|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
|
WO2015105955A1
(en)
|
2014-01-08 |
2015-07-16 |
Flodesign Sonics, Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
|
AU2015289644A1
(en)
|
2014-07-15 |
2017-02-02 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
US20180112213A1
(en)
*
|
2015-03-25 |
2018-04-26 |
Editas Medicine, Inc. |
Crispr/cas-related methods, compositions and components
|
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
|
CN107667173A
(zh)
|
2015-05-06 |
2018-02-06 |
斯尼普技术有限公司 |
改变微生物种群和改善微生物群
|
|
EP3322801A1
(en)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
GB201700621D0
(en)
|
2017-01-13 |
2017-03-01 |
Guest Ryan Dominic |
Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
|
|
MX2019013514A
(es)
*
|
2017-05-12 |
2020-01-20 |
Crispr Therapeutics Ag |
Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
MX2019015505A
(es)
|
2017-06-30 |
2020-07-28 |
Inscripta Inc |
Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
|
|
CN109517820B
(zh)
|
2017-09-20 |
2021-09-24 |
北京宇繁生物科技有限公司 |
一种靶向HPK1的gRNA以及HPK1基因编辑方法
|
|
BR112020006643A2
(pt)
|
2017-10-03 |
2020-09-24 |
Juno Therapeutics Inc |
moléculas de ligação específica ao hpv
|
|
JP2021502077A
(ja)
*
|
2017-11-06 |
2021-01-28 |
エディタス・メディシン,インコーポレイテッド |
免疫療法のためのt細胞におけるcblbのcrispr−cas9編集のための方法、組成物および構成要素
|
|
CN111448313A
(zh)
*
|
2017-11-16 |
2020-07-24 |
阿斯利康(瑞典)有限公司 |
用于改善基于Cas9的敲入策略的有效性的组合物和方法
|
|
WO2019118921A1
(en)
|
2017-12-14 |
2019-06-20 |
Flodesign Sonics, Inc. |
Acoustic transducer drive and controller
|
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
|
KR20210020873A
(ko)
|
2018-04-05 |
2021-02-24 |
주노 쎄러퓨티크스 인코퍼레이티드 |
재조합 수용체를 발현하는 τ 세포, 관련 폴리뉴클레오티드 및 방법
|
|
AU2019249209A1
(en)
|
2018-04-05 |
2020-10-15 |
Juno Therapeutics, Inc. |
T cell receptors and engineered cells expressing same
|
|
CA3094468A1
(en)
|
2018-04-05 |
2019-10-10 |
Juno Therapeutics, Inc. |
Methods of producing cells expressing a recombinant receptor and related compositions
|
|
AU2019252925A1
(en)
*
|
2018-04-13 |
2020-07-30 |
Sigma-Aldrich Co. Llc. |
Modification of immune-related genomic loci using paired CRISPR nickase ribonucleoproteins
|
|
US10526598B2
(en)
|
2018-04-24 |
2020-01-07 |
Inscripta, Inc. |
Methods for identifying T-cell receptor antigens
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
US12227763B2
(en)
|
2018-05-11 |
2025-02-18 |
Crispr Therapeutics Ag |
Methods and compositions for treating cancer
|
|
KR20210045360A
(ko)
|
2018-05-16 |
2021-04-26 |
신테고 코포레이션 |
가이드 rna 설계 및 사용을 위한 방법 및 시스템
|
|
US20200109364A1
(en)
*
|
2018-05-31 |
2020-04-09 |
Washington University |
Methods for genome-editing and activation of cells
|
|
JP7411578B2
(ja)
*
|
2018-06-01 |
2024-01-11 |
マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ |
癌を治療するための物質及び方法
|
|
AU2019292919A1
(en)
|
2018-06-30 |
2021-03-11 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
CN109652380B
(zh)
*
|
2019-01-25 |
2023-04-28 |
苏州茂行生物科技有限公司 |
基于碱基编辑靶向LewisY的CAR-T细胞及其制备方法和应用
|
|
CN110527695B
(zh)
*
|
2019-03-07 |
2020-06-16 |
山东舜丰生物科技有限公司 |
一种用于基因定点突变的核酸构建物
|
|
CN113631713A
(zh)
|
2019-03-25 |
2021-11-09 |
因思科瑞普特公司 |
酵母中的同时多重基因组编辑
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
RU2731293C1
(ru)
*
|
2019-04-12 |
2020-09-01 |
Игорь Петрович Белецкий |
Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний
|
|
EP3962519A1
(en)
|
2019-05-01 |
2022-03-09 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
