JP2019501208A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019501208A5 JP2019501208A5 JP2018541089A JP2018541089A JP2019501208A5 JP 2019501208 A5 JP2019501208 A5 JP 2019501208A5 JP 2018541089 A JP2018541089 A JP 2018541089A JP 2018541089 A JP2018541089 A JP 2018541089A JP 2019501208 A5 JP2019501208 A5 JP 2019501208A5
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- vaccine
- pseudouridine
- thio
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022172576A JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245208P | 2015-10-22 | 2015-10-22 | |
| US201562245031P | 2015-10-22 | 2015-10-22 | |
| US62/245,031 | 2015-10-22 | ||
| US62/245,208 | 2015-10-22 | ||
| US201562247563P | 2015-10-28 | 2015-10-28 | |
| US62/247,563 | 2015-10-28 | ||
| US201562248250P | 2015-10-29 | 2015-10-29 | |
| US62/248,250 | 2015-10-29 | ||
| PCT/US2016/058321 WO2017070622A1 (en) | 2015-10-22 | 2016-10-21 | Respiratory syncytial virus vaccine |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172576A Division JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Division JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501208A JP2019501208A (ja) | 2019-01-17 |
| JP2019501208A5 true JP2019501208A5 (cg-RX-API-DMAC7.html) | 2019-12-05 |
| JP7687767B2 JP7687767B2 (ja) | 2025-06-03 |
Family
ID=58558153
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541089A Active JP7687767B2 (ja) | 2015-10-22 | 2016-10-21 | 呼吸器合胞体ウイルスワクチン |
| JP2022172576A Pending JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Pending JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022172576A Pending JP2023015151A (ja) | 2015-10-22 | 2022-10-27 | 呼吸器合胞体ウイルスワクチン |
| JP2024227631A Pending JP2025041835A (ja) | 2015-10-22 | 2024-12-24 | 呼吸器合胞体ウイルスワクチン |
Country Status (20)
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012116715A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in newborns and infants |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| RS66380B1 (sr) | 2014-04-23 | 2025-02-28 | Modernatx Inc | Vakcine nukleinske kiseline |
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| WO2017020026A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Concatemeric peptide epitopes rnas |
| WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| JP6921833B2 (ja) | 2015-10-22 | 2021-08-18 | モデルナティーエックス， インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
| EP4349405A3 (en) | 2015-10-22 | 2024-06-19 | ModernaTX, Inc. | Respiratory virus vaccines |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| EP3364982A4 (en) | 2015-10-22 | 2019-04-17 | ModernaTX, Inc. | VACCINES AGAINST SEXUALLY TRANSMITTED DISEASES |
| TN2018000152A1 (en) | 2015-10-22 | 2019-10-04 | Modernatx Inc | Nucleic acid vaccines for varicella zoster virus (vzv) |
| WO2017099823A1 (en) | 2015-12-10 | 2017-06-15 | Modernatx, Inc. | Compositions and methods for delivery of therapeutic agents |
| US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
| US11141474B2 (en) * | 2016-05-04 | 2021-10-12 | Curevac Ag | Artificial nucleic acid molecules encoding a norovirus antigen and uses thereof |
| WO2017201342A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| AU2017268394A1 (en) | 2016-05-18 | 2019-01-03 | Modernatx, Inc. | Polynucleotides encoding relaxin |
| CA3036831A1 (en) | 2016-09-14 | 2018-03-22 | Modernatx, Inc. | High purity rna compositions and methods for preparation thereof |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
