MA45747A - Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines - Google Patents
Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humainesInfo
- Publication number
- MA45747A MA45747A MA045747A MA45747A MA45747A MA 45747 A MA45747 A MA 45747A MA 045747 A MA045747 A MA 045747A MA 45747 A MA45747 A MA 45747A MA 45747 A MA45747 A MA 45747A
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- generation
- souh
- human pluripotent
- functional beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/80—Neurotransmitters; Neurohormones
- C12N2501/845—Gamma amino butyric acid [GABA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16157181 | 2016-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA45747A true MA45747A (fr) | 2019-01-02 |
Family
ID=55588039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045747A MA45747A (fr) | 2016-02-24 | 2017-02-24 | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11274280B2 (enExample) |
| EP (1) | EP3420073B1 (enExample) |
| JP (1) | JP7123802B2 (enExample) |
| CN (1) | CN108699515A (enExample) |
| ES (1) | ES2967942T3 (enExample) |
| MA (1) | MA45747A (enExample) |
| WO (1) | WO2017144695A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| KR102580225B1 (ko) | 2013-06-11 | 2023-09-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| US11274280B2 (en) | 2016-02-24 | 2022-03-15 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| EP4691479A3 (en) * | 2016-06-21 | 2026-04-15 | Janssen Biotech, Inc. | Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response |
| US20200199540A1 (en) * | 2017-09-11 | 2020-06-25 | Novo Nordisk A/S | Enrichment of nkx6.1 and c-peptide co-expressing cells derived in vitro from stem cells |
| CN118497104A (zh) | 2017-11-15 | 2024-08-16 | 沃泰克斯药物股份有限公司 | 胰岛细胞制备性组合物和使用方法 |
| EP3758719A4 (en) * | 2018-03-02 | 2021-12-08 | Vertex Pharmaceuticals Inc. | METHODS FOR IMPROVING THE DIFFERENTIATION OF STEM CELLS INTO BETA CELLS |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CA3110932A1 (en) * | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN113728090B (zh) | 2019-04-08 | 2024-04-05 | 诺和诺德股份有限公司 | 从干细胞衍生的定形内胚层生成胰腺内胚层 |
| TW202115245A (zh) | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| CN114729323B (zh) | 2019-11-22 | 2024-09-17 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
| US20240226179A1 (en) * | 2020-02-28 | 2024-07-11 | The Trustees Of The University Of Pennsylvania | Tissue culture media for survival and engraftment of human pancreatic islets |
| EP4114927A1 (en) | 2020-03-02 | 2023-01-11 | Novo Nordisk A/S | Use of pluripotent markers to detect contaminating residual undifferentiated pluripotent stem cells |
| CN116018150A (zh) | 2020-08-28 | 2023-04-25 | 诺和诺德股份有限公司 | 用于筛选干细胞衍生的β样细胞的体外群体的方法及其新型标志物 |
| WO2022129472A1 (en) | 2020-12-18 | 2022-06-23 | Novo Nordisk A/S | Safe immuno-stealth cells |
| WO2022136215A1 (en) | 2020-12-21 | 2022-06-30 | Novo Nordisk A/S | Safe immuno-stealth cells |
| CN113069440A (zh) * | 2021-04-08 | 2021-07-06 | 澳门大学 | 甲状腺素的新的应用、培养多能干细胞的方法和培养基 |
| EP4423254A4 (en) * | 2021-10-28 | 2026-01-14 | Memorial Sloan Kettering Cancer Center | COMPOSITIONS AND PROCESSES TO PROMOTE IN VITRO CELL MATURATION |
| WO2023118050A1 (en) | 2021-12-21 | 2023-06-29 | Novo Nordisk A/S | Use of novel markers to detect pluripotent stem cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| CN121604968A (zh) | 2023-05-22 | 2026-03-03 | 萨那生物科技公司 | 递送胰岛细胞的方法及相关方法 |
| WO2025093467A1 (en) | 2023-10-31 | 2025-05-08 | Novo Nordisk A/S | Methods for preventing unwanted cells arising during differentiation of human pluripotent stem cells |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010333839C1 (en) | 2009-12-23 | 2016-07-21 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
| KR101986176B1 (ko) | 2010-05-12 | 2019-06-05 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| JP6312591B2 (ja) | 2011-06-21 | 2018-04-18 | ノヴォ ノルディスク アー／エス | 多能性幹細胞からの胚体内胚葉の効率的な誘導 |
| CN104411815B (zh) | 2012-04-30 | 2017-11-28 | 大学健康网络 | 用于从hPSC生成胰腺祖细胞和功能性β细胞的方法和组合物 |
| JP6470687B2 (ja) | 2012-09-03 | 2019-02-13 | ノヴォ ノルディスク アー／エス | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 |
| WO2014048788A1 (en) | 2012-09-27 | 2014-04-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for producing a population of pancreatic beta-cells |
| RU2684215C2 (ru) | 2012-12-31 | 2019-04-04 | Янссен Байотек, Инк. | Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток |
| WO2014127219A1 (en) | 2013-02-14 | 2014-08-21 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
| US10920192B2 (en) | 2013-04-23 | 2021-02-16 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
| US9540613B2 (en) | 2013-04-29 | 2017-01-10 | Wisconsin Alumni Research Foundation | Methods for producing insulin-secreting beta cells from human pluripotent stem cells |
| KR102580225B1 (ko) | 2013-06-11 | 2023-09-20 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| WO2015028614A1 (en) * | 2013-08-30 | 2015-03-05 | Novo Nordisk A/S | Generation of endocrine progenitor cells from human pluripotent stem cells using small molecules |
| US20150250824A1 (en) * | 2014-03-07 | 2015-09-10 | The Research Foundation For The State University Of New York | Methods and compositions for expansion of stem cells and other cells |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| US11274280B2 (en) | 2016-02-24 | 2022-03-15 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CA3110932A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
-
2017
- 2017-02-24 US US16/078,763 patent/US11274280B2/en active Active
- 2017-02-24 JP JP2018544785A patent/JP7123802B2/ja active Active
- 2017-02-24 ES ES17709385T patent/ES2967942T3/es active Active
- 2017-02-24 MA MA045747A patent/MA45747A/fr unknown
- 2017-02-24 WO PCT/EP2017/054390 patent/WO2017144695A1/en not_active Ceased
- 2017-02-24 CN CN201780013255.3A patent/CN108699515A/zh active Pending
- 2017-02-24 EP EP17709385.3A patent/EP3420073B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20190085295A1 (en) | 2019-03-21 |
| JP7123802B2 (ja) | 2022-08-23 |
| CN108699515A (zh) | 2018-10-23 |
| EP3420073B1 (en) | 2023-11-08 |
| JP2019510482A (ja) | 2019-04-18 |
| WO2017144695A9 (en) | 2017-10-19 |
| US11274280B2 (en) | 2022-03-15 |
| WO2017144695A1 (en) | 2017-08-31 |
| EP3420073C0 (en) | 2023-11-08 |
| EP3420073A1 (en) | 2019-01-02 |
| ES2967942T3 (es) | 2024-05-06 |
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