JP2019512090A - 寿命イメージングおよび検出用途のためのセンサおよびデバイス - Google Patents
寿命イメージングおよび検出用途のためのセンサおよびデバイス Download PDFInfo
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- JP2019512090A JP2019512090A JP2018544145A JP2018544145A JP2019512090A JP 2019512090 A JP2019512090 A JP 2019512090A JP 2018544145 A JP2018544145 A JP 2018544145A JP 2018544145 A JP2018544145 A JP 2018544145A JP 2019512090 A JP2019512090 A JP 2019512090A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Eye Examination Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022088707A JP2022113726A (ja) | 2016-02-17 | 2022-05-31 | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662296546P | 2016-02-17 | 2016-02-17 | |
| US62/296,546 | 2016-02-17 | ||
| PCT/US2017/018278 WO2017143129A1 (en) | 2016-02-17 | 2017-02-17 | Sensor and device for lifetime imaging and detection applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022088707A Division JP2022113726A (ja) | 2016-02-17 | 2022-05-31 | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019512090A true JP2019512090A (ja) | 2019-05-09 |
| JP2019512090A5 JP2019512090A5 (https=) | 2020-03-26 |
Family
ID=59559972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544145A Pending JP2019512090A (ja) | 2016-02-17 | 2017-02-17 | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
| JP2022088707A Withdrawn JP2022113726A (ja) | 2016-02-17 | 2022-05-31 | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022088707A Withdrawn JP2022113726A (ja) | 2016-02-17 | 2022-05-31 | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10441174B2 (https=) |
| EP (1) | EP3417277A4 (https=) |
| JP (2) | JP2019512090A (https=) |
| KR (1) | KR20180111999A (https=) |
| CN (1) | CN108780044A (https=) |
| AU (1) | AU2017219894B2 (https=) |
| BR (1) | BR112018016018A2 (https=) |
| CA (1) | CA3012705A1 (https=) |
| TW (2) | TWI734748B (https=) |
| WO (1) | WO2017143129A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3471402B1 (en) | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| US10341571B2 (en) * | 2016-06-08 | 2019-07-02 | Invisage Technologies, Inc. | Image sensors with electronic shutter |
| US20180064399A1 (en) * | 2016-09-07 | 2018-03-08 | Heptagon Micro Optics Pte. Ltd. | Imaging systems including multi-tap demodulation pixels for biometric measurements |
| CA3047826A1 (en) | 2016-12-22 | 2018-06-28 | Quantum-Si Incorporated | Integrated photodetector with direct binning pixel |
| JP2018137569A (ja) * | 2017-02-21 | 2018-08-30 | ソニーセミコンダクタソリューションズ株式会社 | 測距装置、および測距方法 |
| EP3417758A1 (en) * | 2017-06-19 | 2018-12-26 | Ambu A/S | A method for processing image data using a non-linear scaling model and a medical visual aid system |
| KR102656419B1 (ko) * | 2017-07-21 | 2024-04-11 | 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) | 건강 모니터링 장치 |
| CN111279222B (zh) * | 2017-10-30 | 2023-07-28 | 深圳源光科技有限公司 | 具有高时间分辨率的lidar检测器 |
| CN107997769A (zh) * | 2017-11-24 | 2018-05-08 | 天津大学 | 一种基于耳垂血液层的微波时延无创血糖浓度检测法 |
| CN119364214A (zh) | 2018-06-22 | 2025-01-24 | 宽腾矽公司 | 具有不同检测时间的电荷存储仓的集成光电检测器 |
| JP2022512369A (ja) * | 2018-12-14 | 2022-02-03 | エコール ポリテクニーク フェデラル デ ローザンヌ (イーピーエフエル) | 非侵襲性グルコースセンサ |
| KR20220138386A (ko) * | 2020-01-14 | 2022-10-12 | 퀀텀-에스아이 인코포레이티드 | 도파관 여기 균일성 |
| JP2023547110A (ja) * | 2020-10-22 | 2023-11-09 | クアンタム-エスアイ インコーポレイテッド | 順次結合電荷蓄積部を備える集積回路および関連技術 |
| US12297496B2 (en) * | 2020-12-11 | 2025-05-13 | Quantum-Si Incorporated | Integrated circuit with improved charge transfer efficiency and associated techniques |
| CA3236899A1 (en) * | 2021-10-28 | 2023-05-04 | The General Hospital Corporation | System and method for intraoperative lifetime imaging |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040004194A1 (en) * | 2000-11-20 | 2004-01-08 | Francois Amblard | Multi-photon imaging installation |
