JP2019506394A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019506394A5 JP2019506394A5 JP2018538085A JP2018538085A JP2019506394A5 JP 2019506394 A5 JP2019506394 A5 JP 2019506394A5 JP 2018538085 A JP2018538085 A JP 2018538085A JP 2018538085 A JP2018538085 A JP 2018538085A JP 2019506394 A5 JP2019506394 A5 JP 2019506394A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- cdr3
- cdr2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 81
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 24
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 23
- 210000004899 c-terminal region Anatomy 0.000 claims 17
- 210000002865 immune cell Anatomy 0.000 claims 17
- 230000004068 intracellular signaling Effects 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 206010073128 Anaplastic oligodendroglioma Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 206010014967 Ependymoma Diseases 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000007641 Pinealoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 206010014968 Ependymoma malignant Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010050487 Pinealoblastoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000008938 Rhabdoid tumor Diseases 0.000 claims 1
- 206010073334 Rhabdoid tumour Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010002224 anaplastic astrocytoma Diseases 0.000 claims 1
- 208000014534 anaplastic ependymoma Diseases 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000010932 epithelial neoplasm Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 208000026436 grade III glioma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 108020001756 ligand binding domains Proteins 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 201000004058 mixed glioma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000003113 pineoblastoma Diseases 0.000 claims 1
- 206010035059 pineocytoma Diseases 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662281533P | 2016-01-21 | 2016-01-21 | |
| US62/281,533 | 2016-01-21 | ||
| US201662431758P | 2016-12-08 | 2016-12-08 | |
| US62/431,758 | 2016-12-08 | ||
| PCT/IB2017/050108 WO2017125830A1 (en) | 2016-01-21 | 2017-01-10 | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177399A Division JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019506394A JP2019506394A (ja) | 2019-03-07 |
| JP2019506394A5 true JP2019506394A5 (cg-RX-API-DMAC7.html) | 2020-02-20 |
| JP6823659B2 JP6823659B2 (ja) | 2021-02-03 |
Family
ID=57868301
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538085A Active JP6823659B2 (ja) | 2016-01-21 | 2017-01-10 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
| JP2020177399A Active JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020177399A Active JP7198797B2 (ja) | 2016-01-21 | 2020-10-22 | 上皮成長因子受容体変異体ｉｉｉを標的とするキメラ抗原受容体 |
Country Status (22)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018008390A2 (pt) | 2015-10-30 | 2018-11-27 | Aleta Biotherapeutics Inc | composições e métodos para transdução tumoral |
| MA43135A (fr) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | Compositions et méthodes pour le du traitement du cancer |
| WO2017125831A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses |
| WO2017125830A1 (en) * | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
