JP2019507583A5 - - Google Patents
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- JP2019507583A5 JP2019507583A5 JP2018530754A JP2018530754A JP2019507583A5 JP 2019507583 A5 JP2019507583 A5 JP 2019507583A5 JP 2018530754 A JP2018530754 A JP 2018530754A JP 2018530754 A JP2018530754 A JP 2018530754A JP 2019507583 A5 JP2019507583 A5 JP 2019507583A5
- Authority
- JP
- Japan
- Prior art keywords
- modified clya
- amino acid
- clya nanopore
- nanopore
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000006467 substitution reaction Methods 0.000 claims description 40
- 150000001413 amino acids Chemical class 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 23
- 229920001184 polypeptide Polymers 0.000 claims description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- 102000040430 polynucleotide Human genes 0.000 claims description 22
- 108091033319 polynucleotide Proteins 0.000 claims description 22
- 239000002157 polynucleotide Substances 0.000 claims description 22
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 7
- 239000000823 artificial membrane Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 230000035772 mutation Effects 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 102220608443 Suppressor of cytokine signaling 2_D64R_mutation Human genes 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 102000004503 Perforin Human genes 0.000 claims 1
- 108010056995 Perforin Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 description 16
- 108020004414 DNA Proteins 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 102000053602 DNA Human genes 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 239000012266 salt solution Substances 0.000 description 6
- 102000023732 binding proteins Human genes 0.000 description 4
- 108091008324 binding proteins Proteins 0.000 description 4
- 230000005945 translocation Effects 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021198939A JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264709P | 2015-12-08 | 2015-12-08 | |
| US62/264,709 | 2015-12-08 | ||
| PCT/IB2016/001841 WO2017098322A1 (en) | 2015-12-08 | 2016-12-08 | Modified nanopores, compositions comprising the same, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021198939A Division JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507583A JP2019507583A (ja) | 2019-03-22 |
| JP2019507583A5 true JP2019507583A5 (https=) | 2020-01-30 |
| JP7237586B2 JP7237586B2 (ja) | 2023-03-13 |
Family
ID=58098655
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530754A Active JP7237586B2 (ja) | 2015-12-08 | 2016-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
| JP2021198939A Pending JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021198939A Pending JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10976300B2 (https=) |
| EP (1) | EP3387432B1 (https=) |
| JP (2) | JP7237586B2 (https=) |
| KR (1) | KR102837999B1 (https=) |
| CN (1) | CN109072295B (https=) |
| AU (1) | AU2016369071B2 (https=) |
| CA (1) | CA3011830C (https=) |
| WO (1) | WO2017098322A1 (https=) |
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| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| JP6749243B2 (ja) | 2014-01-22 | 2020-09-02 | オックスフォード ナノポール テクノロジーズ リミテッド | １つまたは複数のポリヌクレオチド結合タンパク質を標的ポリヌクレオチドに付着させる方法 |
| US10443097B2 (en) | 2014-05-02 | 2019-10-15 | Oxford Nanopore Technologies Ltd. | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| AU2017225374B2 (en) | 2016-03-02 | 2020-03-05 | Oxford Nanopore Technologies Limited | Mutant pore |
| WO2017174990A1 (en) | 2016-04-06 | 2017-10-12 | Oxford Nanopore Technologies Limited | Mutant pore |
| WO2018136495A1 (en) * | 2017-01-18 | 2018-07-26 | Youhealth Biotech, Limited | Methods and compositions for nanopore sequencing |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
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| KR102309424B1 (ko) * | 2020-09-28 | 2021-10-07 | 한국생명공학연구원 | 나노포어를 이용한 리보스위치-표적 물질의 스크리닝 방법 |
| CN117255945A (zh) * | 2021-03-31 | 2023-12-19 | 伊鲁米纳公司 | 纳米孔传感器装置 |
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| GB202113935D0 (en) | 2021-09-29 | 2021-11-10 | Cambridge Entpr Ltd | Nucleic acid characterisation |
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| CN114768530B (zh) * | 2022-04-29 | 2023-03-28 | 中国工程物理研究院材料研究所 | 二硫化钼在电解分离氢同位素中的应用 |
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| JP6749243B2 (ja) | 2014-01-22 | 2020-09-02 | オックスフォード ナノポール テクノロジーズ リミテッド | １つまたは複数のポリヌクレオチド結合タンパク質を標的ポリヌクレオチドに付着させる方法 |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| EP3126515B1 (en) | 2014-04-04 | 2018-08-29 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| US10443097B2 (en) | 2014-05-02 | 2019-10-15 | Oxford Nanopore Technologies Ltd. | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
| FR3023394B1 (fr) | 2014-07-02 | 2017-12-29 | Adn Access Data Networks | Dispositif permettant de faciliter l'enseignement de la langue amharique et d'en normaliser l'ecriture |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| AU2017225374B2 (en) | 2016-03-02 | 2020-03-05 | Oxford Nanopore Technologies Limited | Mutant pore |
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2016
- 2016-12-08 KR KR1020187019163A patent/KR102837999B1/ko active Active
- 2016-12-08 JP JP2018530754A patent/JP7237586B2/ja active Active
- 2016-12-08 CN CN201680081416.8A patent/CN109072295B/zh active Active
- 2016-12-08 EP EP16838062.4A patent/EP3387432B1/en active Active
- 2016-12-08 AU AU2016369071A patent/AU2016369071B2/en active Active
- 2016-12-08 CA CA3011830A patent/CA3011830C/en active Active
- 2016-12-08 WO PCT/IB2016/001841 patent/WO2017098322A1/en not_active Ceased
- 2016-12-08 US US16/060,762 patent/US10976300B2/en active Active
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2021
- 2021-12-08 JP JP2021198939A patent/JP2022046503A/ja active Pending