JP2019506398A5 - - Google Patents
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- JP2019506398A5 JP2019506398A5 JP2018538177A JP2018538177A JP2019506398A5 JP 2019506398 A5 JP2019506398 A5 JP 2019506398A5 JP 2018538177 A JP2018538177 A JP 2018538177A JP 2018538177 A JP2018538177 A JP 2018538177A JP 2019506398 A5 JP2019506398 A5 JP 2019506398A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 6
- 208000005017 glioblastoma Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010014967 Ependymoma Diseases 0.000 claims 4
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 4
- 208000000172 Medulloblastoma Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 208000007641 Pinealoma Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 201000010536 head and neck cancer Diseases 0.000 claims 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 206010061424 Anal cancer Diseases 0.000 claims 2
- 206010073128 Anaplastic oligodendroglioma Diseases 0.000 claims 2
- 208000007860 Anus Neoplasms Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 2
- 108060006698 EGF receptor Proteins 0.000 claims 2
- 206010014968 Ependymoma malignant Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010027406 Mesothelioma Diseases 0.000 claims 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010050487 Pinealoblastoma Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 2
- 206010073334 Rhabdoid tumour Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 206010043276 Teratoma Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 206010002224 anaplastic astrocytoma Diseases 0.000 claims 2
- 208000014534 anaplastic ependymoma Diseases 0.000 claims 2
- 201000011165 anus cancer Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006571 choroid plexus carcinoma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000010932 epithelial neoplasm Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000011610 giant cell glioblastoma Diseases 0.000 claims 2
- 208000002409 gliosarcoma Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010027191 meningioma Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000004058 mixed glioma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000003113 pineoblastoma Diseases 0.000 claims 2
- 206010035059 pineocytoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 208000013938 anaplastic oligoastrocytoma Diseases 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 208000026436 grade III glioma Diseases 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000008205 supratentorial primitive neuroectodermal tumor Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021094240A JP7222024B2 (ja) | 2016-01-21 | 2021-06-04 | 上皮増殖因子受容体変異体ｉｉｉおよびｃｄ３の単一および二重特異性抗体およびそれらの使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281543P | 2016-01-21 | 2016-01-21 | |
| US62/281,543 | 2016-01-21 | ||
| US201662431766P | 2016-12-08 | 2016-12-08 | |
| US62/431,766 | 2016-12-08 | ||
| PCT/IB2017/050109 WO2017125831A1 (en) | 2016-01-21 | 2017-01-10 | Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094240A Division JP7222024B2 (ja) | 2016-01-21 | 2021-06-04 | 上皮増殖因子受容体変異体ｉｉｉおよびｃｄ３の単一および二重特異性抗体およびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506398A JP2019506398A (ja) | 2019-03-07 |
| JP2019506398A5 true JP2019506398A5 (cg-RX-API-DMAC7.html) | 2020-02-20 |
Family
ID=57838442
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538177A Pending JP2019506398A (ja) | 2016-01-21 | 2017-01-10 | 上皮増殖因子受容体変異体ｉｉｉおよびｃｄ３の単一および二重特異性抗体およびそれらの使用 |
| JP2021094240A Active JP7222024B2 (ja) | 2016-01-21 | 2021-06-04 | 上皮増殖因子受容体変異体ｉｉｉおよびｃｄ３の単一および二重特異性抗体およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021094240A Active JP7222024B2 (ja) | 2016-01-21 | 2021-06-04 | 上皮増殖因子受容体変異体ｉｉｉおよびｃｄ３の単一および二重特異性抗体およびそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10221242B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3405490B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2019506398A (cg-RX-API-DMAC7.html) |
| CN (1) | CN109219618B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2954802C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3405490T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2904593T3 (cg-RX-API-DMAC7.html) |
