JP2018537536A5 - - Google Patents
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- JP2018537536A5 JP2018537536A5 JP2018549407A JP2018549407A JP2018537536A5 JP 2018537536 A5 JP2018537536 A5 JP 2018537536A5 JP 2018549407 A JP2018549407 A JP 2018549407A JP 2018549407 A JP2018549407 A JP 2018549407A JP 2018537536 A5 JP2018537536 A5 JP 2018537536A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- therapeutic composition
- cells
- composition according
- activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 13
- 230000001225 therapeutic effect Effects 0.000 claims 12
- 210000000822 natural killer cell Anatomy 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 102000002698 KIR Receptors Human genes 0.000 claims 2
- 108010043610 KIR Receptors Proteins 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000012830 cancer therapeutic Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562265382P | 2015-12-09 | 2015-12-09 | |
| US62/265,382 | 2015-12-09 | ||
| PCT/US2016/066018 WO2017100709A1 (en) | 2015-12-09 | 2016-12-09 | Compositions and methods for treatment of her2 positive metastatic breast cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018537536A JP2018537536A (ja) | 2018-12-20 |
| JP2018537536A5 true JP2018537536A5 (https=) | 2019-12-12 |
Family
ID=59013368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549407A Pending JP2018537536A (ja) | 2015-12-09 | 2016-12-09 | Ｈｅｒ２陽性転移性乳癌の治療のための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180360881A1 (https=) |
| EP (1) | EP3386522A4 (https=) |
| JP (1) | JP2018537536A (https=) |
| KR (1) | KR20180123214A (https=) |
| CN (1) | CN109475576A (https=) |
| AU (1) | AU2016366677A1 (https=) |
| CA (1) | CA3007996A1 (https=) |
| WO (1) | WO2017100709A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7158104B2 (ja) * | 2016-07-15 | 2022-10-21 | ビラクタ セラピューティクス，インク． | Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤 |
| JP2020524992A (ja) * | 2017-06-22 | 2020-08-27 | ユニバーシティ オブ サザン カリフォルニア | キメラ抗原受容体操作ナチュラルキラー細胞を化学療法薬物担体として使用する組み合わせがん療法 |
| KR20220068272A (ko) | 2017-08-15 | 2022-05-25 | 난트셀, 인크. | Hank 세툭시맙 조합 및 방법 |
| CN110484507B (zh) * | 2018-01-31 | 2023-10-13 | 温州医科大学 | 一种靶向肿瘤Her2的新型嵌合抗原受体T细胞的制备技术 |
| IL321548A (en) * | 2018-05-22 | 2025-08-01 | Immunitybio Inc | Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof |
| EA202190471A1 (ru) * | 2018-08-06 | 2021-05-24 | Дайити Санкио Компани, Лимитед | Комбинация конъюгата антитела-лекарственного средства и ингибитора тубулина |
| KR102533540B1 (ko) * | 2018-10-31 | 2023-05-17 | 난트퀘스트, 인크. | Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거(elimination of pd-l1-positive malignancies by pd-l1 chimeric antigen receptor-expressing nk cells) |
| CA3148608A1 (en) * | 2019-07-26 | 2021-02-04 | Immunitybio, Inc. | Antibody pre-loaded cd16+nk-92 cells as an effective therapeutic product for tumor lysis |
| KR20230152783A (ko) | 2020-07-07 | 2023-11-03 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| CN112675313A (zh) * | 2020-12-28 | 2021-04-20 | 烟台大学 | 连接曲妥珠单抗片段的美登素纳米粒组合物 |
| CN114807237A (zh) * | 2022-05-12 | 2022-07-29 | 广东普罗凯融生物医药科技有限公司 | 一种过表达CD16a的NK细胞的制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1485127T3 (da) * | 2002-02-25 | 2011-10-03 | Elan Pharm Inc | Anvendelse af midler til behandling af inflammation |
| CN101103043A (zh) * | 2005-01-06 | 2008-01-09 | 诺和诺德公司 | Kir结合剂和使用其的方法 |
| ES2971647T3 (es) * | 2005-04-15 | 2024-06-06 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| EP2161339A1 (en) * | 2008-08-29 | 2010-03-10 | F. Hoffmann-La Roche Ag | ADCC with modified NK92 cells |
| ES2935906T3 (es) * | 2013-11-01 | 2023-03-13 | Immunitybio Inc | Composiciones y métodos tumoricidas y antimicrobianos |
| PT3122769T (pt) * | 2014-03-28 | 2023-04-24 | Univ Minnesota | Polipéptidos, células e métodos que envolvem cd16 manipulado |
| CN107613993A (zh) * | 2015-03-27 | 2018-01-19 | 南克维斯特公司 | 与癌症药物的联合治疗中的nk‑92细胞 |
-
2016
- 2016-12-09 KR KR1020187019391A patent/KR20180123214A/ko not_active Ceased
- 2016-12-09 EP EP16874010.8A patent/EP3386522A4/en not_active Withdrawn
- 2016-12-09 WO PCT/US2016/066018 patent/WO2017100709A1/en not_active Ceased
- 2016-12-09 AU AU2016366677A patent/AU2016366677A1/en not_active Abandoned
- 2016-12-09 JP JP2018549407A patent/JP2018537536A/ja active Pending
- 2016-12-09 US US15/781,428 patent/US20180360881A1/en not_active Abandoned
- 2016-12-09 CA CA3007996A patent/CA3007996A1/en active Pending
- 2016-12-09 CN CN201680080518.8A patent/CN109475576A/zh active Pending
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