| US20040106163A1 (en) * | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
| JP2010233843A (ja) * | 2009-03-31 | 2010-10-21 | Olympus Medical Systems Corp | 診断支援装置 |
| JP2012132741A (ja) * | 2010-12-21 | 2012-07-12 | Fujifilm Corp | 時間分解蛍光測定装置、及び方法 |
| JP2013500101A (ja) * | 2009-07-28 | 2013-01-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 非侵襲性インビボ光学イメージング方法 |
| JP2013519484A (ja) * | 2010-02-19 | 2013-05-30 | グリシュア リミテッド | 血管内グルコースセンサ |
| US20150173621A1 (en) * | 2011-09-12 | 2015-06-25 | Tufts University | Imaging Fluorescence or Luminescence Lifetime |
| WO2016011534A1 (en) * | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
| CN105300949A (zh) * | 2015-11-26 | 2016-02-03 | 浙江大学 | 一种荧光寿命测量方法及装置 |
| WO2016022998A2 (en) * | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
Family Cites Families (166)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
| WO1991006678A1 (en) | 1989-10-26 | 1991-05-16 | Sri International | Dna sequencing |
| US5355165A (en) | 1992-08-06 | 1994-10-11 | Princeton Scientific Instruments, Inc. | Very high frame rate CCD imager |
| CA2155186A1 (en) | 1993-02-01 | 1994-08-18 | Kevin M. Ulmer | Methods and apparatus for dna sequencing |
| US5471515A (en) | 1994-01-28 | 1995-11-28 | California Institute Of Technology | Active pixel sensor with intra-pixel charge transfer |
| MXPA96005828A (es) | 1994-05-27 | 2005-07-15 | Novartis Ag Tambien Denominada | Proceso para detectar luminescencia excitada evanescentemente. |
| US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
| JP3748571B2 (ja) | 1996-11-18 | 2006-02-22 | ノバルティス アクチエンゲゼルシャフト | 測定装置及びその使用方法 |
| WO1998035012A2 (en) | 1997-02-12 | 1998-08-13 | Chan Eugene Y | Methods and products for analyzing polymers |
| DE69841023D1 (de) | 1997-03-12 | 2009-09-10 | Applied Biosystems Llc | DNA Polymerasen mit verbesserten Fähigkeiten zum Einbau von markierten Nukleotiden |
| US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
| US6825921B1 (en) | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
| DE19748211A1 (de) | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
| EP0921196A1 (en) | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
| DE19810879A1 (de) | 1998-03-13 | 1999-09-16 | Roche Diagnostics Gmbh | Polymerasenchimären |
| CA2325399A1 (en) | 1998-03-23 | 1999-09-30 | Invitrogen Corporation | Modified nucleotides and methods useful for nucleic acid sequencing |
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
| US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
| US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
| JP4326050B2 (ja) | 1998-09-22 | 2009-09-02 | ハイスペック合資会社 | 高速撮像素子 |
| WO2000036152A1 (en) | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis |
| US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
| WO2000053805A1 (en) | 1999-03-10 | 2000-09-14 | Asm Scientific, Inc. | A method for direct nucleic acid sequencing |
| EP1681356B1 (en) | 1999-05-19 | 2011-10-19 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US6137117A (en) | 1999-06-21 | 2000-10-24 | The United States Of America As Represented By The Secretary Of The Navy | Integrating multi-waveguide sensor |
| CN2433618Y (zh) | 1999-10-29 | 2001-06-06 | 中国科学院上海原子核研究所 | 基因芯片检测装置 |
| US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
| JP4433347B2 (ja) | 2000-01-17 | 2010-03-17 | 富士フイルム株式会社 | 蛍光撮像装置 |
| EP1285290A1 (en) | 2000-04-28 | 2003-02-26 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
| US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| US6936702B2 (en) | 2000-06-07 | 2005-08-30 | Li-Cor, Inc. | Charge-switch nucleotides |
| US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
