|
US4164559A
(en)
|
1977-09-21 |
1979-08-14 |
Cornell Research Foundation, Inc. |
Collagen drug delivery device
|
|
US4474752A
(en)
|
1983-05-16 |
1984-10-02 |
Merck & Co., Inc. |
Drug delivery system utilizing thermosetting gels
|
|
US4783443A
(en)
|
1986-03-03 |
1988-11-08 |
The University Of Chicago |
Amino acyl cephalosporin derivatives
|
|
GB9414139D0
(en)
|
1994-07-13 |
1994-08-31 |
Smithkline Beecham Plc |
Novel compounds
|
|
ES2131463B1
(es)
|
1997-04-08 |
2000-03-01 |
Lilly Sa |
Derivados de ciclopropilglicina con propiedades farmaceuticas.
|
|
DE19746287A1
(de)
*
|
1997-10-20 |
1999-04-22 |
Hoechst Marion Roussel De Gmbh |
Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
US6440102B1
(en)
|
1998-07-23 |
2002-08-27 |
Durect Corporation |
Fluid transfer and diagnostic system for treating the inner ear
|
|
DE19853299C2
(de)
|
1998-11-19 |
2003-04-03 |
Thomas Lenarz |
Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs
|
|
US6120484A
(en)
|
1999-02-17 |
2000-09-19 |
Silverstein; Herbert |
Otological implant for delivery of medicament and method of using same
|
|
WO2000071129A1
(en)
|
1999-05-21 |
2000-11-30 |
Bristol-Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
|
PE20010306A1
(es)
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
|
US6967023B1
(en)
|
2000-01-10 |
2005-11-22 |
Foamix, Ltd. |
Pharmaceutical and cosmetic carrier or composition for topical application
|
|
YU54202A
(sh)
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
|
ES2244613T3
(es)
|
2000-04-27 |
2005-12-16 |
Astellas Pharma Inc. |
Derivados de imidazopiridina.
|
|
JP2004536113A
(ja)
|
2001-07-03 |
2004-12-02 |
カイロン コーポレイション |
チロシンキナーゼおよびセリン／スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物
|
|
US6648873B2
(en)
|
2001-09-21 |
2003-11-18 |
Durect Corp. |
Aural catheter system including anchor balloon and balloon inflation device
|
|
IL161576A0
(en)
|
2001-10-26 |
2004-09-27 |
Aventis Pharma Inc |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
|
US7666867B2
(en)
|
2001-10-26 |
2010-02-23 |
University Of Connecticut |
Heteroindanes: a new class of potent cannabimimetic ligands
|
|
FR2831536A1
(fr)
|
2001-10-26 |
2003-05-02 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
|
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
|
MXPA04008130A
(es)
|
2002-02-19 |
2004-11-26 |
Pharmacia Corp |
Derivados triciclicos de pirazol para el tratamiento de la inflamacion.
