JP2019504079A - 高純度シクロへキセノン長鎖アルコールの調製方法 - Google Patents
高純度シクロへキセノン長鎖アルコールの調製方法 Download PDFInfo
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- JP2019504079A JP2019504079A JP2018538103A JP2018538103A JP2019504079A JP 2019504079 A JP2019504079 A JP 2019504079A JP 2018538103 A JP2018538103 A JP 2018538103A JP 2018538103 A JP2018538103 A JP 2018538103A JP 2019504079 A JP2019504079 A JP 2019504079A
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- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical compound O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 title claims abstract description 75
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 238000000034 method Methods 0.000 title claims abstract description 22
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- 238000007184 Barbier reaction Methods 0.000 claims abstract description 16
- 229910052751 metal Inorganic materials 0.000 claims abstract description 15
- 239000002184 metal Substances 0.000 claims abstract description 15
- 230000001404 mediated effect Effects 0.000 claims abstract description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 84
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 74
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 60
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 51
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 51
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 48
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 46
- 238000006243 chemical reaction Methods 0.000 claims description 44
- 238000002360 preparation method Methods 0.000 claims description 40
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 38
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 33
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 32
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 28
- -1 wherein R 5 is H Chemical group 0.000 claims description 28
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 26
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 26
- 230000002378 acidificating effect Effects 0.000 claims description 25
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 24
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 24
- 239000012043 crude product Substances 0.000 claims description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 20
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 18
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 16
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 15
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 15
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 15
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 14
- 239000008096 xylene Substances 0.000 claims description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 239000003054 catalyst Substances 0.000 claims description 12
- 230000035484 reaction time Effects 0.000 claims description 12
- 235000011054 acetic acid Nutrition 0.000 claims description 11
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 10
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 10
