MA45747A - Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines - Google Patents
Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humainesInfo
- Publication number
- MA45747A MA45747A MA045747A MA45747A MA45747A MA 45747 A MA45747 A MA 45747A MA 045747 A MA045747 A MA 045747A MA 45747 A MA45747 A MA 45747A MA 45747 A MA45747 A MA 45747A
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- generation
- souh
- human pluripotent
- functional beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/80—Neurotransmitters; Neurohormones
- C12N2501/845—Gamma amino butyric acid [GABA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157181 | 2016-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45747A true MA45747A (fr) | 2019-01-02 |
Family
ID=55588039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045747A MA45747A (fr) | 2016-02-24 | 2017-02-24 | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11274280B2 (https=) |
| EP (1) | EP3420073B1 (https=) |
| JP (1) | JP7123802B2 (https=) |
| CN (1) | CN108699515A (https=) |
| ES (1) | ES2967942T3 (https=) |
| MA (1) | MA45747A (https=) |
| WO (1) | WO2017144695A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102203056B1 (ko) | 2011-12-22 | 2021-01-14 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 단일 인슐린 호르몬 양성 세포로의 분화 |
| SG11201510177WA (en) | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| US10006006B2 (en) | 2014-05-16 | 2018-06-26 | Janssen Biotech, Inc. | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| WO2017144695A1 (en) | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| WO2017222879A1 (en) * | 2016-06-21 | 2017-12-28 | Janssen Biotech, Inc. | Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response |
| AU2018330499B2 (en) * | 2017-09-11 | 2025-01-30 | Novo Nordisk A/S | Enrichment of NKX6.1 and C-peptide co-expressing cells derived in vitro from stem cells |
| KR20250048146A (ko) | 2017-11-15 | 2025-04-07 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
| CN112074281A (zh) * | 2018-03-02 | 2020-12-11 | 沃泰克斯药物股份有限公司 | 增强干细胞向β细胞分化的方法 |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| AU2018439389A1 (en) * | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN113728090B (zh) | 2019-04-08 | 2024-04-05 | 诺和诺德股份有限公司 | 从干细胞衍生的定形内胚层生成胰腺内胚层 |
| TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| CN114729323B (zh) | 2019-11-22 | 2024-09-17 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
| WO2021174201A1 (en) * | 2020-02-28 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Tissue culture media for survival and engraftment of human pancreatic islets |
| JP2023516672A (ja) | 2020-03-02 | 2023-04-20 | ノヴォ ノルディスク アー／エス | 汚染性残留未分化多能性幹細胞を検出するための多能性マーカーの使用 |
| CN116018150A (zh) | 2020-08-28 | 2023-04-25 | 诺和诺德股份有限公司 | 用于筛选干细胞衍生的β样细胞的体外群体的方法及其新型标志物 |
| WO2022129472A1 (en) | 2020-12-18 | 2022-06-23 | Novo Nordisk A/S | Safe immuno-stealth cells |
| WO2022136215A1 (en) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Safe immuno-stealth cells |
| CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
| WO2023076554A1 (en) * | 2021-10-28 | 2023-05-04 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for promoting in vitro maturation of cells |
| WO2023118050A1 (en) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Use of novel markers to detect pluripotent stem cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| CN121604968A (zh) | 2023-05-22 | 2026-03-03 | 萨那生物科技公司 | 递送胰岛细胞的方法及相关方法 |
| WO2025093467A1 (en) | 2023-10-31 | 2025-05-08 | Novo Nordisk A/S | Methods for preventing unwanted cells arising during differentiation of human pluripotent stem cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG181687A1 (en) | 2009-12-23 | 2012-07-30 | Centocor Ortho Biotech Inc | Differentiation of human embryonic stem cells |
| RU2663339C1 (ru) | 2010-05-12 | 2018-08-03 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| AU2013255031C1 (en) * | 2012-04-30 | 2018-12-06 | University Health Network | Methods and compositions for generating pancreatic progenitors and functional beta cells from hPSCs |
| EP2893000B1 (en) * | 2012-09-03 | 2019-04-10 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| EP2900820B2 (en) * | 2012-09-27 | 2020-11-18 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for producing a population of pancreatic beta-cells |
