JP2019514426A5 - - Google Patents

Info

Publication number

JP2019514426A5

JP2019514426A5 JP2019508165A JP2019508165A JP2019514426A5 JP 2019514426 A5 JP2019514426 A5 JP 2019514426A5 JP 2019508165 A JP2019508165 A JP 2019508165A JP 2019508165 A JP2019508165 A JP 2019508165A JP 2019514426 A5 JP2019514426 A5 JP 2019514426A5

Authority

JP

Japan

Prior art keywords

oligomeric compound

antisense oligomeric

seq

antisense

cpp

Prior art date

2017-04-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims description 50
• 230000000692 anti-sense Effects 0.000 claims description 49
• JCAIWDXKLCEQEO-LXOWHHAPSA-N Copalyl diphosphate Natural products [P@@](=O)(OP(=O)(O)O)(OC/C=C(\CC[C@H]1C(=C)CC[C@H]2C(C)(C)CCC[C@@]12C)/C)O JCAIWDXKLCEQEO-LXOWHHAPSA-N 0.000 claims description 18
• 150000003839 salts Chemical class 0.000 claims description 14
• 239000011780 sodium chloride Substances 0.000 claims description 14
• 208000007932 Progeria Diseases 0.000 claims description 4
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
• 125000005647 linker group Chemical group 0.000 claims description 4
• 239000000203 mixture Substances 0.000 claims description 3
• 239000008194 pharmaceutical composition Substances 0.000 claims description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 2
• 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
• 102000019679 Cell-Penetrating Peptides Human genes 0.000 description 1
• 108010051109 Cell-Penetrating Peptides Proteins 0.000 description 1
• 238000000034 method Methods 0.000 description 1