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- 229910052744 lithium Inorganic materials 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 238000006467 substitution reaction Methods 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims description 8
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 8
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 8
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 8
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims description 8
- 229940092714 benzenesulfonic acid Drugs 0.000 claims description 8
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 claims description 8
- 239000011777 magnesium Substances 0.000 claims description 8
- 229910052749 magnesium Inorganic materials 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- 229910052712 strontium Inorganic materials 0.000 claims description 8
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 8
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims description 7
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 claims description 7
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims description 7
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 6
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 6
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 claims description 6
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 6
- 239000006096 absorbing agent Substances 0.000 claims description 6
- HIYUMYXSGIKHHE-UHFFFAOYSA-M bismuth trifluoromethanesulfonate Chemical compound [Bi+3].[O-]S(=O)(=O)C(F)(F)F HIYUMYXSGIKHHE-UHFFFAOYSA-M 0.000 claims description 6
- FXBYOMANNHFNQV-UHFFFAOYSA-L magnesium;hydrogen sulfate Chemical compound [Mg+2].OS([O-])(=O)=O.OS([O-])(=O)=O FXBYOMANNHFNQV-UHFFFAOYSA-L 0.000 claims description 6
- 239000002808 molecular sieve Substances 0.000 claims description 6
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 6
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical group [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 claims description 6
- 229910000342 sodium bisulfate Inorganic materials 0.000 claims description 6
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 5
- 238000006460 hydrolysis reaction Methods 0.000 claims description 5
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims description 4
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 claims description 4
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- 239000002841 Lewis acid Substances 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 150000008043 acidic salts Chemical class 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- UCYRAEIHXSVXPV-UHFFFAOYSA-K bis(trifluoromethylsulfonyloxy)indiganyl trifluoromethanesulfonate Chemical compound [In+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F UCYRAEIHXSVXPV-UHFFFAOYSA-K 0.000 claims description 4
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 claims description 4
- 238000006482 condensation reaction Methods 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 4
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 claims description 4
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 claims description 4
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 claims description 4
