|
US5112739A
(en)
|
1988-08-02 |
1992-05-12 |
Polaroid Corporation |
Enzyme controlled release system
|
|
DE19512484A1
(de)
|
1995-04-04 |
1996-10-17 |
Bayer Ag |
Kohlenhydratmodifizierte Cytostatika
|
|
EP0795334B1
(de)
|
1996-03-12 |
2006-02-01 |
Sanofi-Aventis Deutschland GmbH |
Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen
|
|
US6218519B1
(en)
|
1996-04-12 |
2001-04-17 |
Pro-Neuron, Inc. |
Compounds and methods for the selective treatment of cancer and bacterial infections
|
|
JP2001505194A
(ja)
|
1996-11-05 |
2001-04-17 |
ブリストル―マイヤーズ・スクイブ・カンパニー |
分枝ペプチド・リンカー
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
JP2006510626A
(ja)
|
2002-12-05 |
2006-03-30 |
シエーリング アクチエンゲゼルシャフト |
増殖疾患の処理における部位特異的供給のためのエポチロン類似体
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
SV2007002227A
(es)
|
2004-09-10 |
2007-03-20 |
Wyeth Corp |
Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina ref. 040000-0317637
|
|
DK3248613T3
(da)
|
2005-07-18 |
2022-03-14 |
Seagen Inc |
Beta-glucuronid-lægemiddel-linkerkonjugater
|
|
CN101287500A
(zh)
|
2005-08-19 |
2008-10-15 |
恩多塞特公司 |
多药物配体缀合物
|
|
EP2064244B1
(en)
*
|
2006-08-03 |
2019-06-05 |
MedImmune Limited |
ANTIBODIES DIRECTED TO alphaVbeta6 AND USES THEREOF
|
|
BRPI0716808A2
(pt)
|
2006-09-15 |
2013-11-05 |
Enzon Pharmaceuticals Inc |
Ligantes poliméricos baseados em lisina
|
|
UA94628C2
(ru)
|
2006-10-27 |
2011-05-25 |
Дженентек, Инк. |
Гуманизированное моноклональное антитело, которое связывается с steap-1, и его применение
|
|
KR101512203B1
(ko)
|
2006-11-10 |
2015-04-15 |
가부시키가이샤 리부텍쿠 |
ｉｎ ｖｉｖｏ 에서 항종양 활성을 갖는 항인간 Ｄｌｋ－１ 항체
|
|
CL2007003622A1
(es)
*
|
2006-12-13 |
2009-08-07 |
Medarex Inc |
Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
|
|
JP5404624B2
(ja)
|
2007-08-01 |
2014-02-05 |
カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチ |
選択的な抗腫瘍薬として有用なピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−グリコシドプロドラッグ
|
|
NZ584514A
(en)
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
US8017118B2
(en)
|
2008-03-17 |
2011-09-13 |
LivTech Inc. — Teikyo University Biotechnology Research Center |
Anti-hDlk-1 antibody having an antitumor activity in vivo
|
|
CA2759733C
(en)
|
2009-04-23 |
2019-09-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-human ror1 antibodies
|
|
WO2011066418A1
(en)
|
2009-11-25 |
2011-06-03 |
Academia Sinica |
The tumor-selective anti-cancer prodrug bqc-g
|
|
FR2960153B1
(fr)
|
2010-05-20 |
2012-08-17 |
Centre Nat Rech Scient |
Nouveaux bras autoreactifs et prodrogues les comprenant
|
|
US9591882B2
(en)
|
2010-08-05 |
2017-03-14 |
Robert LaGrand Duffin |
Absorbent sleeve
|
|
EP3828205A1
(en)
|
2010-10-01 |
2021-06-02 |
Oxford BioTherapeutics Ltd |
Anti-ror1 antibodies
|
|
KR20120107741A
(ko)
|
2011-03-22 |
2012-10-04 |
한국생명공학연구원 |
패혈증 단백질 치료제의 효능 분석 및 스크리닝 방법
|
|
WO2012138102A2
(ko)
|
2011-04-04 |
2012-10-11 |
한국생명공학연구원 |
Ｄｌｋ１ 특이적 인간 항체 및 이를 포함하는 약학적 조성물
|
|
KR101461706B1
(ko)
|
2011-04-04 |
2014-11-18 |
한국생명공학연구원 |
Ｄｌｋ１ 세포 외 수용성 도메인을 포함하는 액티빈 수용체 타입 2ｂ 억제제
|
|
CN103502990A
(zh)
|
2011-04-29 |
2014-01-08 |
惠普发展公司，有限责任合伙企业 |
用于事件的内存中处理的系统和方法
|
|
MX393973B
(es)
|
2011-05-08 |
2025-03-24 |
Legochem Biosciences Inc |
Conjugados de proteína-agente activo y método para su preparación.
