JP2019515027A5 - - Google Patents

Info

Publication number

JP2019515027A5

JP2019515027A5 JP2019505138A JP2019505138A JP2019515027A5 JP 2019515027 A5 JP2019515027 A5 JP 2019515027A5 JP 2019505138 A JP2019505138 A JP 2019505138A JP 2019505138 A JP2019505138 A JP 2019505138A JP 2019515027 A5 JP2019515027 A5 JP 2019515027A5

Authority

JP

Japan

Prior art keywords

binding fragment

antigen

hvegf

hvegf antigen

glycosylated

Prior art date

2017-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000427 antigen Substances 0.000 claims description 31
• 102000036639 antigens Human genes 0.000 claims description 31
• 108091007433 antigens Proteins 0.000 claims description 31
• 239000012634 fragment Substances 0.000 claims description 31
• 210000001525 retina Anatomy 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 2
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 2
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 2
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 2
• 230000002491 angiogenic effect Effects 0.000 claims description 2
• 208000002780 macular degeneration Diseases 0.000 claims description 2
• 108091008695 photoreceptors Proteins 0.000 claims description 2
• 230000002207 retinal effect Effects 0.000 claims description 2
• 230000006107 tyrosine sulfation Effects 0.000 claims 3
• FDJKUWYYUZCUJX-KVNVFURPSA-N N-glycolylneuraminic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-KVNVFURPSA-N 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 241001164825 Adeno-associated virus - 8 Species 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1
• 238000000034 method Methods 0.000 description 8
• 125000003275 alpha amino acid group Chemical group 0.000 description 2