JP2019521668A5 - - Google Patents
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- JP2019521668A5 JP2019521668A5 JP2018563156A JP2018563156A JP2019521668A5 JP 2019521668 A5 JP2019521668 A5 JP 2019521668A5 JP 2018563156 A JP2018563156 A JP 2018563156A JP 2018563156 A JP2018563156 A JP 2018563156A JP 2019521668 A5 JP2019521668 A5 JP 2019521668A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- human
- light chain
- human animal
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims description 51
- 108010008286 DNA nucleotidylexotransferase Proteins 0.000 claims description 47
- 102100033215 DNA nucleotidylexotransferase Human genes 0.000 claims description 47
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 45
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 38
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 33
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 28
- 150000007523 nucleic acids Chemical group 0.000 claims description 27
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 25
- 108060003951 Immunoglobulin Proteins 0.000 claims description 21
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 21
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 21
- 102000018358 immunoglobulin Human genes 0.000 claims description 21
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 18
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 17
- 241000894007 species Species 0.000 claims description 12
- 101001061851 Homo sapiens V(D)J recombination-activating protein 2 Proteins 0.000 claims description 10
- 102000001183 RAG-1 Human genes 0.000 claims description 10
- 108060006897 RAG1 Proteins 0.000 claims description 10
- 102100029591 V(D)J recombination-activating protein 2 Human genes 0.000 claims description 10
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims description 9
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims description 9
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 8
- 210000001948 pro-b lymphocyte Anatomy 0.000 claims description 8
- 210000004602 germ cell Anatomy 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 241000283984 Rodentia Species 0.000 claims description 5
- 108010029485 Protein Isoforms Proteins 0.000 claims description 4
- 102000001708 Protein Isoforms Human genes 0.000 claims description 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000011712 cell development Effects 0.000 claims description 3
- 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 17
- 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 17
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 15
- 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 15
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 15
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 15
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 6
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 6
- 102100029572 Immunoglobulin kappa constant Human genes 0.000 claims 6
- 101710139965 Immunoglobulin kappa constant Proteins 0.000 claims 6
- 101000800646 Homo sapiens DNA nucleotidylexotransferase Proteins 0.000 claims 5
- 101150097493 D gene Proteins 0.000 claims 3
- 108700029228 Immunoglobulin Heavy Chain Genes Proteins 0.000 claims 3
- 101150008942 J gene Proteins 0.000 claims 3
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 24
- 108091008874 T cell receptors Proteins 0.000 description 22
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 210000001744 T-lymphocyte Anatomy 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108700026220 vif Genes Proteins 0.000 description 6
- 238000012239 gene modification Methods 0.000 description 5
- 230000005017 genetic modification Effects 0.000 description 5
- 235000013617 genetically modified food Nutrition 0.000 description 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022058938A JP7274018B2 (ja) | 2016-06-03 | 2022-03-31 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662345524P | 2016-06-03 | 2016-06-03 | |
| US62/345,524 | 2016-06-03 | ||
| PCT/US2017/035731 WO2017210586A1 (en) | 2016-06-03 | 2017-06-02 | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022058938A Division JP7274018B2 (ja) | 2016-06-03 | 2022-03-31 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019521668A JP2019521668A (ja) | 2019-08-08 |
| JP2019521668A5 true JP2019521668A5 (enExample) | 2020-07-09 |
| JP7053499B2 JP7053499B2 (ja) | 2022-04-12 |
Family
ID=59215996
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563156A Active JP7053499B2 (ja) | 2016-06-03 | 2017-06-02 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
| JP2022058938A Active JP7274018B2 (ja) | 2016-06-03 | 2022-03-31 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
| JP2023074624A Active JP7586960B2 (ja) | 2016-06-03 | 2023-04-28 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
| JP2024195337A Pending JP2025020339A (ja) | 2016-06-03 | 2024-11-07 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022058938A Active JP7274018B2 (ja) | 2016-06-03 | 2022-03-31 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
| JP2023074624A Active JP7586960B2 (ja) | 2016-06-03 | 2023-04-28 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
| JP2024195337A Pending JP2025020339A (ja) | 2016-06-03 | 2024-11-07 | 外因性ターミナルデオキシヌクレオチジルトランスフェラーゼを発現する非ヒト動物 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10980221B2 (enExample) |
| EP (3) | EP4218408B1 (enExample) |
| JP (4) | JP7053499B2 (enExample) |
| KR (3) | KR102784608B1 (enExample) |
| CN (3) | CN116458475A (enExample) |
| AU (2) | AU2017272337C1 (enExample) |
| BR (1) | BR112018074794A2 (enExample) |
| CA (1) | CA3026088A1 (enExample) |
| CY (1) | CY1126063T1 (enExample) |
| DK (2) | DK3462853T3 (enExample) |
| ES (2) | ES2941810T3 (enExample) |
| FI (2) | FI3462853T3 (enExample) |
| HR (2) | HRP20230497T1 (enExample) |
| HU (2) | HUE061619T2 (enExample) |
| IL (2) | IL263160B2 (enExample) |
| LT (2) | LT3462853T (enExample) |
| MX (3) | MX385681B (enExample) |
| PL (2) | PL3462853T3 (enExample) |
| PT (2) | PT3462853T (enExample) |
| RS (2) | RS66700B1 (enExample) |
| RU (1) | RU2753585C2 (enExample) |
| SG (2) | SG10201914014XA (enExample) |
| SI (2) | SI4218408T1 (enExample) |
| SM (2) | SMT202300132T1 (enExample) |
| WO (1) | WO2017210586A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| IL263160B2 (en) | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| PL3720279T3 (pl) | 2017-12-05 | 2023-01-16 | Regeneron Pharmaceuticals, Inc. | Myszy posiadające zmodyfikowany sposobami inżynierii łańcuch lekki lambda immunoglobuliny oraz ich zastosowania |
| SMT202500038T1 (it) * | 2018-03-24 | 2025-03-12 | Regeneron Pharma | Topi o ratti geneticamente modificati per la generazione di anticorpi terapeutici contro complessi peptide-mhc, metodi di produzione e loro utilizzo |
| US20210238312A1 (en) * | 2018-06-13 | 2021-08-05 | The Children's Medical Center Corporation | Methods and compositions relating to high-throughput models for antibody discovery and/or optimization |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP3927153A1 (en) * | 2019-02-22 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| CA3136478A1 (en) | 2019-06-05 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| EP4073240A1 (en) * | 2019-12-12 | 2022-10-19 | DNA Script | Chimeric terminal deoxynucleotidyl transferases for template-free enzymatic synthesis of polynucleotides |
| CN111057754B (zh) * | 2019-12-27 | 2021-01-12 | 四川省医学科学院.四川省人民医院实验动物研究所 | 鉴定适用于hbv研究的动物模型的方法和应用 |
| JP2023511626A (ja) | 2020-01-28 | 2023-03-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｐｎｐｌａ３遺伝子座を含む非ヒト動物および使用方法 |
| JP7765403B2 (ja) * | 2020-04-21 | 2025-11-06 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃｘｃｌ１３遺伝子を有する非ヒト動物 |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| EP4262373A1 (en) | 2020-12-16 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| JP7758739B2 (ja) | 2020-12-23 | 2025-10-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンカー改変型抗体をコードする核酸およびその使用 |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| EP4590120A1 (en) * | 2022-09-22 | 2025-07-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| WO2025250011A1 (en) | 2024-05-29 | 2025-12-04 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Treatment for cancer |
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