JP2018532757A5 - - Google Patents
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- JP2018532757A5 JP2018532757A5 JP2018522750A JP2018522750A JP2018532757A5 JP 2018532757 A5 JP2018532757 A5 JP 2018532757A5 JP 2018522750 A JP2018522750 A JP 2018522750A JP 2018522750 A JP2018522750 A JP 2018522750A JP 2018532757 A5 JP2018532757 A5 JP 2018532757A5
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- ctla
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- vaccine
- cancer
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- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 12
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229960005486 vaccine Drugs 0.000 claims 7
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 238000011319 anticancer therapy Methods 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 206010062904 Hormone-refractory prostate cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 238000009175 antibody therapy Methods 0.000 claims 1
- 238000003782 apoptosis assay Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005522 programmed cell death Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250984P | 2015-11-04 | 2015-11-04 | |
| US62/250,984 | 2015-11-04 | ||
| PCT/CN2016/104763 WO2017076360A1 (en) | 2015-11-04 | 2016-11-04 | Title of the invention combination therapy for malignant diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532757A JP2018532757A (ja) | 2018-11-08 |
| JP2018532757A5 true JP2018532757A5 (https=) | 2019-07-25 |
| JP7148399B2 JP7148399B2 (ja) | 2022-10-05 |
Family
ID=58662444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522750A Active JP7148399B2 (ja) | 2015-11-04 | 2016-11-04 | 悪性疾患に対する併用療法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11684656B2 (https=) |
| EP (1) | EP3371210B1 (https=) |
| JP (1) | JP7148399B2 (https=) |
| CN (1) | CN108699128A (https=) |
| TW (1) | TWI705972B (https=) |
| WO (1) | WO2017076360A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121159719A (zh) | 2015-04-17 | 2025-12-19 | 高山免疫科学股份有限公司 | 具有可调的亲和力的免疫调节蛋白 |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| JP7749319B2 (ja) | 2017-10-10 | 2025-10-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用 |
| AU2019205273B2 (en) * | 2018-01-03 | 2024-04-04 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| CA3120868A1 (en) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
| EP4146684A2 (en) | 2020-05-08 | 2023-03-15 | Alpine Immune Sciences, Inc. | April and baff inhibitory immunomodulatory proteins with and without a t cell inhibitory protein and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7595378B2 (en) * | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| PL378812A1 (pl) * | 2003-02-13 | 2006-05-29 | Pfizer Products Inc. | Zastosowania przeciwciał przeciw receptorowi insulinopodobnego czynnika wzrostowego I |
| GB0303663D0 (en) * | 2003-02-18 | 2003-03-19 | Lorantis Ltd | Assays and medical treatments |
| DK2439273T3 (da) * | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| WO2012177624A2 (en) * | 2011-06-21 | 2012-12-27 | The Johns Hopkins University | Focused radiation for augmenting immune-based therapies against neoplasms |
| CN102836441B (zh) | 2011-06-24 | 2019-06-11 | 台北荣民总医院 | 于感染性与恶性疾病的治疗中提升免疫反应的方法 |
| HK1203971A1 (en) * | 2012-05-15 | 2015-11-06 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| CA2889182A1 (en) * | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
| KR20150130284A (ko) * | 2013-03-15 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암 백신 및 이를 이용한 치료 방법 |
| CN104761633B (zh) * | 2015-03-25 | 2018-11-27 | 新乡学院 | 阻断猪pd-1/pd-l1通路的多肽及其应用 |
-
2016
- 2016-11-04 TW TW105136056A patent/TWI705972B/zh active
- 2016-11-04 CN CN201680064281.4A patent/CN108699128A/zh active Pending
- 2016-11-04 WO PCT/CN2016/104763 patent/WO2017076360A1/en not_active Ceased
- 2016-11-04 EP EP16861628.2A patent/EP3371210B1/en active Active
- 2016-11-04 US US15/773,433 patent/US11684656B2/en active Active
- 2016-11-04 JP JP2018522750A patent/JP7148399B2/ja active Active
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