JP2018528966A5 - - Google Patents
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- Publication number
- JP2018528966A5 JP2018528966A5 JP2018514451A JP2018514451A JP2018528966A5 JP 2018528966 A5 JP2018528966 A5 JP 2018528966A5 JP 2018514451 A JP2018514451 A JP 2018514451A JP 2018514451 A JP2018514451 A JP 2018514451A JP 2018528966 A5 JP2018528966 A5 JP 2018528966A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- nicotine
- menthol
- concentration
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 41
- 239000000203 mixture Substances 0.000 claims 41
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 25
- 229960002715 nicotine Drugs 0.000 claims 22
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 22
- 238000000034 method Methods 0.000 claims 16
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 14
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 14
- 229940041616 menthol Drugs 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 3
- 229930006000 Sucrose Natural products 0.000 claims 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 3
- 239000000796 flavoring agent Substances 0.000 claims 3
- 235000019634 flavors Nutrition 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229940112141 dry powder inhaler Drugs 0.000 claims 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022077936A JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/856,102 US9585835B1 (en) | 2015-09-16 | 2015-09-16 | Inhalable nicotine formulations and methods of making and using the same |
| US14/856,102 | 2015-09-16 | ||
| PCT/US2016/051963 WO2017048974A1 (en) | 2015-09-16 | 2016-09-15 | Inhalable nicotine formulations, and methods of making and using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077936A Division JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528966A JP2018528966A (ja) | 2018-10-04 |
| JP2018528966A5 true JP2018528966A5 (https=) | 2019-10-17 |
| JP7575183B2 JP7575183B2 (ja) | 2024-10-29 |
Family
ID=58162192
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514451A Active JP7575183B2 (ja) | 2015-09-16 | 2016-09-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2022077936A Pending JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A Pending JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022077936A Pending JP2022097639A (ja) | 2015-09-16 | 2022-05-11 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
| JP2024065173A Pending JP2024086897A (ja) | 2015-09-16 | 2024-04-15 | 吸入可能なニコチン製剤、ならびにその作製方法および使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9585835B1 (https=) |
| EP (1) | EP3349599B1 (https=) |
| JP (3) | JP7575183B2 (https=) |
| KR (1) | KR102760317B1 (https=) |
| CN (1) | CN106539794B (https=) |
| AU (1) | AU2016323317A1 (https=) |
| BR (1) | BR112018005145B1 (https=) |
| CA (1) | CA2999082A1 (https=) |
| ES (1) | ES2997334T3 (https=) |
| HK (1) | HK1258016A1 (https=) |
| IL (1) | IL258143A (https=) |
| MX (1) | MX394985B (https=) |
| MY (1) | MY184362A (https=) |
| PH (1) | PH12018500544A1 (https=) |
| PL (1) | PL3349599T3 (https=) |
| RU (1) | RU2719228C2 (https=) |
| UA (1) | UA126849C2 (https=) |
| WO (1) | WO2017048974A1 (https=) |
| ZA (1) | ZA201801569B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9968125B2 (en) * | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| ES3055891T3 (en) * | 2016-06-30 | 2026-02-16 | Philip Morris Products Sa | Nicotine particles and compositions |
| KR20190126772A (ko) * | 2017-03-07 | 2019-11-12 | 필립모리스 프로덕츠 에스.에이. | 흡입 가능한 니코틴 제형, 및 이의 제조 및 사용 방법 |
| IL269275B2 (en) | 2017-06-28 | 2023-04-01 | Philip Morris Products Sa | Container with particles for use with an inhaler |
| GB201817862D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817868D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| UA130281C2 (uk) * | 2019-11-14 | 2026-01-07 | Філіп Морріс Продактс С.А. | Сухий порошковий склад зі смаком тютюну, спосіб його одержання та порошкова система |
| ES3040112T3 (en) * | 2020-06-15 | 2025-10-28 | Philip Morris Products Sa | Anatabine powder compositions |
| US12594238B2 (en) | 2020-09-03 | 2026-04-07 | Philip Morris Products S.A. | Low hygroscopicity active powder compositions |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
| US20220313614A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Encapsulated nicotine granules and methods of preparation thereof |
| WO2024090890A1 (ko) * | 2022-10-27 | 2024-05-02 | 주식회사 케이티앤지 | 흡입용 저용량 니코틴 건조 분말 조성물 |
| JP2026509962A (ja) * | 2022-10-27 | 2026-03-26 | ケーティー アンド ジー コーポレイション | 吸入用ニコチン乾燥粉末の製造方法 |
| CN117158443B (zh) * | 2023-09-05 | 2024-03-22 | 贵州大学 | 烟碱在制备贝莱斯芽胞杆菌生防作用增强剂中的应用 |
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| US5441060A (en) | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
| CA2146954C (en) | 1995-04-12 | 2008-06-17 | Arthur Slutsky | Breath activated nicotine inhalers |
| AUPN862596A0 (en) * | 1996-03-12 | 1996-04-04 | F.H. Faulding & Co. Limited | Pharmaceutical compositions |
| US6200391B1 (en) * | 1997-09-22 | 2001-03-13 | Ohshiro Co., Ltd. | Tobacco flavoring agent |
