|
US6074650A
(en)
|
1985-06-24 |
2000-06-13 |
Hoechst Aktiengesellschaft |
Membrane anchor/active compound conjugate, its preparation and its uses
|
|
WO1990009799A1
(en)
|
1989-02-23 |
1990-09-07 |
Colorado State University Research Foundation |
GnRH ANALOGS FOR DESTROYING GONADOTROPHS
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US6106834A
(en)
|
1993-06-02 |
2000-08-22 |
Research Corporation Technologies, Inc. |
Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
|
|
US6024957A
(en)
|
1993-06-02 |
2000-02-15 |
Research Corporation Technologies, Inc. |
Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same
|
|
GB9323199D0
(en)
|
1993-11-10 |
1994-01-05 |
Falkenberg J H F |
Leukaemia treatment
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
US20110045005A1
(en)
|
2001-10-19 |
2011-02-24 |
Craig Crowley |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
US7265212B2
(en)
|
2001-12-03 |
2007-09-04 |
Amgen Fremont Inc. |
Anti-CD45RB antibodies
|
|
DE602004026081D1
(de)
*
|
2003-09-18 |
2010-04-29 |
Novartis Ag |
Therapeutische humanisierte antikörper gegen cd45-isoformen
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
EP1661584A1
(en)
|
2004-11-26 |
2006-05-31 |
Heinz Dr. Faulstich |
Use of conjugates of amatoxins and phallotoxins with macromolecules for cancer and inflammation therapy
|
|
US7947839B2
(en)
|
2004-12-01 |
2011-05-24 |
Genentech, Inc. |
Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
|
|
WO2007087453A2
(en)
|
2006-01-27 |
2007-08-02 |
Cellerant Therapeutics, Inc. |
Compositions and methods for treating haematological proliferative disorders
|
|
EP1993608A1
(en)
|
2006-03-10 |
2008-11-26 |
Diatos |
Anticancer drugs conjugated to antibody via an enzyme cleavable linker
|
|
ATE521366T1
(de)
|
2006-05-27 |
2011-09-15 |
Faulstich Heinz Dr |
Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen
|
|
PT2032606E
(pt)
|
2006-05-30 |
2014-02-05 |
Genentech Inc |
Anticorpos e imunoconjugados e respetivas utilizações
|
|
WO2008045976A2
(en)
*
|
2006-10-10 |
2008-04-17 |
Squicor |
Compositions and methods for treating and diagnosing cancers
|
|
EP3255061B1
(en)
*
|
2006-11-03 |
2021-06-16 |
The Board of Trustees of the Leland Stanford Junior University |
Selective immunodepletion of endogenous stem cell niche for engraftment
|
|
PL2099823T5
(pl)
|
2006-12-01 |
2023-02-20 |
Seagen Inc. |
Wariant środków wiążących cel i jego zastosowania
|
|
PE20120877A1
(es)
*
|
2009-04-01 |
2012-08-06 |
Genentech Inc |
ANTICUERPOS ANTI-FcRH5 E INMUNOCONJUGADOS
|
|
MX2011010469A
(es)
|
2009-04-08 |
2012-03-14 |
Deutsches Krebsforsch |
Radicales de enlace al objetivo, armados con amatoxina para el tratamiento del cancer.
|
|
EP3192529B1
(en)
*
|
2009-04-08 |
2020-03-25 |
Faulstich, Heinz, Dr. |
Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
|
|
CN103068405A
(zh)
|
2010-04-15 |
2013-04-24 |
西雅图基因公司 |
靶向吡咯并苯并二氮杂卓结合物
|
|
ES2402254T3
(es)
|
2010-09-30 |
2013-04-30 |
Heidelberg Pharma Ag |
Conjugados de amatoxinas con ligadores mejorados
|
|
EP2497499A1
(en)
*
|
2011-03-10 |
2012-09-12 |
Heidelberg Pharma GmbH |
Amatoxin-conjugates with improved linkages
|
|
WO2012129514A1
(en)
*
|
2011-03-23 |
2012-09-27 |
Fred Hutchinson Cancer Research Center |
Method and compositions for cellular immunotherapy
|
|
DK2707031T3
(da)
|
2011-05-08 |
2019-10-07 |
Legochem Biosciences Inc |
Protein-active agent conjugates and method for preparing the same
|
|
CA2850375C
(en)
|
2011-10-14 |
2019-07-02 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
CA2850264C
(en)
|
2011-10-14 |
2019-11-05 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
EP3539982B1
(en)
|
2011-12-23 |
2025-02-19 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
EP2684865A1
(en)
|
2012-07-13 |
2014-01-15 |
Heidelberg Pharma GmbH |
Methods for synthesizing amatoxin building block and amatoxins
|
|
US20150218220A1
(en)
|
2012-09-12 |
2015-08-06 |
Brian Alan MENDELSOHN |
Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
|
|
US9324898B2
(en)
*
|
2012-09-25 |
2016-04-26 |
Alliance For Sustainable Energy, Llc |
Varying cadmium telluride growth temperature during deposition to increase solar cell reliability
|
|
AU2013350802B2
(en)
*
|
2012-11-30 |
2016-07-14 |
Novartis Ag |