- 150000007517 lewis acids Chemical class 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- 238000005580 one pot reaction Methods 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 235000011056 potassium acetate Nutrition 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 claims description 4
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 claims description 4
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical group 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims description 3
- WWILHZQYNPQALT-UHFFFAOYSA-N 2-methyl-2-morpholin-4-ylpropanal Chemical compound O=CC(C)(C)N1CCOCC1 WWILHZQYNPQALT-UHFFFAOYSA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 claims description 2
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 claims description 2
- 239000012346 acetyl chloride Substances 0.000 claims description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 2
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 claims description 2
- 229910000024 caesium carbonate Inorganic materials 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 238000011931 intramolecular Barbier reaction Methods 0.000 claims description 2
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 claims description 2
- 229940031993 lithium benzoate Drugs 0.000 claims description 2
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 2
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 2
- LDJNSLOKTFFLSL-UHFFFAOYSA-M lithium;benzoate Chemical compound [Li+].[O-]C(=O)C1=CC=CC=C1 LDJNSLOKTFFLSL-UHFFFAOYSA-M 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims description 2
- 125000005489 p-toluenesulfonic acid group Chemical group 0.000 claims description 2
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- 239000011591 potassium Substances 0.000 claims description 2
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 239000004300 potassium benzoate Substances 0.000 claims description 2
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- 229940103091 potassium benzoate Drugs 0.000 claims description 2
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
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- 125000001424 substituent group Chemical group 0.000 claims description 2
- HZXJVDYQRYYYOR-UHFFFAOYSA-K scandium(iii) trifluoromethanesulfonate Chemical compound [Sc+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F HZXJVDYQRYYYOR-UHFFFAOYSA-K 0.000 claims 4
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 claims 2
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 claims 2
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- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- MJEMIOXXNCZZFK-UHFFFAOYSA-N ethylone Chemical compound CCNC(C)C(=O)C1=CC=C2OCOC2=C1 MJEMIOXXNCZZFK-UHFFFAOYSA-N 0.000 claims 1
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- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- GLOBUAZSRIOKLN-UHFFFAOYSA-N pentane-1,4-diol Chemical compound CC(O)CCCO GLOBUAZSRIOKLN-UHFFFAOYSA-N 0.000 description 1
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- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
- C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
- C07C281/14—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
