JP2019514908A5 - - Google Patents
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- JP2019514908A5 JP2019514908A5 JP2018556275A JP2018556275A JP2019514908A5 JP 2019514908 A5 JP2019514908 A5 JP 2019514908A5 JP 2018556275 A JP2018556275 A JP 2018556275A JP 2018556275 A JP2018556275 A JP 2018556275A JP 2019514908 A5 JP2019514908 A5 JP 2019514908A5
- Authority
- JP
- Japan
- Prior art keywords
- hbd
- medicament according
- motomeko
- defensins
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 claims 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 10
- 102000018568 alpha-Defensin Human genes 0.000 claims 7
- 108050007802 alpha-defensin Proteins 0.000 claims 7
- 102000000541 Defensins Human genes 0.000 claims 6
- 108010002069 Defensins Proteins 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 102100038326 Beta-defensin 4A Human genes 0.000 claims 5
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 5
- 102000012265 beta-defensin Human genes 0.000 claims 5
- 108050002883 beta-defensin Proteins 0.000 claims 5
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- 208000034189 Sclerosis Diseases 0.000 claims 3
- 208000003167 cholangitis Diseases 0.000 claims 3
- 208000019425 cirrhosis of liver Diseases 0.000 claims 3
- 102100026887 Beta-defensin 103 Human genes 0.000 claims 2
- 102100026886 Beta-defensin 104 Human genes 0.000 claims 2
- 101800005309 Carboxy-terminal peptide Proteins 0.000 claims 2
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims 2
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims 2
- 102000011022 Chorionic Gonadotropin Human genes 0.000 claims 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 claims 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 2
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 2
- 108010023302 HDL Cholesterol Proteins 0.000 claims 2
- 101000912247 Homo sapiens Beta-defensin 103 Proteins 0.000 claims 2
- 101000912243 Homo sapiens Beta-defensin 104 Proteins 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 230000001476 alcoholic effect Effects 0.000 claims 2
- 208000026594 alcoholic fatty liver disease Diseases 0.000 claims 2
- 201000001352 cholecystitis Diseases 0.000 claims 2
- 229940015047 chorionic gonadotropin Drugs 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims 2
- 230000002440 hepatic effect Effects 0.000 claims 2
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 2
- 231100000304 hepatotoxicity Toxicity 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 208000004611 Abdominal Obesity Diseases 0.000 claims 1
- 102100037437 Beta-defensin 1 Human genes 0.000 claims 1
- 206010065941 Central obesity Diseases 0.000 claims 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 1
- 229940122904 Glucagon receptor antagonist Drugs 0.000 claims 1
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 206010019668 Hepatic fibrosis Diseases 0.000 claims 1
- 101000952040 Homo sapiens Beta-defensin 1 Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 206010027525 Microalbuminuria Diseases 0.000 claims 1
- 102100040918 Pro-glucagon Human genes 0.000 claims 1
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 102100029613 Transient receptor potential cation channel subfamily V member 1 Human genes 0.000 claims 1
- 108050004388 Transient receptor potential cation channel subfamily V member 1 Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 210000003445 biliary tract Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 108091005995 glycated hemoglobin Proteins 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 208000010157 sclerosing cholangitis Diseases 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201670276 | 2016-04-29 | ||
| DKPA201670276 | 2016-04-29 | ||
| DKPA201670484 | 2016-07-01 | ||
| DKPA201670484 | 2016-07-01 | ||
| PCT/DK2017/050132 WO2017186250A1 (en) | 2016-04-29 | 2017-04-28 | Treatment of liver, biliary tract and pancreatic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019514908A JP2019514908A (ja) | 2019-06-06 |
| JP2019514908A5 true JP2019514908A5 (enExample) | 2020-06-11 |
Family
ID=58992579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556275A Ceased JP2019514908A (ja) | 2016-04-29 | 2017-04-28 | 肝臓、胆管および膵臓の障害の治療 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12076368B2 (enExample) |
| EP (1) | EP3448409B1 (enExample) |
| JP (1) | JP2019514908A (enExample) |
| KR (1) | KR102465341B1 (enExample) |
| CN (1) | CN109414474B (enExample) |
| AU (1) | AU2017258242B2 (enExample) |
| BR (1) | BR112018071972A2 (enExample) |
| CA (1) | CA3022497A1 (enExample) |
| RU (1) | RU2740913C2 (enExample) |