|
|
EP1478357B1
(en)
|
2002-02-19 |
2007-01-31 |
Pfizer Italia S.r.l. |
Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
|
|
AU2003227741A1
(en)
|
2002-05-17 |
2003-12-02 |
Pharmacia Italia S.P.A. |
Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
TW200406385A
(en)
|
2002-05-31 |
2004-05-01 |
Eisai Co Ltd |
Pyrazole compound and pharmaceutical composition containing the same
|
|
CA2487211C
(en)
|
2002-06-04 |
2010-09-14 |
Neogenesis Pharmaceuticals, Inc. |
Pyrazolo(1,5a) pyrimidine compounds as antiviral agents
|
|
GB0218625D0
(en)
|
2002-08-10 |
2002-09-18 |
Astex Technology Ltd |
Pharmaceutical compounds
|
|
FR2845382A1
(fr)
|
2002-10-02 |
2004-04-09 |
Sanofi Synthelabo |
Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique
|
|
BRPI0407811A
(pt)
|
2003-02-27 |
2006-02-14 |
Uriach Y Compania S A J |
composto derivados de pirazolopiridina, processo para a preparação dos mesmos, composição farmacêutica e respectivos uso
|
|
GB0310867D0
(en)
*
|
2003-05-12 |
2003-06-18 |
Novartis Ag |
Organic compounds
|
|
CA2532965C
(en)
|
2003-07-22 |
2013-05-14 |
Astex Therapeutics Limited |
3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
|
|
CN1829713A
(zh)
|
2003-07-30 |
2006-09-06 |
辉瑞大药厂 |
3,5二取代的吲唑化合物、药物组合物和介导或抑制细胞增殖的方法
|
|
US7008953B2
(en)
|
2003-07-30 |
2006-03-07 |
Agouron Pharmaceuticals, Inc. |
3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
|
|
WO2005014554A1
(en)
|
2003-08-08 |
2005-02-17 |
Astex Therapeutics Limited |
1h-indazole-3-carboxamide compounds as mapkap kinase modulators
|
|
JP5095216B2
(ja)
|
2003-11-14 |
2012-12-12 |
ローラス セラピューティクス インコーポレーテッド |
アリールイミダゾールおよびその抗癌剤としての使用
|
|
EP1532980A1
(en)
|
2003-11-24 |
2005-05-25 |
Novo Nordisk A/S |
N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes
|
|
FR2867778B1
(fr)
|
2004-03-16 |
2006-06-09 |
Sanofi Synthelabo |
Utilisation de derives d'indazolecarboxamides pour la preparation d'un medicament destine au traitement et a la prevention du paludisme
|
|
CN103724343A
(zh)
|
2004-03-25 |
2014-04-16 |
记忆药物公司 |
吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
|
|
CA2567977A1
(en)
|
2004-04-22 |
2006-01-05 |
Memory Pharmaceutical Corporation |
Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
|
|
US20060074102A1
(en)
|
2004-05-14 |
2006-04-06 |
Kevin Cusack |
Kinase inhibitors as therapeutic agents
|
|
EP1778687A2
(en)
|
2004-07-27 |
2007-05-02 |
SGX Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
|
WO2006024945A1
(en)
|
2004-09-03 |
2006-03-09 |
Pfizer Inc. |
Pharmaceutical compositions comprising a cdk inhibitor
|
|
US20060116519A1
(en)
|
2004-11-17 |
2006-06-01 |
Agouron Pharmaceuticals, Inc. |
Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
|
|
WO2006054143A1
(en)
|
2004-11-17 |
2006-05-26 |
Pfizer Inc. |
Polymorphs of {5-[3-(4,6-difluoro-1h-benzoimidazol-2-yl)-1h-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine
|
|
US20060127388A1
(en)
|
2004-12-10 |
2006-06-15 |
Wyeth |
Variants of glycogen synthase kinase 3 and uses thereof
|
|
US20060142247A1
(en)
|
2004-12-17 |
2006-06-29 |
Guy Georges |
Tricyclic heterocycles
|
|
EP1861161A4
(en)
|
2005-01-24 |
2012-05-16 |
Neurosystec Corp |
APPARATUS AND METHOD FOR DISPENSING THERAPEUTIC AND / OR OTHER AGENTS IN THE INTERNAL EAR AND OTHER FABRICS
|
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
AR057987A1
(es)
|
2005-11-24 |
2008-01-09 |
Astrazeneca Ab |
Compuestos agonistas de cb1 (receptor cannabinoide)
|
|
EP1957109A2
(en)
|
2005-12-02 |
2008-08-20 |