| EP3538146A4 (en) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | INFLUENZA VACCINE |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| EP3582790A4 (en) | 2017-02-16 | 2020-11-25 | ModernaTX, Inc. | VERY POWERFUL IMMUNOGENIC COMPOSITIONS |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| US11464848B2 (en) | 2017-03-15 | 2022-10-11 | Modernatx, Inc. | Respiratory syncytial virus vaccine |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| MA47790A (fr) | 2017-03-17 | 2021-05-05 | Modernatx Inc | Vaccins à base d'arn contre des maladies zoonotiques |
| EP3607074A4 (en) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| EP3668977A4 (en) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | HPLC ANALYTICAL PROCESSES |
| EP3668971B8 (en) | 2017-08-18 | 2024-05-29 | ModernaTX, Inc. | Rna polymerase variants |
| EP3668979A4 (en) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | METHOD OF HPLC ANALYSIS |
| CA3073211A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| WO2019055807A1 (en) | 2017-09-14 | 2019-03-21 | Modernatx, Inc. | RNA VACCINES AGAINST ZIKA VIRUS |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| EP3768834B1 (en) | 2018-03-19 | 2025-08-13 | CRISPR Therapeutics AG | Novel rna-programmable endonuclease systems and uses thereof |
| EP3775174A4 (en) * | 2018-03-30 | 2022-07-06 | Georgia State University Research Foundation, Inc. | Respiratory syncytial virus (rsv) vaccines |
| DE202019006108U1 (de) * | 2018-04-17 | 2024-12-16 | CureVac SE | Neue RSV-RNA-Moleküle und Zusammensetzungen für die Impfung |
| EP3833382A1 (en) * | 2018-08-07 | 2021-06-16 | GlaxoSmithKline Biologicals S.A. | Processes and vaccines |
| CN112996854B (zh) | 2018-09-19 | 2024-08-30 | 摩登纳特斯有限公司 | 高纯度peg脂质和其用途 |
| EP3852732A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Peg lipids and uses thereof |
| WO2020061457A1 (en) * | 2018-09-20 | 2020-03-26 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| JP7564102B2 (ja) | 2018-11-28 | 2024-10-08 | クリスパー セラピューティクス アクチェンゲゼルシャフト | ＬＮＰでの使用に最適化された、ＣＡＳ９をコードするｍＲＮＡ |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| MA55037A (fr) | 2019-02-20 | 2021-12-29 | Modernatx Inc | Variants d'arn polymérase pour le coiffage co-transcriptionnel |
| JP2022521760A (ja) * | 2019-02-28 | 2022-04-12 | ノババックス，インコーポレイテッド | Ｒｓｖ感染によって引き起こされる疾患又は障害を予防する方法 |
| KR20210149727A (ko) | 2019-03-11 | 2021-12-09 | 모더나티엑스, 인크. | 유가식(fed-batch) 시험관내 전사 공정 |
| SG11202109741VA (en) | 2019-03-12 | 2021-10-28 | Crispr Therapeutics Ag | Novel high fidelity rna-programmable endonuclease systems and uses thereof |
| WO2020190750A1 (en) | 2019-03-15 | 2020-09-24 | Modernatx, Inc. | Hiv rna vaccines |
| CN114957407A (zh) * | 2019-04-02 | 2022-08-30 | 赛诺菲 | 抗原性多聚呼吸道合胞病毒多肽 |
| CN110638759A (zh) * | 2019-10-29 | 2020-01-03 | 珠海丽凡达生物技术有限公司 | 一种用于体外转染和体内递送mRNA的制剂 |
| CN115103682A (zh) * | 2020-01-30 | 2022-09-23 | 摩登纳特斯有限公司 | 呼吸道病毒免疫组合物 |
| KR102813425B1 (ko) | 2020-04-22 | 2025-05-28 | 바이오엔테크 에스이 | 코로나바이러스 백신 |
| CN116322758A (zh) | 2020-05-29 | 2023-06-23 | 库尔维科欧洲股份公司 | 基于核酸的组合疫苗 |
| EP4175967A2 (en) | 2020-07-02 | 2023-05-10 | Life Technologies Corporation | Trinucleotide cap analogs, preparation and uses thereof |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| CN111973563B (zh) * | 2020-09-02 | 2022-06-28 | 崔海港 | 一种鼠李糖脂冻干粉制剂及其制备方法和应用 |
| TW202233232A (zh) | 2020-11-06 | 2022-09-01 | 法商賽諾菲公司 | 遞送mRNA疫苗的脂質奈米顆粒 |