| CA2231968A1 (en) | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| CA2265198C (en) | 1998-03-11 | 2009-01-27 | Zamel, Noe | Method of producing a nicotine medicament and a medicament made by the method |
| US20120042886A1 (en) | 1998-03-11 | 2012-02-23 | Hanna Piskorz | Method of producing a nicotine medicament and a medicament made by the method |
| US6234169B1 (en) | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
| DK1808438T3 (da) | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| SK11142002A3 (sk) | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| CA2418960A1 (en) | 2000-08-07 | 2002-02-14 | Inhale Therapeutic Systems, Inc. | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| FR2815987B1 (fr) | 2000-10-27 | 2003-02-28 | Michel Petiot | Embase enfichable pour poteau ou piquet |
| JP2002161030A (ja) | 2000-11-27 | 2002-06-04 | Unisia Jecs Corp | 異なる粒径をもった混合粉体の吸入方法 |
| ITMI20012174A1 (it) * | 2001-10-18 | 2003-04-18 | Univ Parma | Polvere per somministrazione nasale di farmaci |
| PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| JP2006522634A (ja) | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| KR20060015316A (ko) | 2003-05-28 | 2006-02-16 | 넥타르 테라퓨틱스 | 아미노산 및/또는 인지질로 부분 또는 완전 코팅된수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의분무 건조법 |
| AU2004269986A1 (en) | 2003-09-08 | 2005-03-17 | Pfizer Consumer Healthcare Health Ab | Nicotine formulations and use thereof |
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| FI20060428A7 (fi) * | 2006-05-03 | 2007-11-04 | Esko Kauppinen | Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia |
| WO2008069970A2 (en) | 2006-12-01 | 2008-06-12 | Aradigm Corporation | Nicotine formulations, kits and systems and methods for their use |
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| GB0712308D0 (en) | 2007-06-25 | 2007-08-01 | Kind Group Ltd | An inhalable composition |
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| GB0905840D0 (en) * | 2009-04-06 | 2009-05-20 | Sagentia Ltd | Apparatus and methods |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| WO2013006643A1 (en) * | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| HUE041858T2 (hu) * | 2011-08-01 | 2019-05-28 | Univ Monash | Inhalálásra szolgáló eljárás és kiszerelés |
| GB201113662D0 (en) | 2011-08-08 | 2011-09-21 | Prosonix Ltd | Pharmaceutical compositions |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US20130177646A1 (en) | 2012-01-05 | 2013-07-11 | Mcneil Ab | Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| JP6360039B2 (ja) | 2012-05-03 | 2018-07-18 | カラ ファーマシューティカルズ インコーポレイテッド | 複数の被覆された粒子を含む組成物、医薬組成物、医薬製剤、及び当該粒子の形成方法 |
| GB201215273D0 (en) * | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | Nicotine composition |
| US20140088044A1 (en) * | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
| US20140166027A1 (en) | 2012-12-14 | 2014-06-19 | Richard C. Fuisz | Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor Producing Device Through Use of an Absorption Conditioning Unit |
| US20140261474A1 (en) * | 2013-03-15 | 2014-09-18 | Aradigm Corporation | Methods for inhalation of smoke-free nicotine |
| CA2944471C (en) * | 2014-04-08 | 2020-03-31 | Philip Morris Products S.A. | Nicotine formulations and methods of making the same |
| CA2943746C (en) | 2014-04-28 | 2023-08-15 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
| RU2696570C2 (ru) | 2014-04-28 | 2019-08-06 | Филип Моррис Продактс С.А. | Ингалятор никотинового порошка |
| FR3035826B1 (fr) * | 2015-05-07 | 2018-11-16 | Saint-Gobain Glass France | Vitrage de vehicule comprenant une platine pour la fixation de plusieurs accessoires, platine et procede de fixation. |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
-
2015
- 2015-09-16 US US14/856,102 patent/US9585835B1/en active Active
- 2015-10-29 CN CN201510717990.5A patent/CN106539794B/zh active Active
-
2016
- 2016-09-15 KR KR1020187007673A patent/KR102760317B1/ko active Active
- 2016-09-15 PL PL16847315.5T patent/PL3349599T3/pl unknown
- 2016-09-15 ES ES16847315T patent/ES2997334T3/es active Active
- 2016-09-15 RU RU2018113460A patent/RU2719228C2/ru active
- 2016-09-15 JP JP2018514451A patent/JP7575183B2/ja active Active
- 2016-09-15 CA CA2999082A patent/CA2999082A1/en not_active Abandoned
- 2016-09-15 MX MX2018003272A patent/MX394985B/es unknown
- 2016-09-15 HK HK19100385.2A patent/HK1258016A1/zh unknown
- 2016-09-15 BR BR112018005145-4A patent/BR112018005145B1/pt active IP Right Grant
- 2016-09-15 EP EP16847315.5A patent/EP3349599B1/en active Active
- 2016-09-15 UA UAA201803890A patent/UA126849C2/uk unknown
- 2016-09-15 AU AU2016323317A patent/AU2016323317A1/en not_active Abandoned
- 2016-09-15 WO PCT/US2016/051963 patent/WO2017048974A1/en not_active Ceased
- 2016-09-15 MY MYPI2018700899A patent/MY184362A/en unknown
-
2018
- 2018-03-07 ZA ZA2018/01569A patent/ZA201801569B/en unknown
- 2018-03-13 PH PH12018500544A patent/PH12018500544A1/en unknown
- 2018-03-15 IL IL258143A patent/IL258143A/en unknown
-
2022
- 2022-05-11 JP JP2022077936A patent/JP2022097639A/ja active Pending
-
2024
- 2024-04-15 JP JP2024065173A patent/JP2024086897A/ja active Pending
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