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Abstract
Description
本発明は高純度シクロヘキセノン長鎖アルコールの調製及び精製方法を提供したものであって、文献に報告されたグリニャール反応(グリニャール試薬を単独で調整する必要がある)の代わりに、金属が介在するBarbier反応により、ワンポット法によるシクロヘキセノン長鎖アルコールの調製を実現した。生成物はヒドラジン又はその誘導体との縮合反応によって精製され、カラムクロマトグラフィーの操作を回避する。
(1a)シクロヘキセノン長鎖アルコール粗製品IIIと適当な条件でヒドラジン又はその誘導体R4NHNH2と縮合する反応をし、化合物IIを得るステップと
(1b)化合物IIが酸性物質の存在下で加水分解する反応をし、高純度のシクロヘキセノン長鎖アルコール(化合物I)を得るステップを含む。
前記Barbier反応の温度は−20〜100℃から選ばれ、好ましくは−10〜50℃であり、反応時間は1〜36時間であり、好ましくは2〜24時間である。
調製例1 3−イソブトキシ−2,6,6−トリメチルシクロヘキサ−2−エン−1−オン
調製例9 3−(15−クロロペンタデシルオキシ−2,6,6−トリメチルシクロヘキサ−2−エン−1−オン
実施例1 2,4,4−トリメチル−3−[15−(テトラヒドロ−2−ヒドロ−ピラニル)−2−オキシ−ペンタデシル]シクロヘキサ−2−エン−1−オン
実施例7 3−(15−ヒドロキシペンタデシル)−2,4,4−トリメチルシクロヘキサ−2−エン−1−オン
実施例10 2,4,4−トリメチル−3−[15−(テトラヒドロ−2−ヒドロ−ピラニル)−2−オキシ−ペンタデシル]シクロヘキサ−2−エン−1−オン
実施例15 3−(15−ヒドロキシペンタデシル)−2,4,4−トリメチルシクロヘキサ−2−エン−1−オン
実施例18 [3−(15−ヒドロキシペンタデシル)−2,4,4−トリメチルシクロヘキサ−2−エン]−アミノホルミルヒドラゾン
実施例20 3−(15−ヒドロキシペンタデシル)−2,4,4−トリメチルシクロヘキサ−2−エン−1−オン
Claims (15)
- 以下の反応式によって実現される、式Iに示された高純度シクロヘキセノン長鎖アルコールの調製方法。
R4は好ましくは、
該方法は
(1a)シクロヘキセノン長鎖アルコール粗製品IIIとヒドラジン又はその誘導体R4NHNH2とが縮合する反応をして、化合物IIを得るステップ、
(1b)化合物IIが酸性物質の存在下で加水分解する反応をして、高純度の化合物Iを得るステップ
を含む。 - 前記式Iに示す高純度のシクロヘキセノン長鎖アルコールのHPLC純度は95%を超え、好ましくは、前記式Iに示す高純度のシクロヘキセノン長鎖アルコールのHPLC純度は99%を超え、さらに好ましくは、前記式Iに示す高純度のシクロヘキセノン長鎖アルコールのHPLC純度は99.9%を超えることを特徴とする請求項1に記載の調製方法。
- ステップ(1a)は、酸、アルカリ又は吸水剤が存在下で行われ、前記アルカリはナトリウムアルコキシド、カリウムアルコキシド、酸化マグネシウム、酸化カルシウム、炭酸ナトリウム、炭酸カリウム、炭酸リチウム、炭酸セシウム、炭酸カルシウム、酢酸ナトリウム、酢酸カリウム、酢酸リチウム、安息香酸ナトリウム、安息香酸カリウム、安息香酸リチウム、トリエチルアミン、トリメチルアミン、ジイソプロピルエチルアミン、1,8-ジアザビシクロ[5.4.0]ウンデカ-7-エン、1,5-ジアザビシクロ[4.3.0]ノナ-5-エン及びトリエチレンジアミンから選ばれる1種又は複数種であり、好ましくはナトリウムtert−ブトキシド、カリウムtert−ブトキシド、炭酸ナトリウム、炭酸カリウム、酢酸ナトリウム、酢酸カリウム、トリエチルアミン及びジイソプロピルエチルアミンから選ばれる1種又は複数種であり、前記酸は酢酸、安息香酸、塩酸、硫酸、リン酸、ベンゼンスルホン酸、p−トルエンスルホン酸、カンファースルホン酸、三フッ化ホウ素エチルエーテル、トリフルオロメタンスルホン酸スカンジウム、トリフルオロメタンスルホン酸インジウム及びトリフルオロメタンスルホン酸ビスマスから選ばれる1種又は複数種であり、好ましくは酢酸、p−トルエンスルホン酸、三フッ化ホウ素エチルエーテル及びトリフルオロメタンスルホン酸ビスマスから選ばれる1種又は複数種であり、前記吸水剤は分子篩、硫酸マグネシウム、硫酸ナトリウム及水素化カルシウム等の吸水剤から選ばれる1種又は複数種であり、好ましくは分子篩及び硫酸マグネシウムから選ばれる1種又は複数種であることを特徴とする請求項1に記載の調製方法。
- 前記ヒドラジン又はその誘導体R4NHNH2とシクロヘキセノン長鎖アルコール粗製品IIIとのモル比は0.8:1〜3:1であり、好ましくは0.9:1〜2:1であることを特徴とする請求項1に記載の調製方法。
- 前記縮合する反応は溶媒中で行われ、前記溶媒はメタノール、エタノール、イソプロパノール、n−ブタノール、tert−ブタノール、tert−ペンタノール、アセトニトリル、テトラヒドロフラン、メチルtert−ブチルエーテル、イソプロピルエーテル、1,4−ジオキサン、アセトン、2−ブタノン、酢酸エチル、酢酸イソブチル、トルエン、キシレン、クロロベンゼン、ベンゼン、N,N−ジメチルアセトアミド、N,N−ジメチルホルムアミド、N,N−ジエチルホルムアミド、N−メチルピロリドン、ジクロロメタン、1,2−ジクロロエタン、クロロホルム、n−ヘキサン、n−ヘプタン、シクロヘキサン及び水から選ばれる1種又は複数種であり、好ましくはメタノール、エタノール、テトラヒドロフラン、アセトニトリル及びn−ヘプタンから選ばれる1種又は複数種であり、
前記縮合する反応の温度は0〜149℃であり、好ましくは20〜129℃であり、反応時間は0.5〜24時間であり、好ましくは1〜10時間であることを特徴とする請求項1に記載の調製方法。 - ステップ(1b)中に記載の酸性物質は有機酸、無機酸、ルイス酸、酸性塩又はその他の酸性物質のうち1種又は複数種であり、前記無機酸は硫酸、塩酸、リン酸、ポリリン酸又はリンタングステン酸であり、前記有機酸はギ酸、酢酸、プロピオン酸、蓚酸、フマル酸、マレイン酸、トリフルオロ酢酸、メタンスルホン酸、ベンゼンスルホン酸、p−トルエンスルホン酸、カンファースルホン酸又はトリフルオロメタンスルホン酸であり、前記ルイス酸は三フッ化ホウ素エチルエーテル、三塩化アルミニウム、三塩化鉄、トリフルオロメタンスルホン酸ビスマス又はトリフルオロメタンスルホン酸スカンジウム であり、前記酸性塩は硫酸水素ナトリウム、硫酸水素アンモニウム又は硫酸水素マグネシウム、p−トルエンスルホン酸ピリジニウム、トリエチルアミン塩酸塩、ピリジン塩酸塩等の酸性塩であり、前記その他の酸性物質はシリカゲル、酸性樹脂であり、好ましくは、前記酸性物質はp−トルエンスルホン酸、塩酸、硫酸、硫酸水素ナトリウム又は硫酸水素マグネシウムであり、前記化合物IIと酸性物質の投入量のモル比は1:0.2〜1:10であり、好ましくは1:0.2〜1:2であることを特徴とする請求項1に記載の調製方法。
