JP2019524140A5 - - Google Patents
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- JP2019524140A5 JP2019524140A5 JP2019507817A JP2019507817A JP2019524140A5 JP 2019524140 A5 JP2019524140 A5 JP 2019524140A5 JP 2019507817 A JP2019507817 A JP 2019507817A JP 2019507817 A JP2019507817 A JP 2019507817A JP 2019524140 A5 JP2019524140 A5 JP 2019524140A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- exon
- region
- dgkα
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 49
- 210000002865 immune cell Anatomy 0.000 claims 20
- 150000007523 nucleic acids Chemical group 0.000 claims 19
- 230000000295 complement effect Effects 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108091033409 CRISPR Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 102100035102 E3 ubiquitin-protein ligase MYCBP2 Human genes 0.000 claims 4
- 230000004957 immunoregulator effect Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 241000589875 Campylobacter jejuni Species 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000193996 Streptococcus pyogenes Species 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000000581 natural killer T-cell Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000001814 protein method Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023004738A JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2016-0103308 | 2016-08-12 | ||
| KR1020160103308 | 2016-08-12 | ||
| US201762502822P | 2017-05-08 | 2017-05-08 | |
| US62/502,822 | 2017-05-08 | ||
| PCT/KR2017/008835 WO2018030874A1 (ko) | 2016-08-12 | 2017-08-14 | 조작된 면역조절요소 및 이에 의해 변형된 면역 활성 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023004738A Division JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524140A JP2019524140A (ja) | 2019-09-05 |
| JP2019524140A5 true JP2019524140A5 (https=) | 2020-09-24 |
| JP7215808B2 JP7215808B2 (ja) | 2023-01-31 |
Family
ID=65438099
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507817A Active JP7215808B2 (ja) | 2016-08-12 | 2017-08-14 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2023004738A Pending JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A Pending JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023004738A Pending JP2023052426A (ja) | 2016-08-12 | 2023-01-16 | 操作された免疫調節エレメントおよび変更された免疫 |
| JP2024089774A Pending JP2024113020A (ja) | 2016-08-12 | 2024-06-03 | 操作された免疫調節エレメントおよび変更された免疫 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12012598B2 (https=) |
| EP (1) | EP3498846B1 (https=) |
| JP (3) | JP7215808B2 (https=) |
| KR (1) | KR102276371B1 (https=) |
| CN (1) | CN109844118B (https=) |
| AU (1) | AU2017308473B2 (https=) |
| BR (1) | BR112019002779A2 (https=) |
| CA (1) | CA3033736C (https=) |
| ES (1) | ES2998057T3 (https=) |
| RU (2) | RU2022103870A (https=) |
| SG (1) | SG11201901184QA (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| BR112019002779A2 (pt) * | 2016-08-12 | 2019-05-14 | Toolgen Incorporated | elemento imunorregulador manipulado e imunidade alterada por este |
| JP7235391B2 (ja) * | 2017-05-08 | 2023-03-08 | ツールゲン インコーポレイテッド | 人工的に操作された免疫細胞 |
| CN107164377A (zh) * | 2017-06-12 | 2017-09-15 | 王小平 | 基于碱基编辑的基因敲除方法及其应用 |
| SG11201913852RA (en) | 2017-07-07 | 2020-01-30 | Toolgen Inc | Target-specific crispr mutant |
| CN112040986A (zh) * | 2018-03-15 | 2020-12-04 | Ksq治疗公司 | 用于改进的免疫疗法的基因调控组合物和方法 |
| CN110904045A (zh) * | 2018-09-17 | 2020-03-24 | 中国科学院动物研究所 | 经修饰的t细胞、其制备方法及用途 |
| CN111321171A (zh) * | 2018-12-14 | 2020-06-23 | 江苏集萃药康生物科技有限公司 | 一种应用CRISPR/Cas9介导ES打靶技术制备基因打靶动物模型的方法 |
| CN110373385A (zh) * | 2019-07-12 | 2019-10-25 | 赛德特生物科技开发有限公司 | 改善神经细胞功能的免疫细胞培养基及其制备方法与应用 |
| KR20220051401A (ko) * | 2019-09-06 | 2022-04-26 | 크리스퍼 테라퓨틱스 아게 | 배양 중 개선된 지속성을 갖는 유전적으로 조작된 t 세포 |
| US12152251B2 (en) * | 2020-08-25 | 2024-11-26 | Kite Pharma, Inc. | T cells with improved functionality |
| JP2024506067A (ja) * | 2021-02-10 | 2024-02-08 | カルセリックス ピーティーワイ． リミテッド | 増強された機能を有する幹細胞由来免疫細胞を生成するための方法および組成物 |
| CN114807044B (zh) * | 2021-04-30 | 2023-09-08 | 四川大学华西医院 | 一种具有高nkt细胞比例的car-cik细胞制备方法及应用 |
| CN115894706A (zh) * | 2021-09-30 | 2023-04-04 | 北京康辰药业股份有限公司 | 靶向PD-L1和FasL的融合蛋白、核苷酸序列及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050244851A1 (en) * | 2004-01-13 | 2005-11-03 | Affymetrix, Inc. | Methods of analysis of alternative splicing in human |
| US20050221354A1 (en) * | 2004-02-18 | 2005-10-06 | Wyeth | Nucleic acid arrays for monitoring expression profiles of drug target genes |
| US7901882B2 (en) * | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