| US7158224B2 (en) | 2000-06-25 | 2007-01-02 | Affymetrix, Inc. | Optically active substrates |
| FR2813121A1 (fr) | 2000-08-21 | 2002-02-22 | Claude Weisbuch | Dispositif perfectionne de support d'elements chromophores |
| US7153672B1 (en) | 2000-08-30 | 2006-12-26 | University Of Rochester | Method of performing reverse transcription reaction using reverse transcriptase encoded by non-LTR retrotransposable element |
| US20020031836A1 (en) | 2000-09-11 | 2002-03-14 | Feldstein Mark J. | Fluidics system |
| JP4270742B2 (ja) | 2000-11-30 | 2009-06-03 | Necエレクトロニクス株式会社 | 固体撮像装置 |
| US7668697B2 (en) | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
| US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
| US20070020622A1 (en) | 2001-09-14 | 2007-01-25 | Invitrogen Corporation | DNA Polymerases and mutants thereof |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| GB2382648B (en) * | 2001-12-11 | 2003-11-12 | Amersham Pharm Biotech Uk Ltd | System and method for time correlated multi-photon counting measurements |
| CN1138862C (zh) | 2002-01-28 | 2004-02-18 | 国前 | 一种核酸分析用收集装置及其应用方法 |
| US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
| US6924887B2 (en) | 2002-03-27 | 2005-08-02 | Sarnoff Corporation | Method and apparatus for generating charge from a light pulse |
| US8238993B2 (en) | 2002-04-04 | 2012-08-07 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime |
| US20040144927A1 (en) | 2003-01-28 | 2004-07-29 | Auner Gregory W. | Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| KR100596054B1 (ko) * | 2002-10-31 | 2006-07-03 | 삼성코닝정밀유리 주식회사 | 유리기판의 검사시스템 |
| WO2004047353A2 (en) * | 2002-11-19 | 2004-06-03 | Safetzone Technologies Corporation | Guest communication system and method |
| JP4896708B2 (ja) | 2003-02-05 | 2012-03-14 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 新規リンカー類を有する末端リン酸標識ヌクレオチド類 |
| US7745116B2 (en) | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
| WO2005073407A1 (en) * | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
| DE10348949A1 (de) | 2003-10-18 | 2005-05-19 | Bayer Healthcare Ag | Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer |
| WO2005043137A1 (de) | 2003-10-18 | 2005-05-12 | Bayer Healthcare Ag | Direkte beobachtung molekularer veränderungen in biologischen testsystemen mittels messungen der fluoreszenz-lebensdauer |
| US20070281288A1 (en) | 2004-01-27 | 2007-12-06 | Shimshon Belkin | Method and System for Detecting Analytes |
| WO2005080605A2 (en) | 2004-02-19 | 2005-09-01 | Helicos Biosciences Corporation | Methods and kits for analyzing polynucleotide sequences |
| US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
| US20060019265A1 (en) | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
| EP1622200A1 (en) * | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Solid-state photodetector pixel and photodetecting method |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| US7345764B2 (en) | 2005-02-07 | 2008-03-18 | Vladimir Bulovic | Apparatus and method for a slim format spectrometer |
| US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
| US7738086B2 (en) | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
| US7365299B2 (en) | 2005-05-09 | 2008-04-29 | Sensors Unlimited, Inc. | Method and apparatus for providing flexible photodetector binning |
| EP1907584A2 (en) | 2005-06-28 | 2008-04-09 | Agencourt Personal Genomics Corporation | Methods of producing and sequencing modified polynucleotides |
| DE602006020577D1 (de) | 2005-07-01 | 2011-04-21 | Dako Denmark As | Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen |
| US7426322B2 (en) | 2005-07-20 | 2008-09-16 | Searete Llc. | Plasmon photocatalysis |
| US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