| SG (1) | SG11201809086YA (enExample) |
| WO (1) | WO2017186250A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102244161B1 (ko) * | 2018-08-31 | 2021-04-26 | 주식회사 나이벡 | 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도 |
| AU2020207527A1 (en) * | 2019-01-07 | 2021-08-19 | Aesculus Bio Aps | Defensin fragments for use in therapy or prophylaxis |
| CN110279851A (zh) * | 2019-07-05 | 2019-09-27 | 浙江大学 | Defa4细胞因子在制备治疗肝功能衰竭药剂中的应用 |
| CN114058694A (zh) * | 2021-11-29 | 2022-02-18 | 上海市普陀区中心医院 | Trpv1在筛选或制备预防、缓解和/或治疗肝脏疾病的药物中的应用 |
| KR102735773B1 (ko) * | 2022-11-10 | 2024-11-27 | 을지대학교 산학협력단 | 혈액 내 단백질 바이오마커를 포함하는 암 진단용 키트 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| EP1534306A2 (en) | 2002-05-31 | 2005-06-01 | Ciphergen Biosystems, Inc. | Defensins: use as antiviral agents |
| US7528107B2 (en) | 2005-11-30 | 2009-05-05 | Auburn University | Methods of treating inflammation in mammalian tissues comprising administering human alpha-defensins |
| WO2007081486A2 (en) | 2005-12-15 | 2007-07-19 | Ventria Bioscience | Oral administration of defensins to treat intestinal diseases |
| US20100104529A1 (en) | 2006-05-01 | 2010-04-29 | England Robert L | TNF-alpha VACCINE FOR TREATING DISEASE CONDITIONS MEDIATED BY PATHOLOGICAL TNF-alpha |
| WO2007148078A1 (en) * | 2006-06-20 | 2007-12-27 | Lipopeptide Ab | Use cathelicidin antimicrobial protein (hcap18 ) as anticancer agent |
| WO2008115390A2 (en) | 2007-03-16 | 2008-09-25 | The Hamner Institutes For Health Sciences | Methods of using defensins to treat diabetes |
| RU2010136023A (ru) | 2008-02-01 | 2012-03-10 | Асцендис Фарма Ас (Dk) | Пролекарство, содержащее саморасщепляемый линкер |
| KR20110031962A (ko) | 2008-07-18 | 2011-03-29 | 노보자임스 아데니움 바이오테크 에이/에스 | 포유류 베타 방어소를 이용한 염증 질환의 치료 |
| EP2399600A1 (en) * | 2008-07-18 | 2011-12-28 | Novozymes Adenium Biotech A/S | Treatment of inflammatory bowel diseases with mammal beta defensins |
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| US8410049B2 (en) | 2009-10-28 | 2013-04-02 | Cebix | Methods and kits for preventing hypoglycemia |
| US20110311601A1 (en) | 2010-06-22 | 2011-12-22 | Michael Kleine | Antimicrobial medical devices |
| DE102010040153A1 (de) | 2010-09-02 | 2012-03-08 | Robert Bosch Gesellschaft Für Medizinische Forschung Mbh | Stoffkombination zur Behandlung von entzündlichen oder infektiösen Erkrankungen |
| WO2012177929A2 (en) * | 2011-06-24 | 2012-12-27 | Amylin Pharmaceuticals, Inc. | Methods for treating diabetes with extended release formulations of glp-1 receptor agonists |
| WO2013006692A2 (en) * | 2011-07-06 | 2013-01-10 | The General Hospital Corporation | Methods of treatment using a pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) |
| JP6219277B2 (ja) * | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| US20130052213A1 (en) | 2011-08-19 | 2013-02-28 | Novozymes A/S | Novel immunomodulatory peptide |
| BR112015004734A2 (pt) * | 2012-09-07 | 2017-11-21 | Sanofi Sa | proteínas de fusão para tratar uma síndrome metabólica |
| CN104971343B (zh) * | 2015-07-13 | 2018-02-02 | 韩源平 | 防御素在制备治疗代谢综合征药物方面的应用 |
| CN105504063B (zh) * | 2015-10-19 | 2019-10-01 | 中国医学科学院医药生物技术研究所 | 一类防御素-白蛋白的抗肿瘤融合蛋白及其制备和应用 |
| SG11201805954WA (en) | 2016-01-26 | 2018-08-30 | Defensin Therapeutics Aps | Methods for modulating intestinal microbiota |
| US11040996B2 (en) * | 2016-07-30 | 2021-06-22 | Bontac Bio-Engineering(Shenzhen) Co., Ltd | Method for preparing nicotinamide mononucleotide (NMN) |
| CN114075585A (zh) * | 2020-08-18 | 2022-02-22 | 弈柯莱生物科技(上海)股份有限公司 | 一种β-烟酰胺单核苷酸的制备方法 |
| CN112795606B (zh) * | 2021-04-14 | 2021-07-27 | 深圳瑞德林生物技术有限公司 | 一种β-烟酰胺单核苷酸的酶催化合成方法 |
| CN114107160B (zh) * | 2021-12-27 | 2025-04-25 | 浙江英沃迪生物科技有限公司 | 一种烟酰胺核糖激酶基因工程菌及其应用 |
-
2017
- 2017-04-28 EP EP17727094.9A patent/EP3448409B1/en active Active
- 2017-04-28 CN CN201780039341.1A patent/CN109414474B/zh active Active
- 2017-04-28 CA CA3022497A patent/CA3022497A1/en active Pending
- 2017-04-28 BR BR112018071972-2A patent/BR112018071972A2/pt not_active IP Right Cessation
- 2017-04-28 RU RU2018141326A patent/RU2740913C2/ru active
- 2017-04-28 KR KR1020187033643A patent/KR102465341B1/ko active Active
- 2017-04-28 WO PCT/DK2017/050132 patent/WO2017186250A1/en not_active Ceased
- 2017-04-28 AU AU2017258242A patent/AU2017258242B2/en not_active Expired - Fee Related
- 2017-04-28 US US16/097,072 patent/US12076368B2/en active Active
- 2017-04-28 SG SG11201809086YA patent/SG11201809086YA/en unknown
- 2017-04-28 JP JP2018556275A patent/JP2019514908A/ja not_active Ceased
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