JP2021063058A5 - - Google Patents

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JP2021063058A5
JP2021063058A5 JP2020143359A JP2020143359A JP2021063058A5 JP 2021063058 A5 JP2021063058 A5 JP 2021063058A5 JP 2020143359 A JP2020143359 A JP 2020143359A JP 2020143359 A JP2020143359 A JP 2020143359A JP 2021063058 A5 JP2021063058 A5 JP 2021063058A5
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antibody
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cancer
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JP7770760B2 (ja
JP2021063058A (ja
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JP2020143359A 2019-09-04 2020-08-27 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用 Active JP7770760B2 (ja)

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JP2023135580A JP7570474B2 (ja) 2019-09-04 2023-08-23 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用
JP2025135500A JP2025186244A (ja) 2019-09-04 2025-08-15 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用

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KR1020190109807A KR20210028544A (ko) 2019-09-04 2019-09-04 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
KR10-2019-0109807 2019-09-04

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JP2023135580A Division JP7570474B2 (ja) 2019-09-04 2023-08-23 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用
JP2025135500A Division JP2025186244A (ja) 2019-09-04 2025-08-15 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用

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JP2021063058A JP2021063058A (ja) 2021-04-22
JP2021063058A5 true JP2021063058A5 (https=) 2023-08-31
JP7770760B2 JP7770760B2 (ja) 2025-11-17

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JP2020143359A Active JP7770760B2 (ja) 2019-09-04 2020-08-27 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用
JP2023135580A Active JP7570474B2 (ja) 2019-09-04 2023-08-23 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用
JP2025135500A Pending JP2025186244A (ja) 2019-09-04 2025-08-15 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用

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JP2025135500A Pending JP2025186244A (ja) 2019-09-04 2025-08-15 ヒトｒｏｒ１に対する抗体を含む抗体－薬物コンジュゲートおよびその使用

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US (2) US11707533B2 (https=)
EP (2) EP4025257A4 (https=)
JP (3) JP7770760B2 (https=)
KR (1) KR20210028544A (https=)
CN (2) CN113521300B (https=)
AU (2) AU2020343888A1 (https=)
BR (1) BR112022003589A2 (https=)
CA (1) CA3153069A1 (https=)
IL (2) IL314603A (https=)
MX (1) MX2022002592A (https=)
TW (2) TW202122115A (https=)
WO (1) WO2021044208A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102847350B1 (ko) 2015-11-25 2025-08-19 주식회사 리가켐바이오사이언스 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
HRP20240795T1 (hr) 2015-11-25 2024-09-13 Ligachem Biosciences Inc. Konjugati koji se sastoje od samozapaljujućih skupina i postupci povezani s njima
MX2019011655A (es) 2017-03-29 2019-12-19 Legochem Biosciences Inc Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este.
JP7459063B2 (ja) 2018-05-09 2024-04-01 レゴケム バイオサイエンシズ， インク． 抗－ｃｄ１９抗体薬物複合体に関連する組成物および方法
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
KR20220158181A (ko) * 2021-05-21 2022-11-30 주식회사 레고켐 바이오사이언스 Ror1 및 b7-h3에 결합하는 항체-약물 접합체 및 그 용도
CN115626949B (zh) * 2021-07-14 2026-04-14 南京科默生物医药有限公司 一种bet蛋白靶向降解化合物及其制备方法和用途
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
TW202320858A (zh) 2021-07-19 2023-06-01 美商薩諾管理公司 免疫接合物及方法
CN118574845A (zh) * 2022-01-29 2024-08-30 杭州中美华东制药有限公司 一种靶向ror1的抗体或其抗原结合片段及其应用
KR20250008730A (ko) * 2022-03-09 2025-01-15 산유 바이오파마슈티컬스 씨오., 엘티디. Ror1-표적화 결합 분자 및 이의 용도
WO2023217227A1 (zh) 2022-05-12 2023-11-16 先声再明医药有限公司 喜树碱类衍生物及配体-药物偶联物
WO2024008112A1 (en) * 2022-07-06 2024-01-11 Nona Biosciences (Suzhou) Co., Ltd. Anti-ror1 antibodies
CN119816519A (zh) * 2022-07-15 2025-04-11 Abl生物公司 抗ror1抗体、包含其的双特异性抗体及其用途
WO2024032761A1 (en) * 2022-08-11 2024-02-15 Hansoh Bio Llc Ligand-cytotoxicity drug conjugates and pharmaceutical uses thereof
KR20250130409A (ko) * 2023-01-11 2025-09-01 젠맵 에이/에스 링커, 약물 링커 및 그의 접합체 및 그의 사용 방법
TW202444425A (zh) * 2023-03-23 2024-11-16 大陸商江蘇恆瑞醫藥股份有限公司 抗ror1抗體與pbd類化合物的偶聯物、其製備方法及其應用
EP4696329A1 (en) * 2023-04-11 2026-02-18 BioRay Pharmaceutical Co., Ltd. Anti-ror1 antibody and drug conjugate thereof
CN119744272A (zh) * 2023-07-31 2025-04-01 石药集团巨石生物制药有限公司 一种抗ror1蛋白的抗体及其缀合物
WO2025039809A1 (zh) * 2023-08-21 2025-02-27 上海麦科思生物医药有限公司 抗ror1抗体及其用途
WO2025140358A1 (en) * 2023-12-27 2025-07-03 Genequantum Healthcare (Suzhou) Co., Ltd. A pharmaceutical composition of anti-fgfr3 antibody drug conjugate and applications thereof
CN120829509A (zh) * 2024-04-18 2025-10-24 上海医药集团股份有限公司 抗ror1抗体、其免疫缀合物及其应用
CN118580358B (zh) * 2024-08-08 2024-11-29 南京优宁维生物科技有限公司 抗ror1重组单克隆抗体及其制备与应用

