JP2019524648A5 - - Google Patents
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- JP2019524648A5 JP2019524648A5 JP2018563781A JP2018563781A JP2019524648A5 JP 2019524648 A5 JP2019524648 A5 JP 2019524648A5 JP 2018563781 A JP2018563781 A JP 2018563781A JP 2018563781 A JP2018563781 A JP 2018563781A JP 2019524648 A5 JP2019524648 A5 JP 2019524648A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- particle
- amino acid
- sugar
- micrometers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 21
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 16
- 229960002715 Nicotine Drugs 0.000 claims 14
- 229930015196 nicotine Natural products 0.000 claims 14
- 235000001014 amino acid Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- 239000007788 liquid Substances 0.000 claims 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N Trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 4
- SDVKWBNZJFWIMO-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CN1CCCC1C1=CC=CN=C1.OC(=O)CC(O)(C(O)=O)CC(O)=O SDVKWBNZJFWIMO-UHFFFAOYSA-N 0.000 claims 3
- VWTHFJXLFGINSW-UHFFFAOYSA-N 2-hydroxypropanoic acid;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 VWTHFJXLFGINSW-UHFFFAOYSA-N 0.000 claims 3
- 229940009098 Aspartate Drugs 0.000 claims 3
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-UHFFFAOYSA-N DL-aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 ISOLEUCINE Drugs 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- 229960005190 Phenylalanine Drugs 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- MMOPGICOOYBFJU-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;2-oxopropanoic acid Chemical compound CC(=O)C(O)=O.CN1CCCC1C1=CC=CN=C1 MMOPGICOOYBFJU-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- DNDWZFHLZVYOGF-KKUMJFAQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoic acid Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O DNDWZFHLZVYOGF-KKUMJFAQSA-N 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 108010049589 leucyl-leucyl-leucine Proteins 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Claims (15)
- ニコチンと、
糖と、
アミノ酸または短鎖ペプチド
を含む粒子であって、前記アミノ酸が、ロイシン、アラニン、バリン、イソロイシン、メチオニン、フェニルアラニン、チロシン、トリプトファン、またはその組み合わせを含み、前記ペプチドがトリロイシンを含む、粒子。 - 前記粒子が、約０．５〜約１０マイクロメートルの範囲のサイズ、または約０．５〜約５マイクロメートルの範囲のサイズを有する、請求項１に記載の粒子。
- 前記粒子が、ロイシン、アラニン、バリン、イソロイシン、メチオニン、フェニルアラニン、チロシン、またはトリプトファンを含むアミノ酸を含む、請求項１または２に記載の粒子。
- 前記糖がトレハロース、またはマンニトールを含む、請求項１〜３のいずれか一項に記載の粒子。
- 前記ニコチンが、乳酸ニコチン、ピルビン酸ニコチン、クエン酸ニコチン、およびアスパラギン酸ニコチンを含む群から選択されるニコチン塩を含む、請求項１〜４のいずれか一項に記載の粒子。
- 前記アミノ酸がロイシンを含み、かつ前記糖がトレハロースを含み、かつ前記ニコチンが乳酸ニコチンを含む、請求項１〜５のいずれか一項に記載の粒子。
- 前記ニコチンが、クエン酸ニコチンまたはアスパラギン酸ニコチンを含む、請求項１〜５のいずれか一項に記載の粒子。
- 前記粒子が、約２５ｗｔ％以下のニコチンまたは約５〜約１５ｗｔ％のニコチンを含む、請求項１〜７のいずれか一項に記載の粒子。
- 前記粒子が、約６０ｗｔ％〜約９５ｗｔ％の糖または約７０〜約９０ｗｔ％の糖を含む、請求項１〜８のいずれか一項に記載の粒子。
- 前記粒子が、約１ｗｔ％〜約１０ｗｔ％のアミノ酸または約３〜約７ｗｔ％のアミノ酸を含む、請求項１〜９のいずれか一項に記載の粒子。
- 請求項１〜１０のいずれか一項に記載の粒子を複数含む組成物であって、約９０％の前記複数の粒子が約４．５マイクロメートル以下の粒子サイズを有し、かつ約５０％の前記複数の粒子が約２．５マイクロメートル未満の粒子サイズを有する、組成物。
- ニコチン、糖、およびアミノ酸または短鎖ペプチドを液体担体中で混合して液体混合物を形成する工程と、
前記液体混合物を噴霧乾燥して、約０．５〜約１０マイクロメートルの範囲または約０．５〜約５マイクロメートルの範囲のサイズを有する複数の粒子を形成する工程とを含む、方法。 - 前記混合工程が、鎮咳剤を前記ニコチン、糖、およびアミノ酸またはペプチドと前記液体担体中で混合して前記液体混合物を形成する工程を含む、請求項１２に記載の方法。
- 前記ニコチンが、乳酸ニコチン、ピルビン酸ニコチン、クエン酸ニコチン、およびアスパラギン酸ニコチンから成る群から選択されるニコチン塩であり、かつ前記糖がトレハロース、マンニトール、ショ糖、またはラクトースを含み、かつ前記アミノ酸がロイシン、アラニン、バリン、イソロイシン、メチオニン、フェニルアラニン、チロシン、またはトリプトファンを含む、請求項１２または１３に記載の方法。
