JP2018527386A - ニコチン製剤、ならびにこれを作製および使用する方法 - Google Patents

ニコチン製剤、ならびにこれを作製および使用する方法 Download PDF

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Publication number
JP2018527386A
JP2018527386A JP2018514457A JP2018514457A JP2018527386A JP 2018527386 A JP2018527386 A JP 2018527386A JP 2018514457 A JP2018514457 A JP 2018514457A JP 2018514457 A JP2018514457 A JP 2018514457A JP 2018527386 A JP2018527386 A JP 2018527386A
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nicotine
formulation
particles
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size
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JP2018527386A5 (https=
Inventor
アレックス シュテンツラー
アレックス シュテンツラー
ノエ ザメル
ノエ ザメル
アーサー スルツキー
アーサー スルツキー
スティーヴン エリス
スティーヴン エリス
スティーヴ ハン
スティーヴ ハン
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フィリップ・モーリス・プロダクツ・ソシエテ・アノニム
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Publication of JP2018527386A publication Critical patent/JP2018527386A/ja
Publication of JP2018527386A5 publication Critical patent/JP2018527386A5/ja
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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/20—Devices without heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2018514457A 2015-09-16 2016-09-15 ニコチン製剤、ならびにこれを作製および使用する方法 Pending JP2018527386A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/856,129 2015-09-16
US14/856,129 US11224594B2 (en) 2015-09-16 2015-09-16 Nicotine formulations and methods of making and using the same
PCT/US2016/051961 WO2017048972A1 (en) 2015-09-16 2016-09-15 Nicotine formulations and methods of making and using the same

Publications (2)

Publication Number Publication Date
JP2018527386A true JP2018527386A (ja) 2018-09-20
JP2018527386A5 JP2018527386A5 (https=) 2019-10-17

Family

ID=58257033

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018514457A Pending JP2018527386A (ja) 2015-09-16 2016-09-15 ニコチン製剤、ならびにこれを作製および使用する方法

Country Status (10)

Country Link
US (1) US11224594B2 (https=)
EP (1) EP3349755B1 (https=)
JP (1) JP2018527386A (https=)
KR (1) KR102696600B1 (https=)
CN (1) CN106539793B (https=)
CA (1) CA2998950A1 (https=)
IL (1) IL258139A (https=)
MX (1) MX2018003271A (https=)
RU (1) RU2722446C2 (https=)
WO (1) WO2017048972A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019524648A (ja) * 2016-06-30 2019-09-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチン粒子および組成物

Families Citing this family (7)

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US10149844B2 (en) 2015-09-16 2018-12-11 Philip Morris Products S.A. Inhalable nicotine formulations, and methods of making and using thereof
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
MY200258A (en) * 2017-06-28 2023-12-17 Philip Morris Products Sa Container with particles for use with inhaler
USD1081739S1 (en) 2021-04-06 2025-07-01 Altria Client Services Llc Die for gum forming
CN113208148B (zh) * 2021-05-12 2022-11-04 云南中烟工业有限责任公司 一种协同释放尼古丁和致香成分的超分子凝胶
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
WO2024090892A1 (ko) * 2022-10-27 2024-05-02 주식회사 케이티앤지 흡입용 니코틴 건조 분말의 제조 방법

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WO1994017679A1 (en) * 1993-02-08 1994-08-18 Advanced Therapeutic Products, Inc. Dry powder delivery system
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017679A1 (en) * 1993-02-08 1994-08-18 Advanced Therapeutic Products, Inc. Dry powder delivery system
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
JP2002506017A (ja) * 1998-03-11 2002-02-26 スラトスキー．アート ニコチン吸入器
JP2003519175A (ja) * 1999-12-30 2003-06-17 カイロン コーポレイション インターロイキン−２の肺送達のための方法
JP2003530425A (ja) * 2000-04-17 2003-10-14 ヴェクトゥラ リミテッド 吸入器で使用するための製剤におけるまたはそれに関する改良
JP2004515467A (ja) * 2000-08-07 2004-05-27 ネクター セラピューティックス 吸入可能な、噴霧乾燥した、最少の凝集物を有する４−ヘリックスバンドルタンパク質粉末
US20090068276A1 (en) * 2007-05-22 2009-03-12 Vectura Group Plc Pharmaceutical compositions
JP2011510963A (ja) * 2008-02-01 2011-04-07 ベクトゥラ・リミテッド 懸濁製剤
JP2014522880A (ja) * 2011-08-08 2014-09-08 プロソニックス リミテッド 製剤組成物
WO2015123219A1 (en) * 2014-02-11 2015-08-20 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019524648A (ja) * 2016-06-30 2019-09-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム ニコチン粒子および組成物

Also Published As

Publication number Publication date
CN106539793B (zh) 2020-06-30
IL258139A (en) 2018-05-31
CA2998950A1 (en) 2017-03-23
CN106539793A (zh) 2017-03-29
EP3349755B1 (en) 2025-02-19
MX2018003271A (es) 2018-05-16
EP3349755A1 (en) 2018-07-25
KR102696600B1 (ko) 2024-08-21
WO2017048972A1 (en) 2017-03-23
US20170071929A1 (en) 2017-03-16
RU2722446C2 (ru) 2020-06-01
RU2018113272A (ru) 2019-10-16
KR20180055819A (ko) 2018-05-25
RU2018113272A3 (https=) 2019-10-16
US11224594B2 (en) 2022-01-18
EP3349755C0 (en) 2025-02-19
EP3349755A4 (en) 2019-04-24

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