| CN110545826A (zh) | 2016-12-03 | 2019-12-06 | 朱诺治疗学股份有限公司 | 用于与激酶抑制剂组合使用治疗性t细胞的方法和组合物 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| EP3630132A1 (en) | 2017-06-02 | 2020-04-08 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| WO2019195586A1 (en) * | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| EP3773633A4 (en) | 2018-04-06 | 2022-01-26 | The Regents of The University of California | METHODS OF TREATMENT OF GLIOBLASTOMA |
| TW202020146A (zh) * | 2018-07-26 | 2020-06-01 | 大陸商南京傳奇生物科技有限公司 | 含nef之t細胞及其產生方法 |
| CN109265561B (zh) * | 2018-09-25 | 2021-05-25 | 山东兴瑞生物科技有限公司 | 抗EGFRvⅢ安全型嵌合抗原受体、其制备方法、利用其修饰的NK细胞及应用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| JP7630832B2 (ja) * | 2018-11-19 | 2025-02-18 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｃａｒおよびｔｃｒ形質導入用のモジュール式ポリシストロニックベクター |
| PE20211915A1 (es) * | 2018-12-01 | 2021-09-28 | Allogene Therapeutics Inc | Receptores de antigenos quimericos dirigidos al antigeno de maduracion de celulas b y sus metodos de uso |
| MA54514A (fr) * | 2018-12-21 | 2022-03-30 | Hoffmann La Roche | Anticorps se liant à cd3 |
| SI3911298T1 (sl) * | 2019-01-17 | 2024-03-29 | Immunocore Limited | Formulacije |
| CN111454358A (zh) * | 2019-01-18 | 2020-07-28 | 四川科伦博泰生物医药股份有限公司 | 一种嵌合抗原受体及其应用 |
| CN113710697A (zh) * | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| EA202290208A1 (ru) * | 2019-07-02 | 2022-03-25 | Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз | МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА, КОТОРЫЕ СВЯЗЫВАЮТ EGFRvIII, И ИХ ПРИМЕНЕНИЕ |
| EP4003375A4 (en) * | 2019-07-31 | 2023-09-06 | Forty Seven, Inc. | DEPLETION DIETS FOR MODIFIED T CELL OR NK CELL THERAPY |
| EP4031583A4 (en) * | 2019-09-16 | 2023-11-15 | Fred Hutchinson Cancer Center | CHIMERIC RECEPTOR PROTEINS AND THEIR USES |
| CN115175736A (zh) * | 2019-10-01 | 2022-10-11 | 艾普西洛根有限公司 | 杂交抗体 |
| JP2023507525A (ja) * | 2019-12-23 | 2023-02-22 | セレクティス | 固形腫瘍の癌免疫療法のための新規メソテリン特異性キメラ抗原受容体（ｃａｒ） |
| JP2023515747A (ja) * | 2019-12-28 | 2023-04-14 | シャンハイ セル セラピー グループ カンパニー カンパニー リミテッド | 免疫調節分子を発現する細胞および免疫調節分子を発現するための系 |
| CN111019959B (zh) * | 2019-12-30 | 2022-09-13 | 北京立康生命科技有限公司 | 一种体外转录mRNA的核苷酸分子、呈递细胞及应用 |
| US20230147832A1 (en) * | 2020-01-22 | 2023-05-11 | City Of Hope | Oncolytic virus compositions including il-15 complex and methods for the treatment of cancer |
| KR20230122618A (ko) | 2020-12-21 | 2023-08-22 | 알로젠 테라퓨틱스 인코포레이티드 | 프로테아제 활성화 cd45-게이트 car |
| CA3204417A1 (en) | 2021-01-29 | 2022-08-04 | Allogene Therapeutics, Inc. | Knockdown or knockout of one or more of tap2, nlrc5, ?2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products |
| AU2022312311A1 (en) * | 2021-07-16 | 2024-02-08 | Noile-Immune Biotech Inc. | Anti-EGFRviii antibody, polypeptide, cell capable of expressing said polypeptide, pharmaceutical composition comprising said cell, method for producing said cell, and polynucleotide or vector comprising nucleotide sequence encoding said polypeptide |
| CN118401552A (zh) * | 2021-09-29 | 2024-07-26 | 加拿大国家研究委员会 | 人源化抗egfrviii抗体及其抗原结合片段 |
| EP4562134A1 (en) | 2022-07-29 | 2025-06-04 | Allogene Therapeutics, Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
| CN119013303A (zh) * | 2022-08-05 | 2024-11-22 | 北京鼎成肽源生物技术有限公司 | 靶向EGFRvIII的抗体及其在细胞免疫治疗的应用 |
| CN116284435A (zh) * | 2022-09-19 | 2023-06-23 | 卡瑞济(北京)生命科技有限公司 | EGFRvIII嵌合抗原受体及其用途 |
| CN120936371A (zh) * | 2023-03-30 | 2025-11-11 | 诺沃库勒有限责任公司 | 用于使用肿瘤治疗电场和嵌合抗原受体(car)免疫细胞治疗癌症的组合物、系统和方法 |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| CN117659196B (zh) * | 2023-12-12 | 2024-08-23 | 成都优赛诺生物科技有限公司 | 一种靶向cd7的单域抗体、嵌合抗原受体及其应用 |