|
|
AU2020265741A1
(en)
|
2019-05-01 |
2021-11-25 |
Editas Medicine, Inc. |
Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
|
|
AU2020288623A1
(en)
|
2019-06-06 |
2022-01-06 |
Inscripta, Inc. |
Curing for recursive nucleic acid-guided cell editing
|
|
EP3999187A4
(en)
*
|
2019-07-17 |
2023-07-19 |
Case Western Reserve University |
LONG-LASTING T-CELLS FOR THE TREATMENT OF HIV INFECTION
|
|
EP3999651B1
(en)
*
|
2019-08-26 |
2026-03-18 |
Adoc Ssf, Llc |
Methods of performing guide-seq on primary human t cells
|
|
CN114269941A
(zh)
*
|
2019-09-04 |
2022-04-01 |
博雅辑因(北京)生物科技有限公司 |
基于脱靶评估评价基因编辑治疗的方法
|
|
US12344656B2
(en)
*
|
2019-09-06 |
2025-07-01 |
Crispr Therapeutics Ag |
Genetically engineered T cells having improved persistence in culture
|
|
CA3153700A1
(en)
|
2019-09-09 |
2021-03-18 |
Scribe Therapeutics Inc. |
Compositions and methods for use in immunotherapy
|
|
KR102455623B1
(ko)
*
|
2019-10-29 |
2022-10-18 |
주식회사 진코어 |
CRISPR/Cas12f1 시스템 효율화를 위한 엔지니어링 된 가이드 RNA 및 그 용도
|
|
BR112022009137A2
(pt)
*
|
2019-11-13 |
2022-07-26 |
Crispr Therapeutics Ag |
Métodos de fabricação de células t com receptor de antígeno quimérico (car)
|
|
TW202132333A
(zh)
*
|
2019-11-13 |
2021-09-01 |
瑞士商Crispr治療公司 |
製造可表達嵌合抗原受體的t細胞製法
|
|
US11203762B2
(en)
|
2019-11-19 |
2021-12-21 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
CN120905142A
(zh)
*
|
2019-11-20 |
2025-11-07 |
卡瑟里克斯私人有限公司 |
用于提供具有增强功能的免疫细胞的方法
|
|
US20230008217A1
(en)
*
|
2019-12-17 |
2023-01-12 |
Agilent Technologies, Inc. |
Ligation-based gene editing using crispr nickase
|
|
EP4069851A4
(en)
|
2019-12-18 |
2023-11-22 |
Inscripta, Inc. |
Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
|
|
WO2021123832A1
(en)
|
2019-12-20 |
2021-06-24 |
Instil Bio (Uk) Limited |
Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
|
|
CN110964744A
(zh)
*
|
2019-12-23 |
2020-04-07 |
湖南普拉特泽生物科技有限公司 |
一种能稳定表达Cas9蛋白的人骨肉瘤U-2OS工具细胞株及其制备方法与应用
|
|
CN110951782A
(zh)
*
|
2019-12-23 |
2020-04-03 |
湖南普拉特网络科技有限公司 |
一种能稳定表达Cas9蛋白的细胞株及其制备方法与应用
|
|
JP7670358B2
(ja)
*
|
2020-01-02 |
2025-04-30 |
寧波茂行生物医薬科技有限公司 |
修飾された免疫エフェクター細胞及びその調製方法
|
|
US20240182920A1
(en)
*
|
2020-01-22 |
2024-06-06 |
Carsgen Therapeutics Co., Ltd. |
Method for transducing cells with viral vector
|
|
AU2021213705A1
(en)
|
2020-01-27 |
2022-06-16 |
Inscripta, Inc. |
Electroporation modules and instrumentation
|
|
US20210238535A1
(en)
*
|
2020-02-02 |
2021-08-05 |
Inscripta, Inc. |
Automated production of car-expressing cells
|
|
WO2021216622A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021216623A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
KR20230021657A
(ko)
*
|
2020-05-08 |
2023-02-14 |
메타지노미, 인크. |
Ruvc 도메인을 포함하는 효소
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
EP4171616A1
(en)
|
2020-06-26 |
2023-05-03 |
Juno Therapeutics GmbH |
Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
|
|
WO2022038298A1
(en)
*
|
2020-08-21 |
2022-02-24 |
Université de Lausanne |
Mpc inhibition for producing t-cells with a memory phenotype
|
|
WO2022060749A1
(en)
|
2020-09-15 |
2022-03-24 |
Inscripta, Inc. |
Crispr editing to embed nucleic acid landing pads into genomes of live cells
|
|
JP2023549780A
(ja)
|
2020-11-04 |
2023-11-29 |
ジュノー セラピューティクス インコーポレイテッド |
改変されたインバリアントcd3免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
US20240175013A1
(en)
*
|
2020-12-14 |
2024-05-30 |
Emendobio Inc. |
Biallelic knockout of trac
|
|
AU2021415461A1
