, спосіб його одержання та порошкова система
ES3040112T3 (en) * 2020-06-15 2025-10-28 Philip Morris Products Sa Anatabine powder compositions
US12594238B2 (en) * 2020-09-03 2026-04-07 Philip Morris Products S.A. Low hygroscopicity active powder compositions
WO2022049488A1 (en) * 2020-09-03 2022-03-10 Philip Morris Products S.A. Spray dried low hygroscopicity active powder compositions
US20220313678A1 (en) * 2021-04-06 2022-10-06 Altria Client Services Llc Spray dried nicotine for inclusion in oral products
USD1081739S1 (en) 2021-04-06 2025-07-01 Altria Client Services Llc Die for gum forming
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
WO2024090890A1 (ko) * 2022-10-27 2024-05-02 주식회사 케이티앤지 흡입용 저용량 니코틴 건조 분말 조성물
JP2026509962A (ja) * 2022-10-27 2026-03-26 ケーティー アンド ジー コーポレイション 吸入用ニコチン乾燥粉末の製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
CN1298294A (zh) * 1998-03-11 2001-06-06 阿特·斯卢茨基 尼古丁吸入剂
CN1726076A (zh) * 2002-12-19 2006-01-25 阿库斯菲尔公司 使用喷雾干燥器和内连气流粉碎机制备粒子的方法和设备
CN101106975A (zh) * 2004-11-23 2008-01-16 维克特拉有限公司 包含用抗粘添加剂进行表面修饰的颗粒的干粉吸入制剂

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4655231A (en) 1984-01-09 1987-04-07 Advanced Tobacco Products, Inc. Snuff and preparation thereof
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US20120042886A1 (en) 1998-03-11 2012-02-23 Hanna Piskorz Method of producing a nicotine medicament and a medicament made by the method
US8256433B2 (en) 1999-07-16 2012-09-04 Aradigm Corporation Systems and methods for effecting cessation of tobacco use
US20080138398A1 (en) 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US6799576B2 (en) 1999-07-16 2004-10-05 Aradigm Corporation System for effecting smoking cessation
US6586008B1 (en) * 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
ITMI20051999A1 (it) 2005-10-21 2007-04-22 Eratech S R L Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
FI20060428A7 (fi) 2006-05-03 2007-11-04 Esko Kauppinen Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia
US20080286340A1 (en) 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
JP2012509922A (ja) 2008-11-27 2012-04-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規粉末化結晶質吸入薬
PL3111927T3 (pl) 2009-05-29 2020-06-29 Pearl Therapeutics, Inc. Kompozycje do wziewnego podawania środków aktywnych oraz związane z nimi sposoby i systemy
CN107596518B (zh) 2012-02-29 2021-04-23 普马特里克斯营业公司 可吸入干粉剂
SE536491C2 (sv) 2012-03-26 2013-12-27 Bionicotine Ab Påse innehållande nikotin och en tuggummikomposition
US20140261474A1 (en) 2013-03-15 2014-09-18 Aradigm Corporation Methods for inhalation of smoke-free nicotine
ITMI20130572A1 (it) 2013-04-10 2014-10-11 Eratech Srl Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione
KR102490695B1 (ko) 2013-05-06 2023-01-19 쥴 랩스, 인크. 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법
CA2944471C (en) * 2014-04-08 2020-03-31 Philip Morris Products S.A. Nicotine formulations and methods of making the same
CA2943746C (en) * 2014-04-28 2023-08-15 Philip Morris Products S.A. Flavoured nicotine powder inhaler

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
CN1298294A (zh) * 1998-03-11 2001-06-06 阿特·斯卢茨基 尼古丁吸入剂
CN1726076A (zh) * 2002-12-19 2006-01-25 阿库斯菲尔公司 使用喷雾干燥器和内连气流粉碎机制备粒子的方法和设备
CN101106975A (zh) * 2004-11-23 2008-01-16 维克特拉有限公司 包含用抗粘添加剂进行表面修饰的颗粒的干粉吸入制剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pharmaceutical Particle Engineering via Spray Drying;Reinhard Vehring;《Pharmaceutical Research》;20071108;第25卷(第5期);第999-1022页 *

Also Published As

Publication number Publication date
PH12018502715A1 (en) 2019-07-29
BR112018075017A2 (pt) 2019-03-19
ES3005760T3 (en) 2025-03-17
EP3478265B1 (en) 2025-01-01
EP3478265C0 (en) 2025-01-01
US11458093B2 (en) 2022-10-04
AU2017290610A1 (en) 2018-11-15
MX2018015119A (es) 2019-04-15
RU2018144108A3 (https=) 2020-07-30
US20190117567A1 (en) 2019-04-25
CA3023626A1 (en) 2018-01-04
US20230000767A1 (en) 2023-01-05
ZA201807080B (en) 2019-07-31
UA126853C2 (uk) 2023-02-15
EP3478265A1 (en) 2019-05-08
JP7471774B2 (ja) 2024-04-22
JP2019519542A (ja) 2019-07-11
JP7583764B2 (ja) 2024-11-14
SG11201809630RA (en) 2018-11-29
JP2022116082A (ja) 2022-08-09
RU2018144108A (ru) 2020-07-30
MX387520B (es) 2025-03-18
IL263340A (en) 2018-12-31
KR20190026655A (ko) 2019-03-13
PL3478265T3 (pl) 2025-04-14
WO2018002779A1 (en) 2018-01-04
US12048762B2 (en) 2024-07-30
RU2741309C2 (ru) 2021-01-25
CN109310623A (zh) 2019-02-05
KR102559152B1 (ko) 2023-07-26

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