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5112739A (en) 1988-08-02 1992-05-12 Polaroid Corporation Enzyme controlled release system
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
DK0795334T3 (da) 1996-03-12 2006-06-06 Sanofi Aventis Deutschland Nye prodrugs til behandling af tumorer og betændelsessygdomme
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
JP2001505194A (ja) 1996-11-05 2001-04-17 ブリストル―マイヤーズ・スクイブ・カンパニー 分枝ペプチド・リンカー
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
WO1999057301A1 (en) 1998-04-30 1999-11-11 Maruha Corporation Compounds having glucuronic acid derivatives and glucosamine derivatives in the structure, process for producing the same and utilization thereof
JP2006510626A (ja) 2002-12-05 2006-03-30 シエーリング アクチエンゲゼルシャフト 増殖疾患の処理における部位特異的供給のためのエポチロン類似体
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
PE20100251A1 (es) 2004-09-10 2010-04-10 Wyeth Corp Anticuerpos anti-5t4 humanizados y conjugados anticuerpo anti-5t4/calicheamicina
HUE035853T2 (en) 2005-07-18 2018-05-28 Seattle Genetics Inc Beta-glucuronide-linker-drug conjugates
CN101287500A (zh) 2005-08-19 2008-10-15 恩多塞特公司 多药物配体缀合物
JP2010503706A (ja) 2006-09-15 2010-02-04 エンゾン ファーマスーティカルズ インコーポレイテッド リジン系ポリマーリンカー
CN103073641B (zh) 2006-11-10 2015-01-21 株式会社立富泰克 在体内具有抗肿瘤活性的抗人Dlk-1抗体
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
WO2009016647A1 (en) 2007-08-01 2009-02-05 Council Of Scientific & Industrial Research Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent
WO2010124188A1 (en) 2009-04-23 2010-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-human ror1 antibodies
US9353140B2 (en) 2009-11-25 2016-05-31 Academia Sinica BQC-G, a tumor-selective anti-cancer prodrug
DK2528625T3 (da) 2010-04-15 2013-10-14 Spirogen Sarl Pyrrolobenzodiazepiner og konjugater deraf
FR2960153B1 (fr) 2010-05-20 2012-08-17 Centre Nat Rech Scient Nouveaux bras autoreactifs et prodrogues les comprenant
US9591882B2 (en) 2010-08-05 2017-03-14 Robert LaGrand Duffin Absorbent sleeve
EP3828205A1 (en) 2010-10-01 2021-06-02 Oxford BioTherapeutics Ltd Anti-ror1 antibodies
GB201020995D0 (en) 2010-12-10 2011-01-26 Bioinvent Int Ab Biological materials and uses thereof
KR20120107741A (ko) 2011-03-22 2012-10-04 한국생명공학연구원 패혈증 단백질 치료제의 효능 분석 및 스크리닝 방법
KR101438265B1 (ko) 2011-04-04 2014-09-05 한국생명공학연구원 Ｄｌｋ１ 특이적 인간 항체 및 이를 포함하는 약학적 조성물
WO2012148427A1 (en) 2011-04-29 2012-11-01 Hewlett-Packard Development Company, L.P. Systems and methods for in-memory processing of events
HUE045348T2 (hu) 2011-05-08 2019-12-30 Legochem Biosciences Inc Fehérje-hatóanyag konjugátumok és eljárás elõállításukra
ES2945932T3 (es) 2011-10-14 2023-07-10 Seagen Inc Pirrolobenzodiazepinas y conjugados dirigidos
JP6228551B2 (ja) 2012-01-03 2017-11-08 インビクタス オンコロジー プライベート リミテッド リガンド−標的指向分子およびその方法
CN105189507A (zh) 2012-12-21 2015-12-23 斯皮罗根有限公司 吡咯并苯并二氮杂卓及其结合物
KR20220041957A (ko) 2013-03-15 2022-04-01 아비에 도이치란트 게엠베하 운트 콤파니 카게 항-egfr 항체 약물 접합체 제형
WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052533A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
ES2826398T3 (es) 2013-10-15 2021-05-18 Seagen Inc Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
WO2015079376A1 (en) 2013-11-26 2015-06-04 Novartis Ag Methods for oxime conjugation to ketone-modified polypeptides
JP6701077B2 (ja) 2013-12-19 2020-05-27 シアトル ジェネティックス， インコーポレイテッド 標的化薬物結合体と使用するためのメチレンカルバメートリンカー
EP2913064A1 (en) 2014-02-26 2015-09-02 celares GmbH Branched drug-linker conjugates for the coupling to biological targeting molecules
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
