JP2019504057A5 - - Google Patents
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- JP2019504057A5 JP2019504057A5 JP2018534682A JP2018534682A JP2019504057A5 JP 2019504057 A5 JP2019504057 A5 JP 2019504057A5 JP 2018534682 A JP2018534682 A JP 2018534682A JP 2018534682 A JP2018534682 A JP 2018534682A JP 2019504057 A5 JP2019504057 A5 JP 2019504057A5
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- Prior art keywords
- cys
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- isolated peptide
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- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
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- QHSCIWIRXWFIGH-LURJTMIESA-N (2s)-2-amino-2-methylpentanedioic acid Chemical compound OC(=O)[C@](N)(C)CCC(O)=O QHSCIWIRXWFIGH-LURJTMIESA-N 0.000 claims description 9
- 208000029078 coronary artery disease Diseases 0.000 claims description 7
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- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims description 6
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- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 3
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20150191082 | 2015-12-31 | ||
| KR10-2015-0191082 | 2015-12-31 | ||
| KR20160163737 | 2016-12-02 | ||
| KR10-2016-0163737 | 2016-12-02 | ||
| PCT/KR2016/015554 WO2017116204A1 (ko) | 2015-12-31 | 2016-12-30 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020093904A Division JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504057A JP2019504057A (ja) | 2019-02-14 |
| JP2019504057A5 true JP2019504057A5 (enExample) | 2019-11-28 |
| JP6712323B2 JP6712323B2 (ja) | 2020-06-17 |
Family
ID=59225193
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534682A Active JP6712323B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2018534662A Active JP6712322B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093915A Active JP7526039B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093904A Active JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2022109549A Pending JP2022130723A (ja) | 2015-12-31 | 2022-07-07 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534662A Active JP6712322B2 (ja) | 2015-12-31 | 2016-12-30 | グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093915A Active JP7526039B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
| JP2020093904A Active JP7030894B2 (ja) | 2015-12-31 | 2020-05-29 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体 |
| JP2022109549A Pending JP2022130723A (ja) | 2015-12-31 | 2022-07-07 | グルカゴン、ｇｌｐ－１及びｇｉｐ受容体のすべてに活性を有する三重活性体の持続型結合体 |
Country Status (32)
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| DK3127923T3 (da) * | 2014-03-31 | 2021-11-22 | Hanmi Pharm Ind Co Ltd | Fremgangsmåde til forbedring af oppløselighed af protein og peptid ved hjælp af immunoglobulin-fc-fragment-binding |
| AR103322A1 (es) | 2014-12-30 | 2017-05-03 | Hanmi Pharm Ind Co Ltd | Derivados de glucagón con estabilidad mejorada |
| CR20180034A (es) | 2015-06-30 | 2018-04-16 | Hanmi Pharm Ind Co Ltd | Derivados de glucagón y una composición que comprende un conjugado de acción prolongada del mismo. |
| AU2016382394B2 (en) | 2015-12-31 | 2019-07-04 | Hanmi Pharm. Co., Ltd. | Long-acting conjugate of triple glucagon/GLP-1/GIP receptor agonist |
| PE20190355A1 (es) | 2016-06-29 | 2019-03-07 | Hanmi Pharm Ind Co Ltd | Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo |
| KR102645064B1 (ko) | 2017-02-03 | 2024-03-08 | 한미약품 주식회사 | 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도 |
| CN110545852B (zh) | 2017-02-07 | 2023-05-26 | 韩美药品株式会社 | 非肽聚合物接头化合物、包含该接头化合物的缀合物及制备该接头化合物和缀合物的方法 |
| MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| TWI744579B (zh) * | 2017-12-21 | 2021-11-01 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| TWI767095B (zh) | 2017-12-21 | 2022-06-11 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| CN109239346B (zh) * | 2018-10-31 | 2019-10-11 | 中国药科大学 | 一组代谢标志物在代谢综合征早期诊断方面的应用 |
| EP3900735A4 (en) * | 2018-12-21 | 2022-09-07 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION WITH INSULIN AND TRIPLE AGONOISTS WITH ACTIVITY AGAINST ALL GLUCAGON AND GLP-1 AND GIP RECEPTORS |
| EP3939990A4 (en) * | 2019-02-15 | 2023-05-24 | Hanmi Fine Chemical Co., Ltd. | NOVEL INTERMEDIATE FOR BIOLOGICALLY ACTIVE POLYPEPTIDE AND PROCESS FOR THE PRODUCTION THEREOF |
| WO2020214013A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체의 고지혈증에 대한 치료적 용도 |
| WO2020214012A1 (ko) * | 2019-04-19 | 2020-10-22 | 한미약품 주식회사 | 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 또는 이의 결합체를 포함하는 고지혈증 예방 또는 치료용 약학적 조성물 및 예방 또는 치료 방법 |
| CN114853908B (zh) * | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| HUE066029T2 (hu) * | 2019-06-28 | 2024-07-28 | Hanmi Pharmaceutical Co Ltd | Hármas agonista, amely májbetegségek kezelésére a glukagon, GLP-1 és GIP receptorok mindegyikére hatással van |
| MY201700A (en) | 2019-08-19 | 2024-03-13 | Lilly Co Eli | Methods of making incretin analogs |
| JP7761557B2 (ja) * | 2019-10-04 | 2025-10-28 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、及びｇｌｐ－１受容体及びｇｉｐ受容体二重アゴニストを含む組成物及びその治療学的使用 |
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| EP3384935A4 (en) | 2015-12-02 | 2019-08-21 | Hanmi Pharm. Co., Ltd. | PROTEIN COMPLEX WITH FATTY ACID DERIVATIVE AND MANUFACTURING METHOD THEREFOR |
| AU2016382394B2 (en) * | 2015-12-31 | 2019-07-04 | Hanmi Pharm. Co., Ltd. | Long-acting conjugate of triple glucagon/GLP-1/GIP receptor agonist |
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