CN109219618B - 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途 - Google Patents

针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途 Download PDF

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CN109219618B
CN109219618B CN201780015091.8A CN201780015091A CN109219618B CN 109219618 B CN109219618 B CN 109219618B CN 201780015091 A CN201780015091 A CN 201780015091A CN 109219618 B CN109219618 B CN 109219618B
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CN109219618A (zh
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J·C·周
O·K·黄
B·J·萨苏
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Pfizer Corp SRL
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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CN201780015091.8A 2016-01-21 2017-01-10 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途 Active CN109219618B (zh)

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Application Number Priority Date Filing Date Title
US201662281543P 2016-01-21 2016-01-21
US62/281,543 2016-01-21
US201662431766P 2016-12-08 2016-12-08
US62/431,766 2016-12-08
PCT/IB2017/050109 WO2017125831A1 (en) 2016-01-21 2017-01-10 Mono and bispecific antibodies for epidermal growth factor receptor variant iii and cd3 and their uses

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CN109219618A CN109219618A (zh) 2019-01-15
CN109219618B true CN109219618B (zh) 2022-08-09

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US (2) US10221242B2 (cg-RX-API-DMAC7.html)
EP (1) EP3405490B1 (cg-RX-API-DMAC7.html)
JP (2) JP2019506398A (cg-RX-API-DMAC7.html)
CN (1) CN109219618B (cg-RX-API-DMAC7.html)
CA (1) CA2954802C (cg-RX-API-DMAC7.html)
DK (1) DK3405490T3 (cg-RX-API-DMAC7.html)
ES (1) ES2904593T3 (cg-RX-API-DMAC7.html)
TW (2) TW201936640A (cg-RX-API-DMAC7.html)
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JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
WO2019114804A1 (zh) * 2017-12-13 2019-06-20 凯惠科技发展(上海)有限公司 一种EGFRvIII抗体及其偶联物、制备方法和应用
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CN114539418A (zh) * 2020-11-26 2022-05-27 上海华奥泰生物药业股份有限公司 双特异性抗体及其用途
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