| DE602006016984D1 (de) | 2005-12-12 | 2010-10-28 | Us Gov Health & Human Serv | Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren |
| WO2007075987A2 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
| CA2633524A1 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
| US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US20080050747A1 (en) | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| WO2007119626A1 (ja) | 2006-03-31 | 2007-10-25 | National University Corporation Shizuoka University | 半導体測距素子及び固体撮像装置 |
| DE102006030541B4 (de) | 2006-06-23 | 2010-05-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optische Anordnung |
| WO2008028160A2 (en) | 2006-09-01 | 2008-03-06 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| US8343746B2 (en) | 2006-10-23 | 2013-01-01 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| FR2908888B1 (fr) | 2006-11-21 | 2012-08-03 | Centre Nat Rech Scient | Dispositif pour la detection exaltee de l'emission d'une particule cible |
| JP5270835B2 (ja) * | 2006-12-29 | 2013-08-21 | パナソニック株式会社 | 光検出素子、空間情報の検出装置 |
| WO2008114148A2 (en) | 2007-03-22 | 2008-09-25 | Universite Louis Pasteur | Device for sorting and concentrating electromagnetic energy and apparatus comprising at least one such device |
| EP2134871B1 (en) | 2007-03-30 | 2012-03-07 | Pacific Biosciences of California, Inc. | Systems and methods for enhancing fluorescent signals |
| US7873085B2 (en) | 2007-10-23 | 2011-01-18 | Andrei Babushkin | Method and device for controlling optical output of laser diode |
| WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
| US20110165652A1 (en) | 2008-01-14 | 2011-07-07 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
| WO2009100382A1 (en) | 2008-02-07 | 2009-08-13 | Pacific Biosciences Of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
| US7968702B2 (en) | 2008-03-13 | 2011-06-28 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
| US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
| EP4230747A3 (en) | 2008-03-28 | 2023-11-15 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| EP2881736B1 (en) | 2008-03-31 | 2017-06-07 | Pacific Biosciences of California, Inc. | Single polymerase molecule loading methods and compositions |
| WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| US9127259B2 (en) | 2008-03-31 | 2015-09-08 | Pacific Biosciences Of California, Inc. | Enzymes resistant to photodamage |
| US8760549B2 (en) | 2008-08-28 | 2014-06-24 | Mesa Imaging Ag | Demodulation pixel with daisy chain charge storage sites and method of operation therefor |
| EP2331934B1 (en) | 2008-09-16 | 2020-01-01 | Pacific Biosciences of California, Inc. | Analytic device including a zero mode waveguide substrate |
| US8481264B2 (en) | 2008-09-19 | 2013-07-09 | Pacific Biosciences Of California, Inc. | Immobilized nucleic acid complexes for sequence analysis |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| EP2362947B1 (en) | 2008-09-30 | 2017-05-10 | Pacific Biosciences of California, Inc. | Ultra-high multiplex analytical systems and methods |
| EP2182523B1 (en) | 2008-10-31 | 2013-01-09 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Charge sampling device and method based on a MOS-transmission line |
| WO2010057185A1 (en) | 2008-11-17 | 2010-05-20 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
| EP2380040B1 (en) * | 2008-12-22 | 2017-02-22 | Koninklijke Philips N.V. | High dynamic range light sensor |
| US8338248B2 (en) | 2008-12-25 | 2012-12-25 | National University Corporation Shizuoka University | Semiconductor element and solid-state imaging device |
| KR20110125226A (ko) | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
| JP5519711B2 (ja) * | 2009-03-12 | 2014-06-11 | アールエスピー システムズ アクティーゼルスカブ | 光信号を生体内測定するための光学プローブ |
