JP2019503979A5 - - Google Patents
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- JP2019503979A5 JP2019503979A5 JP2017562973A JP2017562973A JP2019503979A5 JP 2019503979 A5 JP2019503979 A5 JP 2019503979A5 JP 2017562973 A JP2017562973 A JP 2017562973A JP 2017562973 A JP2017562973 A JP 2017562973A JP 2019503979 A5 JP2019503979 A5 JP 2019503979A5
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- Prior art keywords
- ligand
- conjugate
- linker
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- hydrogen
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022010563A JP2022068172A (ja) | 2015-11-25 | 2022-01-27 | ペプチド基を含む複合体及びそれに関連する方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562259997P | 2015-11-25 | 2015-11-25 | |
| US201562260006P | 2015-11-25 | 2015-11-25 | |
| US62/259,997 | 2015-11-25 | ||
| US62/260,006 | 2015-11-25 | ||
| PCT/IB2016/001810 WO2017089894A1 (en) | 2015-11-25 | 2016-11-23 | Conjugates comprising peptide groups and methods related thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022010563A Division JP2022068172A (ja) | 2015-11-25 | 2022-01-27 | ペプチド基を含む複合体及びそれに関連する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503979A JP2019503979A (ja) | 2019-02-14 |
| JP2019503979A5 true JP2019503979A5 (https=) | 2020-01-09 |
| JP7120765B2 JP7120765B2 (ja) | 2022-08-17 |
Family
ID=58763984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562973A Active JP7120765B2 (ja) | 2015-11-25 | 2016-11-23 | ペプチド基を含む複合体及びそれに関連する方法 |
| JP2022010563A Pending JP2022068172A (ja) | 2015-11-25 | 2022-01-27 | ペプチド基を含む複合体及びそれに関連する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022010563A Pending JP2022068172A (ja) | 2015-11-25 | 2022-01-27 | ペプチド基を含む複合体及びそれに関連する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11167040B2 (https=) |
| EP (1) | EP3380125A4 (https=) |
| JP (2) | JP7120765B2 (https=) |
| KR (1) | KR102847348B1 (https=) |
| CN (1) | CN108136038A (https=) |
| AU (1) | AU2016359234B2 (https=) |
| CA (1) | CA3006247A1 (https=) |
| TW (1) | TWI816638B (https=) |
| WO (1) | WO2017089894A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9480731B2 (en) * | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| KR101628872B1 (ko) * | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| WO2017051254A1 (en) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-egfr antibody drug conjugates |
| WO2017051249A1 (en) | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-cd19 antibody drug conjugates |
| CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| KR102847348B1 (ko) * | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법 |
| AU2016359230B2 (en) | 2015-11-25 | 2020-04-23 | Ligachem Biosciences Inc. | Conjugates comprising self-immolative groups and methods related thereto |
| AU2016359235B2 (en) | 2015-11-25 | 2022-09-15 | Ligachem Biosciences Inc. | Antibody-drug conjugates comprising branched linkers and methods related thereto |
| KR102480965B1 (ko) | 2016-09-13 | 2022-12-26 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
| CA3058360A1 (en) | 2017-03-29 | 2018-10-04 | Legochem Biosciences, Inc. | Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same |
| WO2018218004A1 (en) | 2017-05-24 | 2018-11-29 | The Board Of Regents Of The University Of Texas System | Linkers for antibody drug conjugates |
| CN110314238A (zh) * | 2018-03-30 | 2019-10-11 | 烟台药物研究所 | 一种肿瘤靶向的多肽药物偶联物及其制备方法和应用 |
| CN112601555A (zh) | 2018-05-09 | 2021-04-02 | 乐高化学生物科学股份有限公司 | 与抗cd19抗体药物结合物相关的组合物和方法 |
| KR102255487B1 (ko) | 2018-07-03 | 2021-07-21 | 주식회사 엘지에너지솔루션 | 배터리 모듈, 이러한 배터리 모듈을 포함하는 배터리 팩 및 이러한 배터리 팩을 포함하는 자동차 |
| GB201817321D0 (en) | 2018-10-24 | 2018-12-05 | Nanna Therapeutics Ltd | Microbeads for tagless encoded chemical library screening |
| JP2022530482A (ja) * | 2019-05-02 | 2022-06-29 | レゴケム バイオサイエンシズ， インク． | トリス構造を有するリンカーを含むリガンド―薬物複合体 |
| WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