| US12329811B2 (en) | 2021-01-11 | 2025-06-17 | Modernatx, Inc. | Seasonal RNA influenza virus vaccines |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| EP4101928A1 (en) | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| US20240141312A1 (en) | 2021-06-11 | 2024-05-02 | Bayer Aktiengesellschaft | Type v rna programmable endonuclease systems |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| EP4144841A1 (en) | 2021-09-07 | 2023-03-08 | Bayer AG | Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| US20250084391A1 (en) | 2021-12-23 | 2025-03-13 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| EP4469091A1 (en) | 2022-01-28 | 2024-12-04 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| AU2023284048A1 (en) | 2022-06-10 | 2024-11-14 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| CN120153078A (zh) * | 2022-10-27 | 2025-06-13 | 辉瑞大药厂 | 编码rsv-f的rna分子及含所述rna分子的疫苗 |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| CN120752335A (zh) | 2022-12-13 | 2025-10-03 | 拜耳公司 | 工程化v型rna可编程核酸内切酶及其用途 |
| CN120500351A (zh) * | 2023-02-03 | 2025-08-15 | 维纳根有限责任公司 | 呼吸道合胞病毒mRNA疫苗 |
| CN116286672B (zh) * | 2023-02-07 | 2025-01-28 | 金宇保灵生物药品有限公司 | 一种口蹄疫病毒及其应用 |
| CN119137160A (zh) * | 2023-03-02 | 2024-12-13 | 苏州艾博生物科技有限公司 | 呼吸道合胞病毒(rsv)的核酸疫苗 |
| AU2024233180A1 (en) | 2023-03-08 | 2025-09-25 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024194153A1 (en) * | 2023-03-17 | 2024-09-26 | Glaxosmithkline Biologicals Sa | Rsv-f-encoding nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| CN119497628A (zh) * | 2023-06-20 | 2025-02-21 | 石药集团巨石生物制药有限公司 | 一种抵抗呼吸道合胞病毒的mRNA疫苗及其制备方法 |
| WO2024259624A1 (en) * | 2023-06-21 | 2024-12-26 | Shenzhen Genius Biotech Service Co. Ltd | A modified rsv f protein, a nanoparticle, a composition and a vaccine against respiratory syncytial virus infection |
| CN119490569A (zh) * | 2023-08-16 | 2025-02-21 | 深圳瑞吉生物科技有限公司 | 呼吸道合胞病毒抗原性多肽、核酸、疫苗及其应用 |
| CN117487823B (zh) * | 2023-09-28 | 2024-10-29 | 怡道生物科技(苏州)有限公司 | 呼吸道合胞体病毒mRNA疫苗及其制备方法和应用 |
| TW202521691A (zh) | 2023-10-06 | 2025-06-01 | 美商藍岩醫療公司 | 經工程化之v型rna可程式核酸內切酶及其用途 |
| CN120022355A (zh) * | 2023-11-22 | 2025-05-23 | 长春百克生物科技股份公司 | 一种mRNA疫苗及其应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| US6998115B2 (en) | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US7708915B2 (en) | 2004-05-06 | 2010-05-04 | Castor Trevor P | Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein |
| EP2305699B1 (de) | 2001-06-05 | 2014-08-13 | CureVac GmbH | Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose |
| AU2002319668A1 (en) | 2001-07-27 | 2003-02-17 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| US20060051424A1 (en) | 2001-10-03 | 2006-03-09 | Johns Hopkins University | Compositions of oral gene therapy and methods of using same |
| AU2003217531A1 (en) | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| WO2005072710A2 (en) | 2004-01-28 | 2005-08-11 | Johns Hopkins University | Drugs and gene carrier particles that rapidly move through mucous barriers |
| JP2007532629A (ja) | 2004-04-15 | 2007-11-15 | キアスマ， インコーポレイテッド | 生物学的障壁を横切る透過を促進し得る組成物 |
| ES2407979T3 (es) | 2004-12-10 | 2013-06-17 | Kala Pharmaceuticals, Inc. | Copolímeros de bloques de poli(éter-anhídrido) funcionalizados |
| NZ562064A (en) | 2005-04-01 | 2011-03-31 | Intezyne Technologies Inc | Polymeric micelles for drug delivery |
| WO2006110776A2 (en) | 2005-04-12 | 2006-10-19 | Nektar Therapeutics Al, Corporation | Polyethylene glycol cojugates of antimicrobial agents |
| CN101242858B (zh) | 2005-06-16 | 2012-12-19 | 尼克塔治疗公司 | 具有可降解键的轭合物以及用于制备这种轭合物的聚合物试剂 |
| MX2008010841A (es) | 2006-02-21 | 2008-10-27 | Nektar Therapeutics Al Corp | Polimeros degradables segmentados y conjugados hechos de los mismos. |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| US20100215580A1 (en) | 2006-09-08 | 2010-08-26 | The Johns Hopkins University | Compositions and methods for enhancing transport through mucus |
| EP2120859B1 (en) | 2006-12-21 | 2013-11-20 | Stryker Corporation | Sustained-release formulations comprising bmp-7 crystals |