| TW (2) | TW201936640A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017125831A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017125831A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses |
| WO2017125830A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| WO2019114804A1 (zh) * | 2017-12-13 | 2019-06-20 | 凯惠科技发展(上海)有限公司 | 一种EGFRvIII抗体及其偶联物、制备方法和应用 |
| PE20251579A1 (es) | 2018-02-01 | 2025-06-16 | Pfizer | Anticuerpos especificos para cd70 y sus usos |
| IL276396B1 (en) | 2018-02-01 | 2025-09-01 | Pfizer | Chimeric antigen receptors against CD70 |
| US11773172B2 (en) | 2018-03-19 | 2023-10-03 | WuXi Biologics Ireland Limited | Anti-EGFR antibody polypeptide |
| CA3100829A1 (en) * | 2018-05-23 | 2019-11-28 | Pfizer Inc. | Antibodies specific for gucy2c and uses thereof |
| CN109265561B (zh) * | 2018-09-25 | 2021-05-25 | 山东兴瑞生物科技有限公司 | 抗EGFRvⅢ安全型嵌合抗原受体、其制备方法、利用其修饰的NK细胞及应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| MX2021005394A (es) | 2018-11-07 | 2021-07-06 | Merck Sharp & Dohme Llc | Co-formulaciones de anticuerpos anti-gen de activacion de linfocitos 3 (anti-lag3) y anticuerpos anti-muerte programada-1 (anti-pd-1). |
| US12325757B2 (en) * | 2018-12-21 | 2025-06-10 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Protease cleavable bispecific antibodies and uses thereof |
| EP3928790A4 (en) * | 2019-02-22 | 2023-01-11 | Wuhan Yzy Biopharma Co., Ltd. | Cd3 antigen binding fragment and application thereof |
| TW202039578A (zh) * | 2019-03-29 | 2020-11-01 | 荷蘭商美勒斯公司 | Cd3結合分子 |
| CA3162181A1 (en) * | 2019-11-21 | 2021-05-27 | Unity Biotechnology | Antibodies directed to tie-2 and methods of use |
| CN111072772B (zh) * | 2019-12-31 | 2023-08-04 | 上海良润生物医药科技有限公司 | 一种肽标签及其在检测或纯化融合蛋白质的应用 |
| EP4125991A4 (en) * | 2020-04-01 | 2025-02-26 | The Regents of the University of California | IMMUNOTHERANOSIS AGENT TARGETING CANCER CELLS DERIVED FROM MESENCHYMAL STEM CELLS AND MESENCHYMAL STEM CELL-ASSOCIATED DISEASE |
| JP2023545099A (ja) | 2020-10-08 | 2023-10-26 | アフィメド ゲーエムベーハー | 三重特異性バインダー |
| CN112661844B (zh) * | 2020-11-18 | 2022-05-03 | 贵州医科大学 | 一种靶向EGFRvIII的单链抗体及应用 |
| CN114539418A (zh) * | 2020-11-26 | 2022-05-27 | 上海华奥泰生物药业股份有限公司 | 双特异性抗体及其用途 |
| AU2022312311A1 (en) * | 2021-07-16 | 2024-02-08 | Noile-Immune Biotech Inc. | Anti-EGFRviii antibody, polypeptide, cell capable of expressing said polypeptide, pharmaceutical composition comprising said cell, method for producing said cell, and polynucleotide or vector comprising nucleotide sequence encoding said polypeptide |
| EP4376958A1 (en) | 2021-07-30 | 2024-06-05 | Affimed GmbH | Duplexbodies |
| CN118401552A (zh) * | 2021-09-29 | 2024-07-26 | 加拿大国家研究委员会 | 人源化抗egfrviii抗体及其抗原结合片段 |
| KR20240099382A (ko) | 2021-11-03 | 2024-06-28 | 아피메트 게엠베하 | 이중특이적 cd16a 결합제 |
| CN116333117B (zh) * | 2021-12-16 | 2024-04-26 | 徕特康(苏州)生物制药有限公司 | 抗表皮生长因子受体抗体及其制备方法和用途 |
| CN116047081B (zh) * | 2023-01-10 | 2024-02-13 | 北京新源长青生物科技有限公司 | 检测Aβ40、Aβ42的试剂盒与方法 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025257588A1 (en) | 2024-06-10 | 2025-12-18 | Affimed Gmbh | Cd16a/tumor antigen polyspecific binder for use in the treatment of immune checkpoint inhibitor resistance |
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-
2017
- 2017-01-10 WO PCT/IB2017/050109 patent/WO2017125831A1/en not_active Ceased
- 2017-01-10 EP EP17700749.9A patent/EP3405490B1/en active Active
- 2017-01-10 ES ES17700749T patent/ES2904593T3/es active Active
- 2017-01-10 US US15/402,807 patent/US10221242B2/en active Active
- 2017-01-10 JP JP2018538177A patent/JP2019506398A/ja active Pending
- 2017-01-10 TW TW108104245A patent/TW201936640A/zh unknown
- 2017-01-10 DK DK17700749.9T patent/DK3405490T3/da active
- 2017-01-10 CN CN201780015091.8A patent/CN109219618B/zh active Active
- 2017-01-10 TW TW106100739A patent/TWI657096B/zh active
- 2017-01-12 CA CA2954802A patent/CA2954802C/en active Active
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2018
- 2018-10-17 US US16/163,243 patent/US11279764B2/en active Active
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2021
- 2021-06-04 JP JP2021094240A patent/JP7222024B2/ja active Active
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