| CN119912588B (zh) * | 2025-04-01 | 2025-08-12 | 浙江大学 | 嵌合抗原受体、人诱导多能干细胞、髓系前体细胞样巨噬细胞及其制备方法 |
| CN120248142B (zh) * | 2025-06-06 | 2025-09-12 | 上海兴瑞一达生物科技有限公司 | 一种共表达cd47和il-15的双靶点嵌合抗原受体、car-t细胞及其应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU687010B2 (en) | 1992-07-17 | 1998-02-19 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| JP2004500095A (ja) | 2000-02-24 | 2004-01-08 | エクサイト セラピーズ， インコーポレイテッド | 細胞の同時の刺激および濃縮 |
| US7129332B2 (en) * | 2000-02-25 | 2006-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-EGFRvIII scFvs with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof |
| US20100105136A1 (en) | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| SG189482A1 (en) | 2010-10-27 | 2013-05-31 | Cellectis | Method for increasing the efficiency of double-strand break-induced mutagenesis |
| US9249217B2 (en) | 2010-12-03 | 2016-02-02 | Secretary, DHHS | Bispecific EGFRvIII x CD3 antibody engaging molecules |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| TR201815488T4 (tr) * | 2011-04-08 | 2018-11-21 | Health | Anti-epidermal büyüme faktör reseptörü varyant III kimerik antijen reseptörleri ve kanser tedavisi için kullanımı. |
| GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
| US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| US9676858B2 (en) | 2012-06-07 | 2017-06-13 | Duke University | Human bispecific EGFRvIII antibody and CD3 engaging molecules |
| JP2015524255A (ja) * | 2012-07-13 | 2015-08-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法 |
| RU2663725C2 (ru) | 2012-09-04 | 2018-08-08 | Селлектис | Многоцепочечный химерный антигенный рецептор и его применения |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| ES2760023T3 (es) * | 2013-02-20 | 2020-05-12 | Univ Pennsylvania | Tratamiento del cáncer utilizando receptor de antígeno quimérico anti-EGFRvIII humanizado |
| EP2970505A4 (en) | 2013-03-14 | 2016-10-19 | California Inst Biomedical Res | SPECIFIC ANTIBODIES AND USES THEREOF |
| EP3546572B9 (en) | 2013-05-13 | 2024-06-26 | Cellectis | Cd19 specific chimeric antigen receptor and uses thereof |
| WO2014184744A1 (en) | 2013-05-13 | 2014-11-20 | Cellectis | Methods for engineering highly active t cell for immunotherapy |
| JP6608807B2 (ja) | 2013-05-29 | 2019-11-20 | セレクティス | Ｒｎａガイドｃａｓヌクレアーゼ系を用いることによって免疫療法のためにｔ細胞を操作するための方法 |
| AU2014287244B2 (en) | 2013-07-09 | 2017-06-15 | Duke University | Certain improved human bispecific EGFRvIII antibody engaging molecules |
| JP6529498B2 (ja) | 2013-08-07 | 2019-06-12 | アッフィメッド・ゲー・エム・ベー・ハーＡｆｆｉｍｅｄ Ｇｍｂｈ | ＥＧＦＲｖＩＩＩに対して特異的な抗体結合部位 |
| US10239948B2 (en) * | 2013-12-20 | 2019-03-26 | Cellectis | Method of engineering multi-input signal sensitive T cell for immunotherapy |
| AU2015295346A1 (en) | 2014-07-29 | 2017-02-16 | Allogene Therapeutics, Inc. | EGFRvlll specific chimeric antigen receptors for cancer immunotherapy |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| WO2017125830A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Chimeric antigen receptors targeting epidermal growth factor receptor variant iii |
| WO2017125831A1 (en) | 2016-01-21 | 2017-07-27 | Pfizer Inc. | Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses |
-
2017
- 2017-01-10 WO PCT/IB2017/050108 patent/WO2017125830A1/en not_active Ceased
- 2017-01-10 ES ES17701190T patent/ES2942362T3/es active Active
- 2017-01-10 MX MX2018008978A patent/MX2018008978A/es unknown
