JP2018527386A5 - - Google Patents
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- Publication number
- JP2018527386A5 JP2018527386A5 JP2018514457A JP2018514457A JP2018527386A5 JP 2018527386 A5 JP2018527386 A5 JP 2018527386A5 JP 2018514457 A JP2018514457 A JP 2018514457A JP 2018514457 A JP2018514457 A JP 2018514457A JP 2018527386 A5 JP2018527386 A5 JP 2018527386A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- formulation
- particles
- dry powder
- size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 21
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 20
- 229960002715 nicotine Drugs 0.000 claims 19
- 239000002245 particle Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 10
- 239000000843 powder Substances 0.000 claims 9
- 206010057852 Nicotine dependence Diseases 0.000 claims 5
- 230000000954 anitussive effect Effects 0.000 claims 4
- 229940124584 antitussives Drugs 0.000 claims 4
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 claims 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 3
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 3
- 230000036765 blood level Effects 0.000 claims 3
- 229940041616 menthol Drugs 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000019634 flavors Nutrition 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/856,129 | 2015-09-16 | ||
| US14/856,129 US11224594B2 (en) | 2015-09-16 | 2015-09-16 | Nicotine formulations and methods of making and using the same |
| PCT/US2016/051961 WO2017048972A1 (en) | 2015-09-16 | 2016-09-15 | Nicotine formulations and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527386A JP2018527386A (ja) | 2018-09-20 |
| JP2018527386A5 true JP2018527386A5 (https=) | 2019-10-17 |
Family
ID=58257033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514457A Pending JP2018527386A (ja) | 2015-09-16 | 2016-09-15 | ニコチン製剤、ならびにこれを作製および使用する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11224594B2 (https=) |
| EP (1) | EP3349755B1 (https=) |
| JP (1) | JP2018527386A (https=) |
| KR (1) | KR102696600B1 (https=) |
| CN (1) | CN106539793B (https=) |
| CA (1) | CA2998950A1 (https=) |
| IL (1) | IL258139A (https=) |
| MX (1) | MX2018003271A (https=) |
| RU (1) | RU2722446C2 (https=) |
| WO (1) | WO2017048972A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10149844B2 (en) | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| US9585835B1 (en) * | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| KR102523677B1 (ko) * | 2016-06-30 | 2023-04-20 | 필립모리스 프로덕츠 에스.에이. | 니코틴 입자 및 조성물 |
| MY200258A (en) * | 2017-06-28 | 2023-12-17 | Philip Morris Products Sa | Container with particles for use with inhaler |
| USD1081739S1 (en) | 2021-04-06 | 2025-07-01 | Altria Client Services Llc | Die for gum forming |
| CN113208148B (zh) * | 2021-05-12 | 2022-11-04 | 云南中烟工业有限责任公司 | 一种协同释放尼古丁和致香成分的超分子凝胶 |
| US12295412B2 (en) | 2022-01-28 | 2025-05-13 | Altria Client Services Llc | Oral pouch product |
| WO2024090892A1 (ko) * | 2022-10-27 | 2024-05-02 | 주식회사 케이티앤지 | 흡입용 니코틴 건조 분말의 제조 방법 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441060A (en) | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
| US6102036A (en) * | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
| CA2146954C (en) | 1995-04-12 | 2008-06-17 | Arthur Slutsky | Breath activated nicotine inhalers |
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| CA2265198C (en) | 1998-03-11 | 2009-01-27 | Zamel, Noe | Method of producing a nicotine medicament and a medicament made by the method |
| US20120042886A1 (en) | 1998-03-11 | 2012-02-23 | Hanna Piskorz | Method of producing a nicotine medicament and a medicament made by the method |
| US6234169B1 (en) | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
