KR20180083350A - 니코틴아미드 리보시드의 미생물학적 제조 - Google Patents

니코틴아미드 리보시드의 미생물학적 제조 Download PDF

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KR20180083350A
KR20180083350A KR1020187015915A KR20187015915A KR20180083350A KR 20180083350 A KR20180083350 A KR 20180083350A KR 1020187015915 A KR1020187015915 A KR 1020187015915A KR 20187015915 A KR20187015915 A KR 20187015915A KR 20180083350 A KR20180083350 A KR 20180083350A
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gly
val
ile
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아담 지 로렌스
셀리네 비아로게
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디에스엠 아이피 어셋츠 비.브이.
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12P19/00—Preparation of compounds containing saccharide radicals
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    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01022—NAD+ diphosphatase (3.6.1.22)
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    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/01—Acid-ammonia (or amine)ligases (amide synthases)(6.3.1)
    • C12Y603/01005—NAD+ synthase (6.3.1.5)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187015915A 2015-11-13 2016-11-14 니코틴아미드 리보시드의 미생물학적 제조 Withdrawn KR20180083350A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254736P 2015-11-13 2015-11-13
US62/254,736 2015-11-13
PCT/US2016/061905 WO2017083858A2 (en) 2015-11-13 2016-11-14 Microbial production of nicotinamide riboside

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KR20180083350A true KR20180083350A (ko) 2018-07-20

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US (1) US10913965B2 (enExample)
EP (1) EP3374492A4 (enExample)
JP (1) JP2019501638A (enExample)
KR (1) KR20180083350A (enExample)
CN (1) CN108473948A (enExample)
BR (1) BR112018009393A8 (enExample)
WO (1) WO2017083858A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10913965B2 (en) * 2015-11-13 2021-02-09 Dsm Ip Assets B.V. Microbial production of nicotamide riboside
US20200255877A1 (en) * 2017-05-18 2020-08-13 Dsm Ip Assets B.V. Microbial production of nicotinamide riboside
KR20250007638A (ko) 2017-09-29 2025-01-14 미쯔비시 케미컬 주식회사 니코틴아미드모노뉴클레오티드의 제조 방법 및 그 방법에 사용하는 형질 전환체
WO2020094828A1 (en) * 2018-11-09 2020-05-14 Wageningen Universiteit Microbial hosts engineered for increased tolerance to temperature shifts
US20220340945A1 (en) * 2019-10-11 2022-10-27 National Uninversity Corporation Shizuoka University Lactic acid bacteria that produce nicotinamide riboside, and lactic acid bacteria that produce nicotinamide mononucleotide and nicotinamide riboside
CN113755415B (zh) * 2020-06-04 2024-03-29 苏州华赛生物工程技术有限公司 一种新的具有nmn合成路径的重组微生物及生产方法
CN112359082B (zh) * 2020-11-13 2023-02-21 南京工业大学 一种烟酰胺单核苷酸的制备方法
CN112501193B (zh) * 2020-12-09 2022-09-27 江南大学 一种烟酸及烟酰胺生物传感系统
CN112795582B (zh) * 2021-01-22 2022-12-13 江南大学 一种适合在微生物中高效合成nad衍生物的酶基因
CN112852678B (zh) * 2021-03-08 2021-11-05 泓博元生命科技（深圳）有限公司 一株产烟酰胺单核苷酸的成都肠杆菌及其应用
CN112980906B (zh) * 2021-04-14 2021-07-30 深圳瑞德林生物技术有限公司 一种用于制备β-烟酰胺单核苷酸的酶组合物及其应用
CN112795606B (zh) * 2021-04-14 2021-07-27 深圳瑞德林生物技术有限公司 一种β-烟酰胺单核苷酸的酶催化合成方法
CN113528562B (zh) * 2021-06-23 2022-08-16 苏州华赛生物工程技术有限公司 生产β-烟酰胺核糖的重组微生物及其构建方法和应用
CN113897382B (zh) * 2021-09-01 2023-10-20 浙江工业大学 辅酶自足型大肠杆菌及其构建方法与应用
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法
CN114231477B (zh) * 2021-12-27 2024-03-15 天津科技大学 高产β-烟酰胺单核苷酸的基因工程菌株及其构建与应用
CN114854656B (zh) * 2022-05-05 2023-07-18 江南大学 一种产烟酰胺核糖苷的重组菌
CN116286725B (zh) * 2023-03-23 2025-12-12 赛诺根生物科学有限公司 一种催化性能提高的nadh焦磷酸酶突变体及其应用
CN118773286B (zh) * 2024-09-10 2025-02-14 中国科学院深圳先进技术研究院 用于检测qprt活性的组合物、qprt活性的检测方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114626B2 (en) * 2004-02-10 2012-02-14 Trustees Of Dartmouth College Yeast strain and method for using the same to produce nicotinamide riboside
CN102154339A (zh) * 2011-02-16 2011-08-17 南京工业大学 一种产丁二酸大肠杆菌基因工程菌株的构建方法
US20160287621A1 (en) * 2013-11-06 2016-10-06 President And Fellows Of Harvard College Biological production of nad precursors and analogs
US10913965B2 (en) * 2015-11-13 2021-02-09 Dsm Ip Assets B.V. Microbial production of nicotamide riboside

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US10913965B2 (en) 2021-02-09
WO2017083858A2 (en) 2017-05-18
EP3374492A4 (en) 2019-07-24
WO2017083858A3 (en) 2017-06-29
EP3374492A2 (en) 2018-09-19
CN108473948A (zh) 2018-08-31
BR112018009393A2 (pt) 2018-11-13
US20180327797A1 (en) 2018-11-15
JP2019501638A (ja) 2019-01-24
BR112018009393A8 (pt) 2019-02-26

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