- 前記糖がトレハロースを含み、かつ前記アミノ酸がロイシンを含み、かつ前記乾燥粉末組成物が約２５ｗｔ％以下のニコチンまたは約５〜約１５ｗｔ％のニコチンを含む、請求項１２〜１４のいずれか一項に記載の方法。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022031716A JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16177163 | 2016-06-30 | ||
| EP16177163.9 | 2016-06-30 | ||
| PCT/IB2017/053543 WO2018002756A1 (en) | 2016-06-30 | 2017-06-14 | Nicotine particles and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031716A Division JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524648A JP2019524648A (ja) | 2019-09-05 |
| JP2019524648A5 true JP2019524648A5 (ja) | 2020-07-09 |
Family
ID=56296661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563781A Pending JP2019524648A (ja) | 2016-06-30 | 2017-06-14 | ニコチン粒子および組成物 |
| JP2022031716A Pending JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022031716A Pending JP2022071106A (ja) | 2016-06-30 | 2022-03-02 | ニコチン粒子および組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20190133940A1 (ja) |
| EP (1) | EP3478264A1 (ja) |
| JP (2) | JP2019524648A (ja) |
| KR (1) | KR102523677B1 (ja) |
| CN (1) | CN109310622A (ja) |
| AR (1) | AR108920A1 (ja) |
| AU (1) | AU2017286864A1 (ja) |
| BR (1) | BR112018076215A2 (ja) |
| CA (1) | CA3023630A1 (ja) |
| IL (1) | IL263355A (ja) |
| MX (1) | MX2018015118A (ja) |
| PH (1) | PH12018502714A1 (ja) |
| RU (2) | RU2021132299A (ja) |
| SG (1) | SG11201809594WA (ja) |
| TW (1) | TW201801716A (ja) |
| UA (1) | UA124535C2 (ja) |
| WO (1) | WO2018002756A1 (ja) |
| ZA (1) | ZA201806949B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2021132299A (ru) * | 2016-06-30 | 2021-12-10 | Филип Моррис Продактс С.А. | Никотиносодержащие частицы и композиции |
| US20210386665A1 (en) * | 2018-10-02 | 2021-12-16 | Meijo University Educational Foundation | Inhalation powder medicine, evaluation method thereof, and use thereof |
| CN114828825A (zh) * | 2019-08-30 | 2022-07-29 | 塔克索公司 | 装载的颗粒、其生产方法及其用途 |
| CN110384700A (zh) * | 2019-09-03 | 2019-10-29 | 云南喜科科技有限公司 | 一种合成尼古丁的组合物 |
| JP2023502582A (ja) | 2019-11-14 | 2023-01-25 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 改善されたたばこ風味付き乾燥粉末製剤 |
| CA3164634A1 (en) * | 2019-12-19 | 2021-06-24 | Juul Labs, Inc. | Organic-based nicotine gel compositions |
| JPWO2021201258A1 (ja) * | 2020-04-01 | 2021-10-07 | ||
| EP4208151B1 (en) * | 2020-09-03 | 2024-07-10 | Philip Morris Products S.A. | Freeze dried low hygroscopicity active powder compositions |
| EP4208153A1 (en) * | 2020-09-03 | 2023-07-12 | Philip Morris Products S.A. | Spray dried low hygroscopicity active powder compositions |
| IL300741A (en) * | 2020-09-03 | 2023-04-01 | Philip Morris Products Sa | Active powder compositions with low hygroscopicity |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| JP2001151673A (ja) * | 1999-09-06 | 2001-06-05 | Nikken Chem Co Ltd | 吸入用粉末製剤の製造方法 |
| ES2343124T3 (es) * | 1999-10-29 | 2010-07-23 | Novartis Ag | Composiciones de polvo seco con dispersabilidad mejorada. |
| IL150461A0 (en) * | 1999-12-30 | 2002-12-01 | Chiron Corp | Methods for pulmonary delivery of interleukin-2 |
| AU8111301A (en) * | 2000-08-07 | 2002-02-18 | Inhale Therapeutic Syst | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation |
| US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
| BRPI0515932A (pt) * | 2004-10-15 | 2008-08-12 | Pfizer Prod Inc | composições e métodos para distribuição intranasal, bucal, sublingual e pulmonar de vareniclina |
| GB0425758D0 (en) * | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| ITMI20051999A1 (it) * | 2005-10-21 | 2007-04-22 | Eratech S R L | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| FI20060428L (fi) * | 2006-05-03 | 2007-11-04 | Esko Kauppinen | Pintamodifioidut aerosolihiukkaset, menetelmä ja laite niiden tuottamiseksi sekä jauheet ja dispersiot jotka sisältävät kyseisiä hiukkasia |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| GB0801876D0 (en) * | 2008-02-01 | 2008-03-12 | Vectura Group Plc | Suspension formulations |
| US20150283070A1 (en) * | 2014-04-08 | 2015-10-08 | Sansa Corporation (Barbados) Inc. | Nicotine Formulations and Methods of Making the Same |
| KR102428028B1 (ko) * | 2014-04-28 | 2022-08-03 | 필립모리스 프로덕츠 에스.에이. | 향미를 가진 니코틴 분말 흡입기 |
| US11224594B2 (en) * | 2015-09-16 | 2022-01-18 | Philip Morris Products S.A. | Nicotine formulations and methods of making and using the same |
| US9585835B1 (en) * | 2015-09-16 | 2017-03-07 | Sansa Corporation (Barbados) Inc. | Inhalable nicotine formulations and methods of making and using the same |
| US10149844B2 (en) * | 2015-09-16 | 2018-12-11 | Philip Morris Products S.A. | Inhalable nicotine formulations, and methods of making and using thereof |
| EP3478265A1 (en) * | 2016-06-30 | 2019-05-08 | Philip Morris Products S.a.s. | Nicotine particles |
| RU2021132299A (ru) * | 2016-06-30 | 2021-12-10 | Филип Моррис Продактс С.А. | Никотиносодержащие частицы и композиции |
| CA3061895A1 (en) * | 2017-06-28 | 2019-01-03 | Philip Morris Products S.A. | Container with particles for use with inhaler |
-
2017
- 2017-06-14 RU RU2021132299A patent/RU2021132299A/ru unknown
- 2017-06-14 AU AU2017286864A patent/AU2017286864A1/en not_active Abandoned
- 2017-06-14 KR KR1020187035098A patent/KR102523677B1/ko active IP Right Grant
- 2017-06-14 US US16/309,742 patent/US20190133940A1/en not_active Abandoned
- 2017-06-14 UA UAA201810794A patent/UA124535C2/uk unknown
- 2017-06-14 CA CA3023630A patent/CA3023630A1/en not_active Abandoned
- 2017-06-14 MX MX2018015118A patent/MX2018015118A/es unknown
- 2017-06-14 CN CN201780034796.4A patent/CN109310622A/zh active Pending
- 2017-06-14 RU RU2018145313A patent/RU2767064C2/ru active
- 2017-06-14 EP EP17732583.4A patent/EP3478264A1/en active Pending
- 2017-06-14 WO PCT/IB2017/053543 patent/WO2018002756A1/en unknown
- 2017-06-14 SG SG11201809594WA patent/SG11201809594WA/en unknown
- 2017-06-14 JP JP2018563781A patent/JP2019524648A/ja active Pending
- 2017-06-14 BR BR112018076215-6A patent/BR112018076215A2/pt active Search and Examination
- 2017-06-29 AR ARP170101809A patent/AR108920A1/es unknown
- 2017-06-29 TW TW106121799A patent/TW201801716A/zh unknown
-
2018
- 2018-10-18 ZA ZA2018/06949A patent/ZA201806949B/en unknown
- 2018-11-28 IL IL263355A patent/IL263355A/en unknown
- 2018-12-21 PH PH12018502714A patent/PH12018502714A1/en unknown
-
2021
- 2021-08-05 US US17/394,623 patent/US20210361567A1/en active Pending
-
2022
- 2022-03-02 JP JP2022031716A patent/JP2022071106A/ja active Pending
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