TWI805109B (zh) 2014-08-28 2023-06-11 美商奇諾治療有限公司 對cd19具專一性之抗體及嵌合抗原受體
SI3900742T1 (sl) 2014-09-11 2024-10-30 Seagen Inc. Ciljana dostava zdravilnih snovi, ki vsebujejo terciarne amine
BR112017012342A2 (pt) 2014-12-09 2018-02-27 Abbvie Inc compostos inibitórios de bcl-xl e conjugados de anticorpo-fármaco incluindo os mesmos
KR20160080832A (ko) 2014-12-29 2016-07-08 주식회사 레고켐 바이오사이언스 리피바디 유도체-약물 복합체, 그 제조방법 및 용도
EP3244926B8 (en) * 2015-01-14 2024-08-21 The Brigham and Women's Hospital, Inc. Treatment of cancer with anti-lap monoclonal antibodies
JP6865688B2 (ja) 2015-01-16 2021-04-28 ジュノー セラピューティクス インコーポレイテッド Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体
HUE055644T2 (hu) 2015-01-30 2022-03-28 Sutro Biopharma Inc Hemiasterlin származékok konjugációra és terápiára
US11673957B2 (en) * 2015-03-10 2023-06-13 Eureka Therapeutics, Inc. Anti-ROR2 antibodies
EP3842072A1 (en) * 2015-05-18 2021-06-30 Eureka Therapeutics, Inc. Anti-ror1 antibodies
WO2017051249A1 (en) 2015-09-25 2017-03-30 Legochem Biosciences, Inc. Compositions and methods related to anti-cd19 antibody drug conjugates
WO2017051254A1 (en) 2015-09-25 2017-03-30 Legochem Biosciences, Inc. Compositions and methods related to anti-egfr antibody drug conjugates
IL299203A (en) 2015-10-13 2023-02-01 Eureka Therapeutics Inc ׂ A Delaware Corp Antibody factors specific for human differentiation group 19 and their uses
HRP20240795T1 (hr) 2015-11-25 2024-09-13 Ligachem Biosciences Inc. Konjugati koji se sastoje od samozapaljujućih skupina i postupci povezani s njima
AU2016359234B2 (en) 2015-11-25 2022-09-08 Ligachem Biosciences Inc. Conjugates comprising peptide groups and methods related thereto
KR102847350B1 (ko) 2015-11-25 2025-08-19 주식회사 리가켐바이오사이언스 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
RU2651776C2 (ru) 2015-12-01 2018-04-23 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") Биспецифические антитела против cd3*cd19
SG11201806120WA (en) * 2016-01-20 2018-08-30 Scripps Research Inst Ror1 antibody compositions and related methods
KR102618596B1 (ko) 2016-09-30 2023-12-28 엘지디스플레이 주식회사 터치센서 내장형 표시장치
GB201617466D0 (en) * 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP3535299A1 (en) 2016-11-04 2019-09-11 Novimmune S.A. Anti-cd19 antibodies and methods of use thereof
WO2018119314A1 (en) * 2016-12-22 2018-06-28 Ardeagen Corporation Anti-ror1 antibody and conjugates thereof
SI3579883T1 (sl) 2017-02-08 2021-12-31 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo
MX2019011655A (es) * 2017-03-29 2019-12-19 Legochem Biosciences Inc Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este.
AR113224A1 (es) * 2017-04-28 2020-02-19 Novartis Ag Conjugados de anticuerpo que comprenden un agonista de sting
MX2019015057A (es) * 2017-06-23 2020-08-03 Velosbio Inc Inmunoconjugados de anticuerpos receptor huérfano similar al receptor tirosina cinasa 1 (ror1).
KR20190018400A (ko) 2017-08-14 2019-02-22 주식회사 레고켐 바이오사이언스 EGFRvIII에 대한 항체를 포함하는 항체 약물 접합체
KR102125032B1 (ko) 2017-09-08 2020-06-19 주식회사 와이바이오로직스 인간 dlk1에 대한 항체 및 이의 용도
EP3717021A1 (en) * 2017-11-27 2020-10-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
JP7459063B2 (ja) 2018-05-09 2024-04-01 レゴケム バイオサイエンシズ， インク． 抗－ｃｄ１９抗体薬物複合体に関連する組成物および方法
WO2019225777A1 (ko) * 2018-05-23 2019-11-28 에이비엘바이오 주식회사 항-ror1 항체 및 그 용도
EP3936150A4 (en) 2019-03-06 2023-03-29 LegoChem Biosciences, Inc. ANTIBODY-DRUG CONJUGATES COMPRISING ANTIBODY AGAINST HUMAN DLK1 AND USE THEREOF
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도

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