Sirtris Pharmaceuticals, Inc. |
Modulators of cdc2-like kinases (clks) and methods of use thereof
|
|
AU2007228940A1
(en)
|
2006-03-23 |
2007-09-27 |
F. Hoffmann-La Roche Ag |
Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
|
|
EP2001480A4
(en)
|
2006-03-31 |
2011-06-15 |
Abbott Lab |
Indazole CONNECTIONS
|
|
US7998978B2
(en)
*
|
2006-05-01 |
2011-08-16 |
Pfizer Inc. |
Substituted 2-amino-fused heterocyclic compounds
|
|
WO2008061109A2
(en)
|
2006-11-15 |
2008-05-22 |
Forest Laboratories Holdings Limited |
Indazole derivatives useful as melanin concentrating receptor ligands
|
|
ATE507205T1
(de)
|
2006-12-11 |
2011-05-15 |
Genetics Co Inc |
Aromatische 1,4-di-carboxylamide und deren verwendung
|
|
EP1932830A1
(en)
|
2006-12-11 |
2008-06-18 |
The Genetics Company, Inc. |
Sulfonamides and their use as a medicament
|
|
ES2396160T3
(es)
|
2006-12-14 |
2013-02-19 |
Bayer Intellectual Property Gmbh |
Derivados de DIHIDROPIRIDINA que utiliza como inhibidores de la proteina quinasa
|
|
JP2010524858A
(ja)
|
2007-04-10 |
2010-07-22 |
エスジーエックス ファーマシューティカルズ、インコーポレイテッド |
縮合環複素環キナーゼ調節因子
|
|
US20100137394A1
(en)
|
2007-04-30 |
2010-06-03 |
Grenentech, Inc. |
Pyrazole inhibitors of wnt signaling
|
|
CA2871493C
(en)
|
2007-05-10 |
2017-03-28 |
Dogwood Pharmaceuticals, Inc. |
Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
|
|
US8304408B2
(en)
|
2007-05-24 |
2012-11-06 |
The Regents Of The University Of California |
Wnt signaling inhibitors, and methods for making and using them
|
|
TW200908968A
(en)
|
2007-05-29 |
2009-03-01 |
Sgx Pharmaceuticals Inc |
Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
|
|
WO2008154241A1
(en)
|
2007-06-08 |
2008-12-18 |
Abbott Laboratories |
5-heteroaryl substituted indazoles as kinase inhibitors
|
|
EP2157859A4
(en)
|
2007-06-19 |
2011-01-12 |
Takeda Pharmaceutical |
INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE
|
|
WO2009011850A2
(en)
|
2007-07-16 |
2009-01-22 |
Abbott Laboratories |
Novel therapeutic compounds
|
|
WO2009016072A2
(en)
|
2007-08-02 |
2009-02-05 |
Nerviano Medical Sciences S.R.L. |
A morpholinyl anthracycline derivative combined with protein kinase inhibitors
|
|
EP2195328A4
(en)
|
2007-08-15 |
2011-06-15 |
Cytokinetics Inc |
PARTICULAR CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
|
|
US9259399B2
(en)
|
2007-11-07 |
2016-02-16 |
Cornell University |
Targeting CDK4 and CDK6 in cancer therapy
|
|
WO2009085226A2
(en)
|
2007-12-21 |
2009-07-09 |
Sirtris Pharmaceuticals, Inc. |
Inhibitors of cdc2-like kinases (clks) and methods of use thereof
|
|
KR101061599B1
(ko)
|
2008-12-05 |
2011-09-02 |
한국과학기술연구원 |
비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
|
|
CN101440092B
(zh)
|
2008-12-25 |
2010-11-17 |
浙江大学 |
2-吲唑-4-氮杂吲哚-5-氨基衍生物及制备和应用
|
|
UA103918C2
(en)
|
2009-03-02 |
2013-12-10 |
Айерем Элелси |
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
|
|
AU2010226829A1
(en)
|
2009-03-18 |
2011-09-15 |
Schering Corporation |
Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
|
|
AU2010229144B2
(en)
|
2009-03-23 |
2012-07-12 |
Merck Sharp & Dohme Corp. |
P2X3, receptor antagonists for treatment of pain
|
|
EP2456310A4
(en)
|
2009-07-23 |
2013-01-23 |
Univ Vanderbilt |
SUBSTITUTED BENZOIMIDAZOLSULFONAMIDES AND SUBSTITUTED INDOLSULFONAMIDES AS MGLUR4 POTENTIATORS
|
|
BR112012002942A2
(pt)
|
2009-08-10 |
2015-10-13 |
Epitherix Llc |
indazóis como inibidores da trilha de sinalização de wnt/b-catenina e empregos terapêuticos destes.
