JP2019501638A5 - - Google Patents
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- Publication number
- JP2019501638A5 JP2019501638A5 JP2018523761A JP2018523761A JP2019501638A5 JP 2019501638 A5 JP2019501638 A5 JP 2019501638A5 JP 2018523761 A JP2018523761 A JP 2018523761A JP 2018523761 A JP2018523761 A JP 2018523761A JP 2019501638 A5 JP2019501638 A5 JP 2019501638A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- nicotinamide
- bacterium
- blocking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 241000894006 Bacteria Species 0.000 claims 10
- 235000020956 nicotinamide riboside Nutrition 0.000 claims 8
- 239000011618 nicotinamide riboside Substances 0.000 claims 8
- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims 6
- 230000000903 blocking effect Effects 0.000 claims 5
- 102000004157 Hydrolases Human genes 0.000 claims 4
- 108090000604 Hydrolases Proteins 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 101150039167 Bex3 gene Proteins 0.000 claims 2
- 101100001013 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) aah1 gene Proteins 0.000 claims 2
- 108030000910 L-aspartate oxidases Proteins 0.000 claims 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- 102100030830 Nicotinate-nucleotide pyrophosphorylase [carboxylating] Human genes 0.000 claims 2
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 2
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 101150052523 nadA gene Proteins 0.000 claims 2
- 101150116541 nadB gene Proteins 0.000 claims 2
- 101150047250 nadC gene Proteins 0.000 claims 2
- 108090000277 nicotinate-nucleotide diphosphorylase (carboxylating) Proteins 0.000 claims 2
- 108700020464 quinolinate synthase Proteins 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000232299 Ralstonia Species 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- -1 nicotinamide mononucleotide amide Chemical class 0.000 claims 1
- JOUIQRNQJGXQDC-ZYUZMQFOSA-L nicotinate D-ribonucleotide(2-) Chemical compound O1[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C([O-])=O)=C1 JOUIQRNQJGXQDC-ZYUZMQFOSA-L 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000000754 repressing effect Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562254736P | 2015-11-13 | 2015-11-13 | |
| US62/254,736 | 2015-11-13 | ||
| PCT/US2016/061905 WO2017083858A2 (en) | 2015-11-13 | 2016-11-14 | Microbial production of nicotinamide riboside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501638A JP2019501638A (ja) | 2019-01-24 |
| JP2019501638A5 true JP2019501638A5 (enExample) | 2019-12-12 |
Family
ID=58695578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018523761A Pending JP2019501638A (ja) | 2015-11-13 | 2016-11-14 | ニコチンアミドリボシドの微生物生産 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10913965B2 (enExample) |
| EP (1) | EP3374492A4 (enExample) |
| JP (1) | JP2019501638A (enExample) |
| KR (1) | KR20180083350A (enExample) |
| CN (1) | CN108473948A (enExample) |
| BR (1) | BR112018009393A8 (enExample) |
