JP2016117766A5 - - Google Patents
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- JP2016117766A5 JP2016117766A5 JP2016055140A JP2016055140A JP2016117766A5 JP 2016117766 A5 JP2016117766 A5 JP 2016117766A5 JP 2016055140 A JP2016055140 A JP 2016055140A JP 2016055140 A JP2016055140 A JP 2016055140A JP 2016117766 A5 JP2016117766 A5 JP 2016117766A5
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- JP
- Japan
- Prior art keywords
- composition
- light
- molecule
- mutant
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010028980 Neoplasm Diseases 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 101000830594 Homo sapiens Tumor necrosis factor ligand superfamily member 14 Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 102000051198 human TNFSF14 Human genes 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
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- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
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- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 2
- -1 HERB Proteins 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 102000012883 Tumor Necrosis Factor Ligand Superfamily Member 14 Human genes 0.000 claims 2
- 108010065158 Tumor Necrosis Factor Ligand Superfamily Member 14 Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
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- 210000004881 tumor cell Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
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- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
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- 108091026890 Coding region Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102000012220 Member 14 Tumor Necrosis Factor Receptors Human genes 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 1
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
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- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
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- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
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- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576222P | 2011-12-15 | 2011-12-15 | |
| US61/576,222 | 2011-12-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547350A Division JP2015501839A (ja) | 2011-12-15 | 2012-12-11 | 受容体に対する親和性が増大した変異型ｌｉｇｈｔ分子を使用する癌療法のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016117766A JP2016117766A (ja) | 2016-06-30 |
| JP2016117766A5 true JP2016117766A5 (cg-RX-API-DMAC7.html) | 2017-02-16 |
| JP6113883B2 JP6113883B2 (ja) | 2017-04-12 |
Family
ID=47436247
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547350A Pending JP2015501839A (ja) | 2011-12-15 | 2012-12-11 | 受容体に対する親和性が増大した変異型ｌｉｇｈｔ分子を使用する癌療法のための方法および組成物 |
| JP2016055140A Expired - Fee Related JP6113883B2 (ja) | 2011-12-15 | 2016-03-18 | 受容体に対する親和性が増大した変異型ｌｉｇｈｔ分子を使用する癌療法のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547350A Pending JP2015501839A (ja) | 2011-12-15 | 2012-12-11 | 受容体に対する親和性が増大した変異型ｌｉｇｈｔ分子を使用する癌療法のための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9493532B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2790730B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2015501839A (cg-RX-API-DMAC7.html) |
| CN (1) | CN104284680A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012352454A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2858876A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013090293A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012352454A1 (en) | 2011-12-15 | 2014-07-17 | The University Of Chicago | Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors |
| EP2982681B8 (en) | 2013-03-29 | 2018-11-07 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1-antigen peptide conjugate vaccine |
| US11000603B2 (en) | 2015-04-14 | 2021-05-11 | Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. | Multi-specific binding conjugate, related pharmaceutical compositions and use |
| WO2017185662A1 (zh) * | 2016-04-29 | 2017-11-02 | 深圳市中联生物科技开发有限公司 | 多特异性结合偶联物、相关的药物组合物及应用 |
| EP3299028B1 (en) * | 2015-05-20 | 2024-10-30 | Sumitomo Pharma Co., Ltd. | Combination of wt1 antigen peptide, immunomodulator and wt1 helper peptide |
| HK1259029A1 (zh) * | 2015-09-18 | 2019-11-22 | 综合医院公司以麻省总医院名义经营 | 用於治疗癌症的具有抗趋除特性的组合物 |
| CN109689692B (zh) | 2016-06-22 | 2021-11-12 | 本康生物制药（深圳）有限公司 | 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用 |
| CN106701825A (zh) * | 2016-11-17 | 2017-05-24 | 中国科学院生物物理研究所 | 腺病毒疫苗Ad‑LIGHT‑HBsAg及其用于治疗慢性乙肝的用途 |
| JP7209963B2 (ja) | 2016-11-30 | 2023-01-23 | 住友ファーマ株式会社 | Ｗｔ１ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ |
| JP2020508298A (ja) * | 2017-02-17 | 2020-03-19 | ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 移植、組織再生、器官形成及び複数の組織に対する機能のための部位としての脂肪関連リンパ球集積（ｆａｔ−ａｓｓｏｃｉａｔｅｄ ｌｙｍｐｈｏｉｄ ｃｌｕｓｔｅｒ） |
| KR102371420B1 (ko) * | 2017-06-27 | 2022-03-08 | (주)아모레퍼시픽 | Tnfsf14 단백질을 포함하는 미백용 조성물 |
| EP3846829A4 (en) * | 2018-09-05 | 2022-09-14 | Arizona Board of Regents on behalf of Arizona State University | ONCOLYTIC VIRUS PLATFORM FOR THE TREATMENT OF HEMATOLOGICAL CANCER |
| CN116426483B (zh) * | 2021-12-30 | 2024-02-23 | 南京紫珑生物科技有限公司 | Cd258蛋白在免疫治疗中的应用 |
| JP2025521227A (ja) * | 2022-06-08 | 2025-07-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｌｉｇｈｔムテイン及びその使用 |
| CN116083435A (zh) * | 2022-11-04 | 2023-05-09 | 吉林大学 | 以人源light截短型突变蛋白为基础的抗肿瘤的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5874560A (en) | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US6207147B1 (en) | 1996-10-11 | 2001-03-27 | The Regents Of The University Of California | Cancer immunotherapy using tumor cells combined with mixed lymphocytes |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| WO2001079496A2 (en) * | 2000-03-13 | 2001-10-25 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| US7811983B2 (en) * | 2003-06-11 | 2010-10-12 | The University Of Chicago | Increased T-cell tumor infiltration and eradication of metastases by mutant light |
| AU2004253465A1 (en) * | 2003-06-11 | 2005-01-13 | The University Of Chicago | Increased T-cell tumor infiltration by mutant light |
| WO2008144029A1 (en) * | 2007-05-14 | 2008-11-27 | The University Of Chicago | Antibody-light fusion products for cancer therapeutics |
| JP2012507299A (ja) * | 2008-10-31 | 2012-03-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Ｌｉｇｈｔ標的分子およびその使用 |
| AU2012352454A1 (en) | 2011-12-15 | 2014-07-17 | The University Of Chicago | Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors |
-
2012
- 2012-12-11 AU AU2012352454A patent/AU2012352454A1/en not_active Abandoned
- 2012-12-11 WO PCT/US2012/069013 patent/WO2013090293A1/en not_active Ceased
- 2012-12-11 CA CA2858876A patent/CA2858876A1/en not_active Abandoned
- 2012-12-11 US US14/363,243 patent/US9493532B2/en active Active
- 2012-12-11 JP JP2014547350A patent/JP2015501839A/ja active Pending
- 2012-12-11 EP EP12806814.5A patent/EP2790730B1/en active Active
- 2012-12-11 CN CN201280069840.2A patent/CN104284680A/zh active Pending
-
2016
- 2016-03-18 JP JP2016055140A patent/JP6113883B2/ja not_active Expired - Fee Related
- 2016-11-02 US US15/341,678 patent/US10167328B2/en active Active