| ES2569916T3 (es) | 1999-06-29 | 2016-05-13 | Mannkind Corporation | Formulaciones farmacéuticas que comprenden insulina complejada con una dicetopiperazina |
| US20080138399A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| NZ520379A (en) | 1999-12-30 | 2004-05-28 | Chiron Corp | Methods for administrering interleukin-2 by pulmonary inhalation |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| JP2006522634A (ja) | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| RU2364400C2 (ru) | 2003-04-14 | 2009-08-20 | Вектура Лтд | Фармацевтические композиции |
| US20120321717A1 (en) * | 2003-04-14 | 2012-12-20 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| CA2523475C (en) | 2003-05-28 | 2013-02-05 | Nektar Therapeutics | Pharmaceutical formulation comprising a water-insoluble active agent |
| GB0321607D0 (en) | 2003-09-15 | 2003-10-15 | Vectura Ltd | Manufacture of pharmaceutical compositions |
| GB0410398D0 (en) | 2004-05-10 | 2004-06-16 | Arakis Ltd | The treatment of respiratory disease |
| EP2007358A4 (en) | 2006-04-04 | 2012-01-25 | Stc Unm | INFLATING PARTICLES FOR THE ADMINISTRATION OF A MEDICINAL PRODUCT |
| WO2008069972A2 (en) | 2006-12-01 | 2008-06-12 | Aradigm Corporation | Systems for effecting cessation of tobacco use |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| GB0709811D0 (en) | 2007-05-22 | 2007-07-04 | Vectura Group Plc | Pharmaceutical compositions |
| GB0801876D0 (en) * | 2008-02-01 | 2008-03-12 | Vectura Group Plc | Suspension formulations |
| KR20100069333A (ko) | 2008-12-16 | 2010-06-24 | 홍성엽 | 흡입식 경구 투여 금연 보조제 |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| GB201113662D0 (en) | 2011-08-08 | 2011-09-21 | Prosonix Ltd | Pharmaceutical compositions |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| KR102310775B1 (ko) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| GB201215273D0 (en) * | 2012-08-28 | 2012-10-10 | Kind Consumer Ltd | Nicotine composition |
| KR102169734B1 (ko) | 2012-11-28 | 2020-10-26 | 이-니코틴 테크놀로지, 인크. | 화합물 전달을 위한 방법 및 장치 |
| US20140166027A1 (en) | 2012-12-14 | 2014-06-19 | Richard C. Fuisz | Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor Producing Device Through Use of an Absorption Conditioning Unit |
| US10357054B2 (en) | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
| KR20160120739A (ko) * | 2014-02-11 | 2016-10-18 | 램 테라퓨틱스, 인코포레이티드 | 림프관평활근종증의 치료를 위한 라파마이신 |
| CN105828819A (zh) | 2014-04-08 | 2016-08-03 | 桑萨（巴巴多斯）公司 | 烟碱制剂及其制备方法 |
| AU2015254999B2 (en) | 2014-04-28 | 2019-08-01 | Philip Morris Products S.A. | Flavoured nicotine powder inhaler |
| EP3136894B1 (en) | 2014-04-28 | 2019-07-31 | Philip Morris Products S.A. | Nicotine powder inhaler |
| CN113754634A (zh) * | 2014-05-27 | 2021-12-07 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体络合物 |
| US9968125B2 (en) | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| US9585835B1 (en) | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
-
2015
- 2015-09-16 US US14/856,129 patent/US11224594B2/en active Active
- 2015-10-29 CN CN201510717550.XA patent/CN106539793B/zh active Active
-
2016
- 2016-09-15 RU RU2018113272A patent/RU2722446C2/ru active
- 2016-09-15 MX MX2018003271A patent/MX2018003271A/es unknown
- 2016-09-15 JP JP2018514457A patent/JP2018527386A/ja active Pending
- 2016-09-15 CA CA2998950A patent/CA2998950A1/en not_active Abandoned
- 2016-09-15 WO PCT/US2016/051961 patent/WO2017048972A1/en not_active Ceased
- 2016-09-15 KR KR1020187007524A patent/KR102696600B1/ko active Active
- 2016-09-15 EP EP16847313.0A patent/EP3349755B1/en active Active
-
2018
- 2018-03-15 IL IL258139A patent/IL258139A/en unknown
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