| WO (1) | WO2017083858A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10913965B2 (en) * | 2015-11-13 | 2021-02-09 | Dsm Ip Assets B.V. | Microbial production of nicotamide riboside |
| WO2018211028A1 (en) * | 2017-05-18 | 2018-11-22 | Dsm Ip Assets B.V. | Microbial production of nicotinamide riboside |
| KR20230156155A (ko) * | 2017-09-29 | 2023-11-13 | 미쯔비시 케미컬 주식회사 | 니코틴아미드모노뉴클레오티드의 제조 방법 및 그 방법에 사용하는 형질 전환체 |
| EP3877515A1 (en) * | 2018-11-09 | 2021-09-15 | Wageningen Universiteit | Microbial hosts engineered for increased tolerance to temperature shifts |
| JP7684906B2 (ja) * | 2019-10-11 | 2025-05-28 | 国立大学法人静岡大学 | ニコチンアミドリボシドを産生する乳酸菌、並びにニコチンアミドモノヌクレオチド及びニコチンアミドリボシドを産生する乳酸菌 |
| CN113755415B (zh) * | 2020-06-04 | 2024-03-29 | 苏州华赛生物工程技术有限公司 | 一种新的具有nmn合成路径的重组微生物及生产方法 |
| CN112359082B (zh) * | 2020-11-13 | 2023-02-21 | 南京工业大学 | 一种烟酰胺单核苷酸的制备方法 |
| CN112501193B (zh) * | 2020-12-09 | 2022-09-27 | 江南大学 | 一种烟酸及烟酰胺生物传感系统 |
| CN112795582B (zh) * | 2021-01-22 | 2022-12-13 | 江南大学 | 一种适合在微生物中高效合成nad衍生物的酶基因 |
| CN112852678B (zh) * | 2021-03-08 | 2021-11-05 | 泓博元生命科技（深圳）有限公司 | 一株产烟酰胺单核苷酸的成都肠杆菌及其应用 |
| CN112795606B (zh) * | 2021-04-14 | 2021-07-27 | 深圳瑞德林生物技术有限公司 | 一种β-烟酰胺单核苷酸的酶催化合成方法 |
| CN112980906B (zh) * | 2021-04-14 | 2021-07-30 | 深圳瑞德林生物技术有限公司 | 一种用于制备β-烟酰胺单核苷酸的酶组合物及其应用 |
| CN113528562B (zh) * | 2021-06-23 | 2022-08-16 | 苏州华赛生物工程技术有限公司 | 生产β-烟酰胺核糖的重组微生物及其构建方法和应用 |
| CN113897382B (zh) * | 2021-09-01 | 2023-10-20 | 浙江工业大学 | 辅酶自足型大肠杆菌及其构建方法与应用 |
| JP7111878B1 (ja) | 2021-10-27 | 2022-08-02 | 旭化成ファーマ株式会社 | ニコチンアミドモノヌクレオチドの製造方法 |
| CN114231477B (zh) * | 2021-12-27 | 2024-03-15 | 天津科技大学 | 高产β-烟酰胺单核苷酸的基因工程菌株及其构建与应用 |
| CN114854656B (zh) * | 2022-05-05 | 2023-07-18 | 江南大学 | 一种产烟酰胺核糖苷的重组菌 |
| CN116286725B (zh) * | 2023-03-23 | 2025-12-12 | 赛诺根生物科学有限公司 | 一种催化性能提高的nadh焦磷酸酶突变体及其应用 |
| CN118773286B (zh) * | 2024-09-10 | 2025-02-14 | 中国科学院深圳先进技术研究院 | 用于检测qprt活性的组合物、qprt活性的检测方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8114626B2 (en) * | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| CN102154339A (zh) * | 2011-02-16 | 2011-08-17 | 南京工业大学 | 一种产丁二酸大肠杆菌基因工程菌株的构建方法 |
| WO2015069860A1 (en) * | 2013-11-06 | 2015-05-14 | President And Fellows Of Harvard College | Biological production of nad precursors and analogs |
| US10913965B2 (en) * | 2015-11-13 | 2021-02-09 | Dsm Ip Assets B.V. | Microbial production of nicotamide riboside |
-
2016
- 2016-11-14 US US15/774,721 patent/US10913965B2/en not_active Expired - Fee Related
- 2016-11-14 EP EP16865238.6A patent/EP3374492A4/en not_active Withdrawn
- 2016-11-14 BR BR112018009393A patent/BR112018009393A8/pt not_active IP Right Cessation
- 2016-11-14 JP JP2018523761A patent/JP2019501638A/ja active Pending
- 2016-11-14 CN CN201680078334.8A patent/CN108473948A/zh not_active Withdrawn
- 2016-11-14 KR KR1020187015915A patent/KR20180083350A/ko not_active Withdrawn
- 2016-11-14 WO PCT/US2016/061905 patent/WO2017083858A2/en not_active Ceased
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