| EA023175B1 (ru) | 2007-09-28 | 2016-05-31 | Бинд Терапьютикс, Инк. | Таргетирование раковых клеток с использованием наночастиц |
| EA020753B1 (ru) | 2008-06-16 | 2015-01-30 | Бинд Терапьютикс, Инк. | Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение |
| HUE047004T2 (hu) | 2008-06-16 | 2020-04-28 | Pfizer | Hatóanyaggal töltött polimer nanorészecskék és eljárások elõállításukra és alkalmazásukra |
| US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
| PT2285350T (pt) | 2008-06-16 | 2018-01-04 | Pfizer | Métodos para a preparação de copolímeros em dibloco funcionalizados com agente de direcionamento para utilização no fabrico de nanopartículas terapêuticas |
| US20100087337A1 (en) | 2008-09-10 | 2010-04-08 | Bind Biosciences, Inc. | High Throughput Fabrication of Nanoparticles |
| PL2355851T3 (pl) | 2008-11-10 | 2018-08-31 | Arbutus Biopharma Corporation | Nowe lipidy i kompozycje do dostarczania środków terapeutycznych |
| JP2012512175A (ja) | 2008-12-15 | 2012-05-31 | バインド バイオサイエンシズ インコーポレイテッド | 治療薬を徐放するための長時間循環性ナノ粒子 |
| EP3243504A1 (en) * | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| JP5622254B2 (ja) | 2009-03-31 | 2014-11-12 | 国立大学法人東京大学 | 二本鎖リボ核酸ポリイオンコンプレックス |
| US8287910B2 (en) | 2009-04-30 | 2012-10-16 | Intezyne Technologies, Inc. | Polymeric micelles for polynucleotide encapsulation |
| CA2816925C (en) | 2009-11-04 | 2023-01-10 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| EP2515942B1 (en) | 2009-12-15 | 2020-02-12 | Pfizer Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
| JP6175237B2 (ja) | 2009-12-15 | 2017-08-02 | ファイザー・インク | コルチコステロイドを含む治療用ポリマーナノ粒およびそれを製造かつ使用する方法 |
| JP5898627B2 (ja) | 2009-12-15 | 2016-04-06 | バインド セラピューティックス インコーポレイテッド | エポチロンを含む治療用ポリマーナノ粒子ならびにそれを製造および使用する方法 |
| PT2525815E (pt) | 2010-01-24 | 2015-03-05 | Novartis Ag | Micropartículas de polímero biodegradável irradiadas |
| US8207290B2 (en) | 2010-03-26 | 2012-06-26 | Cerulean Pharma Inc. | Methods and systems for generating nanoparticles |
| US20110262491A1 (en) | 2010-04-12 | 2011-10-27 | Selecta Biosciences, Inc. | Emulsions and methods of making nanocarriers |
| JP2013531634A (ja) | 2010-05-24 | 2013-08-08 | メルク・シャープ・エンド・ドーム・コーポレイション | オリゴヌクレオチド送達のための新規なアミノアルコールカチオン性脂質 |
| US20130196948A1 (en) | 2010-06-25 | 2013-08-01 | Massachusetts Insitute Of Technology | Polymers for biomaterials and therapeutics |
| PL2590626T3 (pl) * | 2010-07-06 | 2016-04-29 | Glaxosmithkline Biologicals Sa | Liposomy z lipidami o korzystnej wartości pka do dostarczania rna |
| SI2590676T1 (sl) * | 2010-07-06 | 2016-11-30 | Glaxosmithkline Biologicals, S.A. | Virionu podobni delci za dajanje za samorepliciranje RNA molekul |
| ES2586580T3 (es) * | 2010-07-06 | 2016-10-17 | Glaxosmithkline Biologicals Sa | Inmunización de mamíferos grandes con dosis bajas de ARN |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| US20150056300A1 (en) | 2010-10-22 | 2015-02-26 | Bind Therapeutics, Inc. | Therapeutic nanoparticles with high molecular weight copolymers |
| AU2011323250B2 (en) | 2010-11-05 | 2015-11-19 | The Johns Hopkins University | Compositions and methods relating to reduced mucoadhesion |
| US20120189700A1 (en) | 2011-01-19 | 2012-07-26 | Zoraida Aguilar | Nanoparticle Based Immunological Stimulation |
| WO2012109121A1 (en) | 2011-02-07 | 2012-08-16 | Purdue Research Foundation | Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide |
| WO2012131104A2 (en) | 2011-03-31 | 2012-10-04 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| EP2691078A1 (en) | 2011-03-31 | 2014-02-05 | Ingell Technologies Holding B.V. | Biodegradable compositions suitable for controlled release |
| US8691750B2 (en) | 2011-05-17 | 2014-04-08 | Axolabs Gmbh | Lipids and compositions for intracellular delivery of biologically active compounds |
