JP2017501711A5 - - Google Patents

Info

Publication number

JP2017501711A5

JP2017501711A5 JP2016541346A JP2016541346A JP2017501711A5 JP 2017501711 A5 JP2017501711 A5 JP 2017501711A5 JP 2016541346 A JP2016541346 A JP 2016541346A JP 2016541346 A JP2016541346 A JP 2016541346A JP 2017501711 A5 JP2017501711 A5 JP 2017501711A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

seq

antibody

antigen

Prior art date

2014-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 58
• 239000000427 antigen Substances 0.000 claims 39
• 102000036639 antigens Human genes 0.000 claims 39
• 108091007433 antigens Proteins 0.000 claims 39
• 238000000034 method Methods 0.000 claims 34
• 239000012634 fragment Substances 0.000 claims 31
• 239000003814 drug Substances 0.000 claims 10
• 208000006673 asthma Diseases 0.000 claims 5
• 102000003816 Interleukin-13 Human genes 0.000 claims 4
• 108090000176 Interleukin-13 Proteins 0.000 claims 4
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000002904 solvent Substances 0.000 claims 4
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 230000002209 hydrophobic effect Effects 0.000 claims 3
• 150000007523 nucleic acids Chemical group 0.000 claims 3
• 230000002062 proliferating effect Effects 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 102000009109 Fc receptors Human genes 0.000 claims 2
• 108010087819 Fc receptors Proteins 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010052285 Membrane Proteins Proteins 0.000 claims 2
• 102000018697 Membrane Proteins Human genes 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 238000001727 in vivo Methods 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102000007562 Serum Albumin Human genes 0.000 claims 1
• 108010071390 Serum Albumin Proteins 0.000 claims 1
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
• 201000009961 allergic asthma Diseases 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 230000001028 anti-proliverative effect Effects 0.000 claims 1
• 229940125715 antihistaminic agent Drugs 0.000 claims 1
• 239000000739 antihistaminic agent Substances 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229950000210 beclometasone dipropionate Drugs 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229960000265 cromoglicic acid Drugs 0.000 claims 1
• IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 238000012350 deep sequencing Methods 0.000 claims 1
• 239000012636 effector Substances 0.000 claims 1
• 230000001605 fetal effect Effects 0.000 claims 1
• 125000001165 hydrophobic group Chemical group 0.000 claims 1
• 210000002540 macrophage Anatomy 0.000 claims 1
• 210000000822 natural killer cell Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 229960002052 salbutamol Drugs 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 229960000278 theophylline Drugs 0.000 claims 1
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1