JP2019510482A5 - - Google Patents
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- JP2019510482A5 JP2019510482A5 JP2018544785A JP2018544785A JP2019510482A5 JP 2019510482 A5 JP2019510482 A5 JP 2019510482A5 JP 2018544785 A JP2018544785 A JP 2018544785A JP 2018544785 A JP2018544785 A JP 2018544785A JP 2019510482 A5 JP2019510482 A5 JP 2019510482A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- methods
- derived
- culture medium
- beta cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157181 | 2016-02-24 | ||
| EP16157181.5 | 2016-02-24 | ||
| PCT/EP2017/054390 WO2017144695A1 (en) | 2016-02-24 | 2017-02-24 | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510482A JP2019510482A (ja) | 2019-04-18 |
| JP2019510482A5 true JP2019510482A5 (enExample) | 2020-04-02 |
| JP7123802B2 JP7123802B2 (ja) | 2022-08-23 |
Family
ID=55588039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544785A Active JP7123802B2 (ja) | 2016-02-24 | 2017-02-24 | ヒト多能性幹細胞由来内分泌前駆細胞からの機能的ベータ細胞の産生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11274280B2 (enExample) |
| EP (1) | EP3420073B1 (enExample) |
| JP (1) | JP7123802B2 (enExample) |
| CN (1) | CN108699515A (enExample) |
| ES (1) | ES2967942T3 (enExample) |
| MA (1) | MA45747A (enExample) |
| WO (1) | WO2017144695A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2705001C2 (ru) | 2011-12-22 | 2019-11-01 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки |
| AU2014278178B2 (en) | 2013-06-11 | 2021-01-21 | President And Fellows Of Harvard College | SC-beta cells and compositions and methods for generating the same |
| SG11201609473XA (en) | 2014-05-16 | 2016-12-29 | Janssen Biotech Inc | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| CN107614678B (zh) | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| EP3420073B1 (en) | 2016-02-24 | 2023-11-08 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CA3027879A1 (en) * | 2016-06-21 | 2017-12-28 | Janssen Biotech, Inc. | Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response |
| SG11202001906PA (en) | 2017-09-11 | 2020-04-29 | Novo Nordisk As | Enrichment of nkx6.1 and c-peptide co-expressing cells derived in vitro from stem cells |
| WO2019099725A1 (en) | 2017-11-15 | 2019-05-23 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
| WO2019169351A1 (en) | 2018-03-02 | 2019-09-06 | Semma Therapeutics, Inc. | Methods of enhancing stem cell differentiation into beta cells |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| AU2018439389A1 (en) * | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| EP3953451A1 (en) | 2019-04-08 | 2022-02-16 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
| TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| JP2023503302A (ja) | 2019-11-22 | 2023-01-27 | ノヴォ ノルディスク アー／エス | スピン凝集した神経系マイクロスフェアおよびその応用 |
| WO2021174201A1 (en) * | 2020-02-28 | 2021-09-02 | The Trustees Of The University Of Pennsylvania | Tissue culture media for survival and engraftment of human pancreatic islets |
| US20230340595A1 (en) | 2020-03-02 | 2023-10-26 | Novo Nordisk A/S | Use of pluripotent markers to detect contaminating residual undifferentiated pluripotent stem cells |
| WO2022043518A1 (en) | 2020-08-28 | 2022-03-03 | Novo Nordisk A/S | Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof |
| WO2022129472A1 (en) | 2020-12-18 | 2022-06-23 | Novo Nordisk A/S | Safe immuno-stealth cells |
| WO2022136215A1 (en) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Safe immuno-stealth cells |
| CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
| CA3236375A1 (en) * | 2021-10-28 | 2023-05-04 | Lorenz Studer | Compositions and methods for promoting in vitro maturation of cells |
| WO2023118050A1 (en) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Use of novel markers to detect pluripotent stem cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| WO2024243236A2 (en) | 2023-05-22 | 2024-11-28 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
| WO2025093467A1 (en) | 2023-10-31 | 2025-05-08 | Novo Nordisk A/S | Methods for preventing unwanted cells arising during differentiation of human pluripotent stem cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2516625T3 (da) | 2009-12-23 | 2024-09-09 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller |
| AU2011250912A1 (en) | 2010-05-12 | 2012-11-22 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| DK2844739T3 (da) * | 2012-04-30 | 2019-09-30 | Univ Health Network | FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL GENERERING AF PANCREATISKE PROGENITORER OG FUNKTIONELLE BETA-CELLER UD FRA hPSC'ER |
| EP2893000B1 (en) * | 2012-09-03 | 2019-04-10 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| US9708608B2 (en) * | 2012-09-27 | 2017-07-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for producing a population of pancreatic beta-cells |
| MX2015008578A (es) | 2012-12-31 | 2015-09-07 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9. |
| US20150368616A1 (en) * | 2013-02-14 | 2015-12-24 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| CN105531365A (zh) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | 分离的幼稚多能干细胞和产生所述细胞的方法 |
| WO2014179198A1 (en) | 2013-04-29 | 2014-11-06 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| AU2014278178B2 (en) | 2013-06-11 | 2021-01-21 | President And Fellows Of Harvard College | SC-beta cells and compositions and methods for generating the same |
| DK3039122T3 (da) | 2013-08-30 | 2019-09-30 | Novo Nordisk As | Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| SG11201609473XA (en) | 2014-05-16 | 2016-12-29 | Janssen Biotech Inc | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
| EP3420073B1 (en) | 2016-02-24 | 2023-11-08 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| AU2018439389A1 (en) | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
-
2017
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/en active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/en not_active Ceased
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
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