| WO2012166923A2 (en) | 2011-05-31 | 2012-12-06 | Bind Biosciences | Drug loaded polymeric nanoparticles and methods of making and using same |
| MX350258B (es) * | 2011-07-06 | 2017-08-31 | Novartis Ag | Emulsiones cationicas de aceite en agua. |
| SG10201605537XA (en) * | 2011-07-06 | 2016-09-29 | Novartis Ag | Liposomes having useful n:p ratio for delivery of rna molecules |
| EP2734184B1 (en) | 2011-07-21 | 2018-03-28 | Croda International Plc | Branched polyether-polyamide block copolymers and methods of making and using the same |
| HK1199736A1 (en) | 2011-08-26 | 2015-07-17 | 箭头研究公司 | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| CN103930135A (zh) | 2011-08-31 | 2014-07-16 | 马林克罗特有限公司 | 使用h-膦酸酯的纳米颗粒peg修饰 |
| US20150017245A1 (en) | 2011-09-22 | 2015-01-15 | Bind Therapeutics, Inc. | Methods of treating cancers with therapeutic nanoparticles |
| US9375388B2 (en) | 2011-09-23 | 2016-06-28 | Indian Institute Of Technology, Bombay | Nanoparticle based cosmetic composition |
| DK2768958T3 (da) | 2011-10-18 | 2019-09-16 | Dicerna Pharmaceuticals Inc | Kationiske aminlipider og anvendelser deraf |
| EP4074694A1 (en) | 2011-10-27 | 2022-10-19 | Massachusetts Institute Of Technology | Amino acid-, peptide- an polypeptide-lipids, isomers, compositions, an uses thereof |
| WO2013078199A2 (en) | 2011-11-23 | 2013-05-30 | Children's Medical Center Corporation | Methods for enhanced in vivo delivery of synthetic, modified rnas |
| SMT202200355T1 (it) | 2011-12-16 | 2022-11-18 | Modernatx Inc | Composizioni di mrna modificato |
| CA2863632C (en) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| JP6182159B2 (ja) | 2012-02-03 | 2017-08-16 | ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー | フェノール性単量体から誘導された高分子生体材料およびその医療用途 |
| WO2013120052A1 (en) | 2012-02-10 | 2013-08-15 | E. I. Du Pont De Nemours And Company | Preparation, purification and use of high-x diblock copolymers |
| EP2834260A4 (en) * | 2012-04-02 | 2016-08-10 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS |
| US10245229B2 (en) * | 2012-06-08 | 2019-04-02 | Translate Bio, Inc. | Pulmonary delivery of mRNA to non-lung target cells |
| WO2014089486A1 (en) * | 2012-12-07 | 2014-06-12 | Shire Human Genetic Therapies, Inc. | Lipidic nanoparticles for mrna delivering |
| DK2970398T3 (da) * | 2013-03-13 | 2024-08-05 | Us Health | Præfusions-rsv-f-proteiner og anvendelse deraf |
| US9738689B2 (en) * | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| PL2970456T3 (pl) * | 2013-03-14 | 2022-01-31 | Translate Bio, Inc. | Sposoby i kompozycje do dostarczania przeciwciał kodowanych mrna |
| PL4332576T3 (pl) * | 2013-03-15 | 2025-09-08 | Translate Bio, Inc. | Synergistyczne wzmocnienie dostarczania kwasów nukleinowych poprzez formulacje zmieszane |
| US10590161B2 (en) | 2013-03-15 | 2020-03-17 | Modernatx, Inc. | Ion exchange purification of mRNA |
| EP2971165A4 (en) | 2013-03-15 | 2016-11-23 | Moderna Therapeutics Inc | DISSOLUTION OF DNA FRAGMENTS IN MRNA MANUFACTURING METHODS |
| US20160017313A1 (en) | 2013-03-15 | 2016-01-21 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
| EP4279610A3 (en) | 2013-03-15 | 2024-01-03 | ModernaTX, Inc. | Ribonucleic acid purification |
| US10138507B2 (en) | 2013-03-15 | 2018-11-27 | Modernatx, Inc. | Manufacturing methods for production of RNA transcripts |
| WO2014144039A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
| TW201534578A (zh) * | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| JP6685903B2 (ja) * | 2013-07-25 | 2020-04-22 | アバター・メディカル・エルエルシー | 立体構造的に安定化されたｒｓｖ融合前ｆタンパク質 |