| CN112094321B (zh) * | 2019-06-18 | 2022-04-22 | 首都医科大学 | His-Gly-Glu修饰的甲氨蝶呤,其合成,抗转移活性和应用 |
| KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
| CN111007244B (zh) * | 2019-11-15 | 2021-10-08 | 中国农业科学院油料作物研究所 | 二乙酸镳草镰刀菌烯醇竞争型气压免疫传感器及检测方法 |
| KR20210086557A (ko) * | 2019-12-31 | 2021-07-08 | 주식회사 레고켐 바이오사이언스 | 피롤로벤조디아제핀 유도체 및 이의 리간드-링커 접합체 |
| CN115968304A (zh) * | 2020-04-16 | 2023-04-14 | 瑞泽恩制药公司 | 狄尔斯-阿尔德缀合方法 |
| GB2594753B (en) * | 2020-05-27 | 2022-05-18 | Spirea Ltd | Antibody-drug conjugates |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| CN112679448B (zh) * | 2020-12-31 | 2022-08-19 | 苏州昊帆生物股份有限公司 | N-(2-氨基乙基)吗啉的制备方法 |
| EP4301782A1 (en) | 2021-03-05 | 2024-01-10 | Go Therapeutics, Inc. | Anti-glyco-cd44 antibodies and their uses |
| JP2024520444A (ja) | 2021-05-24 | 2024-05-24 | プロヴェンション・バイオ・インコーポレイテッド | １型糖尿病を治療するための方法 |
| US20250101126A1 (en) | 2021-08-05 | 2025-03-27 | Go Therapeutics, Inc. | Anti-glyco-muc4 antibodies and their uses |
| CN113636931B (zh) * | 2021-08-05 | 2024-02-13 | 康龙化成(宁波)科技发展有限公司 | 基因编码化合物库起始头片段化合物及其在基因编码化合物库合成上的应用 |
| WO2026080692A1 (en) * | 2024-10-09 | 2026-04-16 | Sutro Biopharma, Inc. | Branched beta-glucuronide linker-payloads, protein conjugates thereof, and methods thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112739A (en) | 1988-08-02 | 1992-05-12 | Polaroid Corporation | Enzyme controlled release system |
| EP0795334B1 (de) | 1996-03-12 | 2006-02-01 | Sanofi-Aventis Deutschland GmbH | Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen |
| US6218519B1 (en) | 1996-04-12 | 2001-04-17 | Pro-Neuron, Inc. | Compounds and methods for the selective treatment of cancer and bacterial infections |
| JP2001505194A (ja) | 1996-11-05 | 2001-04-17 | ブリストル―マイヤーズ・スクイブ・カンパニー | 分枝ペプチド・リンカー |
| US6759509B1 (en) | 1996-11-05 | 2004-07-06 | Bristol-Myers Squibb Company | Branched peptide linkers |
| JP2006510626A (ja) | 2002-12-05 | 2006-03-30 | シエーリング アクチエンゲゼルシャフト | 増殖疾患の処理における部位特異的供給のためのエポチロン類似体 |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| SV2007002227A (es) | 2004-09-10 | 2007-03-20 | Wyeth Corp | Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637 |
| DK3248613T3 (da) | 2005-07-18 | 2022-03-14 | Seagen Inc | Beta-glucuronid-lægemiddel-linkerkonjugater |
| BRPI0716808A2 (pt) | 2006-09-15 | 2013-11-05 | Enzon Pharmaceuticals Inc | Ligantes poliméricos baseados em lisina |
| KR101512203B1 (ko) | 2006-11-10 | 2015-04-15 | 가부시키가이샤 리부텍쿠 | ｉｎ ｖｉｖｏ 에서 항종양 활성을 갖는 항인간 Ｄｌｋ－１ 항체 |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| JP5404624B2 (ja) | 2007-08-01 | 2014-02-05 | カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ | 選択的な抗腫瘍薬として有用なピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−グリコシドプロドラッグ |
| CA2759733C (en) | 2009-04-23 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human ror1 antibodies |
| WO2011066418A1 (en) | 2009-11-25 | 2011-06-03 | Academia Sinica | The tumor-selective anti-cancer prodrug bqc-g |
| FR2960153B1 (fr) | 2010-05-20 | 2012-08-17 | Centre Nat Rech Scient | Nouveaux bras autoreactifs et prodrogues les comprenant |
| US9591882B2 (en) | 2010-08-05 | 2017-03-14 | Robert LaGrand Duffin | Absorbent sleeve |
| EP3828205A1 (en) | 2010-10-01 | 2021-06-02 | Oxford BioTherapeutics Ltd | Anti-ror1 antibodies |
| KR20120107741A (ko) | 2011-03-22 | 2012-10-04 | 한국생명공학연구원 | 패혈증 단백질 치료제의 효능 분석 및 스크리닝 방법 |
| KR101461706B1 (ko) | 2011-04-04 | 2014-11-18 | 한국생명공학연구원 | Ｄｌｋ１ 세포 외 수용성 도메인을 포함하는 액티빈 수용체 타입 2ｂ 억제제 |
| CN103502990A (zh) | 2011-04-29 | 2014-01-08 | 惠普发展公司，有限责任合伙企业 | 用于事件的内存中处理的系统和方法 |
| MX393973B (es) | 2011-05-08 | 2025-03-24 | Legochem Biosciences Inc | Conjugados de proteína-agente activo y método para su preparación. |
| CA2850373C (en) | 2011-10-14 | 2019-07-16 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| EP2800586A1 (en) * | 2012-01-03 | 2014-11-12 | Invictus Oncology Pvt. Ltd. | Ligand-targeted molecules and methods thereof |
