JP2017140051A5 - - Google Patents
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- Publication number
- JP2017140051A5 JP2017140051A5 JP2017102733A JP2017102733A JP2017140051A5 JP 2017140051 A5 JP2017140051 A5 JP 2017140051A5 JP 2017102733 A JP2017102733 A JP 2017102733A JP 2017102733 A JP2017102733 A JP 2017102733A JP 2017140051 A5 JP2017140051 A5 JP 2017140051A5
- Authority
- JP
- Japan
- Prior art keywords
- targeting construct
- cell
- cancer
- cell targeting
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 35
- 230000008685 targeting Effects 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 238000006467 substitution reaction Methods 0.000 claims 16
- 238000012217 deletion Methods 0.000 claims 14
- 230000037430 deletion Effects 0.000 claims 14
- 102000001398 Granzyme Human genes 0.000 claims 5
- 108060005986 Granzyme Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 3
- 101100046559 Mus musculus Tnfrsf12a gene Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims 1
- -1 Ala amino acid Chemical class 0.000 claims 1
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 241000223782 Ciliophora Species 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims 1
- 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims 1
- 102220467434 Hypoxia-inducible lipid droplet-associated protein_K27E_mutation Human genes 0.000 claims 1
- 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006994 Precancerous Conditions Diseases 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims 1
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 102220470249 Voltage-dependent L-type calcium channel subunit beta-2_R28A_mutation Human genes 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002471 spleen cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261709763P | 2012-10-04 | 2012-10-04 | |
| US61/709,763 | 2012-10-04 | ||
| US201361762216P | 2013-02-07 | 2013-02-07 | |
| US201361762173P | 2013-02-07 | 2013-02-07 | |
| US61/762,216 | 2013-02-07 | ||
| US61/762,173 | 2013-02-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Division JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017165526A Division JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017140051A JP2017140051A (ja) | 2017-08-17 |
| JP2017140051A5 true JP2017140051A5 (cg-RX-API-DMAC7.html) | 2017-10-12 |
| JP6722134B2 JP6722134B2 (ja) | 2020-07-15 |
Family
ID=49447827
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Active JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
| JP2017102733A Active JP6722134B2 (ja) | 2012-10-04 | 2017-05-24 | セリンプロテアーゼ分子および療法 |
| JP2017165526A Withdrawn JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
| JP2019177328A Withdrawn JP2019214628A (ja) | 2012-10-04 | 2019-09-27 | セリンプロテアーゼ分子および療法 |
| JP2021215386A Active JP7403521B2 (ja) | 2012-10-04 | 2021-12-29 | セリンプロテアーゼ分子および療法 |
| JP2023013891A Pending JP2023041829A (ja) | 2012-10-04 | 2023-02-01 | セリンプロテアーゼ分子および療法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015535813A Active JP6306596B2 (ja) | 2012-10-04 | 2013-10-04 | セリンプロテアーゼ分子および療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017165526A Withdrawn JP2017205128A (ja) | 2012-10-04 | 2017-08-30 | セリンプロテアーゼ分子および療法 |
| JP2019177328A Withdrawn JP2019214628A (ja) | 2012-10-04 | 2019-09-27 | セリンプロテアーゼ分子および療法 |
| JP2021215386A Active JP7403521B2 (ja) | 2012-10-04 | 2021-12-29 | セリンプロテアーゼ分子および療法 |
| JP2023013891A Pending JP2023041829A (ja) | 2012-10-04 | 2023-02-01 | セリンプロテアーゼ分子および療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US9096840B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP4029937A1 (cg-RX-API-DMAC7.html) |
| JP (6) | JP6306596B2 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2013326933B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2885376C (cg-RX-API-DMAC7.html) |
| DK (1) | DK3456734T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014055836A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4029937A1 (en) | 2012-10-04 | 2022-07-20 | Research Development Foundation | Serine protease molecules and therapies |
| KR102488961B1 (ko) * | 2014-05-19 | 2023-01-16 | 삼성전자주식회사 | 그랜자임 b를 포함하는 융합 단백질 및 이의 용도 |