| JP6557147B2 (ja) | 2012-12-31 | 2019-08-07 | ヤンセン バイオテツク，インコーポレーテツド | Ｈｂ９調節物を用いたヒト胚性幹細胞の膵臓内分泌細胞への分化 |
| US20150368616A1 (en) * | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| JP2016521971A (ja) | 2013-04-23 | 2016-07-28 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法１１９条第（ｅ）項に基づき、２０１４年１月２９日出願の米国特許仮出願第６１／９３２，９３５号、２０１３年９月１７日出願の米国特許仮出願第６１／８７８，７６９号、および２０１３年４月２３日出願の米国特許仮出願第６１／８１４，９２０号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、ＹａｑｕｂＨＡＮＮＡ、ＮｏａＮＯＶＥＲＳＨＴＥＲＮ、およびＹｏａｃｈＲＡＩＳによる米国特許出願（発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法（ＩＳＯＬＡＴＥＤＮＡＩＶＥＰＬＵＲＩＰＯＴＥＮＴＳＴＥＭＣＥＬＬＳＡＮＤＭＥＴＨＯＤＳＯＦＧＥＮＥＲＡＴＩＮＧＳＡＭＥ）」）（代理人事件記録簿第５８８７０号）にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。 |
| WO2014179198A1 (en) | 2013-04-29 | 2014-11-06 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| SG11201510177WA (en) * | 2013-06-11 | 2016-01-28 | Harvard College | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
| DK3039122T3 (da) | 2013-08-30 | 2019-09-30 | Novo Nordisk As | Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| US10006006B2 (en) | 2014-05-16 | 2018-06-26 | Janssen Biotech, Inc. | Use of small molecules to enhance MAFA expression in pancreatic endocrine cells |
| WO2017144695A1 (en) | 2016-02-24 | 2017-08-31 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| AU2018439389A1 (en) | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
-
2017
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/en not_active Ceased
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/en active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017144695A1 (en) | 2017-08-31 |
| EP3420073C0 (en) | 2023-11-08 |
| JP2019510482A (ja) | 2019-04-18 |
| WO2017144695A9 (en) | 2017-10-19 |
| CN108699515A (zh) | 2018-10-23 |
| US20190085295A1 (en) | 2019-03-21 |
| EP3420073A1 (en) | 2019-01-02 |
| JP7123802B2 (ja) | 2022-08-23 |
| EP3420073B1 (en) | 2023-11-08 |
| ES2967942T3 (es) | 2024-05-06 |
| US11274280B2 (en) | 2022-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA45747A (fr) | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines | |
| EA201992610A1 (ru) | Экспансия -t-клеток, композиции и способы их применения | |
| CO2021001893A2 (es) | Anticuerpos anti-gdf15, composiciones y métodos de uso | |
| CL2018001223A1 (es) | Locus óptimo de la soja (divisional de solicitud 201601063) | |
| MX2020001270A (es) | Anticuerpos anti-cd39, composiciones que comprenden anticuerpos anti-cd39, y metodos de uso de anticuerpos anti-cd39. | |
| CL2019002251A1 (es) | Anticuerpos contra triptasa, composiciones de estos y usos de estos. | |
| CL2019002793A1 (es) | Composición para producir tagatosa y procedimiento de producción de tagatosa usando la misma. | |
| CO2018001149A2 (es) | Anticuerpos monoclonales contra bcma | |
| CO2023006684A2 (es) | Anticuerpos contra sars-cov-2 y usos de los mismos | |
| UY37563A (es) | Aislados de bacillus y usos de los mismos | |
| MA43018B1 (fr) | Anticorps anti-pd1 et procédés d'utilisation | |
| MA47664A1 (fr) | Anticorps anti-c10orf54 et leurs utilisations | |
| CR20130458A (es) | Formas sólidas sde 3-(5-amino-2-metil-4-oxo-4h-quinazolin-3-il)-piperidin-2,6-diona, y sus composiciones farmacéuticas y usos | |
| UY37564A (es) | Aislados de lysinibacillus y usos de los mismos | |
| MX390083B (es) | Formulaciones de (r)-2-amino-3-fenilpropil carbamato. | |
| MX353706B (es) | Anticuerpos contra csf-1r humano y usos de los mismos. | |
| EA201592074A1 (ru) | Композиции и способы изменения сигнальной системы вторичного мессенджера | |
| MX2017013562A (es) | Reguladores de microbioma y usos relacionados de los mismos. | |
| AR090465A1 (es) | Formas solidas de un profarmaco de nucleotidos de tiofosforamidato | |
| CU23978B1 (es) | Composiciones para anticuerpos que se dirigen a la proteína de complemento c5 | |
| EA201991798A1 (ru) | Стабильные при хранении составы | |
| EA201500943A1 (ru) | Составы для мобилизации, хоуминга, размножения и дифференцировки стволовых клеток и способы применения составов | |
| MX2021000066A (es) | Métodos y composiciones para la preparacion de tagatosa a partir de fructosa. | |
| CL2019002574A1 (es) | Moduladores de la expresión de pcsk9. | |
| BR112022001207A2 (pt) | Método de obtenção de mitocôndrias de células e mitocôndrias obtidas |