|
|
WO2011019651A1
(en)
|
2009-08-10 |
2011-02-17 |
Epitherix, Llc |
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
|
|
WO2011050245A1
(en)
|
2009-10-23 |
2011-04-28 |
Yangbo Feng |
Bicyclic heteroaryls as kinase inhibitors
|
|
US7998878B2
(en)
|
2009-11-20 |
2011-08-16 |
Eastman Kodak Company |
Method for selective deposition and devices
|
|
SMT201700581T1
(it)
|
2009-12-21 |
2018-01-11 |
Samumed Llc |
1h-pirazolo[3,4-b]piridine e loro usi terapeutici
|
|
UA108222C2
(xx)
|
2009-12-21 |
2015-04-10 |
|
СПОЛУКИ ЗАМІЩЕНОГО N-(1H-ІНДАЗОЛ-4-ІЛ)ІМІДАЗОЛ$1,2-а]ПІРИДИН-3-КАРБОКСАМІДУ ЯК ІНГІБІТОРИ cFMS
|
|
MX2012010666A
(es)
|
2010-03-31 |
2012-10-05 |
Actelion Pharmaceuticals Ltd |
Derivados de isoquinolin-3-ilurea antibacterianos.
|
|
EP2556058B1
(en)
|
2010-04-06 |
2017-06-14 |
Peter MacCallum Cancer Institute |
Radioprotector compounds and methods
|
|
WO2012068589A2
(en)
|
2010-11-19 |
2012-05-24 |
Constellation Pharmaceuticals |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
PH12013501489A1
(en)
*
|
2010-12-17 |
2013-08-28 |
Hoffmann La Roche |
Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
|
|
CN102558173B
(zh)
*
|
2010-12-31 |
2015-05-20 |
广州源生医药科技有限公司 |
抑制wnt信号传导的化合物、组合物及其应用
|
|
US8889684B2
(en)
|
2011-02-02 |
2014-11-18 |
Boehringer Ingelheim International Gmbh |
Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
|
|
US9464065B2
(en)
|
2011-03-24 |
2016-10-11 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
JP5855253B2
(ja)
|
2011-08-12 |
2016-02-09 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
インダゾール化合物、組成物及び使用方法
|
|
EP3473099A1
(en)
*
|
2011-09-14 |
2019-04-24 |
Samumed, LLC |
Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
|
|
WO2013169793A2
(en)
*
|
2012-05-09 |
2013-11-14 |
Ipierian, Inc. |
Methods and compositions for tdp-43 proteinopathies
|
|
US9557993B2
(en)
|
2012-10-23 |
2017-01-31 |
Analog Devices Global |
Processor architecture and method for simplifying programming single instruction, multiple data within a register
|
|
CA2897400A1
(en)
|
2013-01-08 |
2014-07-17 |
Samumed, Llc |
3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
|
|
EP2945636B1
(en)
|
2013-01-16 |
2017-06-28 |
Signal Pharmaceuticals, LLC |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
|
|
CA2942687A1
(en)
|
2014-03-20 |
2015-09-24 |
Samumed, Llc |
5-substituted indazole-3-carboxamides and preparation and use thereof
|
|
WO2016040181A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
|
WO2016040185A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
|
|
WO2016040180A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
|
WO2016040188A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
|
WO2016040182A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
|
|
WO2016040190A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
|
WO2016040193A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
|
WO2016040184A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
|
GB201416754D0
(en)
|
2014-09-23 |
2014-11-05 |
Mission Therapeutics Ltd |
Novel compounds
|
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
AR108326A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
US10722515B2
(en)
|
2016-09-30 |
2020-07-28 |
Sri International |
Dual CLK/CDK1 inhibitors for cancer treatment
|
|
US20220062240A1
(en)
|
2018-06-26 |
2022-03-03 |
Biosplice Therapeutics, Inc. |
Methods of treating cancer using a clk inhibitor
|
|
WO2020150545A1
(en)
|
2019-01-17 |
2020-07-23 |
Samumed, Llc |
Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
|