(en)
|
2021-01-04 |
2023-08-17 |
Inscripta, Inc. |
Mad nucleases
|
|
US20240376451A1
(en)
|
2021-01-07 |
2024-11-14 |
Inscripta, Inc. |
Mad nucleases
|
|
EP4288541A1
(en)
|
2021-02-05 |
2023-12-13 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
JP2024509853A
(ja)
|
2021-03-03 |
2024-03-05 |
ジュノー セラピューティクス インコーポレイテッド |
T細胞療法およびdgk阻害剤の組合せ
|
|
JP2024527557A
(ja)
*
|
2021-07-01 |
2024-07-25 |
寧波茂行生物医薬科技有限公司 |
B7h3を標的とする抗原結合ポリペプチド及びその応用
|
|
EP4377459A2
(en)
|
2021-07-30 |
2024-06-05 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
WO2023010135A1
(en)
|
2021-07-30 |
2023-02-02 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
CA3225082A1
(en)
|
2021-08-27 |
2023-03-02 |
Brian C. Thomas |
Enzymes with ruvc domains
|
|
AU2022366987A1
(en)
|
2021-10-14 |
2024-05-16 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
EP4448775A1
(en)
|
2021-12-17 |
2024-10-23 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
MX2024007790A
(es)
|
2021-12-22 |
2024-09-06 |
Camp4 Therapeutics Corp |
Modulación de la transcripción génica utilizando oligonucleótidos antisentido dirigidos a arn reguladores.
|
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
WO2023137472A2
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
US20250144235A1
(en)
|
2022-02-02 |
2025-05-08 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
|
CA3261865A1
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
|
|
CN115947861B
(zh)
*
|
2022-07-25 |
2023-11-17 |
南京佰抗生物科技有限公司 |
一种高效杂交瘤融合方法
|
|
JP2025527567A
(ja)
|
2022-08-19 |
2025-08-22 |
チューン セラピューティクス インコーポレイテッド |
ターゲティングされた遺伝子抑制によるb型肝炎ウイルスの調節のための組成物、システム、および方法
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
CN120152717A
(zh)
|
2022-09-08 |
2025-06-13 |
朱诺治疗学股份有限公司 |
T细胞疗法和连续或间歇dgk抑制剂给药的组合
|
|
CN120239746A
(zh)
|
2022-09-19 |
2025-07-01 |
图恩疗法股份有限公司 |
用于调节t细胞功能的组合物、系统和方法
|
|
US20260098062A1
(en)
|
2022-09-21 |
2026-04-09 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
EP4615960A1
(en)
|
2022-11-09 |
2025-09-17 |
C3S2 GmbH |
Methods for manufacturing engineered immune cells
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
CN121002052A
(zh)
|
2023-02-03 |
2025-11-21 |
C3S2 有限公司 |
用于非病毒生产工程化免疫细胞的方法
|
|
KR20250158048A
(ko)
|
2023-03-03 |
2025-11-05 |
아스널 바이오사이언시스, 인크. |
Psma 및 ca9을 표적으로 하는 시스템
|
|
EP4698666A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
EP4698665A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
KR20260016952A
(ko)
|
2023-05-23 |
2026-02-04 |
사나 바이오테크놀로지, 인크. |
탠덤 퓨소젠 및 관련 지질 입자
|
|
CN121909284A
(zh)
|
2023-07-31 |
2026-04-21 |
图恩疗法股份有限公司 |
用于调节il-2基因表达的组合物和方法
|
|
WO2025029840A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
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Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
WO2025137646A1
(en)
|
2023-12-22 |
2025-06-26 |
Recode Therapeutics, Inc. |
Gene editing methods and compositions for treating cystic fibrosis
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
US20250345431A1
(en)
|
2024-05-10 |
2025-11-13 |
Juno Therapeutics, Inc. |
Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026015647A1
(en)
|
2024-07-09 |
2026-01-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
|
|
WO2026025092A1
(en)
|
2024-07-26 |
2026-01-29 |
Juno Therapeutics, Inc. |
Synthetic promoters for t cell expression
|
|
WO2026064753A1
(en)
|
2024-09-23 |
2026-03-26 |
Tune Therapeutics, Inc. |
Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing
|