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
EP2800586A1
(en)
|
2012-01-03 |
2014-11-12 |
Invictus Oncology Pvt. Ltd. |
Ligand-targeted molecules and methods thereof
|
|
DK3725807T3
(da)
|
2012-12-03 |
2026-01-12 |
Novimmune Sa |
Anti-cd47 antistoffer og fremgangsmåder til anvendelse deraf
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
MX2015012549A
(es)
|
2013-03-15 |
2016-06-21 |
Abbvie Deutschland |
Formulaciones de conjugado anticuerpo anti-egfr-farmaco.
|
|
WO2014194030A2
(en)
|
2013-05-31 |
2014-12-04 |
Immunogen, Inc. |
Conjugates comprising cell-binding agents and cytotoxic agents
|
|
US20160256561A1
(en)
|
2013-10-11 |
2016-09-08 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
NZ758049A
(en)
|
2013-10-15 |
2024-03-22 |
Seagen Inc |
Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
|
|
EA201691075A1
(ru)
|
2013-11-26 |
2016-09-30 |
Новартис Аг |
Способы оксимной конъюгации с кетон-модифицированными полипептидами
|
|
KR102442906B1
(ko)
|
2013-12-19 |
2022-09-14 |
씨젠 인크. |
표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
|
|
EP2913064A1
(en)
|
2014-02-26 |
2015-09-02 |
celares GmbH |
Branched drug-linker conjugates for the coupling to biological targeting molecules
|
|
KR101628872B1
(ko)
|
2014-05-28 |
2016-06-09 |
주식회사 레고켐 바이오사이언스 |
자가-희생 기를 포함하는 화합물
|
|
WO2015197582A1
(en)
|
2014-06-27 |
2015-12-30 |
Innate Pharma |
Monomeric multispecific antigen binding proteins
|
|
TWI751102B
(zh)
*
|
2014-08-28 |
2022-01-01 |
美商奇諾治療有限公司 |
對ｃｄ１９具專一性之抗體及嵌合抗原受體
|
|
FI3900742T3
(fi)
|
2014-09-11 |
2024-08-16 |
Seagen Inc |
Tertiääristä amiinia sisältävien lääkeaineiden kohdennettu antaminen
|
|
CN107207553A
(zh)
|
2014-12-09 |
2017-09-26 |
艾伯维公司 |
Bcl‑xl抑制性化合物和包括其的抗体药物缀合物
|
|
KR20160080832A
(ko)
|
2014-12-29 |
2016-07-08 |
주식회사 레고켐 바이오사이언스 |
리피바디 유도체-약물 복합체, 그 제조방법 및 용도
|
|
WO2016115345A1
(en)
|
2015-01-14 |
2016-07-21 |
The Brigham And Women's Hospital, |
Treatment of cancer with anti-lap monoclonal antibodies
|
|
ES2818103T3
(es)
|
2015-01-16 |
2021-04-09 |
Juno Therapeutics Inc |
Anticuerpos y receptores de antígenos quiméricos específicos para ROR1
|
|
PT3250237T
(pt)
|
2015-01-30 |
2021-06-30 |
Sutro Biopharma Inc |
Derivados de hemiasterlina para conjugação e terapêutica
|
|
US11673957B2
(en)
|
2015-03-10 |
2023-06-13 |
Eureka Therapeutics, Inc. |
Anti-ROR2 antibodies
|
|
WO2017051254A1
(en)
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-egfr antibody drug conjugates