| GB2530479A (en) * | 2014-08-06 | 2016-03-30 | Hilmar Meek Warenius | Peptides useful for treating cancer |
| WO2016100233A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| DK3240805T3 (da) | 2014-12-15 | 2025-02-10 | Univ California | Bispecifik or-gate kimærisk antigenreceptor, som reagerer på cd19 og cd20 |
| RU2020127887A (ru) | 2015-03-11 | 2020-10-02 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Полипептиды транспозазы и их применение |
| CA3004306A1 (en) | 2015-11-04 | 2017-05-11 | Stephen J. Forman | Chimeric antigen receptors targeting her2 |
| GB201602409D0 (en) * | 2016-02-10 | 2016-03-23 | Warenius Hilmar M | Compositions and uses thereof |
| DK3417058T3 (da) | 2016-02-16 | 2021-11-15 | Res Found Dev | Sortase-modificerede molekyler og anvendelser deraf |
| JP7068702B2 (ja) * | 2016-06-02 | 2022-05-17 | 国立研究開発法人理化学研究所 | アジュバント組成物とその利用 |
| JP7239987B2 (ja) * | 2016-06-06 | 2023-03-15 | アスクリピウム タイワン シーオー．， エルティーディー． | 薬物送達のための抗体融合タンパク質 |
| CA3039136A1 (en) | 2016-09-02 | 2018-03-08 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| CN106554422A (zh) * | 2016-10-26 | 2017-04-05 | 天津科技大学 | 高透皮吸收皮下靶向释放型因子及构建方法和应用 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2019075270A1 (en) * | 2017-10-12 | 2019-04-18 | Amesino Llc | VEGFR ANTIBODY LIGHT CHAIN FUSION PROTEIN |
| WO2019126960A1 (zh) * | 2017-12-25 | 2019-07-04 | 清华大学 | 一种具有蛋白酶活性的多肽及其应用 |
| CN112041333B (zh) * | 2018-04-26 | 2024-06-28 | 古德T细胞有限公司 | 新型融合蛋白和用于预防或治疗癌症的包含该融合蛋白的药物组合物 |
| KR102875649B1 (ko) * | 2018-11-26 | 2025-10-23 | 삼성디스플레이 주식회사 | 유기금속 화합물 및 이를 포함한 유기 발광 소자 |
| CA3127113A1 (en) | 2019-01-30 | 2020-08-06 | Dongxu Sun | Anti-gal3 antibodies and uses thereof |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング，インコーポレイテッド | ガレクチン－３を遮断することにより炎症性疾患を処置する方法 |
| US20230203108A1 (en) * | 2020-05-28 | 2023-06-29 | Chugai Seiyaku Kabushiki Kaisha | Improved granzyme b variant |
| AU2022361048A1 (en) * | 2021-10-07 | 2024-05-02 | Omeros Corporation | Targeted catalytic complement-activating molecules and methods of use thereof |
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| EP4029937A1 (en) | 2012-10-04 | 2022-07-20 | Research Development Foundation | Serine protease molecules and therapies |
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2013
- 2013-10-04 EP EP22150046.5A patent/EP4029937A1/en active Pending
- 2013-10-04 WO PCT/US2013/063402 patent/WO2014055836A2/en not_active Ceased
- 2013-10-04 EP EP18202465.3A patent/EP3456734B1/en active Active
- 2013-10-04 CA CA2885376A patent/CA2885376C/en active Active
- 2013-10-04 EP EP13779684.3A patent/EP2904004B1/en active Active
- 2013-10-04 AU AU2013326933A patent/AU2013326933B2/en active Active
- 2013-10-04 DK DK18202465.3T patent/DK3456734T3/da active
- 2013-10-04 JP JP2015535813A patent/JP6306596B2/ja active Active
- 2013-10-04 US US14/046,211 patent/US9096840B2/en active Active
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2014
- 2014-07-02 US US14/322,485 patent/US9951325B2/en active Active
- 2014-07-02 US US14/322,083 patent/US9499807B2/en active Active
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2017
- 2017-05-24 JP JP2017102733A patent/JP6722134B2/ja active Active
- 2017-08-30 JP JP2017165526A patent/JP2017205128A/ja not_active Withdrawn
- 2017-09-12 AU AU2017228534A patent/AU2017228534B2/en active Active
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2018
- 2018-03-09 US US15/916,743 patent/US10323239B2/en active Active
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2019
- 2019-04-30 US US16/399,339 patent/US10738295B2/en active Active
- 2019-09-19 US US16/575,715 patent/US10920211B2/en active Active
- 2019-09-27 JP JP2019177328A patent/JP2019214628A/ja not_active Withdrawn
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2020
- 2020-06-15 US US16/901,460 patent/US11535838B2/en active Active
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2021
- 2021-12-29 JP JP2021215386A patent/JP7403521B2/ja active Active
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2022
- 2022-11-03 US US18/052,476 patent/US20230203467A1/en active Pending
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2023
- 2023-02-01 JP JP2023013891A patent/JP2023041829A/ja active Pending