| WO2010111674A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Methods and apparatus for single molecule sequencing using energy transfer detection |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| US10514337B2 (en) | 2009-04-15 | 2019-12-24 | Koninklijke Philips N.V. | Device for time controlled fluorescence detection |
| WO2010148252A1 (en) * | 2009-06-17 | 2010-12-23 | Jody Vykoukal | Method and apparatus for quantitative microimaging |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| JP5648922B2 (ja) | 2009-10-05 | 2015-01-07 | 国立大学法人静岡大学 | 半導体素子及び固体撮像装置 |
| US8278728B2 (en) | 2009-10-17 | 2012-10-02 | Florida Institute Of Technology | Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels |
| WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| JP6017107B2 (ja) | 2009-12-28 | 2016-10-26 | ソニー株式会社 | イメージセンサ及びその製造方法、並びにセンサデバイス |
| WO2011090745A1 (en) | 2009-12-29 | 2011-07-28 | Life Technologies Corporation | Single molecule detection and sequencing using fluorescence lifetime imaging |
| EP2362207A1 (de) * | 2010-01-28 | 2011-08-31 | F. Hoffmann-La Roche AG | Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung |
| EP3460458B1 (en) | 2010-02-19 | 2021-08-11 | Pacific Biosciences of California, Inc. | A method for nucleic acid sequencing |
| JP2013534614A (ja) | 2010-03-25 | 2013-09-05 | モコン・インコーポレーテッド | 発光寿命に基づく分析物検出装置及び校正技術 |
| US20130149734A1 (en) | 2010-05-28 | 2013-06-13 | The Regents Of The University Of Colorado, A Body Corporate | Multi-photon Tissue Imaging |
| US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| WO2012161773A1 (en) | 2011-02-21 | 2012-11-29 | The Regents Of The University Of Michigan | Organic photovoltaic cell incorporating electron conducting exciton blocking layers |
| EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| US20130090537A1 (en) * | 2011-10-07 | 2013-04-11 | 2M Engineering Limited | Blood glucose sensor |
| EP3305400A3 (en) | 2011-10-28 | 2018-06-06 | Illumina, Inc. | Microarray fabrication system and method |
| WO2013066959A1 (en) * | 2011-10-31 | 2013-05-10 | The Trustees Of Columbia University In The City Of New York | Systems and methods for imaging using single photon avalanche diodes |
| US9606060B2 (en) | 2012-01-13 | 2017-03-28 | California Institute Of Technology | Filterless time-domain detection of one or more fluorophores |
| US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
| US9062091B2 (en) | 2012-02-15 | 2015-06-23 | Pacific Biosciences Of California, Inc. | Polymerase enzyme substrates with protein shield |
| DE102012206089B4 (de) | 2012-03-15 | 2017-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren |
| CN102914525B (zh) * | 2012-04-10 | 2016-06-01 | 广东工业大学 | 基于光学加法外差调制的新型荧光寿命显微成像装置及方法 |
| WO2013171197A1 (en) | 2012-05-15 | 2013-11-21 | Ait Austrian Institute Of Technology Gmbh | Compact plasmon-enhanced fluorescence biosensor |
| US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
| JP2014032174A (ja) * | 2012-07-13 | 2014-02-20 | Ricoh Co Ltd | 撮像装置、付着物検出装置、移動装置用機器制御システム及び移動装置 |
| WO2014031157A1 (en) | 2012-08-20 | 2014-02-27 | Illumina, Inc. | Method and system for fluorescence lifetime based sequencing |
| NL2011568A (en) | 2012-10-31 | 2014-05-06 | Asml Netherlands Bv | Sensor and lithographic apparatus. |
| EP2936222B1 (en) | 2012-12-18 | 2019-07-03 | Pacific Biosciences Of California, Inc. | An optical analytical device |
| GB201302664D0 (en) | 2013-02-15 | 2013-04-03 | Cmosis Nv | A pixel structure |
| WO2015006345A2 (en) | 2013-07-09 | 2015-01-15 | Nd Industries, Inc. | Multi-row magnetic dial for the conveyance of workpieces and related method |
| US20150042954A1 (en) * | 2013-08-08 | 2015-02-12 | University Of Rochester | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics |
| WO2015074001A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| CN103728446B (zh) | 2013-12-11 | 2016-02-24 | 天津大学 | 光子计数型多通道时间分辨荧光免疫分析系统及计数方法 |
| US9736388B2 (en) | 2013-12-13 | 2017-08-15 | Bio-Rad Laboratories, Inc. | Non-destructive read operations with dynamically growing images |
| DK3099232T3 (da) * | 2014-01-31 | 2021-11-22 | Massachusetts Gen Hospital | System og fremgangsmåde til fotoluminescensdetektion |
| US9765395B2 (en) | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
| CA2957543A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| EP4421188A3 (en) | 2014-08-08 | 2024-10-23 | Quantum-Si Incorporated | Integrated device with external light source for probing, detecting, and analyzing molecules |
| US9871065B2 (en) | 2014-12-22 | 2018-01-16 | Google Inc. | RGBZ pixel unit cell with first and second Z transfer gates |
| US9666748B2 (en) | 2015-01-14 | 2017-05-30 | International Business Machines Corporation | Integrated on chip detector and zero waveguide module structure for use in DNA sequencing |
| WO2016128198A1 (de) | 2015-02-09 | 2016-08-18 | Espros Photonics Ag | Tof entfernungssensor |
| EP3271762B1 (en) | 2015-03-16 | 2023-01-04 | Pacific Biosciences of California, Inc. | Analytical system comprising integrated devices and systems for free-space optical coupling |
| WO2016187580A1 (en) | 2015-05-20 | 2016-11-24 | Quantum-Si Incorporated | Method of determining the sequence of a nuclear acid using time resolved luminescence |
| US10976257B2 (en) | 2015-06-08 | 2021-04-13 | The Regents Of The University Of Michigan | Pixel circuit and method for optical sensing |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| TWI755400B (zh) | 2016-06-01 | 2022-02-21 | 美商寬騰矽公司 | 脈衝命名器及基質命名器、識別核苷酸之方法、校準定序儀器之方法、識別發生核苷酸併入事件之時間的方法、非暫時性電腦可讀儲存媒體、及定序儀器 |
| CA3047826A1 (en) | 2016-12-22 | 2018-06-28 | Quantum-Si Incorporated | Integrated photodetector with direct binning pixel |
| CN119364214A (zh) | 2018-06-22 | 2025-01-24 | 宽腾矽公司 | 具有不同检测时间的电荷存储仓的集成光电检测器 |
| AU2019330042A1 (en) | 2018-08-29 | 2021-03-11 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
-
2017
- 2017-02-17 KR KR1020187026360A patent/KR20180111999A/ko not_active Ceased
- 2017-02-17 TW TW106105392A patent/TWI734748B/zh not_active IP Right Cessation
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- 2017-02-17 WO PCT/US2017/018278 patent/WO2017143129A1/en not_active Ceased
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- 2022-05-31 JP JP2022088707A patent/JP2022113726A/ja not_active Withdrawn
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040004194A1 (en) * | 2000-11-20 | 2004-01-08 | Francois Amblard | Multi-photon imaging installation |
| US20040106163A1 (en) * | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
| JP2010233843A (ja) * | 2009-03-31 | 2010-10-21 | Olympus Medical Systems Corp | 診断支援装置 |
| JP2013500101A (ja) * | 2009-07-28 | 2013-01-07 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 非侵襲性インビボ光学イメージング方法 |
| JP2013519484A (ja) * | 2010-02-19 | 2013-05-30 | グリシュア リミテッド | 血管内グルコースセンサ |
| JP2012132741A (ja) * | 2010-12-21 | 2012-07-12 | Fujifilm Corp | 時間分解蛍光測定装置、及び方法 |
| US20150173621A1 (en) * | 2011-09-12 | 2015-06-25 | Tufts University | Imaging Fluorescence or Luminescence Lifetime |
| WO2016011534A1 (en) * | 2014-07-24 | 2016-01-28 | University Health Network | Collection and analysis of data for diagnostic purposes |
| WO2016022998A2 (en) * | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| CN105300949A (zh) * | 2015-11-26 | 2016-02-03 | 浙江大学 | 一种荧光寿命测量方法及装置 |
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| US20220273174A1 (en) | 2022-09-01 |
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