|
|
WO2017051249A1
(en)
*
|
2015-09-25 |
2017-03-30 |
Legochem Biosciences, Inc. |
Compositions and methods related to anti-cd19 antibody drug conjugates
|
|
MY196631A
(en)
*
|
2015-10-13 |
2023-04-24 |
Eureka Therapeutics Inc |
Antibody Agents Specific for Human Cd19 and uses Thereof
|
|
KR102847348B1
(ko)
|
2015-11-25 |
2025-08-19 |
주식회사 리가켐바이오사이언스 |
펩타이드 그룹을 포함하는 접합체 및 이와 관련된 제조방법
|
|
AU2016359235B2
(en)
|
2015-11-25 |
2022-09-15 |
Ligachem Biosciences Inc. |
Antibody-drug conjugates comprising branched linkers and methods related thereto
|
|
AU2016359230B2
(en)
|
2015-11-25 |
2020-04-23 |
Ligachem Biosciences Inc. |
Conjugates comprising self-immolative groups and methods related thereto
|
|
RU2651776C2
(ru)
|
2015-12-01 |
2018-04-23 |
Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") |
Биспецифические антитела против cd3*cd19
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
WO2018083535A1
(en)
*
|
2016-11-04 |
2018-05-11 |
Novimmune Sa |
Anti-cd19 antibodies and methods of use thereof
|
|
TWI822055B
(zh)
|
2016-11-21 |
2023-11-11 |
台灣浩鼎生技股份有限公司 |
共軛生物分子、醫藥組成物及方法
|
|
HUE056289T2
(hu)
|
2017-02-08 |
2022-02-28 |
Adc Therapeutics Sa |
Pirrolobenzodiazepin-antitest konjugátumok
|
|
CA3058360A1
(en)
|
2017-03-29 |
2018-10-04 |
Legochem Biosciences, Inc. |
Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
|
|
WO2018182341A1
(ko)
|
2017-03-29 |
2018-10-04 |
주식회사 레고켐 바이오사이언스 |
피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
AU2018289581C1
(en)
|
2017-06-23 |
2025-01-30 |
VelosBio Inc. |
ROR1 antibody immunoconjugates
|
|
KR20190018400A
(ko)
|
2017-08-14 |
2019-02-22 |
주식회사 레고켐 바이오사이언스 |
EGFRvIII에 대한 항체를 포함하는 항체 약물 접합체
|
|
CN111278860B
(zh)
|
2017-09-08 |
2024-03-29 |
Y生物股份有限公司 |
抗人dlk1的抗体及其用途
|
|
CN112601555A
(zh)
|
2018-05-09 |
2021-04-02 |
乐高化学生物科学股份有限公司 |
与抗cd19抗体药物结合物相关的组合物和方法
|
|
WO2019225777A1
(ko)
|
2018-05-23 |
2019-11-28 |
에이비엘바이오 주식회사 |
항-ror1 항체 및 그 용도
|
|
KR20200084802A
(ko)
|
2019-01-03 |
2020-07-13 |
주식회사 레고켐 바이오사이언스 |
안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
|
|
EP3936150A4
(en)
|
2019-03-06 |
2023-03-29 |
LegoChem Biosciences, Inc. |
ANTIBODY-DRUG CONJUGATES COMPRISING ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF
|
|
CN110784759B
(zh)
|
2019-08-12 |
2022-08-12 |
腾讯科技（深圳）有限公司 |
弹幕信息处理方法、装置、电子设备及存储介质
|
|
KR20210028544A
(ko)
|
2019-09-04 |
2021-03-12 |
주식회사 레고켐 바이오사이언스 |
인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
|