CA3019665A1 - Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab - Google Patents
Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab Download PDFInfo
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- CA3019665A1 CA3019665A1 CA3019665A CA3019665A CA3019665A1 CA 3019665 A1 CA3019665 A1 CA 3019665A1 CA 3019665 A CA3019665 A CA 3019665A CA 3019665 A CA3019665 A CA 3019665A CA 3019665 A1 CA3019665 A1 CA 3019665A1
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| US62/460,428 | 2017-02-17 | ||
| PCT/US2017/027650 WO2017181021A1 (en) | 2016-04-15 | 2017-04-14 | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
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| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CA3010056A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| KR102574810B1 (ko) | 2016-04-15 | 2023-09-08 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 습성 연령 관련 황반 변성의 치료를 위한 조성물 |
| KR20200060456A (ko) * | 2017-09-27 | 2020-05-29 | 리젠엑스바이오 인크. | 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료 |
| EA202091509A1 (ru) * | 2017-12-19 | 2020-09-22 | Акуос, Инк. | Aav-опосредованная доставка терапевтических антител во внутреннее ухо |
| US20210093734A1 (en) * | 2018-02-20 | 2021-04-01 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-realted macular degeneration |
| CN112203679A (zh) | 2018-03-02 | 2021-01-08 | 科达制药股份有限公司 | Il-6抗体及其融合构建体和缀合物 |
| EP3814513B1 (en) * | 2018-06-28 | 2025-04-09 | The University of North Carolina at Chapel Hill | Optimized cln5 genes and expression cassettes and their use |
| JP2022506613A (ja) * | 2018-11-07 | 2022-01-17 | アコーオス インコーポレイテッド | 内耳の有毛細胞及び支持細胞における遺伝子欠陥／発現タンパク質を修正するためのアデノ随伴ウイルスベクターの使用 |
| EP3946467A1 (en) | 2019-04-03 | 2022-02-09 | REGENXBIO Inc. | Gene therapy for eye pathologies |
| CA3137284A1 (en) * | 2019-04-24 | 2020-10-29 | Regenxbio Inc. | Fully-human post-translationally modified antibody therapeutics |
| KR20220049568A (ko) * | 2019-08-22 | 2022-04-21 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 엔젤만 증후군의 치료를 위한 ube3a |
| CN114502197A (zh) | 2019-08-26 | 2022-05-13 | 再生生物股份有限公司 | 用全人经翻译后修饰的抗VEGF Fab治疗糖尿病性视网膜病变 |
| JP2022552262A (ja) | 2019-10-07 | 2022-12-15 | リジェネックスバイオ インコーポレイテッド | アデノ随伴ウイルスベクター医薬組成物および方法 |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| CN113952474A (zh) * | 2020-07-21 | 2022-01-21 | 英斯培瑞有限公司 | 用于治疗眼部疾病的组合物和方法 |
| JP2023544803A (ja) | 2020-10-07 | 2023-10-25 | レジェンクスバイオ インコーポレーテッド | Ｃｌｎ２疾患の眼症状に対する遺伝子療法 |
| MX2023004005A (es) | 2020-10-07 | 2023-06-06 | Regenxbio Inc | Formulaciones para administración supracoroidea tales como formulaciones de gel. |
| EP4225270A1 (en) | 2020-10-07 | 2023-08-16 | RegenxBio Inc. | Formulations for suprachoroidal administration such as high viscosity formulations |
| EP4225381A1 (en) | 2020-10-07 | 2023-08-16 | RegenxBio Inc. | Formulations for suprachoroidal administration such as formulations with aggregate formation |
| US20230391864A1 (en) * | 2020-10-28 | 2023-12-07 | Regenxbio, Inc. | Vectorized anti-tnf-alpha antibodies for ocular indications |
| PH12023551518A1 (en) | 2020-12-01 | 2024-05-13 | Akouos Inc | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| KR20230121096A (ko) * | 2020-12-18 | 2023-08-17 | 에이씨 이뮨 에스에이 | 항체 전달 |
| BR112023015303A2 (pt) | 2021-02-01 | 2023-11-14 | Regenxbio Inc | Método para tratar doença cln2 devido a deficiência de tpp1 em um sujeito |
| JP2024513205A (ja) * | 2021-03-31 | 2024-03-22 | ウーシー バイオロジクス アイルランド リミテッド | 二重特異性抗ｐｄ－ｌ１／ｖｅｇｆ抗体およびその使用 |
| TW202404651A (zh) | 2022-04-06 | 2024-02-01 | 美商銳進科斯生物股份有限公司 | 用於脈絡膜上投與之調配物諸如形成聚集體之調配物 |
| TW202345913A (zh) | 2022-04-06 | 2023-12-01 | 美商銳進科斯生物股份有限公司 | 用於脈絡膜上投與之調配物諸如凝膠調配物 |
| AU2023250660A1 (en) | 2022-04-06 | 2024-10-24 | Regenxbio Inc. | Pharmaceutical composition comprising a recombinant adenoassociated virus vector with an expression cassette encoding a transgene for suprachoroidal administration |
| IL319873A (en) | 2022-09-30 | 2025-05-01 | Regenxbio Inc | Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB |
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| BR0014945A (pt) * | 1999-10-21 | 2004-08-31 | Monsanto Co | Modificação pós-traducional de proteìnas recombinantes produzidas em plantas |
| CA2417508A1 (en) * | 2000-07-26 | 2002-01-31 | Ludwig Institute For Cancer Research | Glycosylated vegf-b and method for increasing the amount of soluble vegf-b |
| WO2010148223A2 (en) * | 2009-06-17 | 2010-12-23 | Facet Biotech Corporation | Anti-vegf antibodies and their uses |
| US20130090375A1 (en) * | 2011-10-06 | 2013-04-11 | Cornell University | Virus-mediated delivery of bevacizumab for therapeutic applications |
| TWI698240B (zh) * | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| JP6974943B2 (ja) * | 2014-05-13 | 2021-12-01 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ２種の抗体構築物を発現するａａｖを含む組成物およびこの使用 |
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2018
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2019
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