- 前記加水分解する反応は溶媒中で行われ、前記溶媒はベンゼン、トルエン、クロロベンゼン、キシレン、アセトニトリル、2−ブタノン、アセトン、1,2−ジメチル−2−イミダゾロン、ジメチルスルホキシド、ジメチルスルホン、スルホラン、ヘキサメチルリン酸トリアミド、N,N−ジメチルホルムアミド、N,N−ジメチルアセトアミド、N,N−ジエチルホルムアミド、N−メチルピロリドン、メタノール、エタノール、イソプロパノール、n−ブタノール、エチレングリコール、ポリエチレングリコール、1,4−ジオキサン、メチルtert−ブチルエーテル、イソプロピルエーテル、テトラヒドロフラン、n−ヘキサン、シクロヘキサン、ジクロロメタン、1,2−ジクロロエタン、クロロホルム及び水から選ばれる1種又は複数種であり、好ましくは、前記溶媒はトルエン、アセトニトリル、メタノール、エタノール、水、テトラヒドロフラン、メチルtert−ブチルエーテル及びジクロロメタンから選ばれる1種又は複数種であり、
前記加水分解する反応における反応温度は20〜139℃であり、反応時間は0.5〜24時間であり、好ましい反応温度は20〜100℃であり、反応時間は0.5〜10時間であることを特徴とする請求項1に記載の調製方法。 - 前記シクロヘキセノン長鎖アルコール粗製品IIIは以下の反応式によって得られ、
(2a)化合物IV及びVは金属が介在するBarbier反応をして、化合物VIを生成するステップ、
(2b)化合物VIは酸性物質の存在の下で脱保護する反応をして保護基を除去してシクロヘキセノン長鎖アルコール粗製品IIIを得るステップを含むことを特徴とする請求項1に記載の調製方法。 - ステップ(2a)において、前記金属はリチウム、ナトリウム、ストロンチウム、マグネシウム又は亜鉛であり、好ましくはリチウム、ストロンチウム又はマグネシウムであり、前記金属と化合物IVのモル比は1:1〜12:1であり、好ましくは2:1〜10:1であり、VとIVのモル比は0.6:1〜6:1であり、好ましくは0.8:1〜4:1であることを特徴とする請求項8に記載の調製方法。
- 前記Barbier反応は、触媒があり又はない条件で行われ、前記触媒はテトラメチルエチレンジアミン、ヘキサメチルリン酸トリアミドから選ばれる1種又は複数種であり、触媒と化合物IVのモル比は0.2:1〜2:1であり、好ましくは0.4:1〜1.2:1であり、
前記Barbier反応は適宜な溶媒中で行われ、前記溶媒はベンゼン、トルエン、クロロベンゼン、キシレン、テトラヒドロフラン、メチルテトラヒドロフラン、1,4−ジオキサン、メチルtert−ブチルエーテル、n−ヘキサン、n−ヘプタン、シクロヘキサン、アセトニトリル、ヘキサメチルリン酸トリアミド及びスルホランから選ばれる1種又は複数種であり、好ましくはトルエン、キシレン、テトラヒドロフラン、メチルテトラヒドロフラン及びn−ヘキサンのうちの1種又は複数種であり、
前記Barbier反応の温度は−20〜100℃から選ばれ、好ましくは−10〜50℃であり、反応時間は1〜36時間であり、好ましくは2〜24時間であることを特徴とする請求項8に記載の調製方法。 - ステップ(2b)において、前記酸性物質はメタンスルホン酸、ベンゼンスルホン酸、p−トルエンスルホン酸、カンファースルホン酸、p−トルエンスルホン酸ピリジニウム、トリエチルアミン塩酸塩、塩酸、硫酸、リン酸、硫酸水素ナトリウム、硫酸水素マグネシウム、酸性分子篩、酸性樹脂、酢酸、トリフルオロ酢酸、トリフルオロメタンスルホン酸、三塩化鉄、三フッ化ホウ素エチルエーテル、クロロトリメチルシラン及び塩化アセチルのうちの1種又は複数種であり、好ましくはベンゼンスルホン酸、p−トルエンスルホン酸、カンファースルホン酸、p−トルエンスルホン酸ピリジニウム、塩酸及び酢酸のうちの1種又は複数種であり、酸性物質と化合物VIのモル比は0.02:1〜1:1であり、好ましくは0.05:1〜0.2:1であり、
前記脱保護する反応は適宜な溶媒中で行われ、前記溶媒はメタノール、エタノール、イソプロパノール、n−ブタノール、tert−ブタノール、tert−ペンタノール、アセトニトリル、テトラヒドロフラン、メチルtert−ブチルエーテル、イソプロピルエーテル、1,4−ジオキサン、アセトン、2−ブタノン、酢酸エチル、酢酸イソブチル、トルエン、キシレン、クロロベンゼン、ベンゼン、N,N−ジメチルアセトアミド、N,N−ジメチルホルムアミド、N,N−ジエチルホルムアミド、N−メチルピロリドン、ジクロロメタン、1,2−ジクロロエタン、クロロホルム、n−ヘキサン、n−ヘプタン、シクロヘキサン及び水のうちの1種又は複数種であり、好ましくはメタノール、エタノール、テトラヒドロフラン、アセトニトリル、n−ヘプタン及び水のうちの1種又は複数種であり、
前記脱保護する反応における反応温度は−20〜100℃であり、好ましくは0〜50℃であり、反応時間は0.1〜10時間であり、好ましくは0.5〜5時間であることを特徴とする請求項8に記載の調製方法。 - 前記ステップ(2a)及びステップ(2b)は段階に分けて行われてもよく、ワンポット法で反応されでもよいことを特徴とする請求項8に記載の調製方法。
- 前記シクロヘキセノン長鎖アルコール粗製品IIIは以下の反応式によって得られ、
- 前記金属はリチウム、ナトリウム、ストロンチウムまたはマグネシウム又は亜鉛であり、好ましくはリチウム、ストロンチウムまたはマグネシウムであり、前記金属と化合物IXとのモル比は1:1〜12:1であり、好ましくは2:1〜10:1であることを特徴とする請求項13に記載の調製方法。
- 前記Barbier反応は、触媒があり又はない条件で行われ、前記触媒はテトラメチルエチレンジアミン、ヘキサメチルリン酸トリアミドから選ばれる1種又は複数種であり、触媒とIXとのモル比は0.2〜2:1であり、好ましくは0.4〜1.2:1であり、
前記Barbier反応は適宜な溶媒中で行われ、前記溶媒はベンゼン、トルエン、クロロベンゼン、キシレン、テトラヒドロフラン、メチルテトラヒドロフラン、1,4−ジオキサン、メチルtert−ブチルエーテル、n−ヘキサン、n−ヘプタン、シクロヘキサン、アセトニトリル、ヘキサメチルリン酸トリアミド及びスルホランから選ばれる1種又は複数種であり、好ましくはトルエン、キシレン、テトラヒドロフラン、メチルテトラヒドロフラン及びn−ヘキサンのうちの1種又は複数種であり、
前記Barbier反応における反応温度は−20〜100℃であり、好ましくは−10〜50℃であり、反応時間は1〜36時間であり、好ましくは2〜24時間であることを特徴とする請求項13に記載の調製方法。
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49110835A (ja) * | 1973-02-13 | 1974-10-22 | ||
JPH1017520A (ja) * | 1996-06-26 | 1998-01-20 | Nippon Kayaku Co Ltd | 芳香族化合物のホルミル化法 |
JP2001515058A (ja) * | 1997-08-13 | 2001-09-18 | 明治乳業株式会社 | シクロヘキセノン長鎖アルコール及びこれを含有する医薬 |
JP2003081979A (ja) * | 2001-09-13 | 2003-03-19 | Japan Science & Technology Corp | 有機金属化合物の新規調製法 |
JP2003212811A (ja) * | 2002-01-22 | 2003-07-30 | Meiji Milk Prod Co Ltd | シクロヘキセノン長鎖アルコールの製造法 |
