JP2019510482A5 - - Google Patents
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- JP2019510482A5 JP2019510482A5 JP2018544785A JP2018544785A JP2019510482A5 JP 2019510482 A5 JP2019510482 A5 JP 2019510482A5 JP 2018544785 A JP2018544785 A JP 2018544785A JP 2018544785 A JP2018544785 A JP 2018544785A JP 2019510482 A5 JP2019510482 A5 JP 2019510482A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- methods
- derived
- culture medium
- beta cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157181 | 2016-02-24 | ||
| EP16157181.5 | 2016-02-24 | ||
| PCT/EP2017/054390 WO2017144695A1 (en) | 2016-02-24 | 2017-02-24 | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510482A JP2019510482A (ja) | 2019-04-18 |
| JP2019510482A5 true JP2019510482A5 (https=) | 2020-04-02 |
| JP7123802B2 JP7123802B2 (ja) | 2022-08-23 |
Family
ID=55588039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544785A Active JP7123802B2 (ja) | 2016-02-24 | 2017-02-24 | ヒト多能性幹細胞由来内分泌前駆細胞からの機能的ベータ細胞の産生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11274280B2 (https=) |
| EP (1) | EP3420073B1 (https=) |
| JP (1) | JP7123802B2 (https=) |
| CN (1) | CN108699515A (https=) |
| ES (1) | ES2967942T3 (https=) |
| MA (1) | MA45747A (https=) |
| WO (1) | WO2017144695A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI2794857T3 (fi) | 2011-12-22 | 2026-03-25 | Janssen Biotech Inc | Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| MD4194548T2 (ro) * | 2016-06-21 | 2026-02-28 | Janssen Biotech Inc | Generarea de celule beta funcționale derivate din celule stem pluripotente umane care posedă respirație mitocondrială dependentă - de glucoză și răspuns la secreția de insulină în două faze |
| KR102738995B1 (ko) | 2017-09-11 | 2024-12-06 | 노보 노르디스크 에이/에스 | 시험관 내 줄기 세포로부터 유래된 nkx6.1 및 c-펩티드 공발현 세포의 농축 |
| EP3710021A4 (en) | 2017-11-15 | 2021-08-11 | Semma Therapeutics, Inc. | ISLAND CELL MANUFACTURING COMPOSITIONS AND METHOD OF USE |
| EP3758719A4 (en) * | 2018-03-02 | 2021-12-08 | Vertex Pharmaceuticals Inc. | METHODS FOR IMPROVING THE DIFFERENTIATION OF STEM CELLS INTO BETA CELLS |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| WO2020043292A1 (en) * | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| US20220177849A1 (en) | 2019-04-08 | 2022-06-09 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
| TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| CN114729323B (zh) | 2019-11-22 | 2024-09-17 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
| WO2021174201A1 (en) * | 2020-02-28 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Tissue culture media for survival and engraftment of human pancreatic islets |
| WO2021175768A1 (en) | 2020-03-02 | 2021-09-10 | Novo Nordisk A/S | Use of pluripotent markers to detect contaminating residual undifferentiated pluripotent stem cells |
| US20230313145A1 (en) | 2020-08-28 | 2023-10-05 | Novo Nordisk A/S | Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof |
| WO2022129472A1 (en) | 2020-12-18 | 2022-06-23 | Novo Nordisk A/S | Safe immuno-stealth cells |
| WO2022136215A1 (en) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Safe immuno-stealth cells |
| CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
| EP4423254A4 (en) * | 2021-10-28 | 2026-01-14 | Memorial Sloan Kettering Cancer Center | COMPOSITIONS AND PROCESSES TO PROMOTE IN VITRO CELL MATURATION |
| WO2023118050A1 (en) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Use of novel markers to detect pluripotent stem cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| EP4716541A2 (en) | 2023-05-22 | 2026-04-01 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
| WO2025093467A1 (en) | 2023-10-31 | 2025-05-08 | Novo Nordisk A/S | Methods for preventing unwanted cells arising during differentiation of human pluripotent stem cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| EP2723852B1 (en) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| HRP20191677T1 (hr) | 2012-04-30 | 2019-12-13 | Univ Health Network | POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC |
| CN104903440B (zh) * | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| ES2666465T3 (es) * | 2012-09-27 | 2018-05-04 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos para producir una población de células beta pancreáticas |
| DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
| US20150368616A1 (en) * | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| CN105531365A (zh) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | 分离的幼稚多能干细胞和产生所述细胞的方法 |
| US9540613B2 (en) | 2013-04-29 | 2017-01-10 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| CN105683361B (zh) * | 2013-08-30 | 2021-04-02 | 诺和诺德股份有限公司 | 使用小分子从人多能干细胞产生内分泌祖细胞 |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| WO2020043292A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
-
2017
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/en active Active
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/en not_active Ceased
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
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