CA2858876A1 - Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors - Google Patents

Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors Download PDF

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Publication number
CA2858876A1
CA2858876A1 CA2858876A CA2858876A CA2858876A1 CA 2858876 A1 CA2858876 A1 CA 2858876A1 CA 2858876 A CA2858876 A CA 2858876A CA 2858876 A CA2858876 A CA 2858876A CA 2858876 A1 CA2858876 A1 CA 2858876A1
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Prior art keywords
light
tumor
antibody
cells
composition
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Abandoned
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CA2858876A
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English (en)
French (fr)
Inventor
Yang-Xin Fu
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University of Chicago
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University of Chicago
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Publication of CA2858876A1 publication Critical patent/CA2858876A1/en
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2858876A 2011-12-15 2012-12-11 Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors Abandoned CA2858876A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576222P 2011-12-15 2011-12-15
US61/576,222 2011-12-15
PCT/US2012/069013 WO2013090293A1 (en) 2011-12-15 2012-12-11 Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

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CA2858876A1 true CA2858876A1 (en) 2013-06-20

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CA2858876A Abandoned CA2858876A1 (en) 2011-12-15 2012-12-11 Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

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US (2) US9493532B2 (cg-RX-API-DMAC7.html)
EP (1) EP2790730B1 (cg-RX-API-DMAC7.html)
JP (2) JP2015501839A (cg-RX-API-DMAC7.html)
CN (1) CN104284680A (cg-RX-API-DMAC7.html)
AU (1) AU2012352454A1 (cg-RX-API-DMAC7.html)
CA (1) CA2858876A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013090293A1 (cg-RX-API-DMAC7.html)

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AU2012352454A1 (en) 2011-12-15 2014-07-17 The University Of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors
EP2982681B8 (en) 2013-03-29 2018-11-07 Sumitomo Dainippon Pharma Co., Ltd. Wt1-antigen peptide conjugate vaccine
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
WO2017185662A1 (zh) * 2016-04-29 2017-11-02 深圳市中联生物科技开发有限公司 多特异性结合偶联物、相关的药物组合物及应用
EP3299028B1 (en) * 2015-05-20 2024-10-30 Sumitomo Pharma Co., Ltd. Combination of wt1 antigen peptide, immunomodulator and wt1 helper peptide
HK1259029A1 (zh) * 2015-09-18 2019-11-22 综合医院公司以麻省总医院名义经营 用於治疗癌症的具有抗趋除特性的组合物
CN109689692B (zh) 2016-06-22 2021-11-12 本康生物制药（深圳）有限公司 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用
CN106701825A (zh) * 2016-11-17 2017-05-24 中国科学院生物物理研究所 腺病毒疫苗Ad‑LIGHT‑HBsAg及其用于治疗慢性乙肝的用途
JP7209963B2 (ja) 2016-11-30 2023-01-23 住友ファーマ株式会社 Ｗｔ１ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
JP2020508298A (ja) * 2017-02-17 2020-03-19 ユニバーシティ オブ ピッツバーグ −オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 移植、組織再生、器官形成及び複数の組織に対する機能のための部位としての脂肪関連リンパ球集積（ｆａｔ−ａｓｓｏｃｉａｔｅｄ ｌｙｍｐｈｏｉｄ ｃｌｕｓｔｅｒ）
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