| ES2747762T3 (es) * | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
-
2016
- 2016-10-21 JP JP2018541089A patent/JP7687767B2/ja active Active
- 2016-10-21 MA MA046317A patent/MA46317A/fr unknown
- 2016-10-21 TW TW105134193A patent/TW201729836A/zh unknown
- 2016-10-21 EA EA201891000A patent/EA201891000A1/ru unknown
- 2016-10-21 BR BR112018008102A patent/BR112018008102A2/pt not_active Application Discontinuation
- 2016-10-21 EP EP16858402.7A patent/EP3365008A4/en active Pending
- 2016-10-21 KR KR1020187014339A patent/KR20180096592A/ko not_active Withdrawn
- 2016-10-21 WO PCT/US2016/058321 patent/WO2017070622A1/en not_active Ceased
- 2016-10-21 SG SG10201914006UA patent/SG10201914006UA/en unknown
- 2016-10-21 CA CA3002820A patent/CA3002820A1/en active Pending
- 2016-10-21 MX MX2018004917A patent/MX2018004917A/es unknown
- 2016-10-21 PE PE2018000599A patent/PE20181530A1/es unknown
- 2016-10-21 AU AU2016341311A patent/AU2016341311B2/en not_active Expired - Fee Related
- 2016-10-21 TN TNP/2018/000154A patent/TN2018000154A1/en unknown
- 2016-10-21 CN CN201680075062.6A patent/CN108472354A/zh active Pending
- 2016-10-21 SG SG11201803363YA patent/SG11201803363YA/en unknown
- 2016-10-21 US US15/767,613 patent/US20180271970A1/en not_active Abandoned
-
2018
- 2018-04-20 CL CL2018001053A patent/CL2018001053A1/es unknown
- 2018-04-20 PH PH12018500856A patent/PH12018500856A1/en unknown
- 2018-04-22 IL IL258831A patent/IL258831A/en unknown
- 2018-05-18 CO CONC2018/0005229A patent/CO2018005229A2/es unknown
-
2022
- 2022-10-27 JP JP2022172576A patent/JP2023015151A/ja active Pending
-
2023
- 2023-05-10 US US18/314,980 patent/US20230390379A1/en active Pending
-
2024
- 2024-12-24 JP JP2024227631A patent/JP2025041835A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019501208A5 (cg-RX-API-DMAC7.html) | ||
| US12240873B2 (en) | Respiratory syncytial virus (RSV) vaccine | |
| US11964010B2 (en) | Prefusion coronavirus spike proteins and their use | |
| JP2018536023A5 (cg-RX-API-DMAC7.html) | ||
| JP2018531996A5 (cg-RX-API-DMAC7.html) | ||
| JP2019535665A5 (cg-RX-API-DMAC7.html) | ||
| JP2021504445A5 (cg-RX-API-DMAC7.html) | ||
| RU2018118337A (ru) | Вакцина против вируса гриппа широкого спектра действия | |
| US10751407B2 (en) | PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof | |
| RU2016145597A (ru) | Вакцины на основе нуклеиновых кислот | |
| WO2014134439A1 (en) | Immunogenic composition for mers coronavirus infection | |
| WO2019092002A1 (en) | Pharmaceutical compositions for treatment or prevention of viral infections | |
| US11274282B2 (en) | Vesicular stomatitis vectors encoding Crimean-Congo hemorrhagic fever antigen | |
| IL293666A (en) | Mumps and measles virus immunogens and their use | |
| EP3035960B1 (en) | Respiratory syncytial virus (rsv) vaccine | |
| CA3130956A1 (en) | Novel vaccine effective to prevent infection by sars-cov variants | |
| US20230364220A1 (en) | SAR-COV-2 DNA Vaccine and Method of Administering Thereof | |
| WO2024073552A2 (en) | Combination exosomal immunogenic compositions and methods | |
| WO2024249651A2 (en) | Sars cov-2 vaccines, associated polynucleotides, and methods of use | |
| CN119264229A (zh) | 基于SARS-CoV-2的不同奥密克戎变异型的S蛋白的疫苗和组合物 | |
| HK40057100A (en) | Prrsv minor protein-containing recombinant viral vectors and methods of making and use thereof | |
| CN120359299A (zh) | 一种广谱流感mRNA疫苗 | |
| Tachibana et al. | 666. Type-I IFN Signaling Is Required for the Induction of Antigen-Specific CD8+ T Cell Responses by Adenovirus Vector Vaccine in the Gut-Mucosal Compartment | |
| EA041575B1 (ru) | Рекомбинантные вирусные векторы, содержащие минорные белки prrsv, и способы их получения и применения |