| CN102333277B (zh) * | 2011-07-29 | 2014-08-06 | 上海合合信息科技发展有限公司 | 结合地理位置信息和蓝牙技术的电子名片传递方法及系统 |
| WO2013033627A2 (en) * | 2011-09-01 | 2013-03-07 | The Regents Of The University Of California | Diagnosis and treatment of arthritis using epigenetics |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| WO2014039513A2 (en) * | 2012-09-04 | 2014-03-13 | The Trustees Of The University Of Pennsylvania | Inhibition of diacylglycerol kinase to augment adoptive t cell transfer |
| AU2013329186B2 (en) | 2012-10-10 | 2019-02-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| EP3031921B1 (en) * | 2012-12-12 | 2025-03-12 | The Broad Institute, Inc. | Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications |
| IL239344B2 (en) | 2012-12-12 | 2024-06-01 | Broad Inst Inc | Systems engineering, methods and optimal guiding components for sequence manipulation |
| CN113355357B (zh) * | 2012-12-12 | 2024-12-03 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| US11311575B2 (en) | 2013-05-13 | 2022-04-26 | Cellectis | Methods for engineering highly active T cell for immunotherapy |
| CN105683376A (zh) | 2013-05-15 | 2016-06-15 | 桑格摩生物科学股份有限公司 | 用于治疗遗传病状的方法和组合物 |
| WO2014191128A1 (en) | 2013-05-29 | 2014-12-04 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| ES2883131T3 (es) * | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| CA3051222C (en) * | 2013-06-10 | 2023-01-24 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for reducing immunosupression by tumor cells |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| WO2015121454A1 (en) | 2014-02-14 | 2015-08-20 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| US20170335281A1 (en) * | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| KR20170032406A (ko) | 2014-07-15 | 2017-03-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료를 위한 조작된 세포 |
| JP6598860B2 (ja) * | 2014-08-06 | 2019-10-30 | カレッジ オブ メディシン ポチョン チャ ユニバーシティ インダストリー−アカデミック コーオペレイション ファウンデーション | Ｈｌａをコードする遺伝子のヌクレアーゼ媒介編集により作製される免疫適合性細胞 |
| US20170335331A1 (en) | 2014-10-31 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | Altering Gene Expression in CART Cells and Uses Thereof |
| WO2016080097A1 (ja) | 2014-11-17 | 2016-05-26 | 国立大学法人東京医科歯科大学 | 簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法 |
| WO2016123578A1 (en) | 2015-01-30 | 2016-08-04 | The Regents Of The University Of California | Protein delivery in primary hematopoietic cells |
| KR102888521B1 (ko) * | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| WO2018030874A1 (ko) | 2016-08-12 | 2018-02-15 | 주식회사 툴젠 | 조작된 면역조절요소 및 이에 의해 변형된 면역 활성 |
| BR112019002779A2 (pt) | 2016-08-12 | 2019-05-14 | Toolgen Incorporated | elemento imunorregulador manipulado e imunidade alterada por este |
| KR20260019012A (ko) | 2016-10-07 | 2026-02-09 | 인티그레이티드 디엔에이 테크놀로지스 아이엔씨. | Ｓ. 피오게네스 ｃａｓ９ 돌연변이 유전자 및 이에 의해 암호화되는 폴리펩티드 |
| EP3336107A1 (en) | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
| JP7235391B2 (ja) | 2017-05-08 | 2023-03-08 | ツールゲン インコーポレイテッド | 人工的に操作された免疫細胞 |
| WO2019070704A1 (en) | 2017-10-02 | 2019-04-11 | Georgia Tech Research Corporation | METHODS AND COMPOSITIONS FOR ENGINEERING SYNTHESIS BIOLOGICAL SWITCHES FOR REMOTE CONTROL OF BIOLOGICAL ACTIVITY |
| US12161670B2 (en) | 2017-12-08 | 2024-12-10 | Juno Therapeutics, Inc. | Phenotypic markers for cell therapy and related methods |
| WO2020014235A1 (en) | 2018-07-09 | 2020-01-16 | The Regents Of The University Of California | Gene targets for t-cell-based immunotherapy |
-
2017
- 2017-08-14 BR BR112019002779-3A patent/BR112019002779A2/pt not_active Application Discontinuation
- 2017-08-14 CN CN201780063250.1A patent/CN109844118B/zh active Active
- 2017-08-14 ES ES17839891T patent/ES2998057T3/es active Active
- 2017-08-14 RU RU2022103870A patent/RU2022103870A/ru unknown
- 2017-08-14 AU AU2017308473A patent/AU2017308473B2/en active Active
- 2017-08-14 SG SG11201901184QA patent/SG11201901184QA/en unknown
- 2017-08-14 EP EP17839891.3A patent/EP3498846B1/en active Active
- 2017-08-14 US US16/324,955 patent/US12012598B2/en active Active
- 2017-08-14 RU RU2019106669A patent/RU2767206C2/ru active
- 2017-08-14 CA CA3033736A patent/CA3033736C/en active Active
- 2017-08-14 JP JP2019507817A patent/JP7215808B2/ja active Active
-
2019
- 2019-06-11 KR KR1020190068999A patent/KR102276371B1/ko active Active
-
2023
- 2023-01-16 JP JP2023004738A patent/JP2023052426A/ja active Pending
-
2024
- 2024-05-07 US US18/657,145 patent/US20240301424A1/en active Pending
- 2024-06-03 JP JP2024089774A patent/JP2024113020A/ja active Pending
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