WO2004087630A1 (en) * | 2003-03-28 | 2004-10-14 | Meiji Dairies Corporation | Process for producing cyclohexenone long-chain alcohols |
JP2011051904A (ja) * | 2009-08-31 | 2011-03-17 | Kansai Electric Power Co Inc:The | 第3級アルコールの製造方法 |
WO2013147072A1 (ja) * | 2012-03-29 | 2013-10-03 | 大鵬薬品工業株式会社 | 3-(15-ヒドロキシペンタデシル)-2,4,4-トリメチル-2-シクロヘキセン-1-オンの共結晶 |
JP2013538220A (ja) * | 2010-09-16 | 2013-10-10 | ビーエーエスエフ ソシエタス・ヨーロピア | パラ異性体純度の高い2−メチル−3−(4−tert−ブチルフェニル)プロパナールを製造するための方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3924241A1 (de) * | 1989-07-21 | 1991-01-31 | Shell Int Research | Neue glyoxyl-cyclohexendione, verfahren zu ihrer herstellung, diese verbindungen enthaltende formulierungen und ihre verwendung |
JP4469441B2 (ja) * | 1999-02-10 | 2010-05-26 | 明治乳業株式会社 | 神経変性疾患の予防又は治療薬 |
CA2424207C (en) | 2000-10-04 | 2013-03-26 | Meiji Dairies Corporation | Stem cell differentiation-inducing promoter |
JP4861560B2 (ja) | 2001-02-19 | 2012-01-25 | 株式会社明治 | 糖尿病合併症治療剤 |
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Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49110835A (ja) * | 1973-02-13 | 1974-10-22 | ||
JPH1017520A (ja) * | 1996-06-26 | 1998-01-20 | Nippon Kayaku Co Ltd | 芳香族化合物のホルミル化法 |
JP2001515058A (ja) * | 1997-08-13 | 2001-09-18 | 明治乳業株式会社 | シクロヘキセノン長鎖アルコール及びこれを含有する医薬 |
JP2003081979A (ja) * | 2001-09-13 | 2003-03-19 | Japan Science & Technology Corp | 有機金属化合物の新規調製法 |
JP2003212811A (ja) * | 2002-01-22 | 2003-07-30 | Meiji Milk Prod Co Ltd | シクロヘキセノン長鎖アルコールの製造法 |
WO2004087630A1 (en) * | 2003-03-28 | 2004-10-14 | Meiji Dairies Corporation | Process for producing cyclohexenone long-chain alcohols |
JP2011051904A (ja) * | 2009-08-31 | 2011-03-17 | Kansai Electric Power Co Inc:The | 第3級アルコールの製造方法 |
JP2013538220A (ja) * | 2010-09-16 | 2013-10-10 | ビーエーエスエフ ソシエタス・ヨーロピア | パラ異性体純度の高い2−メチル−3−(4−tert−ブチルフェニル)プロパナールを製造するための方法 |
WO2013147072A1 (ja) * | 2012-03-29 | 2013-10-03 | 大鵬薬品工業株式会社 | 3-(15-ヒドロキシペンタデシル)-2,4,4-トリメチル-2-シクロヘキセン-1-オンの共結晶 |
Non-Patent Citations (4)
Title |
---|
ARKIVOC, vol. Part(i), p.34-39, JPN7019002299, 2007, ISSN: 0004258231 * |
GREENE'S PROTECTIVE GROUPS IN ORGANIC SYNTHESIS. FIFTH EDITION, JPN6019027929, 2014, pages 33 - 43, ISSN: 0004258233 * |
マクマリー 有機化学(中) 第4版, JPN6019027927, 1998, pages 740 - 745, ISSN: 0004258230 * |
有機合成化学, vol. 第36巻第9号, JPN6019027928, 1978, pages 715 - 722, ISSN: 0004258232 * |
Cited By (1)
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CA3011913A1 (en) | 2017-07-27 |
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TW201728561A (zh) | 2017-08-16 |
CA3011913C (en) | 2023-02-14 |
WO2017125087A1 (zh) | 2017-07-27 |
EP3406586B1 (en) | 2020-12-30 |
RU2018130292A (ru) | 2020-02-25 |
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AU2017209644A2 (en) | 2018-08-30 |
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EP3406586A1 (en) | 2018-11-28 |
US11485696B2 (en) | 2022-11-01 |
AU2017209644B2 (en) | 2020-08-13 |
KR102387362B1 (ko) | 2022-04-15 |
RU2729186C2 (ru) | 2020-08-05 |
EP3406586A4 (en) | 2019-09-11 |
RU2018130292A3 (ja) | 2020-03-12 |
BR112018014841A2 (pt) | 2018-12-18 |
MX2018008936A (es) | 2018-11-09 |
BR112018014841B1 (pt) | 2022-03-03 |
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