ES2967942T3 - Generación de células beta funcionales a partir de progenitoras endocrinas derivadas de células madre pluripotentes humanas - Google Patents
Generación de células beta funcionales a partir de progenitoras endocrinas derivadas de células madre pluripotentes humanas Download PDFInfo
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- ES2967942T3 ES2967942T3 ES17709385T ES17709385T ES2967942T3 ES 2967942 T3 ES2967942 T3 ES 2967942T3 ES 17709385 T ES17709385 T ES 17709385T ES 17709385 T ES17709385 T ES 17709385T ES 2967942 T3 ES2967942 T3 ES 2967942T3
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| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
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| SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| EP2723852B1 (en) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| HRP20191677T1 (hr) | 2012-04-30 | 2019-12-13 | Univ Health Network | POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC |
| CN104903440B (zh) * | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| ES2666465T3 (es) * | 2012-09-27 | 2018-05-04 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Métodos para producir una población de células beta pancreáticas |
| DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
| US20150368616A1 (en) * | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| CN105531365A (zh) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | 分离的幼稚多能干细胞和产生所述细胞的方法 |
| US9540613B2 (en) | 2013-04-29 | 2017-01-10 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| CN105683361B (zh) * | 2013-08-30 | 2021-04-02 | 诺和诺德股份有限公司 | 使用小分子从人多能干细胞产生内分泌祖细胞 |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| WO2015175307A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| WO2020043292A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
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| EP3420073C0 (en) | 2023-11-08 |
| EP3420073A1 (en) | 2019-01-02 |
| JP7123802B2 (ja) | 2022-08-23 |
| JP2019510482A (ja) | 2019-04-18 |
| CN108699515A (zh) | 2018-10-23 |
| MA45747A (fr) | 2019-01-02 |
| WO2017144695A9 (en) | 2017-10-19 |
| US20190085295A1 (en) | 2019-03-21 |
| US11274280B2 (en) | 2022-03-15 |
| EP3420073B1 (en) | 2023-11-08 |
| WO2017144695A1 (en) | 2017-08-31 |
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