- 2017-01-10 UA UAA201808794A patent/UA125252C2/uk unknown
- 2017-01-10 EP EP17701190.5A patent/EP3405481B1/en active Active
- 2017-01-10 TW TW106100738A patent/TWI634125B/zh active
- 2017-01-10 TW TW107120550A patent/TWI755547B/zh active
- 2017-01-10 SG SG11201805872SA patent/SG11201805872SA/en unknown
- 2017-01-10 NZ NZ744821A patent/NZ744821A/en unknown
- 2017-01-10 SG SG10202111458RA patent/SG10202111458RA/en unknown
- 2017-01-10 PH PH1/2018/501473A patent/PH12018501473B1/en unknown
- 2017-01-10 BR BR112018014585A patent/BR112018014585A2/pt not_active Application Discontinuation
- 2017-01-10 CA CA2954014A patent/CA2954014A1/en active Pending
- 2017-01-10 JP JP2018538085A patent/JP6823659B2/ja active Active
- 2017-01-10 US US15/402,760 patent/US10259876B2/en active Active
- 2017-01-10 RU RU2018130088A patent/RU2751662C2/ru active
- 2017-01-10 MY MYPI2018702481A patent/MY192474A/en unknown
- 2017-01-10 DK DK17701190.5T patent/DK3405481T5/da active
- 2017-01-10 KR KR1020187023865A patent/KR102479606B1/ko active Active
- 2017-01-10 EA EA201891641A patent/EA201891641A1/ru unknown
- 2017-01-10 CN CN201780012883.XA patent/CN108699124A/zh active Pending
- 2017-01-10 AU AU2017208834A patent/AU2017208834B2/en active Active
-
2018
- 2018-07-19 SA SA518392058A patent/SA518392058B1/ar unknown
- 2018-07-19 IL IL260666A patent/IL260666B2/en unknown
-
2019
- 2019-01-23 US US16/255,348 patent/US11267892B2/en active Active
-
2020
- 2020-10-22 JP JP2020177399A patent/JP7198797B2/ja active Active
-
2022
- 2022-01-27 US US17/586,321 patent/US20220227874A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019506394A5 (cg-RX-API-DMAC7.html) | ||
| JP2019506398A5 (cg-RX-API-DMAC7.html) | ||
| RU2018130088A (ru) | Химерные антигенные рецепторы, нацеливающиеся на вариант iii рецептора эпидермального фактора роста | |
| JP2017506217A5 (cg-RX-API-DMAC7.html) | ||
| IL256871B2 (en) | Constructs for bispecific antibodies binding dll3 and cd3 and uses thereof | |
| JP2017140051A5 (cg-RX-API-DMAC7.html) | ||
| HRP20240926T1 (hr) | Claudin-6-specifični imunoreceptori i epitopi t stanica | |
| JP2016508725A5 (cg-RX-API-DMAC7.html) | ||
| JP2017520575A5 (cg-RX-API-DMAC7.html) | ||
| JP2017527274A5 (cg-RX-API-DMAC7.html) | ||
| HRP20150256T1 (hr) | Djelatna sredstva za vezanje notch1-receptora i postupci njihove uporabe | |
| RU2021114500A (ru) | НАПРАВЛЕННОЕ ИНГИБИРОВАНИЕ TGFβ | |
| EA201890294A1 (ru) | Химерный полипептидный комплекс и способы его получения и применения | |
| EP4424376A3 (en) | Chimeric antigen receptors based on single-domain antibodies and methods of use thereof | |
| RU2018104703A (ru) | Опухолеспецифичное антитело против egfr и его применение | |
| WO2015197016A1 (zh) | 时空可调性抑制病理性靶细胞的系统 | |
| JP2017104113A (ja) | 前立腺特異幹細胞抗原に対する抗体およびその使用 | |
| JP2021501567A5 (cg-RX-API-DMAC7.html) | ||
| MX2020012081A (es) | Anticuerpos totalmente humanos contra ox40, metodo para preparar los mismos y su uso. | |
| CR20200325A (es) | Constructo de anticuerpo biespecífico dirigido a muc17 y cd3 | |
| Ahmed et al. | Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody | |
| FI3806895T3 (fi) | Kasvainkudosta sitovia vasta-aineita ja niiden diagnostisia ja terapeuttisia käyttöjä | |
| HRP20180917T1 (hr) | Novi fragmenti protutijela, pripravci i njihova upotreba | |
| EP4630042A1 (en) | Chimeric antigen receptor | |
| CN104877028A (zh) | 抗dota嵌合抗原受体修饰的t细胞及其抗肿瘤的应用 |