Methods for making conjugates from disulfide-containing proteins
|
|
WO2014134539A1
(en)
|
2013-02-28 |
2014-09-04 |
President And Fellows Of Harvard College |
Methods and compositions for mobilizing stem cells
|
|
EP2774624A1
(en)
|
2013-03-04 |
2014-09-10 |
Heidelberg Pharma GmbH |
Amatoxin derivatives
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
EP2968591A1
(en)
*
|
2013-03-15 |
2016-01-20 |
Novartis AG |
Cell proliferation inhibitors and conjugates thereof
|
|
US9803002B2
(en)
|
2013-05-31 |
2017-10-31 |
Genentench, Inc. |
Anti-wall teichoic antibodies and conjugates
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
CN110251683A
(zh)
|
2013-06-24 |
2019-09-20 |
Abl生物公司 |
具有改进的稳定性的抗体-药物缀合物及其用途
|
|
FR3008408B1
(fr)
|
2013-07-11 |
2018-03-09 |
Mc Saf |
Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
|
|
CN105377304B
(zh)
*
|
2014-03-10 |
2018-05-15 |
海德堡医药有限责任公司 |
鹅膏毒肽衍生物
|
|
WO2015187596A2
(en)
|
2014-06-02 |
2015-12-10 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses
|
|
US20170226209A1
(en)
*
|
2014-08-01 |
2017-08-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
An anti-cd45rc antibody for use as drug
|
|
RU2715905C2
(ru)
|
2014-10-01 |
2020-03-04 |
МЕДИММЬЮН, ЭлЭлСи |
Способ конъюгации полипептида
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|
|
EP3215519A1
(en)
*
|
2014-11-06 |
2017-09-13 |
Novartis AG |
Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
|
|
EP3026060A1
(en)
*
|
2014-11-26 |
2016-06-01 |
Miltenyi Biotec GmbH |
Humanized antibody or fragment thereof specific for CD45R0
|
|
US9729129B2
(en)
*
|
2014-12-05 |
2017-08-08 |
Bhaskar Gopalan |
System and method for reducing metastability in CMOS flip-flops
|
|
US20160220687A1
(en)
|
2015-02-02 |
2016-08-04 |
National Guard Health Affairs |
Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
|
|
DK3268047T3
(da)
|
2015-03-09 |
2024-01-02 |
Heidelberg Pharma Res Gmbh |
Amatoxin/antistof-konjugater
|
|
HK1256681A1
(zh)
*
|
2015-04-06 |
2019-10-04 |
President And Fellows Of Harvard College |
用於非清髓性预处理的组合物和方法
|
|
JP6880005B2
(ja)
|
2015-05-21 |
2021-06-02 |
アクティニウム ファーマシューティカルズ インコーポレイテッド |
結合型モノクローナル抗体の注入投与
|
|
WO2017051249A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-cd19 antibody drug conjugates
|
|
MA43354A
(fr)
|
2015-10-16 |
2018-08-22 |
Genentech Inc |
Conjugués médicamenteux à pont disulfure encombré
|
|
US10723766B2
(en)
|
2015-11-27 |
2020-07-28 |
Heidelberg Pharma Research Gmbh |
Derivatives of gamma-amanitin
|
|
EP3222292A1
(en)
|
2016-03-03 |
2017-09-27 |
Heidelberg Pharma GmbH |
Amanitin conjugates
|
|
CA3016901C
(en)
|
2016-03-07 |
2023-06-13 |
Actinium Pharmaceuticals, Inc. |
Stabilized radiolabeled anti-cd45 immunoglobulin compositions
|
|
MX2018012803A
(es)
|
2016-04-20 |
2019-06-24 |
Hangzhou Dac Biotech Co Ltd |
Derivados de las toxinas de amanita y su conjugacion a una molecula de union celular.
|
|
US10464969B2
(en)
|
2016-05-05 |
2019-11-05 |
Novartis Ag |
Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
|
|
EP3464363A1
(en)
|
2016-05-27 |
2019-04-10 |
Actinium Pharmaceuticals, Inc. |
Low dose antibody-based methods for treating hematologic malignancies
|
|
US11013816B2
(en)
|
2016-05-31 |
2021-05-25 |
Sorrento Therapeutics, Inc. |
Antibody drug conjugates having derivatives of amatoxin as the drug
|
|
US10111966B2
(en)
|
2016-06-17 |
2018-10-30 |
Magenta Therapeutics, Inc. |
Methods for the depletion of CD117+ cells
|
|
CN110023489A
(zh)
|
2016-08-29 |
2019-07-16 |
Pdi医药发展国际股份公司 |
提供治疗活性细胞产物
|
|
US10112266B2
(en)
*
|
2016-09-09 |
2018-10-30 |
Baltic Innovation Holding PRO, AS |
Pressed thermite rod for a self-contained portable cutting device
|
|
WO2018071871A1
(en)
*
|
2016-10-13 |
2018-04-19 |
President And Fellows Of Harvard College |
Compositions and methods for non-myeloablative conditioning
|
|
BR112019012937A2
(pt)
|
2016-12-23 |
2019-12-10 |
Heidelberg Pharma Research Gmbh |
novo conjugado de amanitina
|
|
SG11201906319XA
(en)
|
2017-01-20 |
2019-08-27 |
Magenta Therapeutics Inc |
Compositions and methods for the depletion of cd137+ cells
|
|
IL301075B2
(en)
|
2017-01-30 |
2024-05-01 |
Univ Leland Stanford Junior |
A genotoxic matching regimen for stem cell transplantation
|
|
CN110997676B
(zh)
|
2017-08-07 |
2022-12-20 |
海德堡医药研究有限责任公司 |
合成鹅膏蕈碱的新方法
|