| CN105189507A (zh) | 2012-12-21 | 2015-12-23 | 斯皮罗根有限公司 | 吡咯并苯并二氮杂卓及其结合物 |
| MX2015012549A (es) | 2013-03-15 | 2016-06-21 | Abbvie Deutschland | Formulaciones de conjugado anticuerpo anti-egfr-farmaco. |
| WO2014194030A2 (en) | 2013-05-31 | 2014-12-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| US20160256561A1 (en) | 2013-10-11 | 2016-09-08 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| KR102442906B1 (ko) | 2013-12-19 | 2022-09-14 | 씨젠 인크. | 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커 |
| EP2913064A1 (en) | 2014-02-26 | 2015-09-02 | celares GmbH | Branched drug-linker conjugates for the coupling to biological targeting molecules |
| KR101628872B1 (ko) | 2014-05-28 | 2016-06-09 | 주식회사 레고켐 바이오사이언스 | 자가-희생 기를 포함하는 화합물 |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對ｃｄ１９具專一性之抗體及嵌合抗原受體 |
| FI3900742T3 (fi) | 2014-09-11 | 2024-08-16 | Seagen Inc | Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen |
| CN107207553A (zh) | 2014-12-09 | 2017-09-26 | 艾伯维公司 | Bcl‑xl抑制性化合物和包括其的抗体药物缀合物 |
| KR20160080832A (ko) | 2014-12-29 | 2016-07-08 | 주식회사 레고켐 바이오사이언스 | 리피바디 유도체-약물 복합체, 그 제조방법 및 용도 |
| ES2818103T3 (es) | 2015-01-16 | 2021-04-09 | Juno Therapeutics Inc | Anticuerpos y receptores de antígenos quiméricos específicos para ROR1 |
| PT3250237T (pt) | 2015-01-30 | 2021-06-30 | Sutro Biopharma Inc | Derivados de hemiasterlina para conjugação e terapêutica |
| WO2017051249A1 (en) | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-cd19 antibody drug conjugates |
| WO2017051254A1 (en) | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-egfr antibody drug conjugates |
| MY196631A (en) | 2015-10-13 | 2023-04-24 | Eureka Therapeutics Inc | Antibody Agents Specific for Human Cd19 and uses Thereof |
| KR102847348B1 (ko) | 2015-11-25 | 2025-08-19 | 주식회사 리가켐바이오사이언스 | 펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법 |
| AU2016359230B2 (en) | 2015-11-25 | 2020-04-23 | Ligachem Biosciences Inc. | Conjugates comprising self-immolative groups and methods related thereto |
| AU2016359235B2 (en) | 2015-11-25 | 2022-09-15 | Ligachem Biosciences Inc. | Antibody-drug conjugates comprising branched linkers and methods related thereto |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| WO2018083535A1 (en) | 2016-11-04 | 2018-05-11 | Novimmune Sa | Anti-cd19 antibodies and methods of use thereof |
| CA3058360A1 (en) | 2017-03-29 | 2018-10-04 | Legochem Biosciences, Inc. | Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same |
| AU2018289581C1 (en) | 2017-06-23 | 2025-01-30 | VelosBio Inc. | ROR1 antibody immunoconjugates |
| KR20190018400A (ko) | 2017-08-14 | 2019-02-22 | 주식회사 레고켐 바이오사이언스 | EGFRvIII에 대한 항체를 포함하는 항체 약물 접합체 |
| CN111278860B (zh) | 2017-09-08 | 2024-03-29 | Y生物股份有限公司 | 抗人dlk1的抗体及其用途 |
| CN112601555A (zh) | 2018-05-09 | 2021-04-02 | 乐高化学生物科学股份有限公司 | 与抗cd19抗体药物结合物相关的组合物和方法 |
| WO2019225777A1 (ko) | 2018-05-23 | 2019-11-28 | 에이비엘바이오 주식회사 | 항-ror1 항체 및 그 용도 |
| EP3936150A4 (en) | 2019-03-06 | 2023-03-29 | LegoChem Biosciences, Inc. | ANTIBODY-DRUG CONJUGATES COMPRISING ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF |
-
2016
- 2016-11-23 KR KR1020187018067A patent/KR102847348B1/ko active Active
- 2016-11-23 CA CA3006247A patent/CA3006247A1/en active Pending
- 2016-11-23 US US15/779,450 patent/US11167040B2/en active Active
- 2016-11-23 AU AU2016359234A patent/AU2016359234B2/en active Active
- 2016-11-23 WO PCT/IB2016/001810 patent/WO2017089894A1/en not_active Ceased
- 2016-11-23 JP JP2017562973A patent/JP7120765B2/ja active Active
- 2016-11-23 EP EP16868095.7A patent/EP3380125A4/en active Pending
- 2016-11-23 CN CN201680030739.4A patent/CN108136038A/zh active Pending
- 2016-11-25 TW TW105138779A patent/TWI816638B/zh active
-
2022
- 2022-01-27 JP JP2022010563A patent/JP2022068172A/ja active Pending
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